• Clinical and Experimental Pediatrics
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• 제49권11호
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• pp.1125-1139
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• 2006

In 1991, the Ministry of Health & Social affairs adopted a nationwide service program for neonatal screening of phenylketonuria, galactosemia, maple syrup urine disease, homocystinuria, histidinemia & congenital hypothyroidism for newborns delivered from low class pregnant women registered in health centers. Government decreased the test items from six to two, PKU & congenital hypothyroidism to increase test numbers with same budget from 1995. Government decided to test PKU & hypothyroidism for all newborns from 1997. 78 laboratories wanted to participate for neonatal screening test in 1999. Government didn't decide laboratory center for a certain district and placed responsibility on free competition. Government are planning to test 573,000 newborns from 1998, Government decided to screen 6 items PKU, congenital hypothyroidism, maple syrup urine disese, homocystinuria, galactosemia and congenital adrenal hyperplasia from 2006. 17 laboratores are participating now. The cost of screening test is supported by both the federal government and local government on a 40-60 basis. In case a patient with an inherited metabolic disease is diagnosed by screening of government program, special milk is provided at government's expense. Interlaboratory quality control was started 6 times a year from 1994. According to the government project, 3,707,773 newborns were screened. 86 PKU, 718 congenital hypothyroidism were detected. So incidence of PKU is 1/43,114 and congenital hypothyroidism is 1/4,612. Maeil dairy company produced new special formula for PKU, MMA and PA, MSUD, urea cycle disorder, homocystinuria, isovaleric acidemia from Oct. 1999. The cost benefit of performing screening procedures coupled with treatment has been estimated to be as high as 1.77 times in PKU, 11.11 times in congenital hypothyroidism than cost without screening. We are trying to increase the budget to test all newborns for Tandem mass sereening & Wilson disease from 2008. Now it is a very important problem to decrease laboratory numbers of neonatal screening in Korea. So we are considering 4-5 central laboratories which cover all newborns and are equipped with tandem mass spectrometer & enzyme immunoassay for TSH, 17OHP & enzyme colorimetric assay for galactose.

• 기술사
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• 제17권3호
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• pp.22-31
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• 1984

Sardine ant mackerel so called dark muscled fish have been underutilized due to the disadvantages in bloody meat color, high content of fat, and postmortem instability of protein. Recent efforts were made to overcome these defects and develope new types of product such as texturized protein concentrates and dark muscle eliminated minced fish. Approach of this study is based on the rapicl dehydration of foamed fish-starch paste by dielectric heating. In process comminuted sardine meat was washed more than three times by soaking and decanting in chilled water and finally centrifuged. The meat was ground in a stone mortar added with adequate amounts of salt, foaming agent, and other ingredients for aid to elasticity and foam stability. The ground meat paste was extruded in finger shape and heated in a microwave oven to give foamed, expanded, and porous solid structure by dehydration. Dielectric constant ($\varepsilon$′) and dielectric loss ($\varepsilon$") vcalues of sardine meat paste were influenced by wavelength and moisture level. Those values at 100KHz and 15MHz were ranged 2.25∼9.86 ; 2.22∼4.18 for $\varepsilon$′ and 0.24∼19.24 ; 0.16∼1.25 for $\varepsilon$", respectively, at the moisture levels of 4.2∼13.8％. For a formula for fish-starch paste preparation, addition of 20∼30% starch (potato starch) to the weight of fish meat, 2∼4% salt, and 5∼10% soybean protein was adequate to yield 4∼5 folds of expansion in volume when heated. Addition of egg yolk was of benefit to micronize foam size and better crispness. In order to provide better foaming and dehydration, addition of 0.2∼0.5% sodium bicarbonate foaming agent, was proper to result in foam size of 0.5∼0.7mm and foam density of 200∼400/$\textrm{cm}^2$ which gave a good crispness.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권1호
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• pp.1-14
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• 2020

