• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.11
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• pp.1337-1342
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• 2019

Medical institutions face the challenge of securing competitiveness among medical institutions due to the rapid spread of ICT convergence, and managing data that is growing at an enormous rate due to the emergence of big data and the emergence of the Internet of Things. The big data paradigm of the medical community is not just about large data or tools and processes for processing and analyzing it, but also means a computerized shift in the way people live, think and study. As the medical data is recently released, the demand for the use of medical data is increasing. Therefore, the research on disease detection system based on public data using open source that can help rational and efficient decision making was conducted. As a result of the experiment, unlike a simple disease inquiry or a symptom inquiry about a single disease provided by a public institution, related diseases are searched by a symptom or a cause.

• Journal of Life Science
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• v.32 no.12
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• pp.919-928
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• 2022

As seen in the COVID-19 pandemic, unexpected emergence of new viruses presents serious concern on public health. Especially, the absence of effective vaccines or antiviral drugs against emerging viruses significantly increases the severity of disease and duration of viral circulation among population. Natural products have served as a major source for safe and effective antiviral drugs. In this study, we examined the virucidal activity of medical herb extracts with a view to discover novel antiviral agents with desired levels of safety and antiviral efficacy. Ethanol extracts of ten selected medical herbs were tested for antioxidant activity and in-vitro cytotoxicity in various animal cell lines. Of note, the herbal extracts showed broad and potent virucidal activities against rotavirus, hepatitis A virus, and influenza A virus. The extracts of Sorbus commixta and Glycyrrhiza uralensis showed strong virucidal activities against influenza A virus. We also examined whether the extracts of Sorbus commixta and Glycyrrhiza uralensis can be used as inactivating agents to prepare an inactivated viral vaccine. In a mouse model, influenza A virus inactivated by the extracts elicited high levels of neutralizing antibodies, and the vaccination provided complete protection against lethal challenge. These results suggest that herb-derived natural products can be developed to antiviral drugs as well as inactivating agents for preparation of inactivated viral vaccines.

• IE interfaces
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• v.21 no.2
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• pp.209-220
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• 2008

Recently, innovative medical services are fast emerging, which include customized medical services based on bio-informatics, composition of cure and well-being exploiting ubiquitous technology, hospital supply chain management using RFID, and so forth. However, conventional approaches for new service development hardly give us systematic model to analyze and produce creative medical services. Because most of them are static and concentrate on microscopic tools or techniques. Thus, it is highly desirable to suggest an integrative framework to organize the whole transformation process from technology to medical service. The objective of this study is to propose a medical service engineering model based on the dynamic innovation theory. The proposed model contains objectives of service system, strategies of hospital, stages, activities required to deal with medical service life cycle, which incorporates the acquisition of new technology, transformation to the product, penetration into market, and adoption of consumers. In addition, the usefulness and applicability of the newly proposed model are provided using catholic medical center example.

• Genomics & Informatics
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• v.12 no.1
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• pp.42-47
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• 2014

Asian populations contain a variety of ethnic groups that have ethnically specific genetic differences. Ethnic variants may be highly relevant in disease and human differentiation studies. Here, we identified ethnically specific variants and then investigated their distribution across Asian ethnic groups. We obtained 58,960 Pan-Asian single nucleotide polymorphisms of 1,953 individuals from 72 ethnic groups of 11 Asian countries. We selected 9,306 ethnic variant single nucleotide polymorphisms (ESNPs) and 5,167 ethnic variant copy number polymorphisms (ECNPs) using the nearest shrunken centroid method. We analyzed ESNPs and ECNPs in 3 hierarchical levels: superpopulation, subpopulation, and ethnic population. We also identified ESNP- and ECNP-related genes and their features. This study represents the first attempt to identify Asian ESNP and ECNP markers, which can be used to identify genetic differences and predict disease susceptibility and drug effectiveness in Asian ethnic populations.

