• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.1
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• pp.124-132
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• 2002

Daebangpung-tang(DBPT) is one of the prescriptions used for the treatment of rheumatoid arthritis(RA) in oriental medicine. The present study aimed to examine the analgesic effect of DBPT on a rat model of CFA-induced arthritis, which is not identical to human auto-immune arthritis although it does have many features in common with RA, and the relation between DBPT-induced analgesia and steroid hormones. CFA-induced arthritis rat model used to test the effect of DBPT was chronic pain model. After the induction of arthritis, rats subsequently showed a reduced stepping force of the affected limb for at least the next 18 days. The reduced stepping force of the limb was presumably due to a painful knee, since oral injection of indomethacin produced temporary improvement of weight bearing. DBPT dissolved in water was orally administrated. After the treatment, behavioral tests measuring stepping force were periodically conducted during the next 4 hours. DBPT produce significant improvement of stepping force of the hindlimb affected by the arthritis lasting at least 3 hours. The magnitude of this improvement was equivalent to that obtained after an oral injection of 3mg/kg of indomethacin and this improvement of stepping force was interpreted as an analgesic effect. The reduced stepping force was divided into three stages(10-30g, 30-50g, and 50-70g). All experiments was performed at 50-70g of stepping force, since both DBPT and indomethacin showed the most excellent analgesic effect at 50-70g of stepping force. DBPT produced the improvement of stepping force of the affected hindlimb in a dose-dependent manner and showed analgesic effect on neuropathic pain as well. DBPT-induced analgesic effect could not be blocked by systemic injection of steroid antagonist mifepristone. The present study suggest 1) that DBPT produces a potent analgesic effect on the chronic knee arthritis pain model in the rat and 2) that steroids system does not mediate DBPT-induced analgesia.

• Knowledge Management Research
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• v.22 no.1
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• pp.39-56
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• 2021

In the current knowledge society, mobile devices have become a useful tool for performing work. In the context of COVID-19 which has made digital transformation inevitable, the importance of mobile work behaviors - performing work tasks through mobile devices - is further highlighted. Drawing from the behavioral immune system theory and cognitive appraisal theory of emotions, this study proposes that individual workers' concern about getting infected by COVID-19 will be negatively related to job satisfaction but positively related to mobile work behaviors. We further propose that leaders' communality and agency trait will be positively related to both job satisfaction and the increase of mobile work behaviors. Analyses of a matched dataset comprising survey data and mobile application usage data from 407 workers showed that their leaders' agency and communality were significantly related to the workers' job satisfaction. However, their mobile productivity was significantly related only to the communality of their leaders. The results of this study will provide useful theoretical and practical implications for researchers and managers who aim to understand and promote the technology adoption and knowledge productivity of workers in a pandemic situation.