• 대한두경부종양학회지
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• 제15권2호
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• pp.205-210
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• 1999

Objectives: Major salivary gland tumor mainly develops in the parotid gland and pleomorphic adenoma is a large percentage. The aim of this study is to get clinicopathologic characteristics of overall major salivary gland tumors and suggestions regarding surgical management through collective review of 315 cases. Materials and Methods: This is a clinicopathologic review of 315 cases of major salivary gland tumor who were treated surgically at Department of Surgery, Head and Neck Clinic, Pusan Paik Hospital, Inje University during the period of 18 years from 1980 to 1997. Analysis was performed regarding the incidence, classification, surgery and its complications, and survival rate of salivary gland cancer. Results : 1) Parotid gland was the most prevalent site of salivary gland tumor(78%) and submandibular gland(21%) was next in order. Benign tumors were 257cases(81%) and malignant tumors were 58 cases(19%). 2) Male to female sex ratio was 1:1.2, the most prevalent age group was 3rd decade and the second group was 4th decade. 3) Histopathologically, the most common benign salivary gland tumor was pleomorphic adenoma. Warthin's tumor was next common. Among the malignant tumors, mucoepidermoid carcinoma was most common, and the next were adenoid cystic carcinoma and acinic cell carcinoma. 4) In pleomorphic adenoma, superficial parotidectomy was performed in 129 cases, and extracapsular tumorectomy was performed in 3 cases. In non-pleomorphic benign tumor, tumorectomy was performed in 21 cases. In 40 cases of deep lobe tumor, total parotidectomy was performed in only 2 cases and deep parotidectomy was performed in 38 cases. 5) Surgical complications were facial nerve injury 19 cases, Frey syndrome 13 cases, and salivary fistula 3 cases. 6) Overall 5-year survival rate of salivary gland cancer was 63%. Conclusion: Postoperative recurrence rate is low in benign tumor, but high in cancer of salivary gland tumor. Surgical procedure should not be aggressive in benign tumor, especially in parotid tumor, but should be aggressive in malignant salivary gland tumors.

• 대한영상의학회지
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• 제82권5호
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• pp.1103-1123
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• 2021

자궁은 크게 자궁체부와 자궁경부로 나뉜다. 이 중 자궁내막과 자궁근층으로 이루어진 자궁체부에는 양성에서 악성 종양까지 다양한 질환이 발생한다. 비침습적인 일차적 평가로 초음파와 컴퓨터단층촬영이 있으나 비특이적인 영상 소견으로 감별이 어려운 경우가 있다. 반면 높은 해상도와 병리학적 특성 파악이 가능한 자기공명영상은 병변의 위치 확인뿐만 아니라 조직학적 특징, 그리고 악성 종양의 병기 설정에도 도움을 준다. 이 종설에서는 영상의학과 의사들이 알아야 할 자궁체부에서 볼 수 있는 다양한 양성과 악성 종양들의 특징적인 자기공명영상 소견들과 이들의 감별점에 대해 정리했다.

• 대한두경부종양학회지
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• 제27권2호
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• pp.204-209
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• 2011

Background and Objectives : The usefulness of fine needle aspiration biopsy(FNAB) for diagnosis of parotid gland tumors is controversial, because of the generalized belief requiring surgery for most parotid tumors. The aim of this study was to evaluate the efficacy of FNAB for diagnosis in parotid gland tumors. Material and Methods : FNAB was performed in 91 patients who underwent parotid surgery at Kangbuk Samsung Hospital from January 2007 to December 2010. The result of FNAB, 11 malignancies and 75 benign tumors and 5 non-neoplasms were analyzed and compared with the final histopathologic diagnoses. Sensitivity, specificity, accuracy, positive predictive value(PPV), and negative predictive value(NPV) were calculated using final histopathologic diagnosis of the surgical specimen as the standard diagnostic reference for comparative analysis. Results : 86 specimens(94.5%) were suitable for evaluation. We compared the result of FNAB and the final histopathology in 79(89.4%) cases. The sensitivity, specificity, accuracy, PPV, and NPV of FNAB for detecting pleomorphic adenoma was 95.8%, 88.4%, 92.3%, 90.2%, and 95.0%. In Warthin's tumor, results were 86.4%, 94.2%, 92.3%, 82.6%, and 95.6%. Among 11 patients who were diagnosed with malignancy on final histopathologic report, only 3(30%) patients were diagnosed with the same as on FNAB, the other 8 patients were initially diagnosed incorrectly as benign tumors in FNAB. There were no complications related to FNAB. Conclusion : Diagnostic accuracy for FNAB in benign parotid tumors was high. However, in malignant tumors, FNAB shows low diagnostic usefulness compared with benign tumors. FNAB can be effective and safe diagnostic technique for evaluating the benign parotid glands tumors.