• Fisheries and Aquatic Sciences
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• v.16 no.3
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• pp.143-147
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• 2013

The influence of carrageenan addition on the gelatinization of salt-based surimi gels was investigated by measuring compressive properties and Hunter color scale values. Hydrocolloid kappa (${\kappa}$)-carrageenan at 0%, 0.2%, and 1.0% and NaCl (2% w/w), KCl (1.5% w/w), and a mixture of NaCl (2% w/w) and KCl (1.5% w/w), were added to Alaska pollock surimi. Gel compressive properties were assessed by measuring the breaking force and gel strength. The gelling property of ${\kappa}$-carrageenan-induced surimi gel was significantly increased by the incorporation of KCl rather than NaCl. The addition of ${\kappa}$-carrageenan increased the breaking force and gel strength of surimi gels. Gels with 1% ${\kappa}$-carrageenan and KCl had the highest breaking force and gel strength. The addition of ${\kappa}$-carrageenan caused an increase in the whiteness values of the surimi gels.

• Composites Research
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• v.27 no.5
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• pp.196-200
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• 2014

A novel, simple and totally recyclable method has been developed for the synthesis of nontoxic, biocompatible and biodegradable bio-composite films from soy protein and silk protein. Bio films are defined as flexible films prepared from biological materials such as protein. These materials have potential application in medical and food as a packaging material. Their use depends on various parameters such as mechanical (strength and modulus), thermal, among others. In this study, prepare and characterization of bio films made from Soy Protein Isolate (SPI) (matrix) and Silk Fiber (SF) (reinforcement) through solution casting method by the addition of plasticizer and crosslinking agent. The obtained SPI and SPI/SF composites were subsequently subjected to evaluate their mechanical and thermal properties by using Universal Testing Machine and Thermal Gravimetric Analyzer respectively. The tensile testing showed significant improvements in strength with increasing amount of SF content and the % elongation at break of the composites of the SPI/SF was lower than that of the matrix. Though the interfacial bonding was moderate, the improvement in tensile strength and modulus was attributed to the higher tensile properties of the silk fiber.

• Proceedings of the Korean Society of Life Science Conference
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• 2006.09a
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• pp.33.2-33.2
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• 2006

• The Korea Genome Conference
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• 2003.09a
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• pp.53.2-53.2
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• 2003

• Journal of Korea Multimedia Society
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• v.18 no.5
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• pp.652-662
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• 2015

It is necessary to develop small, implantable bio-telemetry systems which can measure and transmit patients' bio-signals from internal body to external receiver. When measuring bio-signals, like electrical bio-signals, acoustic bio-signal measurement has also a big clinical usefulness. But, sound signal has larger frequency bandwidth than any other bio-signals. When considering these issues, a wireless telemetry system which has rapid data transmission rate proportional to wide frequency bandwidth is necessary to be developed. The bluetooth module is used to overcome the data rate limitation caused by the large frequency bandwidth. In this paper, a novel multimedia bluetooth biotelemetry system was developed which consists of transmitter module located in the body and receiver device located outside of the body. The transmitter consists of microphone, bluetooth, and wireless charging device. And the receiver consists of bluetooth and codec system. The sound inside the skin is captured by microphone and sent to receiver by bluetooth while charging. The wireless charging system constantly supplies the electric power to the system. To verify the performance of the developed system, an in vitro experiment has been performed. The results show that the proposed biotelemetry system has ability to acquire the sound signals under the skin.

• Journal of the Institute of Electronics and Information Engineers
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• v.51 no.1
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• pp.233-240
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• 2014

According to the recent increasing trend of the ages, numbers of patients with chronic diseases are increasing and issues for health care are importantly emerged. In this thesis the research implements U-health care system for health care of patients with chronic diseases. The suggested system for health care of patients with chronic diseases composes bio measurement system, mobile gateway and medical information management server, and bio-signals are composed with modules such as electrocardiogram, blood pressure, blood sugar, oxygen saturation if configured as client. Blood sugar check was considered and implemented to be chosen the ways to transmit through bio measurement system or through gateway. Suggested bio measurement system and mobile gateway are transmitted through Bluetooth. The transmitted biodata is searched by observing health check through mobile gateway, by transmitting through network server, and by using client. By implementing bio signal observation system of patients with chronic diseases, present health check is available by monitoring measured bio data, and various bio signals are transmitted in the mobile environment.