• 한국결정성장학회지
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• 제5권4호
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• pp.343-350
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• 1995

$\alpha$ - 및 $\beta$-SiC를 출발원료로 하여 일축성형한 후 $1800^{\circ}C$에서 고온가압법으로 소결한 탄화규소에 나타난 우선방위의 정도를 X-ray pole figure analysis로 조사하였다. $\alpha$-SiC를 출발원료로 사용한 경우에 고온 가압소결 후 약한 집합조직을 보인 반면, $\beta$ - SiC를 출발원료로 사용한 경우 고온가압소결 후 강한 집합조직을 보였으며, 이 경우 ${\beta} {\rightarrow} {\alpha}$ 상변태에 기인한 이중미세구조를 나타내었다. 또한, 집합조직의 강도는 고온가압소결 후 행해진 열처리 조건에 따라서도 변화를 보였다.

• 대한수학회논문집
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• 제30권4호
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• pp.403-414
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• 2015

Extensions of some classical special functions, for example, Beta function B(x, y) and generalized hypergeometric functions $_pF_q$ have been actively investigated and found diverse applications. In recent years, several extensions for B(x, y) and $_pF_q$ have been established by many authors in various ways. Here, we aim to generalize Appell's hypergeometric functions of two variables and Lauricella's hypergeometric function of three variables by using the extended generalized beta type function $B_p^{({\alpha},{\beta};m)}$ (x, y). Then some properties of the extended generalized Appell's hypergeometric functions and Lauricella's hypergeometric functions are investigated.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.136.1-136.1
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• 2003

$\beta$-amyloid (A$\beta$) peptide produced from amyloid precursor protein (APP) is a major cause of Alzheimer's disease (AD). Therefore, in early phase of AD, imbalance of the production and the clearance of $A\beta$ is regarded as an important factor to progressive AD presenting senile plaque, a hallmark of AD. In the present study, we wanted to verify whether Rg3 can playa role in helping microglia engulfing $A\beta$ peptides. Validations for the study was conducted by using DiI-Ac-LDL, which attached only on type A macrophage scavenger receptor (MSR-A) and ligands for he receptor, fucoidan. (omitted)

• Clinical and Experimental Reproductive Medicine
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• 제28권4호
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• pp.279-286
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• 2001

Objective: To elucidate 1) whether there are any differences in the urine concentrations of steroid hormone metabolites between patients with leiomyoma and normal controls 2) the correlation between urinary profiles of steroid hormones and leiomyomas of the uterus according to their type, location, volume, and weight. Materials of Methods : The study population consisted of 37 premenopausal patients with uterine leiomyoma and the control group consisted of 25 premenopausal normal volunteer women without uterine leiomyoma. Confirmation of the existence of uterine leiomyoma was done by ultrasonography and histopathological examination after surgery. The volume of the leiomyoma was estimated by trans-abdominal and/or trans-vaginal ultrasonography. The Leiomyomas were divided into 3 types (subserosal, intramural and submucosal). Seventeen patients had subserosal type of leiomyoma, 10 with the intramural type and 10 with the submucosal type. The locations of the leiomyoma were also divided into 3 groups (fundus, body and isthmus). Seventeen patients showed a fundus location, 10 in body, and 10 in isthmus. We compared urinary profiles of the endogenous steroids between patients with leiomyomas and normal controls, and also investigated the relationship between urinary profiles of the endogenous steroids and leiomyomas according to their type, location, volume and weight by using highly sensitive Gas Chromatography-Mass Spectrometry (GC-MS) system. Results: The mean ages of the patients with leiomyomas and the control group were $43.1{\pm}5.6$ and $40.6{\pm}7.2$ years, the weights were $63.4{\pm}7.3$ and $59.4{\pm}8.1\;kg$, and their heights were $155.4{\pm}4.8$ and $159.3{\pm}4.8\;cm$ respectively. Seventeen patients had subserosal, 10 had intramural, and 10 had submucosal leiomyomas. There were 17 patients with leiomyoma located in fundus, 10 in body and 10 in isthmus. $17{\beta}$-estradiol, 5-AT, 11-keto ET, $11{\beta}$-hydroxy An, $11{\beta}$-hydroxy Et, THS, THA, THE, a-cortolone, a-cortol, $\beta$-cortol, $11{\beta}$-OH Et/$11{\beta}$-OH An and E2/E1 were significantly increased in patients with leiomyoma than in the control group. $17{\beta}$-estradiol was significantly increased in the intramural and the submucosal types than in the subserosal type. There was no significant difference in the concentrations of urinary steroids according to the locations of leiomyomas. There was no significant relationship between the concentration of urinary steroids and the volume of the leiomyomas. $17{\beta}$-estradiol significantly decreased as the weight of uterus increased (r=-0.322, p=0.04). Conclusion: The concentrations of steroid hormone metabolites were generally increased in patients with leiomyoma but were not significantly related to the volume and weight of the leiomyomas. Our study suggests that steroid hormones may be involved in the initiation of leiomyomas but may not be involved in their progression. In addition, the concentrations of steroid hormone metabolites are not related to the leiomyoma type and location.

