• Journal of Korea Multimedia Society
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• v.18 no.5
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• pp.652-662
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• 2015

It is necessary to develop small, implantable bio-telemetry systems which can measure and transmit patients' bio-signals from internal body to external receiver. When measuring bio-signals, like electrical bio-signals, acoustic bio-signal measurement has also a big clinical usefulness. But, sound signal has larger frequency bandwidth than any other bio-signals. When considering these issues, a wireless telemetry system which has rapid data transmission rate proportional to wide frequency bandwidth is necessary to be developed. The bluetooth module is used to overcome the data rate limitation caused by the large frequency bandwidth. In this paper, a novel multimedia bluetooth biotelemetry system was developed which consists of transmitter module located in the body and receiver device located outside of the body. The transmitter consists of microphone, bluetooth, and wireless charging device. And the receiver consists of bluetooth and codec system. The sound inside the skin is captured by microphone and sent to receiver by bluetooth while charging. The wireless charging system constantly supplies the electric power to the system. To verify the performance of the developed system, an in vitro experiment has been performed. The results show that the proposed biotelemetry system has ability to acquire the sound signals under the skin.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.233-240
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• 2014

According to the recent increasing trend of the ages, numbers of patients with chronic diseases are increasing and issues for health care are importantly emerged. In this thesis the research implements U-health care system for health care of patients with chronic diseases. The suggested system for health care of patients with chronic diseases composes bio measurement system, mobile gateway and medical information management server, and bio-signals are composed with modules such as electrocardiogram, blood pressure, blood sugar, oxygen saturation if configured as client. Blood sugar check was considered and implemented to be chosen the ways to transmit through bio measurement system or through gateway. Suggested bio measurement system and mobile gateway are transmitted through Bluetooth. The transmitted biodata is searched by observing health check through mobile gateway, by transmitting through network server, and by using client. By implementing bio signal observation system of patients with chronic diseases, present health check is available by monitoring measured bio data, and various bio signals are transmitted in the mobile environment.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.10a
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• pp.198-201
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• 2015

Using Arduino with a pressure sensor to create an interest in modern health care program is aimed. Currently, Korea is estimated that there are 4.2 million people in total incontinence. Through the convergence of Bio Technology and InformationTechnology these patients it is easy and simple to induce urinary incontinence, erectile dysfunction treatment, etc., and to prevent the most effective pelvic floor muscle exercises (Kegel exercises below). The Kegel medical equipments which are currently sold in the market make users exercise by giving electrical stimulations compulsively. Users need to take off their bottoms and take the Femcon therapy in a closed room. This causes various restrictions of time, space and hygiene. This thesis designs a Kegel medical equipment which combines BT and IT, free form restraint in regard to space and hygiene, without the need to take off bottoms.

• Journal of Life Science
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• v.22 no.12
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• pp.1724-1728
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• 2012

A marine bacterial strain that degraded fucoidan from Ecklonia cava was isolated from seawater. The crude fucoidanase of this strain efficiently degraded fucoidan at pH 8 and $50^{\circ}C$. The crude enzyme hydrolyzed 7.1% (w/w) fucoidan within 24 hrs from an 1% (w/v) fucoidan solution and produced oligosaccharides by endo-type hydrolysis as the reaction products. The results of 16S rRNA gene sequence analysis and biochemical tests permitted a tentative identification of strain SB 1493 as a Pseudoalteromonas species.

• Journal of Adhesion and Interface
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• v.20 no.2
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• pp.71-75
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• 2019

Tannic acid is one of the most commonly found polyphenols in the vegetable field. Initially, research on tannins concentrated on physiological functions such as antioxidants. Recently, however, tannic acid has attracted much interest as a molecular glue as it has been found to interact virtually all bio-macromolecules such as proteins and DNA. The various properties of tannic acid are expected to control the wettability of the surface, contribute to energy storage and generation, and show potential as a medical agent. Here, tannic acid will be discussed about the interaction of with bio-macromolecules as a molecular glue, surface modification, and utilization of itself as biomaterials.

