• Title/Summary/Keyword: bias reference

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Evaluation of the proficiency testing results using river water-based reference materials for heavy metal analysis (중금속분석용 하천수 매질표준물질을 이용한 숙련도 결과 평가)

  • Song, Ko-Bong;Kim, Young-Hee;Shin, Sun-Kyoung;Lee, Su-Yeong;Kim, Hyun-Jung;Kang, Hak-Gu;Kim, Il-Gyu;An, Hee-Ju
    • Analytical Science and Technology
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    • v.23 no.3
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    • pp.284-294
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    • 2010
  • In this study, river water-based reference materials (RMs), NIER-I08RW and NIER-I09, for trace metal analysis were prepared and certified for Pb, Cd, Cr and Cu with evaluation of uncertainties. The RMs were confirmed to be homogeneous enough to be used as proficiency testing materials since within-bottle homogenieties of the RMs were lower than 0.3 times of targeted standard deviation of proficiency testing. The RMs were distributed to environmental testing laboratories for the proficiency testing and the variation of Z scores of the proficiency testing results were compared for different assigned values. The relative bias, $B_{relative}$, deviations between reference values and consensus values, were lower than ${\pm}$1 except for cadmium of NIERI08RW. The results showed both values were in a good agreement and only 2.9% of Z scores changed by using a different assigned values such as consensus and reference values.

Geoid Determination in South Korea from a Combination of Terrestrial and Airborne Gravity Anomaly Data

  • Jekeli, Christopher;Yang, Hyo Jin;Kwon, Jay Hyoun
    • Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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    • v.31 no.6_2
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    • pp.567-576
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    • 2013
  • The determination of the geoid in South Korea is a national imperative for the modernization of height datums, specifically the orthometric height and the dynamic height, that are used to monitor hydrological systems and environments with accuracy and easy revision, if necessary. The geometric heights above a reference ellipsoid, routinely obtained by GPS, lead immediately to vertical control with respect to the geoid for hydrological purposes if the geoid height above the ellipsoid is known accurately. The geoid height is determined from gravimetric data, traditionally ground data, but in recent times also from airborne data. This paper illustrates the basic concepts for combining these two types of data and gives a preliminary performance assessment of either set or their combination for the determination of the geoid in South Korea. It is shown that the most critical aspect of the combination is the gravitational effect of the topographic masses above the geoid, which, if not properly taken into account, introduces a significant bias of about 8 mgal in the gravity anomalies, and which can lead to geoid height bias errors of up to 10 cm. It is further confirmed and concluded that achieving better than 5 cm precision in geoid heights from gravimetry remains a challenge that can be surmounted only with the proper combination of terrestrial and airborne data, thus realizing higher data resolution over most of South Korea than currently available solely from the airborne data.

CMOS Voltage down converter using the self temperature-compensation techniques (자동 온도 보상 기법을 이용한 CMOS 내부 전원 전압 발생기)

  • Son, Jong-Pil;Kim, Soo-Won
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.43 no.12 s.354
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    • pp.1-7
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    • 2006
  • An on chip voltage down converter (VDC) using the self temperature-compensation techniques is proposed. At a different gate bias voltage, PMOSFET shows different source to drain current characteristic according to the temperature variation. The proposed VDC can reduce its temperature dependency by the source to drain current ratio of two PMOSFET with different gate bias respectively. Proposed circuit is fabricated in Dongbu-anam $0.18{\mu}m$ CMOS process and experimental results show its temperature dependency of $-0.49mV/^{\circ}C$ and external supply dependency of 6mV/V. Total current consumption is only $1.1{\mu}A@2.5V$.

