• 대한의용생체공학회:의공학회지
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• 제17권2호
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• pp.227-234
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• 1996

This paper is the study of the diffusion constant in order to calculate the percent oxygenation and percent blood volume using reflectance light within biological tissue. The diffusion constant play major role in percent oxygenation and percent blood volume and varies with the biological material such as hemolyzed blood, whole blood, dermis and epidermis in vivo tissue. The diffusion constant can be modeled to consist of a contribution from bloodless tissue and blood present in tissue. The reflectance light for experimental are red light of 660nm, infrared light of 880nm, green light of 569nm. The correlation between the diffusion constant and biological tissue was analyzed by the intensity of reflectance light at different depth within human limb. The reflectance light was changed in response to physiological changes within biological tissue. The data for diffusion constant were obtained at different depth beneath the surface of the skin and will be utilized to amen the percent oxygenation and percent blood volume.

• 대한의용생체공학회:의공학회지
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• 제14권3호
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• pp.273-282
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• 1993

This study is concerned with the temperature dependence characteristics of ultrasound parameters in biological tissues, which are basic on the noninvasive deep body temperature estimation. Used parameters are ultrasonic attenuation coefficient and sound velocity In order to accomplishment our purpose, several signal processing methods were used. Attenua4iorl coefficient was estimated by spectral difference method and sound velocity was estimated by P-P method. And we also examined these methods through a series of IN VITRO experi mentis that used tissue-mimicking phantom samples and biological tissue samples. In order to imitate the biological soft tissue two kinds of phantom samples are used, one is agar phantom sample which is composed of agar, graphite, N-propyl alcohol and distilled water, and the other is fat phantom sample which is composed of pure animal fat. And the ultrasound transmission mode and reflection mode experiments are performed on the pig's spleen, kidney and fat. As a result, it is found that the temperature characteristics are uniform in case of phan- tom samples but not in biological tissues because of complicate wave propagation within them. Consequently, the possibility of temperature measurement using ultrasound on biological tissue is confirmed and its results may contribute to the establishment of reference values of internal temperature measurement of biological tissues.

• 대한의용생체공학회:의공학회지
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• 제20권2호
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• pp.199-204
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• 1999

생체조직내의 정확한 광선량 측정이 PDT 치료의 효과에 중요한 영향을 주므로 본 연구에서는 광선량 측정을 위해서 Monte Carlo 시뮬레이션을 이용하였다. 실험에 사용한 계수는 실제 생체조직의 광학계수이고 위상함수는 Henyey-Greenstein 위상함수를 사용하였다. 결과는 깊이에 따른 Fluency rate의 변화로 나타내었으며 기존 이론과의 차이는 0.35%에 지나지 않았다. 실험에 사용한 생체조직은 인체조직, 돼지조직, 쥐간조직, 토기근육조직이다. 대부분의 생체조직은 가시광선영역에서 큰 산란계수를 가지고 있으며 이것은 투과도에 큰 영향을 미치는 것으로 밝혀졌다. 가시광선 영역에서 인체조직의 투과 깊이는 1.5~2cm이었다. Monte Carlo 시뮬레이션을 이용하여 생체조직내의 광전파(light propagation), 광선량(light dosimetry), 에너지율(fluence rate), 투과깊이(penetration depth)를 효과적으로 측정할 수 있음을 보여주었다.

• 대한기계학회논문집B
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• 제41권5호
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• pp.303-309
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• 2017

본 연구에서는 비정상조직(파라핀)을 가진 생체조직에 광을 조사하고 그에 따른 조직의 표면온도와 비정상조직 주위에서의 온도분포를 실험과 해석적 방법을 통해 분석하였다. 파라핀을 이용하여 비정상 조직을 모사한 후 조사하는 광의 파장과 시간을 변화시키면서 조직 주위에서의 온도를 K형 열전대를 사용하여 측정하였다. 또한 전산열전달 기법을 이용하여 해석적으로 조직에 대한 온도분포를 예측하였다. 정상조직과 비정상조직의 주위에서의 온도는 차이가 있었으며, 비정상조직이 있는 경우 표면과 조직 주위의 온도가 높게 나타났다.

• Journal of Microbiology and Biotechnology
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• 제27권6호
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• pp.1180-1188
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• 2017

Neuronatin (NNAT) is known to regulate ion channels during brain development and plays a role in maintaining the structure of the nervous system. A previous in silico analysis showed that Nnat was overexpressed in the adipose tissue of an obese rodent model relative to the wild type. Therefore, the aim of the present study was to investigate the function of Nnat in the adipose tissue. Because obesity is known to systemically induce low-grade inflammation, the Nnat expression level was examined in the adipose tissue obtained from C57BL/6 mice administered lipopolysaccharide (LPS). Unexpectedly, the Nnat expression level decreased in the white adipose tissue after LPS administration. To determine the role of NNAT in inflammation, 3T3-L1 cells overexpressing Nnat were treated with LPS. The level of the p65 subunit of nuclear factor-kappa B ($NF-{\kappa}B$) and the activity of $NF-{\kappa}B$ luciferase decreased following LPS treatment. These results indicate that NNAT plays an anti-inflammatory role in the adipose tissue.

• 대한의용생체공학회:의공학회지
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• 제5권1호
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• pp.39-46
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• 1984

In order to improve the performance of ultrasonic diagnostic equipment, it is important to development the signal processing considering the ultrasonic properties of biological medium and propagation mechanism in tissue. Attenuation coefficient is not only important factor to analyze propagation properties, but also it is significant to estimate it in view of tissue characterization, so we show one of the method to estimate attenuation coefficient of biological tissue and the results of estimation.

• 한국식물학회:학술대회논문집
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• 한국식물학회 2002년도 춘계학술발표대회:발표눈문요지록
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• pp.86-86
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• 2002

• 한국기계기술학회지
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• 제20권6호
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• pp.770-775
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• 2018

In this study, the characteristics of muscle relaxation were analyzed by the experimental and numerical method. A skin tissue was produced by imitational biological tissue using the agar powder, saline solution and sugar. The tissue was exposed to three types of wavelength-blue visible radiation(410 nm), red visible radiation(635 nm), and infrared ray(830 nm). The temperature results along the depth of tissue were measured according to the variation of light wavelength and irradiation time. The temperature change of the tissue shown up similar pattern regardless of the light wavelength kinds. The wavelength of infrared ray penetrated strongly into tissue between 3.2 mm and 11.4 mm. Also, the temperature change with the irradiation time was small, and the temperature value of the infrared ray was the largest. As a result, the muscle relaxation will occur mainly at the infrared wavelength.

• 대한전자공학회논문지
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• 제25권6호
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• pp.654-662
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• 1988

A simple and useful model of light distribution for the biologhical tissue to the Gaussian beam is proposed. This model assumes that the incident Gaussian beam broadens into two Gaussian beams, travelling in the opposite directions as the result of both isotropic scattering and absorption in the tissue. With this assumption, two-dimensional light intensity of each flux as well as the equations of both absorption and scattering have been derived, and the validity of modeling has been confirmed experimentally. Consequently, the results paved a way for easy evaluation of the light distribution in the biological tissue.

• Molecules and Cells
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• 제41권10호
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• pp.900-908
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• 2018

Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) ${\gamma}$. Although TZDs are synthetic ligands for $PPAR{\gamma}$, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.