• 대한두경부종양학회지
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• 제13권2호
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• pp.180-186
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• 1997

Objectives: Salivary gland tumors pose considerable difficulty in diagnostic and prognostic assessment based on the histopathologic features alone. We studied the expression of type IV collagen and fibronectin in salivary gland tumors with special emphasis on the differential diagnostic significance. Materials and Methods: We did immunohistochemical stain on paraffin embedded tissues of 33 benign and 24 malignant salivary gland tumors using monoclonal antibody for type IV collagen and polyclonal antibody for fibronectin. Results: 1) Well preserved linear basement membrane-like staining of type IV collagen was detected in duct-cell-derived benign salivary gland tumors. But pleomorphic adenoma exhibited a heterogeneous pattern as focal augmentation and interruption. 2) In malignant tumors, type IV collagen was distributed in an irregular, interrupted manner or completely absent. Adenoid cystic carcinomas displayed a marked staining of the basal membrane associated substances in the pseudocysts. 3) The staining pattern of fibronectin was similar to that of type IV collagen execpt more dense in the stroma. 4) Salivary gland tumors which have a prominent myoepithelial cell component revealed a particular deposition of basement membrane materials adjacent to the myoepithelial cells. Conclusion: The study of the basal membrane substances may be helpful for differential diagnosis of benign and malignant salivary gland tumors and identifying special features of salivary gland tumors such as pseudocystic pattern of adenoid cystic carcinoma. Also we think that the myoepithelial cells contribute to the formation of basement membrane materials.

• 대한골관절종양학회지
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• 제5권1호
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• pp.35-43
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• 1999

1984년 2월부터 1997년 11월까지 한양대학교 의과대학교 정형외과학교실에서 경험한 양성 연부조직 종양 중 병리조직학적으로 확진된 총 230례에 대하여 임상적으로 분석하여 다음과 같은 결과를 얻었다. 1. 양성 연부조직 종양중 결절종(26.5%)이 가장 많았고, 혈관종(19.6%), 지방종(17.0%), 슬와낭종(13.0%), 신경초종(7.0%)의 순으로 발생하였다. 그리고, 임파관종(3.9%), 섬유종증(3.0%), 사구종(3.0%), 신경 섬유종(2.2%), 평활근종(0.9%), 색소 융모결절성 활막염(0.9%), 점액종(0.9%), 외상성 신경종(0.9%), 황색종(0.4%), 활액막성 연골종증(0.4%), 골화성 근염(0.4%)이 발생하였다. 2. 종양의 분포 연령은 비교적 전 연령층에 걸쳐 고르게 발생하였다. 이 중 혈관종과 임파관종은 20세 이전에 호발하는 경향을 보였다. 3. 성별 분포는 남자 98례, 여자 132례로 여자에게 약 1.3배 많았으나, 슬와낭종과 신경초종은 남자에게 호발하였다. 4. 15세 이하의 소아에서는 혈관종, 결절종, 임파관종, 지방종의 순으로 발생하였고, 16세 이상의 성인에서는 결절종, 지방종, 슬와낭종, 혈관종의 순으로 발생하였다. 5. 발생 부위는 하지(60.0%)에 호발하였고, 상지(35.2%), 체간(4.8%)의 순으로 발생하였다. 6. 크기가 1cm 미만인 종양은 결절종, 사구종, 혈관종, 임파관종의 순으로 발생하였고, 1-5cm인 종양은 결절종, 혈관종, 슬와낭종, 지방종, 신경초종의 순으로 발생하였다. 5cm 이상인 종양은 지방종, 혈관종, 임파관종, 결절종의 순으로 발생하였다. 7. 모든 환자는 절제술로 치료받았고, 국소 재발은 22례(9.6%)에서 나타났으며 혈관종이 12례로 가장 많았다. 재발율은 외상성 신경종, 색소 융모결절성 활막염, 신경 섬유종, 섬유종증, 혈관종의 순으로 나타났다.