The latest definition of a prebiotic is "a substrate that is selectively utilized by host microorganisms conferring a health benefit"; it now includes non-food elements and is applicable to extra-intestinal tissues. Prebiotics are recognized as a promising tool in the promotion of general health and in the prevention and treatment of numerous juvenile diseases. Prebiotics are considered an immunoactive agent, with the potential for long-lasting effects extending past active administration of the prebiotic. Because of its extremely low risk of serious adverse effects, ease of administration, and strong potential for influencing the composition and function of the microbiota in the gut and beyond, the beneficial clinical applications of prebiotics are expanding. Prebiotics are the third largest component of human breast milk. Preparations including galactooligosaccharides (GOS), fructooligosaccharides (FOS), 2'-fucosyllactose, lacto-N-neo-tetraose are examples of commonly used and studied products for supplementation in baby formula. In particular, the GOS/FOS combination is the most studied. Maintaining a healthy microbiome is essential to promote homeostasis of the gut and other organs. With more than 1,000 different microbial species in the gut, it is likely more feasible to modify the gut microbiota through the use of certain prebiotic mixtures rather than supplementing with a particular probiotic strain. In this review, we discuss the latest clinical evidence regarding prebiotics and its role in gut immunity, allergy, infections, inflammation, and functional gastrointestinal disorders.

• 농촌의학ㆍ지역보건
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• 제16권2호
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• pp.179-194
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• 1991

Despite its universal coverage of health insurance, the rural health insurance program(RHIP) stands at the crossroads in Korea. The RHIP has weaknesses in stability of financing, problems of inequities in the provision of health services and has suffered from high cost of running the program. The author has analyzed these problems from the perspective of health insurance policy and presented several options for improvement. First of all, this study urged the importance of a firm Governmental commitment of RHIP with the 50% subsidization of contributions as the Government had promised, instead of the current 40%. This can be justified from the 20% subsidization by the Government for the contributions of private school teachers and their dependents, who belong to richer segments of the population. Second, various cost containment measures ought to be sought curbing the rising demand for medical through strengthening health education and increasing individual responsibility, and tightening the claim review process. Third, this study requires the Government to run a demonstration project on the introduction of case payment system for primary health care. Fourth introducing an income-related cost sharing scheme is another possibility. Reforming the cost sharing formula for large medical expenditures is recommendable for a beginning. This measure can take the form of tax credit for medical expenditures of the poor. Fifth, the degree of financial adjustment among health insurance plans should be levelled up for enhancing stability of RHIP and social solidarity. Sixth, health policy should be redirected toward development of rural health resources and higher priority should be put on relieving difficulties in access to care. Seventh. the insurance plan owned-hospital needs to be developed or provision of health services in the medically underserved areas, and the need of such facilities is particularly acute for geriatric care, rehabilitation and renal dialysis, etc. Eighth, more generous insurance benefits are required of the elderly who are suffering the most : elimination of the maximum 180 days of benefit period and provision of glasses and artificial dentures, etc. Ninth. the economies of scale principle is working for the operating expenses of regional self-employed insurance plan. Thus, measures should be instituted to pursue an optimum size of health insurance plans. Lastly, excessive dependence on exclusion items is an evil so that some radical remedies are urgently required to cut them.

• Toxicological Research
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• 제22권4호
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• pp.339-348
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• 2006

Misaengtang (MST), a formula of Korean herbal medicines, has been used as a weight-controlling recipe. We have investigated two experiment of body weight regulation by MST In rats. i) The anti-obesity effect of MTS on a high fat diet-induced obesity, male Sprague-Dawley rats were fed with a high-fat diet containing 30% in the absence or presence of MST (0.3, 1 or 3%) or a reference orlistat (0.05%) for 6 weeks. ii) weight-decrease effect of MST on normal diet, same animal were fed with a normal diet in the absence or presence of MST (3%) for 6 weeks. And the body weights, daily feed and water consumptions, organ weights, fat weights serum biochemistry were measured. In both experiments, MST and orlistat did not affect the body weight gain. But orlistat significantly increased the feed and water consumptions, leading to low-feed efficiency, and orlistat markedly reduced abdominal, paratesticular and perirenal fat weights, although increased the kidney weights. In MST, low dose (0.3%) of MST decreased the perirenal fat and increased the kidney weights in rats fed HFD, and MST 3% decreased the abdominal fat weights in rats fed normal diet. In addition, Orlistat caused changes in parameters of hepatotoxicity (AST and glucose), nephrotoxicity (BUN and B/C ratio) and lipid metabolism (HDL and triglycerides). In comparison, MST decreased AST, ALP and ALT, the hepatotoxicity markers, and somewhat improved the hepatic fatty degeneration. Taken together, it is suggested that MST does not exert anti-obesity activity as well as remarkably direct effects, but MST may be potentially benefit for dietary cure and exercise-cure of obesity.

