• Journal of Life Science
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• v.12 no.1
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• pp.33-42
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• 2002

In several species, a short period of ischemic preconditioning protects the heart by reducing the size of infarcts resulting from subsequent prolonged bouts of ischemia. The mechanism by which activation of ATP-sensitive $K^+$($K_ATP$) channels could provide the memory associated with ischemic preconditioning is still under debate. Several signal transduction pathways have been implicated in the mechanisms of protection induced by ischemic preconditioning. The exact receptor-coupled pathways involved in preconditioning remain to be identified. Likely extracellular agonists are those whose circulating levels increase under conditions that activate $K_ATP$ channels; these conditions include ischemia and ischemic preconditioning. Potential physiological agonists include the following: (1) nitric oxide; (2) catecholamine; (3) adenosine; (4) acetylcholine; (5) bradykinin and (6) prostacycline. The purpose of this review was to understand the mechanism by which biological signal transduction mechanism acts as a link in one or more known receptor-mediated pathways to increase $K_ATP$ channel activity during ischemic preconditioning.

• Journal of Biomedical Engineering Research
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• v.14 no.4
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• pp.387-396
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• 1993

In this paper, a laryngeal function identification system based-on the EGG signal is proposed as the decision basis whether the laryngeal function is normal or abnormal. The normal EGG signal is approved an autoregressive model which has the optimal order of 9. It can be analized by determining the transfer function. But it is not meaningful that the determi- nation is made using the transfer function of an autoregressive model on the abnormal EGG signal. The power spectral analysis was applied to discriminate the normal or abnormal cases. The SNR of the EGG signal was enhanced by the optimal position of electrodes.

• Journal of Biomedical Engineering Research
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• v.28 no.1
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• pp.24-28
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• 2007

Presuming that firing neurons have motions inside the MRI magnet due to the interaction between the neuronal magnetic field and the main magnetic field, we applied motion encoding gradients to dissected snail ganglia to observe faster responding MRI signal than the BOLD signal. To activate the snail ganglia in synchronization with the MRI pulse sequence, we used electrical stimulation with the frequency of 30 Hz and the pulse width of 2s. To observe the fast responding signal, we used the volume selected MRI sequence. The magnetic resonance signal intensity, measured with 8 ms long motion encoding gradient with a 20mT/m gradient strength, decreased about $3.46{\pm}1.48%$ when the ganglia were activated by the electrical stimulation.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.12
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• pp.81-84
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• 1994

A clinically oriented EEG and EP mapping system was developed with user-friendly interface and easy interactive operations. The system was based on the graphical user interface developed with C/C++ and Software Development Kit (SDK) operated under Microsoft Windows 3.1. Continuous acquisition for the EEG signal and burst mode acquisition for EEG signal syncronized to the external stimuli arc implemented with real time display. A neural network based automatic artifact discrimation is developed and implemented with which examination time can be reduced by a factor of 3 or more. Several bands of spectral maps and spectrums arc displayed for EEG diagnosis. Amplitude maps of EP signal at specified times by operator are displayed together with cine mode of EP maps for dynamic study. Source localization and other statistical signal processing are also included.

• Proceedings of the KOSOMBE Conference
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• v.1994 no.12
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• pp.124-127
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• 1994

A technique based on bispectrun averaging is described for generally recovering the signal waveform from a set of noisy signals with variable signal delay. The technique does not require explicit tune alignment of signals and any initial estimate of signal. The new method is suggested and is compared with other methods. This method are numerically investigated using computer generated-data and a physiological signal and noise Some experimental results for the evoked potential studios that demonstrate the technique are given. The results show the effectiveness of the technique: various potential applications of the technique might be expected.

• Proceedings of the KOSOMBE Conference
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• v.1985 no.06
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• pp.15-19
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• 1985

This study deals with a kind of signal processing, Kalman filtering techniques, which are applied to ultrasound signal to improve resolution capability. The main advantage of Kalman filter algorithm for the analysis of reflected ultrasound signal is its recursive structure which can be easily adapted to time-varing system. In state-space description of the system, the 6th order system produces the best spectral approximation to the source pulse. As a result of spectrum analysis, 6th order estimator for two closely spaced (0.5mm) reflectors enhance resolution by 4dB - 10dB. By using this result, the possibility to detect even minute tumor is found.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.83-86
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• 1997

To provide ameliorated aided environment to hearing impaired listeners, background noise reduction techniques are investigated as a front-end of conventional hearing aids, and their effects are tested in a subjective manner. Several speech enhancement schemes were implemented and preference tests or normal listeners are performed to select the best possible scheme or hearing impaired listeners. Results indicated that SDT scores without the speech enhancement scheme drop more sharply as SNR decreases than those with the speech enhancement techniques. SDT scores obtained or hearing impaired listeners with hearing aids showed large variability. However, all impaired listeners preferred noise suppressed sounds to unsuppressed ones.

• Proceedings of the KOSOMBE Conference
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• v.1998 no.11
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• pp.68-69
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• 1998

Discriminating the clutter signal from Doppler signal is the main function of CDP(color Doppler processor). Up to now, a general method of eliminating clutter signal is using IIR high pass filter. There are many filters that were introduced in other paper. In this paper, we propose the new method of filtering clutter signal. To the new method, we adopt an appropriate filter that can eliminate clutter filter most effectively.

• Archives of Pharmacal Research
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• v.21 no.5
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• pp.487-495
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• 1998

Gorwth factors such as TGF-beta, PDGF and FGF are thought to play important roles in wound healing. However, thier biological activity and signal transduction during wound repair remain poorly understood. Growth factors are often ligands for receptor tyrosine kinase and receptor serine/threonine kinases. With recent advances in signal transduction by receptor kinases, we are beginning to understand the underlying mechanism of how growth factors may regulate cutaneous wound repair. In this paper, we will describe the pharmacological effects of growth factors on wound healing, and dscuss the potential underlying signaing mechanisms. thus, we hope to provide the basis for designing more specific therapeutics for wound healing in the near future.

• Journal of Biomedical Engineering Research
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• v.7 no.1
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• pp.21-34
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• 1986

In this paper, we described the ECG telemetry system via the Public Telephone Line. The system consist of a signal acquisition and measurement section, a signal processing section, and a signal transmission section. It used 8 bits microprocessor. The transmission section is composed of 3 ch. analog modulators and 1 ct. digital modem. Especially, using the digital modem, signal is transmitted with about 50n data reduction ratio by the TP (Turning Point) algorithm. The acoustic coupler or inductive coil for linking the public telephone line are used. The speed of the digital modem is 300 baud rate. The MCBS (Multi Channel Biotelemetry System) is tested and evaluated through the experiment.