• 전력전자학회논문지
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• 제22권2호
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• pp.102-108
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• 2017

Proper design guides are proposed for a practical dual-active bridge (DAB) converter based on the mathematical model on the steady state. The DAB converter is popular in bidirectional application due to its zero-voltage capability and easy bidirectional operation for seamless control, high efficiency, and performance. Some design considerations are taken to overcome the limitation of the DAB converter. The practical design methodology of power stage is discussed to minimize the conduction and switching losses of the DAB converter. Small-signal model and frequency response are derived and analyzed based on the generalized average method, which considers equivalent series resistance, to improve the dynamics, stability, and reliability with voltage regulation of the practical DAB converter. The design of closed-loop control is discussed by the derived small-signal model to obtain the pertinent gain and phase margin in steady-state operation. Experimental results of a 3.3 kW prototype of DAB converter demonstrate the validity and effectiveness of the proposed methods.

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3015-3023
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• 2012

The mitochondrial antioxidant protein manganese superoxide dismutase (MnSOD) may represent a new type of tumor suppressor protein. Overexpression of the cDNA of this gene by plasmid or recombinant lentiviral transfection in various types of cancer leads to growth suppression both in vitro and in vivo. We previously determined that changes in MnSOD expression had bidirectional effects on adriamycin (ADR) when combined with nitric oxide (NO). Radiation induces free radicals in a manner similar to ADR, so we speculated that MnSOD combined with NO would also have a bidirectional effect on cellular radiosensitivity. To examine this hypothesis, TE-1 human esophageal squamous carcinoma cells were stably transfected using lipofectamine with a pLenti6-DEST plasmid containing human MnSOD cDNA at moderate to high overexpression levels or with no MnSOD insert. Blastidicin-resistant colonies were isolated, grown, and maintained in culture. We found that moderate overexpression of MnSOD decreased growth rates, plating efficiency, and increased apoptosis. However, high overexpression increased growth rates, plating efficiency, and decreased apoptosis. When combined with NO, moderate overexpression of MnSOD increased the radiosensitivity of esophageal cancer cells, whereas high MnSOD overexpression had the opposite effect. This finding suggests a potential new method to kill certain radioresistant tumors and to provide radioresistance to normal cells.

• 정신신체의학
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• 제20권2호
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• pp.135-138
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• 2012

기능성 위장관 장애(functional gastrointestinal disorder, FGID)의 생물학적 병태생리는 아직 명확하지 않은 실정이나 최근에 뇌-장관 축(brain-gut axis, BGA) 모델이 각광받고 있다. BGA 모델은 중추신경계(CNS)와 장관신경계(ENS)가 신경계, 신경내분비계, 신경면역계 등으로 밀접하게 연계되어 양방향성으로 항상성을 유지한다는 이론이다. 또한 BGA는 FGID에 대한 항우울제 효과의 이론적 근거를 제공한다. 저자들은 세로토닌 노르에프네프린 재흡수 차단제인 duloxetine이 목 이물감, 우울감을 보이는 환자와 상부 위장관 팽만감, 건강염려증적 불안을 보이는 환자에서 위장관 증상 및 정신의학적 증상에 효과적이었음을 경험하였다. 이에 두 증례보고를 통하여 BGA에 대해서 간략히 검토하고 duloxetine의 효과를 BGA의 측면에서 고찰하였다. 이 두 증례에서 duloxetine의 장관에서 뇌로의 영향(bottom-up regulation)으로는 세로토닌 수용체, 노르에피네프린 수용체 그리고 부신피질자극호르몬방출인자(CRF) 길항효과를 통해서 내장과민성(visceral hypersensitivity) 및 정신의학적 증상을 호전시키고, 뇌에서 장관으로의 영향(top-down regulation)으로는 우울과 불안을 호전시킴으로 위장관 증상에 영향을 미친 것으로 추정해 볼 수 있다.