• Fisheries and Aquatic Sciences
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• v.25 no.2
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• pp.90-100
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• 2022

Cardiovascular diseases (CVDs) have posed serious public health problems, accounting for nearly 30% of mortality worldwide and their incidence is still increasing. Therefore, new treatment resources are necessary to prevent or manage the ever-increasing population of patients with CVDs. Sea cucumber is well known for its medical and health benefit effects, but it is not well known what/how effect it has on vascular disease. In the present study, we examined the protect effect of sea cucumber, Apostichopus japonicus 80% ethanol extract (AJE) on zebrafish embryo with the stimulation of free fatty acid, palmitate (PA). In vivo study showed that AJE can attenuate PA-induced toxicity through relieving the rapid heartbeat, increasing the survival rate and reducing the malformation in both wild type and Tg (fli1a:eGFP) transgenic zebrafish lines. Additionally, compare with PA treated embryos, the yolk sac area, body length, axial vascular segment (AVS) and intersegmental vessel (ISV) of the co-treatment group of AJE and PA were comparable to the control group. Moreover, AJE lowered the expression of inducible nitric oxide synthase (iNOS), nitric oxide (NO) and inflammation-related genes induced by PA, and inhibited PA-induced vascular development disorders. Our data preliminarily verify that AJE could be a candidate resource for the prevention or therapy of CVDs.

• BMB Reports
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• v.34 no.2
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• pp.176-181
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• 2001

Using a retrovirus, foreign genes can be introduced into mammalian cells. The purpose of this study is to produce a retrovirus that can make the infected cells express two genes; the human multidrug resistance gene (MDR1) and the HLA-B7 gene, which is one of the major human histocompatibility complex (MHC) class I genes. For the expression of these genes, the internal ribosome entry site (IRES) was used, which was derived from the encephalomyocarditis (EMC) virus. In order to produce retroviruses, a retroviral vector was transfected into a packaging cell line and the transfected cells were treated with vincristine, which is an anti-cancer drug and a substrate for the MDRI gene product. This study revealed that two genes were incorporated into chromosomes of selected cells and expressed in the same cells. The production of the retrovirus was confirmed by the reverse transcription (RT)-PCR of the viral RNA. The retrovirus that was produced infected mouse fibroblast cells as well as the human U937. This study showed that packaging cells produced the retroviruses, which can infect the target cells. Once the conditions for the high infectivity of retrovirus into human cells are optimized, thus virus will be used to infect hematopoietic stem cells to co-express MDRl and HLA-B7 genes, and develop the lymphocytes that can be used for the immnogene therapy.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.47 no.5
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• pp.24-32
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• 2010

In this study, we have proposed a pre-processing algorithm newly developed for improving the tracking efficiency of the optical flow method. The developed pre-processing algorithm consists of a median filter, binarization, morphology, canny edge, contour detecting and an approximation method. In order to evaluate whether the optical flow tracking capacity increases, this study applied the pre-processing algorithm to the Lucas-Kanade(LK) optical flow algorithm, and comparatively analyzed its images and tracking results with those of optical flow without the pre-processing algorithm and with the existing pre-processing algorithm(composed of median filter and histogram equalization). As a result, it was observed that the tracking performance derived from the LK optical flow algorithm with the pre-processing algorithm, shows better tracking accuracy, compared to the one without the pre-processing algorithm and the one with the existing pre-processing algorithm. It seems to have resulted by successful segmentation for characteristic areas and subdivision into inner and outer contour lines.

• Korean Journal of Environmental Agriculture
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• v.29 no.4
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• pp.421-426
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• 2010

Benzene is one of volatile environmental pollutants to induce asthma and allergy in respiratory system. The airway epithelium is a physical barrier to inhaled toxicants and particulates. However, the effect of benzene in lung epithelial cell viability has not been elucidated. Thus, this study was conducted to investigate the effect of benzene on apoptosis in A549 cells, lung epithelial cell line. In this study, benzene decreased cell viability of A549 cells in a dose-dependent manner (> $10{\mu}M$). Benzene-induced decrease of cell viability was blocked by the treatment of antioxidants (vitamin C and NAC). Indeed, benzene induced lipid peroxide formation in A549 cells. Benzene decreased Bcl-2 expression but increased Bax expression in A549 cells. In addition, benzene also increased the cleaved form of caspase-3. In conclusion, benzene induced apoptosis via oxidative stress in cultured epithelial cells.

• Korean Journal of Medicinal Crop Science
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• v.19 no.3
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• pp.191-197
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• 2011

In this study, we investigated antioxidant activities and whitening effects of Acer mono sap by encapsulation of nanoparticles. Acer mono sap was through ultra high pressure process and then encapsulated by lecithin. Nano-encapsulated The nanoparticles of Acer mono sap showed highest free radical scavengering effect as 89.7% in adding sample (1.0 mg/ml), compared to sap of non-encapsulation. It was showed strong inhibition effect on melanin production test by Clone M-3 cells as 47.8%. High inhibitory of tyrosinase was also measured as 85.8% by adding lecithin nano-particle of 1.0 mg/ml. The nano-particles also showed 14.8% of low cytotoxicity against human normal fibroblast cells in adding 1.0 mg/ml of the highest concentration. These results indicate that Acer mono sap may be a source of cosmetic agents capable of improving whitening effect and antioxidant activites.