• Journal of Korean Medicine Rehabilitation
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• v.31 no.1
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• pp.17-32
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• 2021

Objectives The present study was designed to find out the therapeutic effects and possible underlying mechanism of Buja-tang, a herbal complex formula on experimental monosodium iodoacetate (MIA)-induced osteoarthritis. Methods Osteoarthritis models were created via intra-joint injection of MIA (50 μL with 80 mg/mL) in rats. Rats were divided into five groups and each group consisted of seven. Normal group was not injected MIA and did a normal diet. Control group injected MIA and received distilled water. Indo injected MIA and oral administration of 5 mg/kg of indomethacin. BJTL injected MIA and oral administration of 100 mg/kg of Buja-tang. BJTH injected MIA and oral administration of 200 mg/kg of Buja-tang. We analyzed weight-bearing ability of hind paws, oxidative stress related factor, antioxidant protein, inflammatory protein, inflammatory messenger and cytokine in joint tissue. Pathological observation of knee cartilage tissue structures was also performed with hematoxylin & eosin and safranin-O chromosomes. Results Weight-bearing ability of hind paws showed a tendency to reduce pain. The incidence of nicotinamide adenine dinucleotide phosphate oxidase and p22phox in articular tissue was significantly reduced, and the incidence of nuclear factor-erythroid 2-related factor 2 and heme oxygenase-1 and superoxide dismutases was significantly increased. The incidence of phosphorylated inhibitor of κBα, nuclear factor-kappa B p65, inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β decreased significantly. In pathological observation, cartilage tissue damaged by MIAs in biopsy has significantly recovered from Buja-tang administration. Conclusions Buja-tang has anti-inflammation, antioxidation and pain relief effects. So this is thought to inhibit the progress of osteoarthritis in rat caused by the MIA.

• Geotechnical Engineering
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• v.12 no.6
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• pp.185-198
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• 1996

EPS is increasingly used as a filling material in soft ground. The beneficial effects of the use of EPS derive from minimizing the stress increment, which, in turn, increases the bearing capacity and reduces the settlement. EPS can also be used as a backfill material for retaining walls and abutments to reduce the horizontal earth pressure. However, there is no rational application for the selection of the EPS fill which is essential to the selection of the filling configuration and the settlement calculation. In this paper, therefore, the nonlinear numerical model developed from the results of triaxial compression tests is applied to the construction of EPS and verified through the comparison between the prediction and in-situ measurements.

• Geotechnical Engineering
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• v.1 no.2
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• pp.17-26
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• 1985

This study was carried out for the purpose of comparing in reference to sand drain in the next three different cases. First, The case of drain material (sand pile) has some rigidity during embankment and consolidation. Second, In usual case of no rigidity as a paper drain without permeability during embankment and consolidation Third, Check up clay behavior when above the two cases carried out respectively. This FEM analysis is consisted with Biot's consolidation equation when it is used for Christian Boehmer's numerical technique. The main results are obtained from above the Analysis When sand drain has some rigidity, the lateral and vertical deformation of clay foundation is restrained considerable amount and .exhibited bearing capacity of load as a pile According to the foundation in drained condition and untrained condition, the results are much variable in this analysis method. Also, The behaviors of stress path and pore water pressure met our expectation during , consolidation. This analysis should be considered to put into use of sand drain and design in future.

• The Journal of Korean Medicine
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• v.25 no.4
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• pp.43-50
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• 2004