• 한국정보통신학회논문지
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• 제8권6호
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• pp.1188-1193
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• 2004

비도 높은 암호용으로 연구된 유한체 곱셈 연산기는 크게 직렬 유한체 곱셈기, 배열 유한체 곱셈기, 하이브리드 유한체 곱셈기으로 분류되어 왔다. 직렬 유한체 곱셈기는 마스트로비토 (Mastrovito) (1)에 의하여 제안되어 유한체 곱셈기의 가장 기본적인 구조로 자리잡아 왔고, 이를 병렬로 처리하기 위해 m 배의 자원을 투자하여 m 배의 속도를 얻어낸 결과가 2차원 배열 유한체 곱셈기이며 (2), 이들 기존 방식의 장점만을 취하여 제안된 방식이 1999년 Paar에 의해 제안된 하이브리드 (hybrid) 곱셈기이다 (3). 반면 이 하이브리드 곱셈기는 사용 가능한 유한체로서 유한체의 차수를 합성수로 사용해야 한다는 제약이 따른다. 본 논문에서는 마스트로비토의 곱셈기의 구조를 기본으로 하고, 수식적으로 공통인수를 끌어내어 후처리하는 기법을 유도하여 적용한다. 제안한 방식으로 설계한 새로운 유한체 곱셈기는 HDL로 구현하여 소프트웨어 측면 뿐 아니라 하드웨어 측면에서도 그 기능과 성능을 검증하였다. 제안된 방식에서 직렬 다항 기준식 (polynomial)을 t (t는 1보다 큰 양의 정수) 부분으로 나누어 적용하였을 경우 곱셈기는 t 배의 속도 향상을 보일 수 있다.

• 대한약침학회지
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• 제3권2호
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• pp.1-25
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• 2000

We were trying to study the validity of Puffer fish's poison(Tetrodotoxin- TTX) to make a traditional Korean Medical treatment. The following conclusions were made after literary studies. 1. The first record of the puffer fish dates back 2000 years ago in the Chinese text Book of Mountain and Sea and other texts from the similar period. 2. Puffer fish's poison IS known as tetrodotoxin which is an amino perhydroquinazoline compound. It has a chemical formula of $C_{11}H_{17}N_3O_8$ in the hemiacetal structure and has the molecular weight of 319. 3. Tetrodotoxin (TTX) plays a role as potent neurotransmitter blocker by blocking the $Na^+$ -gate channel which hinders the influx of $Na^+$ ion into the cell. 4. Symptoms of the puffer fish poisoning ranges from blunted sense in the lips and tongue, occasional vomiting in the first degree to sudden descending of the blood pressure, apnea, and other critical conditions in the fourth degree. Intoxication of the puffer fish poison progresses at a rapid pace as death may occur after an hour and half up to eight hours in maximum. Typical death occurs after four to six hours. 5. Ways to treat the puffer fish poisoning include gastric irrigation, induce vomiting, purgation, intravenous fluid injection, and correcting electrolytic imbalance and acidosis. In cases of dyspnea, apply oxygen inhalation and conduct artificial respiration. 6. Tetrodotoxin (TTX) may be applied in treating brain disorders, ocular pain, excess pain in the large intestine and ileum, and relieving tension of the skeletal museles, neuralgia, rheumatism, arthritis, and etc. 7. In terms of Oriental medicine, the puffer fish poison has characteristics of sweet, warm, and poisonous. It's known efficacies are to tonify weakness, dispel damp, benefit the lower back, relieve hemorrhoid, kills parasites, remove edema, and so forth. And the puffer fish eggs processed with ginger are said to be effective against tuberculosis and lung cancer, thus, it's validity must be investigated and further research should be followed.

• Computers and Concrete
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• 제30권5호
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• pp.311-321
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• 2022

The interfacial bond strength of partially encased composite (PEC) structure tends to 0, therefore, the cast-in-place concrete theoretically cannot embody better composite effect than the fabricated structure. A total of 12 specimens were designed and experimented to investigate the energy dissipation and damage of fabricated PEC beam through unidirectional cyclic loading test. Because the concrete on both sides of the web was relatively independent, some specimens showed obvious asymmetric concrete damage, which led to specimens bearing torsion effect at the later stage of loading. Based on the concept of the ideal elastoplastic model of uniaxial tensile steel and the principle of equivalent energy dissipation, the energy dissipation ductility coefficient is proposed, which can simultaneously reflect the deformability and bearing capacity. In view of the whole deformation of the beam, the calculation formula of energy dissipation is put forward, and the energy dissipation and its proportion of shear-bending region and pure bending region are calculated respectively. The energy dissipation efficiency of the pure bending region is significantly higher than that of the shear-bending region. The setting of the screw arbors is conducive to improving the energy dissipation capacity of the specimens. Under the condition of setting the screw arbors and meeting the reasonable shear span ratio, reducing the concrete pouring thickness can lighten the deadweight of the component and improve the comprehensive benefit, and will not have an adverse impact on the energy dissipation capacity of the beam. A damage model is proposed to quantify the damage changes of PEC beams under cyclic load, which can accurately reflect the load damage and deformation damage.