Value of Contrast-Enhanced Ultrasonography in the Differential Diagnosis of Enlarged Lymph Nodes: a Meta-Analysis of Diagnostic Accuracy Studies

  • Jin, Ya;He, Yu-Shuang;Zhang, Ming-Ming;Parajuly, Shyam Sundar;Chen, Shuang;Zhao, Hai-Na;Peng, Yu-Lan
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.6
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    • pp.2361-2368
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    • 2015
  • Objective: To evaluate the diagnostic accuracy of contrast-enhanced ultrasonography (CEUS) in differentiating between benign and malignant enlarged lymph nodes using meta-analysis. Materials and Methods: Pubmed, Embase, SCI and Cochrane databases were searched for studies (up to September 1, 2014) reporting the diagnostic performance of CEUS in discriminating between benign and malignant lymph nodes. Inclusion criteria were: prospective study; histopathology as the reference standard; and sufficient data to construct $2{\times}2$ contingency tables. Methodological quality was assessed using Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2). Patient clinical characteristics, sensitivity and specificity were extracted. The summary receiver operating characteristic curve was used to examine the accuracy of CEUS. A meta-analysis was performed to evaluate the clinical utility in identification of benign and malignant lymph nodes. Sensitivity analysis was performed after omitting outliers identified in a bivariate boxplot and publication bias was assessed with Egger testing. Results: The pooled sensitivity, specificity and AUROC were 0.92 (95%CI, 0.85-0.96), 0.91 (95%CI, 0.82-0.95) and 0.97 (95%CI, 0.95-0.98), respectively. After omitting 3 outlier studies, heterogeneity decreased. Sensitivity analysis demonstrated no disproportionate influences of individual studies. Publication bias was not significant. Conclusions: CEUS is a promising diagnostic modality in differentiating between benign and malignant lymph nodes and can potentially reduce unnecessary fine-needle aspiration biopsies of benign nodes.

Evluation of the DINAMAP 8100 Automated Blood Pressure monitor ; comparison with the Mercury Sphygmomanometer (수은 혈압계와 DINAMAP 8100 자동 혈압계의 혈압측정치 비교연구)

  • Kim Mee-Yeon;Choi Hee-Kang;Kim Nam-Jin
    • Journal of Korean Academy of Fundamentals of Nursing
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    • v.3 no.1
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    • pp.96-107
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    • 1996
  • Automated blood pressure monitors have gained acceptance in many clinical settings with the increasing demand, the accurate BP measuring devices reguire the need for validation. We have evaluated the Dinamap 8100, an oscillometric automated blood pressure monitor, using the Mercury sphygmomanometer as a reference. Comparison of sphygmomanometers was conducted 60 patients (30-Normotensive group, 30-Hypertensive group at Seoul National University Hospital. Two trained observers took measure blood pressure(systolic/diastolic) at the same time using the Dinamap 8100 on one arm and the Mercury on the other. For each measurement, the device was randomly selected from a group of devices repetively used for the experiment. Mean readings for systolic pressure with the Dinamap 8100 in normotensive group were lower(mean difference ; 4.26mmHg) than the Mercury type. Mean readings for systolic pressure with the Dinamap 8100 in hypertensive group were lower(mean difference ; 9.05mmHg) than the Mercury type. Mean readings for diastolic pressure with the Dinamap 8100 in normotensive group were lower (mean difference ; 7.46mmHg) than the Mercury type. Mean readings for diastolic pressure with the Dinamap 8100 in hypertensive group were lower(mean difference ; 9.03mmHg) than the Mercury type. We have found that blood pressure readings with the Dinamap 8100 were lower than those with the Mercury type. we are using the Mercury type in clinics, although it has observer bias and terminal digit preference. But the Dinamap 8100 is readily portable, simple to use, and capable of preventing observer bias and terminal digit preference. The Dinamap 8100 is acceptable for blood pressure determination in subjects who are normotensive or hypertensive ones.