• Journal of Electrical Engineering and Technology
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• 제12권6호
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• pp.2208-2218
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• 2017

To resolve overload in a distribution system, a distribution system operator (DSO) often performs a load transfer using normally open tie points and switches in the distribution line. During this process, the distribution system is momentarily operated in closed-loop operation. A closed-loop current in the distribution system can cause a power failure due to excess breaking current in the circuit breakers and reclosers. Therefore, it is necessary to calculate the closed-loop current exactly. However, if there are a large number of distributed generation (DG) systems in the distribution system, such as energy storage systems (ESS), they might obstruct the closed-loop operation based on bidirectional power flow. For quick and precise operation of a closed-loop system, the ESS has to regulate the power generation while satisfying closed-loop operation in the worst cases. We propose a strategy for balanced power regulation of an ESS. Simulations were carried out using PSCAD/EMTDC, and the results were compared with calculation results.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2004년도 춘계학술대회 논문집
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• pp.1374-1378
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• 2004

Railway conflict detection and resolution problem (RCDRP) involves complicated field constraints that should be considered for practical service. In this paper, we address those constraints in brief. Particularly, following situations are addressed; (1) temporal change of network topology, (2) consideration of diverse conditions of track and train, for example, single/double tracks and passenger/freight service, (3) siding capacity limitation, (4) bidirectional sides used by both inbound and outbound trains, (5) regulation for passenger transfer service, (6) consideration of siding length, (7) Restriction on stopping before the track segment with steep slope.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.177-178
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• 2008

Recently, the concern of PV(Photovoltaic) systems has increased because of an environmental problem and limitation of fossil fuel. In this paper, distribution system of existing one-way power flow and distribution system generating bidirectional power flow analyze voltage variation at distribution system interconnected multiple PV systems. Also, we analyze a supply voltage range of distribution system using LDC and ULTC voltage regulation method by case study.

• Journal of Ginseng Research
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• 제47권6호
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• pp.714-725
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• 2023

Background: Our previous investigation indicated that the preparation of Panax ginseng Meyer (P. ginseng) inhibited melanogenesis. It comprised salicylic acid (SA), protocatechuic acid (PA), p-coumaric acid (p-CA), vanillic acid (VA), and caffeic acid (CA). In this investigation, the regulatory effects of P. ginseng phenolic acid monomers on melanin production were assessed. Methods: In vitro and in vivo impact of phenolic acid monomers were assessed. Results: SA, PA, p-CA and VA inhibited tyrosinase (TYR) to reduce melanin production, whereas CA had the opposite effects. SA, PA, p-CA and VA significantly downregulated the melanocortin 1 receptor (MC1R), cycle AMP (cAMP), protein kinase A (PKA), cycle AMP-response element-binding protein (CREB), microphthalmia-associated transcription factor (MITF) pathway, reducing mRNA and protein levels of TYR, tyrosinase-related protein 1 (TYRP1), and TYRP2. Moreover, CA treatment enhanced the cAMP, PKA, and CREB pathways to promote MITF mRNA level and phosphorylation. It also alleviated MITF protein level in α-MSH-stimulated B16F10 cells, comparable to untreated B16F10, increasing the expression of phosphorylation glycogen synthase kinase 3β (p-GSK3β), β-catenin, p-ERK/ERK, and p-p38/p38. Furthermore, the GSK3β inhibitor promoted p-GSK3β and p-MITF expression, as observed in CA-treated cells. Moreover, p38 and ERK inhibitors inhibited CA-stimulated p-p38/p38, p-ERK/ERK, and p-MITF increase, which had negative binding energies with MC1R, as depicted by molecular docking. Conclusion: P. ginseng roots' phenolic acid monomers can safely inhibit melanin production by bidirectionally regulating melanin synthase transcription. Furthermore, they reduced MITF expression via MC1R/cAMP/PKA signaling pathway and enhanced MITF post-translational modification via Wnt/mitogen-activated protein kinase signaling pathway.