• 응용통계연구
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• 제28권4호
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• pp.741-762
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• 2015

본 연구는 동학적 미시모의실험(Micro-simulation) 모형인 MMESP(ver. 2.1)를 활용하여 절대빈곤선으로 간주되는 최저생계비를 기준으로 공적연금 수급액수준을 장기적으로 전망 평가한다. 즉, 본 논문에서 제시하는 노인빈곤율은 공적연금소득만을 고려한 전망치임을 주의할 필요가 있다. 그 주요 결과는 다음과 같다. 첫째, 공적연금액의 장기적 변화는 경제성장효과와 제도효과로 분해할 수 있다. 두 효과를 모두 고려하는 경우, 공적연금액이 최저생계비 이하인 노인가구는 2040년대에 20% 정도수준까지 감소한다. 그러나 경제성장효과를 제외한 제도효과만을 고려하는 경우 노인빈곤율은 장기적으로 90% 내외 수준에 이를 것으로 전망된다. 둘째, 기초연금을 A값의 10% 수준으로 고정한다고 할지라도 경제성장효과를 제외한 공적연금 제도 효과만을 보면, CPI에 연동하는 현행 제도에 비해 노인빈곤율을 10%p 정도 더 축소시킬 뿐이다. 셋째, 현행 국민연금의 급여산식에는 소득수준과 가입기간의 현실적인 상관관계가 고려되지 못함으로써 소득계층간 연금급여의 소득대체율이 역전될 가능성이 높다. 넷째, 2007년 개혁으로 소득대체율이 인하되지 않았다면 현행 체계(국민연금+기초연금)에 비해 과거 체계가 노인빈곤 완화 측면에서는 더 효과적일 수 있다. 즉, 개혁 이전의 제도 하에서는 국민연금만으로도 노인빈곤율은 약 70% 수준까지 축소되었을 것이다. 이것은 2007년 개혁을 통한 연금재정 상의 이득을 얻기 위해 지불한 비용이다. 연금개혁의 올바른 평가는 사회적 편익과 비용을 동시에 고려할 때 가능하다는 점에서 기존 논의에 대한 재검토와 향후 발전적인 논의가 필요하다.

• 한국학교수학회논문집
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• 제3권1호
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• pp.189-200
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• 2000

The purpose of this thesis is that the students understand the sentence stated math problems closely related to the real life and adapted the right solving strategies try to find the solution to a problem. The following research problem were proposed. 1. How repeated thinking lessons develop the understanding of problems and influence the usage of correct problem solving strategies and extensions of problem solving. 2. There are how much differences of achievement for each type of sentence stated problems by using comparative analysis of upper class, intermediate class, and lower class for each level between the experimental and comparative classes. In order to conduct this research the classes were divided into three different level - upper class, intermediate class and lower class. Each level include an experimental class and a comparative class. The two classes (experimental class and comparative class) of the same level were tested on the basis of class division record with the experimental class repeated learning papers for two weeks were used to guide the fixed thinking algorism for each sentence stated math problems. Eight common problems were chosen from a variety of textbooks : number calculation problems, velocity-distance-time problems, the density of a mixture, benefit problems, distribution problems, problems about working, ratio problems, the length of a figure problems. After conducting this research experiment The differences in achievement level between the experimental class and comparative class, were compared and analyzed through achievement tests made from the achievement test papers with seven problems, which were worth seventy points (total score). The conclusions of this thesis are as follows: Firstly, leaning activities through the usage of repeated learning papers for each level class produce an even development of achievement level especially in the case of the upper class learners, they have particular differences (between experimental class and comparative class) compared to the intermediate level and lower classes. Secondly, according to the analysis about achievement development each problems, learners easily accept the strategies of solution through the formula setting up to the problem of velocity -distance-time, and to the density of the mixture they adapted the picture drawing strategies interestingly, However each situation requires a variety of appropriate solution strategies. Teachers will have to employ other interesting solution strategies which relate to real life.