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Effects of Workplace Risk Assessment-based Ergonomic Intervention on Work-Related Muscular Skeletal Disorders: Systematic Literature Review and Meta-Analysis (작업장 유해요인조사에 기반한 인체공학적 중재가 작업 관련성 근골격계 질환의 증상에 미치는 효과: 체계적 문헌고찰 및 메타분석)

  • Cho, Jung Young;Kim, Gaeun
    • Korean Journal of Occupational Health Nursing
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    • v.29 no.4
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    • pp.342-353
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    • 2020
  • Purpose: This study aimed to systematically review literature and conduct a meta-analysis to comprehensively identify and evaluate the effects of workplace risk assessment-based ergonomic intervention on work-related muscular-skeletal disorders in workers. Methods: We searched the Ovid-Medline, EMBASE, and Cochrane library and up to 2018 using search terms such as muscular-skeletal, disorder, impairment, work-related muscular-skeletal disorders, ergonomic, intervention, management with no language limitations; screened reference lists; and contacted experts in the field. Results: We identified 545 references and included 13 randomized controlled tests (3,368 workers). We judged nine studies to have a low risk of bias, while the other four studies have a high risk of bias. Conclusion: Ergonomic intervention based on risk assessment in the workplace did not significantly differ in terms of the intensity of pain or duration of workers in the workplace, but low-quality evidence decreased the frequency of musculoskeletal disorder pain in three to six months moderate-quality evidence and in six to nine months low-quality evidence. Besides, low-quality evidence to reduce discomfort and moderate-quality evidence to improve worker posture. Therefore, ergonomic intervention based on the assessment of risk factors in the workplace should be applied to reduce pain frequency and discomfort and improve workers posture among musculoskeletal disorders.

Depression and the Risk of Breast Cancer: A Meta-Analysis of Cohort Studies

  • Sun, Hui-Lian;Dong, Xiao-Xin;Cong, Ying-Jie;Gan, Yong;Deng, Jian;Cao, Shi-Yi;Lu, Zu-Xun
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.8
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    • pp.3233-3239
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    • 2015
  • Background: Whether depression causes increased risk of the development of breast cancer has long been debated. We conducted an updated meta-analysis of cohort studies to assess the association between depression and risk of breast cancer. Materials and Methods: Relevant literature was searched from Medline, Embase, Web of Science (up to April 2014) as well as manual searches of reference lists of selected publications. Cohort studies on the association between depression and breast cancer were included. Data abstraction and quality assessment were conducted independently by two authors. Random-effect model was used to compute the pooled risk estimate. Visual inspection of a funnel plot, Begg rank correlation test and Egger linear regression test were used to evaluate the publication bias. Results: We identified eleven cohort studies (182,241 participants, 2,353 cases) with a follow-up duration ranging from 5 to 38 years. The pooled adjusted RR was 1.13(95% CI: 0.94 to 1.36; $I^2=67.2%$, p=0.001). The association between the risk of breast cancer and depression was consistent across subgroups. Visual inspection of funnel plot and Begg's and Egger's tests indicated no evidence of publication bias. Regarding limitations, a one-time assessment of depression with no measure of duration weakens the test of hypothesis. In addition, 8 different scales were used for the measurement of depression, potentially adding to the multiple conceptual problems concerned with the definition of depression. Conclusions: Available epidemiological evidence is insufficient to support a positive association between depression and breast cancer.

Diagnostic methods for assessing maxillary skeletal and dental transverse deficiencies: A systematic review

  • Sawchuk, Dena;Currie, Kris;Vich, Manuel Lagravere;Palomo, Juan Martin;Flores-Mir, Carlos
    • The korean journal of orthodontics
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    • v.46 no.5
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    • pp.331-342
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    • 2016
  • Objective: To evaluate the accuracy and reliability of the diagnostic tools available for assessing maxillary transverse deficiencies. Methods: An electronic search of three databases was performed from their date of establishment to April 2015, with manual searching of reference lists of relevant articles. Articles were considered for inclusion if they reported the accuracy or reliability of a diagnostic method or evaluation technique for maxillary transverse dimensions in mixed or permanent dentitions. Risk of bias was assessed in the included articles, using the Quality Assessment of Diagnostic Accuracy Studies tool-2. Results: Nine articles were selected. The studies were heterogeneous, with moderate to low methodological quality, and all had a high risk of bias. Four suggested that the use of arch width prediction indices with dental cast measurements is unreliable for use in diagnosis. Frontal cephalograms derived from cone-beam computed tomography (CBCT) images were reportedly more reliable for assessing intermaxillary transverse discrepancies than posteroanterior cephalograms. Two studies proposed new three-dimensional transverse analyses with CBCT images that were reportedly reliable, but have not been validated for clinical sensitivity or specificity. No studies reported sensitivity, specificity, positive or negative predictive values or likelihood ratios, or ROC curves of the methods for the diagnosis of transverse deficiencies. Conclusions: Current evidence does not enable solid conclusions to be drawn, owing to a lack of reliable high quality diagnostic studies evaluating maxillary transverse deficiencies. CBCT images are reportedly more reliable for diagnosis, but further validation is required to confirm CBCT's accuracy and diagnostic superiority.