• 대한두경부종양학회지
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• 제13권2호
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• pp.206-212
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• 1997

H$\"{u}$rthle cell neoplasm of the thyroid gland is an uncommon, but potentially malignant lesion. However, in many instances, the malignant potential of the H$\"{u}$rthle cell neoplasm is very difficult to judge histologically. For this reason, the biologic behavior of this tumor and its optimal treatment have come under considerable debate in recent years. In order to review the clinicopathologic features of the H$\"{u}$rthle cell neoplasm and to determine its optimal treatment modalities, we studied 26 patients with path logical proof of H$\"{u}$rthle cell tumor from January 1987 to September 1997. We also performed an immunohistochemical study using the monoclonal antibodies against antigen CD34 for the angiogenic activity of this tumor and evaluated the differences of microvessel density(MVD) between benign and malignant tumors. The age of the patients ranged from 1 to 71 years with a mean of 44.2 years. There were 6 males and 20 females(M : F= 1 : 3.3). The accuracies of fine needle aspiration biopsy and frozen section were very low; 6.3% and 34.8%, respectively. There were 20 benign tumors and 6 malignant tumors(23.1%). All the malignant tumors were microinvasive(intermediate) type which had minimal capsular invasion and most of them(5 cases) were diagnosed postoperatively. Any specific clinicopathologic differences were not seen between benign and intermediate groups. Most of the cases had conservative surgeries(15 ipsilateral lobectomy-isthmusectomy, 7 subtotal thyroidectomy) while total thyroidectomy was performed in 4 cases. Of the cases with malignant tumor, 2 had ipsilateral lobectomy-isthmusectomy, 3 had subtotal thyroidectomy and the remaining 1 had total thyroidectomy. Mean size of the tumors was 3.0 cm(0.1- 8.5 cm) in the greatest diameter and multiple tumors were seen in 6 cases(23.1 %). During the follow-up period, only one recurrence(3.8%) of benign tumor occurred but distant metastasis or cause-specific death was seen in the benign or intermediate groups. Mean MVDs of the benign(n=13) and intermediate(n=6) groups were $121.7{\pm}35.3$ and $114.3{\pm}31.7$, respectively and there was no statistical significance between them. In conclusion, because of the low accuracies of fine needle aspiration biopsy and frozen section for the H$\"{u}$rthle cell neoplasm, the extent of surgery could be individualized based on permanent pathologic examination; Conservative surgery would be adequate for patients with benign or intermediate H$\"{u}$rthle cell neoplasm and total or near-total thyroidectomy for those with definite malignancy.

• 대한수의학회지
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• 제56권4호
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• pp.229-232
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• 2016

Mammary gland tumors are very rare in male dogs. In this study, four mammary gland tumors from 3 male dogs (2 intact, 1 neutered) were collected from local animal hospitals. The dogs included two purebred Shih Tzu (1 intact, 1 neutered) and one intact purebred Cocker Spaniel. The mean age of dogs with mammary gland tumors was 9 years (5-12 years). Two dogs had a solitary mass, whereas one dog had two mammary masses. Of the four tumor masses, three were observed in the fourth or fifth mammary glands, and one was observed in the third mammary gland. According to histopathologic examinations, all four mammary masses from three dogs were benign tumors including two benign mixed tumors in one case and two complex adenomas. There were no history of obesity, testicular tumors, diabetes, and sex hormonal therapy in any male dogs with mammary tumors. Surgical excision was the only reported treatment for these tumors. No recurrence or metastasis was recorded up to 25 months after surgery.

