Culture of rabbit chondrocytes on the HA-agarose scaffold for artificial cartilage

  • Hong, Sung-Ran (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administration) ;
  • Nguyen, Lan-Anh (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Kwon, O-Hee (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Shin, In-Soo (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Kim, Soon-Nam (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Man, Choong-Hong (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Lee, Ki-Hong (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Oh, Ho-Jung (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administratio) ;
  • Yoo, Si-Hyung (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administration) ;
  • Kang, Hye-Na (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administration) ;
  • Choi, Seoung-Eun (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administration) ;
  • Lee, Seok-Ho (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administration) ;
  • Hong, Seoung-Hwa (Blood products division, Biologics Evaluation Department. Korea Food and Drug Administration) ;
  • Lee, Young-Moo (School of Chemical Engineering, Hanyang University)
  • Published : 2002.10.01

Abstract

Emerging medical technologies for effective and lasting repair of articular cartilage include delivery of cells or cell-seeded scaffolds to a defective site to initiate de novo tissue regeneration. In this respect. the availability of an appropriate biomaterial scaffold is crucial to allow chondrocyte growth and cartilaginous matrix deposition in a three-dimensional geometry. Hyaluronic acid (HA) molecules are anchored to the chondrocyte membrane via receptors, such as CD44. (omitted)

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