• 한국어류학회지
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• 제23권1호
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• pp.21-29
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• 2011

볼락의 성장단계에 따른 차등발현 유전자를 탐색하기 위하여 6개월령 및 18개월령 근육조직을 사용하여 subtracted cDNA library를 제작하였고, 각각의 연령에서 발현량 차이를 나타낸 202개의 cDNA 단편을 확보하였으며, 발현량 차이가 뚜렷한 32개의 cDNA 클론은 성장단계별 특이발현 후 보유전자로 선발하여 염기서열을 분석하였다. Myosin, adenylate kinase, calsequestrin, dystrobrevin beta, diphosphate kinase 유전자는 6개월령 근육조직에서 발현량이 많았으며, desmin, TGFBR2 (transforming growth factor-beta receptor), creatine kinase (muscle type), cathepsin D 유전자는 18개월령 근육조직에서 발현량이 많았다. 볼락의 성장초기와 성장절정기에서 차등발현 양상을 나타낸 유전자는 6, 18, 30, 42개월령 근육조직에서 연령 증가에 따른 발현양상을 분석하였으며, dystrobrevin beta와 diphosphate kinase-Z1은 6개월령 이후에는 발현량이 급격히 감소하여 18개월령, 30개월령 및 42개월령에서는 발현량이 극히 적었으며, creatine kinase (muscle type)와 cathepsin D 유전자는 연령 이 증가함에 따라 발현량이 증가되어 18개월령 이후, 30개월령과 42개월령 근육조직에서도 발현량이 많았다. 이와 같이 성장단계에 따른 차등발현 유전자를 탐색하고 연령 증가에 따른 발현양상을 비교 분석한 결과로부터 본 연구에서는 어류의 성장 초기단계 근육조직에서는 근육수축 관련 유전자가 많이 발현되고, 성장 절정기에는 근육 내 에너지 양 조절 관련 유전자가 많이 발현되는 것을 확인하였다.

• Biomolecules & Therapeutics
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• 제26권6호
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• pp.560-567
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• 2018

In the present study, we tried to examine whether resveratrol regulates the expression of matrix metalloproteinases (MMPs) through affecting nuclear factor-kappa B ($NF-{\kappa}B$) in articular chondrocytes. Rabbit articular chondrocytes were cultured in a monolayer, and reverse transcription-polymerase chain reaction (RT-PCR) was used to measure interleukin-${\beta}$ ($IL-1{\beta}$)-induced gene expression of MMP-3, MMP-1, MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), ADAMTS-5 and type II collagen. Effect of resveratrol on $IL-1{\beta}$-induced secretion of MMP-3 was investigated in rabbit articular chondrocytes using western blot analysis. To elucidate the action mechanism of resveratrol, effect of resveratrol on $IL-1{\beta}$-induced $NF-{\kappa}B$ signaling pathway was investigated in SW1353, a human chondrosarcoma cell line, by western blot analysis. The results were as follows: (1) resveratrol inhibited the gene expression of MMP-3, MMP-1, MMP-13, ADAMTS-4, and ADAMTS-5, but increased the gene expression of type II collagen; (2) resveratrol reduced the secretion of MMP-3; (3) resveratrol inhibited $IL-1{\beta}$induced activation (phosphorylation) of inhibitory kappa B kinase (IKK), and thus phosphorylation and degradation of inhibitory kappa $B{\alpha}$ ($I{\kappa}B{\alpha}$); (4) resveratrol inhibited $IL-1{\beta}$-induced phosphorylation and nuclear translocation of $NF-{\kappa}B$ p65. This, in turn, led to the down-regulation of gene expression of MMPs in SW1353 cells. These results suggest that resveratrol can regulate the expression of MMPs through affecting $NF-{\kappa}B$ by directly acting on articular chondrocytes.

