• Animal cells and systems
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• v.7 no.1
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• pp.81-87
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• 2003

While screening proteins that interact with DnaA protein, the initiator protein for Escherichia coil chromosomal DNA replication, we found a 52-kD sized protein which bound to DnaA protein in a salt-dependent manner. This protein was identified as trigger factor, a ribosome-associated peptidyl-prolyl- cisltrans isomerase with chaperone activity. Trigger factor was overproduced and purified to near homogeneity, and its effect on the function of DnaA protein was examined, Enhanced binding of DnaA protein to DnaA box with no apparent supershift in the gel-shift experiments suggested that trigger factor, by virtue of its chaperone activity, exerts a change on DnaA protein thus increasing its binding affinity for DnaA box.

• Korean Journal of Soil Science and Fertilizer
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• v.47 no.6
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• pp.518-524
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• 2014

Heavy metal pollution in agricultural field near at the abandoned metal mines has been a critical issue in Korea. In particular, bioaccumulation in plants can have detrimental effect on human health. Main objective of this research was to examine arsenic (As) concentration in soil with varied extraction methods and to determine bioaccumulation and biological transfer factor in different crops. Results showed that bioaccumulation ratio of As for total contents in soil was ordered leafy and stem vegetables (1.19%) > fruit bearing vegetables (0.79%) > pulses (0.40%) > root vegetables (0.36%) with different crop species. Among 6 different extraction methods, all of extraction methods showed high correlation ($R^2=0.87-0.97$) except DTPA ($R^2=0.25$) when comparing As concentration in soil extracted with different extractants and As concentration in each crops. Calculated biological transfer factor was ranged 0.002-0.018 depending on crop species. Overall, concentration of As in crops can be varied and best management practice for minimizing bioaccumulation of As should be considered depending on crop species.

• Molecules and Cells
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• v.20 no.3
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• pp.364-370
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• 2005

We show that sulforaphane inhibits osteoclastogenesis in the presence of macrophage colony-stimulating factor (M-CSF) and receptor for activation of nuclear factor-${\kappa}B$ ligand (RANKL) in osteoclast (OC) precursors. Sulforaphane, an aliphatic isothiocyanate, is a known cancer chemo-preventative agent with anti-oxidative properties. Nuclear factor-${\kappa}B$ (NF-${\kappa}B$) is a critical transcription factor in RANKL-induced osteoclastogenesis, and electrophoretic mobility shift assays (EMSAs) and assay of NF-${\kappa}B$-mediated secreted alkaline phosphatase (SEAP) revealed that sulforaphane selectively inhibited NF-${\kappa}B$ activation induced by RANKL. Inhibition may involve interaction of sulforaphane with thiol groups, since it was prevented by reducing agents.

• Environmental Mutagens and Carcinogens
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• v.21 no.2
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• pp.106-112
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• 2001

In view of the effect of factor Ⅶ as a risk factor for essential hypertension, we investigated the length (I/D) polymorphism at position 323 promoter region and exon 8-Msp I RFLP of the human factor Ⅶ gene in the Korean patients with essential hypertension and normal controls. There were no significant differences in the allele, genotype and haplotype frequencies of these polymorphisms between normotensive and essential hypertensive subjects. The significant linkage disequilibrium was however, detected between two polymorphic sites. The Msp I RFLP and I/D polymorphism were also significantly associated with plasma triglyceride (TG) levels. Therefore, our results suggest that the significant association between two genetic variations in the human factor Ⅶ gene and plasma TG level may reflect the potential role of human factor Ⅶ gene as one of the genetic components for cardiovascular risk.

• Journal of Korean Society on Water Environment
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• v.27 no.2
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• pp.218-227
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• 2011

The objective approach for assessment of stream naturalness is an essential part of the stream restoration project. This study proposes the methodology for the assessment of stream naturalness considering physical, biological and chemical factors. Physical factors consists of riffle and pool, river bed material, bank protection, floodplain vegetation and levee materials; biological factors are benthic macroinvertebrate, KSI (Korean Saprobic Index), and IBI (Index of Biological Integrity) and chemical factors are pH, DO (dissolved oxygen), and TP (total phosphorus). This procedure is applied to the Mokgamcheon. As a result, the downstream of Mokgamcheon (zone I) needs the prompt improvement of stream naturalness, compared to the others (zone II and III). This evaluation technique will be an effective tool to quantify the stream naturalness and can be used to set the target of stream restoration project.

