• Genomics & Informatics
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• v.12 no.4
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• pp.187-194
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• 2014

Metabolic syndrome (METS) is a disorder of energy utilization and storage and increases the risk of developing cardiovascular disease and diabetes. To identify the genetic risk factors of METS, we carried out a genome-wide association study (GWAS) for 2,657 cases and 5,917 controls in Korean populations. As a result, we could identify 2 single nucleotide polymorphisms (SNPs) with genome-wide significance level p-values (< $5{\times}10^{-8}$), 8 SNPs with genome-wide suggestive p-values ($5{\times}10^{-8}{\leq}$ p < $1{\times}10^{-5}$), and 2 SNPs of more functional variants with borderline p-values ($5{\times}10^{-5}{\leq}$ p < $1{\times}10^{-4}$). On the other hand, the multiple correction criteria of conventional GWASs exclude false-positive loci, but simultaneously, they discard many true-positive loci. To reconsider the discarded true-positive loci, we attempted to include the functional variants (nonsynonymous SNPs [nsSNPs] and expression quantitative trait loci [eQTL]) among the top 5,000 SNPs based on the proportion of phenotypic variance explained by genotypic variance. In total, 159 eQTLs and 18 nsSNPs were presented in the top 5,000 SNPs. Although they should be replicated in other independent populations, 6 eQTLs and 2 nsSNP loci were located in the molecular pathways of LPL, APOA5, and CHRM2, which were the significant or suggestive loci in the METS GWAS. Conclusively, our approach using the conventional GWAS, reconsidering functional variants and pathway-based interpretation, suggests a useful method to understand the GWAS results of complex traits and can be expanded in other genomewide association studies.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.10 no.8
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• pp.1955-1961
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• 2009

As a core technology realizing ubiquitous world, recent researches are being concentrated to wireless sensor network. However, most research results were focused to the sensor network technology itself, even though interworking between the sensor network and Internet is also one of primitive requirements for ubiquitous world. In this paper, we design the tiny TCP/IPv6 profile which makes it possible to inter-connect the sensor network device to IPv6 based Internet. To confirm operation of the designed profile, we experimentally implemented and evaluated minimum TCP/IPv6 based on TinyOS. The evaluation result shows that throughput of our tiny TCP/IPv6 is almost same as that of TinyOS component.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.961-961
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• 2005

• Journal of Yeungnam Medical Science
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• v.6 no.2
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• pp.217-222
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• 1989

In this study, high frequency oscillatory ventilator was designed and constructed. Using designed by phase-lock loop system, in order to accurately and easily treat both the outlet volume and rpm. A system has been designed and is being evaluated using CD4046A PLL IC. We use this PLL IC for the purpose of motor controls. The device consists of PLL system, pumping mechanism, piston, cylinder, and special crank shaft are required. This system characteristics were as follows : 1) Frequency : 20-1800rpm. 2) Outlet air volume : 1-50cc.

• Molecules and Cells
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• v.28 no.6
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• pp.515-520
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• 2009

Applications of bone marrow-derived mesenchymal stem cells in gene therapy have been hampered by the low efficiency of gene transfer to these cells. In current transduction protocols, retrovirus particles with foreign genes make only limited contact with their target cells by passive diffusion and have short life spans, thereby limiting the chances of viral infection. We theorized that mechanically agitating the virus-containing cell suspensions would increase the movement of viruses and target cells, resulting in increase of contact between them. Application of our mechanical agitation for transduction process has increased the absorption of retrovirus particles more than five times compared to the previous static method without changing cell growth rate and viability. The addition of a mechanical agitation step increased transduction efficiency to 42%, higher than that of any other previously-known static transduction protocol.

• Applied Chemistry for Engineering
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• v.20 no.5
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• pp.517-521
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• 2009

In this study, the productivity of bio-ethanol obtained from various brown-algae raw materials was examined. Brown-algae polysaccharide, consisting of alginate and laminaran, is usable for the effective production of bio-ethanol if it is hydrolyzed to monomer unit. The objective of this study is the production of bio-ethanol from brown-algae using a heat-treatment and acid-treatment. Bio-ethanol was produced by Saccharomyces cerevisiae KCCM1129 and Pachysolen tannophilus KCTC 7937 strains. Laminaran japonica was higher than Sagassum fulvellum and Hizikia fusiformis, Laminaran japonica optimum pre-treatment is used to derive the ethanol production of Saccharomyces cerevisiae KCCM1129 and Pachysolen tannophilus KCTC 7937 respectively 9.16 g/L, 9.80 g/L. The maximum output of Sargassum fulvellum and Hizikia fusiformis was very low as 0.22 g/L.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2002.05a
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• pp.366-372
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• 2002

Tele-medicine and emergency medical system are necessary for moving from an accidental point or far distance to a hospital and emergency treatment or home treatment before a hospital. Emergency treatment is extremely important in the case of death before arriving a hospital and deformed or disabled by medical treatment delay. A necessary element for this medical system is the emergency communication system. This system is on preparing for an ability of furnishing patient status to a corresponding health service by monitoring the patient at an ambulance of the accident place. This is the transportation of basic biological information of a patient to a medical center by wireless communication system and the corresponding hospital or medical center examine the patient by monitoring, then they can send emergency medical order to the patient for emergency treatment. The TRS is most efficient way of emergency medical communication system, which is currently used with popularity. In this paper studied simultaneously a way of detecting and transporting bio-logical signals, and monitoring of transporting data with communication of voice in the accident place or ambulance.

• Journal of Biomedical Engineering Research
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• v.26 no.6
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• pp.399-406
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• 2005

In these days, HIS(Hospital Information System) raise the quality of medical services by effective management of medical records. As computing environment was developed, it is possible to search information quickly. But, standard medical data exchange is not completed between medical clinic and another organ so far. In case of patient transfer, past medical record was not efficiently transmitted. It be feasible treatment delay or medical accident. It is trouble that medical records is transferred by a person and communicate with each other. Extensible Markup Language (XML) is a simple, very flexible text format derived from SGML. Originally designed to meet the challenges of large-scale electronic publishing, XML is also playing an increasingly important role in the exchange of a wide variety of data on the Web and elsewhere. Form in system of company product, relative organs that handle bio-signal data is each other dissimilar and integration and to transmit to supplement bottleneck this research uses XML. In this study, it is discussed about sharing of medical data using XML web technology to standard medical record between hospital and relative organization The data structure model was designed to manage bio-signal data and patient record. We experimented about data transmission and all-in-one between different systems (one make use of MS-SQL database system and the other manage existent bio-signal data in itself form in file in this research). In order to search and refer medical record, the web-based system was implemented. The system that can be shared medical data was tested to estimate the merits of XML. Implemented XML schema confirms data transmission between different data system and integration result.

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.218-219
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.352-353
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• 2011