• Title/Summary/Keyword: biologics

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Culture of rabbit chondrocytes on the HA-agarose scaffold for artificial cartilage

  • Hong, Sung-Ran;Nguyen, Lan-Anh;Kwon, O-Hee;Shin, In-Soo;Kim, Soon-Nam;Man, Choong-Hong;Lee, Ki-Hong;Oh, Ho-Jung;Yoo, Si-Hyung;Kang, Hye-Na;Choi, Seoung-Eun;Lee, Seok-Ho;Hong, Seoung-Hwa;Lee, Young-Moo
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.366.1-366.1
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    • 2002
  • Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defective site to initiate de novo tissue regeneration. In this respect. the availability of an appropriate biomaterial scaffold is crucial to allow chondrocyte growth and cartilaginous matrix deposition in a three-dimensional geometry. Hyaluronic acid (HA) molecules are anchored to the chondrocyte membrane via receptors, such as CD44. (omitted)

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A Collaborative Study to Establish a Korea National Biological Standard for Antithrombin III Concentrate

  • Kang, Hye-Na;Oh, Ho-Jung;Kim, Soon-Nam;Hong, Choong-Man;Lee, Ki-Hong;Yoo, Si-Hyung;Shin, In-Soo;Choi, Seung-Eun;Lee, Seok-Ho
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.149.2-149.2
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    • 2003
  • We have carried out a collaborative study to evaluate a candidate preparation of antithrombin III concentrate whether it is suitable to serve as a Korea National Biological Standard. Three National Control Laboratories and three manufacturers participated in this study. The potency of this candidate preparation was determined by using a heparin cofactor chromogenic method described in the Minimum Requirements for Biological Products and the European Phamacopoeia. (omitted)

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A study on the evaluation of artificial cartilage using synthetic biodegradable polymers

  • Oh, Ho-Jung;Lee, Nam-Kyung;Kim, Soon-Nam;Hong, Choong-Man;Lee, Ki-Hong;Yoo, Si-Hyung;Shin, In-Soo;Lim, Jae-Hyun;Choi, Seung-Eun
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.100.1-100.1
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    • 2003
  • Tissue engineering has arisen to address the extreme shortage of tissues and organs for transplantation and repair. One of the most successful techniques has been the seeding and culturing cells on three-dimensional biodegradable scaffolds in vitro followed by implantaion in vivo. We used PLA and PLGA as biodegradable polymers and rabbit chondrocytes were isolated and applied to PLA and PLGA to make artificial cartilage. To evaluate the biocompatibility and biological safety of polymers, in vitro cytotoxicity and in vivo animal tests were investigated. (omitted)

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A NAT for reliable HCV RNA detection from plasma and plasma-derived medicinal products

  • Yoo, Si-Hyung;Jung, Sa-Rah;Park, Su-Jin;Kim, Sun-Nam;Hong, Choong-Man;Lee, Ki-Hong;Oh, Ho-Jung;Kang, Hye-Na;Shin, In-Soo;Choi, Seoung-Eun;Hong, Sung-Ran;Lee, Seok-Ho;Hong, Seung-Hwa
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.300.2-301
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    • 2002
  • HCV is transmitted via various plasma-derived medicinal products. The transmission of HCV could. however, be prevented by screening plasma pools with NAT and validating HCV viral clearance during the manufacturing of plasma derivatives, Although various screening methods including commercial kits are available. it is yet to develop an analytical method to detect HCV in both plasma and plasma derivatives. The objective of this study was to develop a reliable in house method for reliable for the HCV RNA detection from plasma and plasma derivatives. (omitted)

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