• Journal of Korean Society of Water and Wastewater
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• v.20 no.6
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• pp.837-848
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• 2006

This paper presents the test results of biological aerated filtration(BAF) process to replace activated sludge process by enhancing treated effluent quality and reducing the costs. In BAF process both BOD and SS compounds in wastewater are degraded and removed by biological reaction and filtration. Upflow BAF with expanded polypropylene media and downflow BAF with ceramic media were used to investigate the effects of hydraulic and organic loads on effluent quality. As a result, in BAF processes which has different media, upflow BAF reactor shows 5% higher efficiency than downflow BAF and this phenomena caused by backwashing methods and operational conditions. The results of influence factors analyzed by Factor Analysis Method in BOD and SS treatment efficiency are the size of media, hight of media bed and type of media. The quantitative effects of media size are 5.73% in TBOD, 5.78% in SBOD and 7.65% in TSS, so we confirmed the main factor is media size.

• Journal of applied mathematics & informatics
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• v.40 no.3_4
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• pp.515-530
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• 2022

A factor graph and belief propagation can be used for finding stochastic values of link weights in biological networks. However it is not easy to follow the process of use and so we presented the process with a toy network of three nodes in our prior work. We extend this work more generally and present numerical example for a network of 100 nodes.

• The Journal of Korean Academic Society of Nursing Education
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• v.8 no.1
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• pp.61-71
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• 2002

purpose : The purpose of this study was to find out the influencing factors of smoking-cessation behavior of patients with coronary heart disease and to suggest the model of smoking-cessation behavior which was based on the relationship between influencing factors and then to test its fitness empirically. method : This study was based on the Theory of Reasoned Action and a hypothetical model was constructed with fifteen paths in consideration of main predictive factors of smoking-cessation behavior such as biological factor, disease-related characteristics, self-efficacy, supportive factor, environmental factor, disease-related perception factor, intention-to-quit, and psychological factor. The validity of a smoking- cessation model was tested to 264 patients with coronary heart disease by using SPSS 8.0 and Window LISREL 8.12a. results : 1. Seven of the 15 paths of smoking-cessation behavior proved to be significant. 2. The final model excluded three paths in the hypothetical model was demonstrated to be improved by $x^2$=44.31 (df=38, p=.22), Goodness of Fit Index (GFI)=.98, Adjusted Goodness of Fit Index (AGFI)=.96, Non-Normed Fit Index(NNFI)=1.00, Normed Fit Index(NFI)=1.00, and Root Mean Square Residual(RMR)=.24. 3.The smoking-cessation behavior was influenced directly by biological factor, self-efficacy, supportive factor, environmental factor, intention-to-quit, and psychological factor. The smoking-cessation behavior was accounted for 82% of variance by these factors. conclusion : although the adolescents' smoking behavior can be predicted by only smoking intention, it is hard to predict the adults' smoking-cessation behavior by only this factor. Therefore, intention-to-quit, self-efficacy, supportive factor should be improved because these are promotive factors for smoking-cessation behavior. Biological factor, environmental factor, and psychological factor are inhibitive factors, so nicotine replacement therapy is helpful to the high nicotine-dependents, and ex-smokers avoid other smokers in their environment and also patients should learn and practice the stress coping-skills.

• Molecules and Cells
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• v.45 no.11
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• pp.789-791
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• 2022

Targeting fibroblast growth factor receptors (FGFRs) has been slow compared to other targeted cancer therapies for receptor tyrosine kinases, such as epidermal growth factor receptors. The low efficacy and variable response have limited the growth of FGFR inhibitors in clinical use. Nevertheless, recent systematic and genomic approaches have identified the biological conditions for effectively targeting FGFRs and can accelerate the development of targeted drugs. Under clinical and preclinical trials, the inhibitors started fast growing furious races to target FGFRs. Finally, FGFRs will be more actionable and targetable with more precise and effective drugs at the end of the race, passing the finish line.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.191-191
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• 2005