An Intercomparison of Counting Efficiency and the Performance of Two Whole-Body Counters According to the Type of Phantom

  • Pak, Minjung;Yoo, Jaeryong;Ha, Wi-Ho;Jin, Young-Woo
    • Journal of Radiation Protection and Research
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    • v.41 no.3
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    • pp.274-281
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    • 2016
  • Background: Whole-body counters are widely used to evaluate internal contamination of the internal presence of gamma-emitting radionuclides. In internal dosimetry, it is a basic requirement that quality control procedures be applied to verify the reliability of the measured results. The implementation of intercomparison programs plays an important role in quality control, and the accuracy of the calibration and the reliability of the results should be verified through intercomparison. In this study, we evaluated the reliability of 2 whole-body counting systems using 2 calibration methods. Materials and Methods: In this study, 2 whole-body counters were calibrated using a reference male bottle manikin absorption (BOMAB) phantom and a Radiation Management Corporation (RMC-II) phantom. The reliability of the whole-body counting systems was evaluated by performing an intercomparison with International Atomic Energy Agencyto assess counting efficiency according to the type of the phantom. Results and Discussion: In the analysis of counting efficiency using the BOMAB phantom, the performance criteria of the counters were satisfied. The relative bias of activity for all radionuclides was -0.16 to 0.01 in the Fastscan and -0.01 to 0.03 in the Accuscan. However, when counting efficiency was analyzed using the RMC- II phantom, the relative bias of $^{241}Am$ activity was -0.49 in the Fastscan and 0.55 in the Accuscan, indicating that its performance criteria was not satisfactory. Conclusion: The intercomparison process demonstrated the reliability of whole-body counting systems calibrated with a BOMAB phantom. However, when the RMC-II phantom was used, the accuracy of measurements decreased for low-energy nuclides. Therefore, it appears that the RMC-II phantom should only be used for efficiency calibration for high-energy nuclides. Moreover, a novel phantom capable of matching the efficiency of the BOMAB phantom in low-energy nuclides should be developed.

Semi Automatic Adjustment Method Development of Cadastral Non-coincidence based on knowledge of an expert on Cadastral (지적전문가 지식 기반의 반자동 방식에 의한 지적불부합지 정리 방법 개발)

  • Hong, Sung-Eon;Kim, Hyun-Suk
    • Spatial Information Research
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    • v.14 no.3 s.38
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    • pp.271-284
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    • 2006
  • This study suggests the adjustment method of cadastral non-coincidence using spatial data referenced digital cadastral map and a present state. In designing the methodology, we should introduce the semi-automatic method for guaranteeing the stability and the accuracy at the arrangement of cadastral non-coincidence based on some cadastral specialist. This study could mainly show you rotation type, bias type, and rotation/bias type among cadastral non-coincidence types. We selected the matching reference point through the prototype system which automatically arranges in the study area. And then, we analysis the optimum rotation ratio(-0.4%). Finally, this paper show you calibrating cadastral non-coincidence using the rotation ratio. The methodology of this study has a limitation for arranging in case of cadastral non-coincidence by the area variation and some irregular types with unknown reason. Therefore, this case should be surveyed in direct method.

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