• Journal of Chest Surgery
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• 제37권12호
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• pp.1036-1039
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• 2004

기관 및 기관지 종양은 대부분이 악성 종양이며 양성 종양은 10% 이내에 불과하다. 특히 폐에 발생하는 원발성 신경성 종양은 전체 폐종양의 2% 이하로 대부분이 Schwann세포에서 기원한다고 알려져 있다. 이러한 종양은 주로 고립성 양성 종양으로 나타나며 드문 경우에 악성의 형태를 보이기도 한다. 기관지내 신경초종은 폐의 원발성 종양 중에서 발생빈도가 매우 낮은 것으로 알려져 있다. 저자들은 기관지내 신경초종으로 폐엽절제술을 시행한 2예를 보고하는 바이다.

• 대한두경부종양학회지
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• 제12권2호
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• pp.230-234
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• 1996

Benign nonepithelial tumors of the thyroid gland are very rare and include lesions such as vascular tumors, smooth muscle tumors and neurogenic tumors. Schwannoma and neurofibroma are benign neoplasms of mesenchymal origin which frequently occur in the head and neck, but their origin within the thyroid gland has rarely been reported. Recently, we encountered two cases of neurogenic tumor of thyroid gland(l schwannoma, 1 neurofibroma) and report them to support the view that Schwannoma and neurofibroma may occur in thyroid gland, which is an unusual site, and are recognizable entities.

• Journal of Chest Surgery
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• 제31권10호
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• pp.988-994
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• 1998

연구배경 : 흉벽종양은 연부조직 종양과 골조직 종양으로 대별할 수 있으며 이를 다시 양성종양과 악성종양으로 구분할 수 있다. 재료 및 방법 : 한양대학병원 흉부외과 교실에서는 1973년 1월 부터 1997년 9월까지 치료한 원발성 흉벽종양 68례를 경험한 바, 이에 보고하는 바이다. 결과 : 환자는 총 68명으로 이중 남자가 33명 (48.5%), 여자가 35명(51.5%) 이었다. 환자의 연령은 10세에서 79세 사이로 평균연령은 39.4세이었다. 환자의 연령별 분포는 30대가 23명 (33.8%), 50대가 12명 (17.6%), 40대가 10명 (14.7%) 순이었다. 전체 종양중 양성종양이 53례이었고, 악성종양이 15례이었다. 양성종양은 30대에서 17례(32.1%), 악성종양은 30대에서 6례 (40%)로 나타나, 악성종양과 양성종양 모두 30대에서 가장 많았다. 양성종양중 섬유성 이형성증과 연골종이 각각 14례 (26.4%) 씩으로 가장 많았고, 골연골종과 지방종이 각각 8례 (15.1%) 씩이었다. 악성종양은 골육종이 8례(53.3%)로 가장 많았다. 종양의 발생부위는 골 및 연골조직이 49례, 연부조직이 19례이었다. 환자의 증상은 전례에서 종괴가 만져졌고 압통을 호소한 환자가 51례, 흉벽종양이 폐를 침범한 3례에서 호흡곤란을 호소하였다. 악성종양중 6례 (40%)에서 광범위 절제술을 하였고, 양성종양은 4례 (7.7%)에서 광범위 절제술을 하였다. 수술 후 인대양 종양 1례에서 재발을 하였다. 수술이나 수술 후 합병증으로 인한 사망자는 없었다. 결론 : 원발성 흉벽종양은 환자의 대부분에서 종괴가 만져져 내원하는 경우가 많았으며, 양성종양인 경우 절개로 치유되지만 악성종양인 경우 흉벽의 광범위 절개가 요구되고 이에 따른 흉벽 재건술이 필요할 수 있다.