• Title/Summary/Keyword: bio-synthesis

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Synthesis and Herbicidal Activities of Hydantoin Derivatives Possessing Amide Subgroup (아미드 치환체를 갖는 히단토인계 화합물의 합성과 제초활성 연구)

  • Ko, Young-Kwan;Chung, Keun-Hoe;Ryu, Jae-Wook;Woo, Jae-Chun;Koo, Dong-Wan;Choi, Jung-Sub;Kim, Jun-Young;Kim, Tae-Joon;Kwon, Oh-Yeon;Chung, Bong-Jin;Kim, Dae-Whang
    • The Korean Journal of Pesticide Science
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    • v.10 no.2
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    • pp.153-156
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    • 2006
  • As an ongoing research program for the development of environmentally friendly new herbicide, several hydantoin derivatives 5a - 5i possessing amide subgroup were synthesized and shown to have interesting herbicidal activities exhibiting symptoms as Protoporphyrinogen IX oxidase inhibitor under postemergence upland greenhouse screening. Among derivatives tested, compound 5h showed superior herbicidal activity against upland problem weed, digitaria sanguinalis and aeschynomene indica to reference compound fluthiacet-methyl.

FDM 3D Printing of Environmental Friendly and High Strength Bio-based PC Filaments for Baby Toys

  • Park, Seong Je;Lee, Ji Eun;Park, Jean Ho;Lyu, Min-Young;Park, Keun;Koo, Myung Sool;Jin, Sun Chul;Kim, Ki Yong;Son, Yong
    • Elastomers and Composites
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    • v.52 no.2
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    • pp.99-104
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    • 2017
  • Due to the depletion of fossil oil and the increasing oil price, bio-plastic is currently topical. Bio-based plastics are synthesized from plant resources, unlike conventional petroleum-based counterparts. Therefore, the former minimizes global warming and reduces carbon dioxide emission. Fossil polycarbonate (PC)has good mechanical and optical properties, but its synthesis requires bisphenol-A and phosgene gas, which are toxic to humans. To address these problems, the fused deposition 3D printing process (hereafter, FDM) is studied using environmentally-friendly and high-strength bio-based PC. A comparisonof the environmental impact and tensile strength of fossil PC versus bio-based PC is presented herein, demonstrating that bio-based PC is more environmentally-friendly with higher tensile strength than fossil PC. The advantages of bio-based PC are applied in the FDM process for the fabrication of environmentally-friendly baby toys.

Synthesis and Herbicidal Activities of Tetrahydroindazole Derivatives Possessing Hydroxyalkyl Subgroup (하이드록시알킬 치환체를 갖는 테트라하이드로인다졸계 화합물의 합성과 제초활성 연구)

  • Ko, Young-Kwan;Chung, Kun-Hoe;Ryu, Jae-Wook;Woo, Jae-Chun;Koo, Dong-Wan;Choi, Jung-Sup;Kim, Jun-Young;Kim, Su-Ho;Kim, Tae-Joon;Choi, In-Young;Seok, Mee-Young;Choi, Jun-Hyuk;Chung, Bong-Jin
    • The Korean Journal of Pesticide Science
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    • v.12 no.2
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    • pp.201-205
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    • 2008
  • As an ongoing research program for the development of environmental friendly new soil-surface treatment herbicide, several tetrahydroindazole derivatives 6a - 6h possessing hydroxyalkyl subgroup were synthesized and shown to have interesting herbicidal activities exhibiting sumptoms as protoporphyrinogen IX oxidase inhibitor under pre-emergence upland greenhouse screening. Among derivatives tested, compound 6f showed superior herbicidal activity against problem weeds.

A Study on Observation of Lunar Permanently Shadowed Regions Using GAN (GAN을 이용한 달의 영구 그림자 영역 관찰에 관한 연구)

  • Park, Sung-Wook;Kim, Jun-Yeong;Park, Jun;Lee, Han-Sung;Jung, Se-Hoon;Sim, Chun-Bo
    • Proceedings of the Korea Information Processing Society Conference
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    • 2022.05a
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    • pp.520-523
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    • 2022
  • 일본 우주항공연구개발기구(Japan Aerospace Exploration Agency, JAXA)는 2007년부터 2017년까지 달 탐사선 셀레네(Selenological and Engineering Explorer, SelEnE)가 관측한 데이터를 수집하고, 연구했다. JAXA는 지구 상층 대기에 존재하는 산소가 자기장의 꼬리 부분에 실려 달로 이동한다는 사실을 발견했다. 하지만 이 연구는 아직 진행 중이며 달의 산화 과정 규명에 추가 연구가 필요하다. 본 논문에서는 생성적 적대 신경망(Generative Adversarial Networks, GAN)으로 달 분화구의 영구 그림자 영역을 제거하고, 물과 얼음을 발견하여 선행 연구의 완성도를 향상하고자 한다. 실험에 사용할 모델은 CIPS(Conditionally Independent Pixel Synthesis)다. CIPS는 실제 같은 영상을 고해상도로 합성한다. 합성할 데이터의 최적인 가중치 초기화 및 파라미터 갱신 방법, 활성 함수 조합은 실험을 통해 확인한다. 필요에 따라 앙상블 학습을 할 수도 있다. 성능평가는 FID(Frechet Inception Distance), 정밀도, 재현율을 사용한다. 제안한 방법은 진행 중인 연구의 시간과 비용을 절약하고, 인과관계를 더욱 명확히 밝히는 데 도움 될 수 있다고 사료된다.

Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells

  • Park, Sun-Young;Kim, Young-Hun;Kim, Young-Hee;Park, Geun-Tae;Lee, Sang-Joon
    • BMB Reports
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    • v.43 no.12
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    • pp.824-829
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    • 2010
  • Melanin synthesis is regulated by melanocyte specific enzymes and related transcription factors. $\beta$-carboline alkaloids including harmaline and harmalol are widely distributed in the environment including several plant families and alcoholic beverages. Presently, melanin content and tyrosinase activity were increased in melanoma cells by harmaline and harmalol in concentration- and time-dependent manners. Increased protein levels of tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 were also evident. In addition, immunofluorescence and Western blot analyses revealed harmaline and harmalol increased cAMP response element binding protein phosphorylation and microphthalmia-associated transcription factor expression. In addition to studying the signaling that leads to melanogenesis, roles of the p38 MAPK pathways by the harmaline and harmalol were investigated. Harmaline and harmalol induced time-dependent phosphorylation of p38 MAPK. Harmaline and harmalol stimulated melanin synthesis and tyrosinase activity, as well as expression of tyrosinase and TRP-1 and TRP-2 indicating that these harmaline and harmalol induce melanogenesis through p38 MAPK signaling.