• 대한간호학회지
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• 제53권6호
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• pp.571-583
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• 2023

Purpose: This study used a self-deterministic approach to explore the relationship between emotional intelligence (EI), academic motivation (AM), and achievement among health science students. Methods: A descriptive cross-sectional study was conducted in three cities of Saudi Arabia (Dammam, Riyadh, and Jeddah). A convenience sample of 450 students was incorporated using the multistage cluster sampling technique. The online survey contained three sections: students' basic data and academic achievement level, the modified Schutte self-report inventory, and the Academic Motivation Scale lowercase. Results: This study revealed moderate overall scores for EI (57.1%), AM (55.6%), and grade point average (GPA) (57.6%). The overall EI score, its domains, and GPA had significant positive correlations with overall AM and intrinsic and extrinsic motivation (p < .01). Amotivation had an insignificant correlation with GPA (p < .05), but it was negatively correlated with EI and its domains (p < .01). Multiple regression analysis proved that EI domains predicted 5.0% of GPA variance; emotions appraisal and expression (β = .02, p = .024), regulation (β = .11, p = .032), and utilization (β = .24, p < .01). EI domains also predicted 26.0% of AM variance; emotions appraisal and expression (β = .11, p = .04), regulation (β = .33, p < .01), and utilization (β = .23, p < .01). Moreover, AM predicted 4.0% of the variance in GPA; intrinsic (β = .25, p = .004) and extrinsic (β = .11, p = .022) motivation. AM also predicted 25.0% of the variance in EI: intrinsic (β = .34, p < .01) and extrinsic motivation (β = .26, p = .026). Conclusion: EI and AM have a bidirectional influence on each other, significantly shaping the GPA of health sciences students in Saudi Arabia, where intrinsic motivation has a predominant role. Thus, promoting students' AM and EI is recommended to foster their academic achievement.

• IMMUNE NETWORK
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• 제1권3호
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• pp.203-212
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• 2001

Background: Rapid advances in neuroendocrine immunology have established the concept of bidirectional communication between the immune and neuroendocrine systems. Capsaicin suppresses the immune function by destroying substance P acting as mediatior of neuroendocrine immune system. Methods and Results: In this study, effect of capsaicin on mature murine lymphocyte functions and lymphoid tissue morphology was examined. Formally, capsaicin showed the strong cytotoxic effect on splenocyte over $10{\mu}g/ml$ concentration in citro. And proliferation and Th1-cytokine expression of splenic cells in mice that received high dose of capsaicin ($100{\mu}g/mouse$) were significantly diminished. However, low dose of capsaicin treatment did not influence these responses in vivo($1{\mu}g/mouse$) and in vitro (under $5{\mu}g/ml$). And the morphology of spleen and lymph nodes after capsaicin treatment was observed. In the spleen of mice injected with high dose of capsaicin (100, $200{\mu}g/mouse$), the size of white pulp was significantly decreased and the length of red pulp was increased, Moreover, vascularity index was diminished in a dose dependent manner. Conclusion: These results implies that immunosuppressive effect of capsaicin is associated with cytotoxic activity on lymphocyte, Th1-cytokine down-regulation and lymphoid tissue abnormalization, and this report is expected to give a hand to the study for the mechanism of action of neurotoxin of the immune system.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.134-139
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• 2005

This paper presents a cost effective quasi-resonant soft-switching PWM high frequency inverter with minimum circuit components. This inverter can achieve wider soft commutation, simpler power circuit configuration, smaller volumetric size, lower cost and wider power regulation range, higher-efficiency as compared with single ended quasi-resonant ZVS-PFM inverter and active voltage clamped quasi-resonant ZVS-PWM inverter. The operation principle of the proposed inverter is described on the basis of the simulation and experimental results, together with its operating performances in steady state. The operating performances of this unique proposed high frequency inverter based on ZVS and ZCS arms-related soft commutation principle is evaluated and discussed as compared with the active voltage-clamped ZVS-PWM inverter and a conventional single-ended ZVS-PFM inverter. The practical effectiveness of a novel type quasi-resonant soft-switching PWM high frequency inverter using IGBT is actually proved for consumer induction heated appliances as rice cooker, hot water producer, steamer and super heated steamer. The extended bidirectional circuit topology of quasi-resonant PWM high frequency inverter with minimum circuit components is demonstrated, which operate as the direct frequency changer.