• 한국잠사곤충학회지
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• 제40권1호
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• pp.52-59
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• 1998

For the construction of plasmid and bmNPV sarrying the FRT recognition site for the FLP recombinases, we synthesized the wild type FRT dligonucleotides. The target FRT sequences consist of three 13bp repeated DNA sequences; two repeats in a direct orientation and one inverted relative to the other two. In addition, there is an 8bp spacer region between the repeats which determune the orientation of the FRT recombination site. In order to place the FRT site both in target BmNPV genome and the transfer vector, we constructed a plasmid, FRT site both in the target BmNPv genome and the transfer vector, we constructed a plasmid, pFRT$\beta$-gal, carrying the FRT sites within the cloning sites of pSV vector and a recombinant BmNPV, vFRTPH, carrying the FRT sites at a downstream of polyhedrin promotor, respectively. In order to test the functionality of the FLP/FRT site-specific recombination system, vFRTPH, pFRT$\beta$-gal and pHsFLP DNA were co-transfected into BmN-4 cells. The resulting recombinant virus was designated a vFRT$\beta$2-gal. From construction analysis of the vFRT$\beta$2-gal with PCR technique it was concluded that the entire pFRT$\beta$-gal plasmid with $\beta$-galactosidase gene and origines of replication flanked by two functional hybrid FRT sequences. The efficiency of recombination was 8.7%, which was higher than that(2.2%) of recombination between a conventional transfer vector and the wild type BmNPV.

• 한국콘텐츠학회논문지
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• 제16권2호
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• pp.503-512
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• 2016

본 연구의 목적은 유방암 생존자의 사회경제적 지위가 삶의 질에 미치는 영향을 검토하는 것으로, 자료수집은 우리나라에서 유방암 발생률이 가장 높은 40대 유방암 생존자들을 대상으로 이루어졌다. 총 607사례가 분석에 포함되었으며, FACT-B로 측정된 대상자의 삶의 질 총점평균은 93.75(SD=21.50)이었다. 다른 인구사회학적 변수와 의료적 변수를 통제하였을 때, 삶의 질은 소득 및 직업유형과 유의미한 관계가 있는 것으로 나타나 높은 수준의 사회경제적 지위와 높은 삶의 질 간의 관계를 확인해주었다. 구체적으로 자영업이나(${\beta}=0.10$, p= .01) 전문/사무직에 종사할수록(${\beta}=0.17$, p< .001), 또한 소득수준이 400만 원 이상일수록(${\beta}=0.11$, p= .03) 유의미하게 삶의 질이 높은 것으로 나타났다. 공적 사적 자원을 포함하여 사회경제적 지위가 낮은 유방암 생존자에 대한 관심과 지원의 필요성과 실천상의 함의가 논의되었다.

• Corrosion Science and Technology
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• 제6권3호
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• pp.128-132
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• 2007

For a quantitative inspection on the performance of weathering steel bridges, we have investigated the relationship between the corrosion rate and the composition of the rust layers formed on weathering steel bridges located in various environments in Japan and applied a protective ability index (PAI) to the bridges. The corrosion rates were clearly classified by the PAI, ${\alpha}/{\gamma}*$ and sub index of $({\beta}+s)/{\gamma}*$, where $\alpha$, \gamma*, $\beta$ and s are the mass ratio of crystalline $\alpha-FeOOH$, the total of $\gamma$-FeOOH+ $\beta$-FeOOH + the spinel-type iron oxide (mainly $Fe_3O_4$), $\beta-FeOOH$ and spinel-type iron oxide, analyzed by powder X-ray diffraction, respectively. In the case of ${\alpha}/{\gamma}$*>1, the rust layer works protective enough to reduce the corrosion rate less than 0.01 mm/y. The sub index $({\beta}+s)/{\gamma}*$<0.5 or >0.5 classifies the corrosion rate of the non-protective rust layers, therefore the former state of the rust layer terms inactive and the latter terms active. The quantitative inspection of a weathering steel bridge requires a performance-inspection (PI) and periodical deteriorationinspections (DI). The PI can be completed by checking of the PAI, ${\alpha}/{\gamma}*$. The DI on the weathering steel bridges where deicing salt is sprinkled can be performed by checking the PAI, $({\beta}+s)/{\gamma}*$.

• 한국보건간호학회지
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• 제28권2호
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• pp.228-240
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• 2014

Purpose: This study was conducted in order to determine the influences of knowledge, self-efficacy, and social support on sick role behavior in patients with coronary artery disease. Methods: The participants were 192 patients with coronary artery disease in D city. Data were collected from January 1, 2014 to April 30, 2014 using a questionnaire. Data analysis was performed using SPSS/WIN 19.0 using ANOVA, t-test, Pearson correlation, and stepwise multiple regression. Results: Factors having an influence on sick role behavior were age (70 years old ${\beta}$=.275, p<.001), occupation (Office job ${\beta}$=-.230, p<.001), knowledge (${\beta}$=.204, p<.001), self-efficacy (${\beta}$=.188, p<.001), underlying disease (stroke ${\beta}$=.142, p=.008), and family type (live with their children ${\beta}$=-.128, p=.038). These factors explained 56% of the variance in sick role behavior. Conclusions: More positive knowledge and self-efficacy are needed for the sick role behavior. In addition, results of the study indicated that age, occupation, underlying disease, and family type were very important in predicting health behaviors of patients with coronary artery disease. Thus, it would be necessary to include patients' characteristics in designing an education program for people with coronary artery disease.