Objective : Obesity is associated with degenerative arthropathy giving stress on joints. It also amplifies loads of weight bearing joints by changing the gravity line of the body. Our aim is to investigate the correlation between obesity and lumbar lordosis in obese pre-menopausal Korean females. The hypothesis was tested that there is a correlation between obesity and lumbar lordosis. Methods : A cross-sectional evaluation of 44 Females (baseline age 30.77 ± 6.46) with BMI 31.53 ± 3.82 (kg/㎡) was done. Body composition was measured using bio-impedance analysis (BIA), and anthropometry was done by the same observer. A lateral whole spine X-ray was taken in standing position to measure the lumbar lordotic angle (LLA), Ferguson angle (FA) and lumbar gravity line (LGL). A Pearson correlation was used to measure the correlation between obesity and lumbar lordosis (SPSS 10.0 for windows). Results : Body mass index (BMI kg/㎡) had a negative relationship with LLA((equation omitted)=-0.469), FA((equation omitted) =-0.347) and LGL((equation omitted)=-0.389). Body fat rate had a negative relationship with LLA only(γ=-0.385). Waist circumference had a negative relationship with LLA((equation omitted)=-0.345) and LGL((equation omitted)=-0.346). WH ratio had no relationship with lumbar lordosis. Conclusion : These data show that obesity is related to mechanical structures, such as lumbar lordosis. BMI was the most useful index, which reflects a change of mechanical structure of lumbar, more than other variables in this study.

• Journal of Pharmacopuncture
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• v.17 no.2
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• pp.7-17
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• 2014

Objectives: Condurango is widely used in various systems of complementary and alternative medicines (CAM) against oesophageal and stomach ailments including certain types of cancer. However, until now no systematic study has been conducted to verify its efficacy and dose with proper experimental support. Therefore, we examined if ethanolic extract of Condurango could ameliorate benzo[a]pyrene (BaP)-induced lung cancer in rats, in vivo to validate its use as traditional medicine. Methods: Fifteen male and 15 female Sprague-Dawley (SD) rats were treated with 0.28 mg/kg of Sweet Bee Venom (SBV) (high-dosage group) and the same numbers of male and female SD rats were treated with 0.2 mL/kg of normal saline (control group) for 13 weeks. We selected five male and five female SD rats from the high-dosage group and the same numbers of male and female SD rats from the control group, and we observed these rats for four weeks. We conducted body-weight measurements, ophthalmic examinations, urinalyses and hematology, biochemistry, histology tests. Results: A histological study revealed gradual progress in lung tissue-repair activity in Condurango-fed cancer-bearing rats, showing gradual tissue recovery after three months of drug administration. Condurango has the capacity to generate reactive oxygen species (ROS), which may contribute to a reduction in anti-oxidative activity and to an induction of oxidative stress-mediated cancer cell-death. Condurango-activated pro-apoptotic genes (Bax, caspase-3, caspase-9, p53, cytochrome-c, apaf-1, ICAD and PARP) and down-regulated antiapoptotic-Bcl-2 expression were noted both at mRNA and protein levels. Studies on caspase-3 activation and PARP cleavage by western blot analysis revealed that Condurango induced apoptosis through a caspase-3-dependent pathway. Conclusion: The anticancer efficacy of an ethanolic extract of Condurango for treating BaP-induced lung cancer in rats lends support for its use in various traditional systems of medicine.

• Journal of the Korean Geotechnical Society
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• v.35 no.12
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• pp.15-24
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• 2019

Weathered granite zone exists in most regions of Korea and it is often used as a bearing stratum of geotechnical structures. So it is very important to estimate the characteristics of weathered granite zone. SPT (Standard penetration test) is usually performed to investigate the characteristics of the weathered zone because undisturbed samples suitable for laboratory testing are hardly retrieved. PMT (Pressuremeter test) can reliably evaluate the in situ stress-strain behavior, but it is rarely conducted because of their high cost and time-consuming procedure. In this study, the correlation between the SPT-N values and the PMT results, obtained from the weathered granite zone, was analyzed. Empirical equations for pressuremeter modulus (E_m) and limit pressure (P_L) were suggested and compared with the previous research.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.1
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• pp.21-29
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• 2017

In this paper, the total procedure for composite laminate mechanical joint (ASTM D5961 Proc. A, B) from fixture design to test analysis was showed. Composite laminate mechanical joints were analyzed using the FEM(Finite Element Method) and compared to test results. A progressive failure analysis was applied to FEM to analyze the failure behavior of test specimens. Three failure theories - maximum stress, maximum strain, and Tsai-Wu were applied to FEM to predict test failure load. General parameters for composite laminate joints were reviewed and the differences of bearing strength were compared with major parameters.

• Journal of the Korean GEO-environmental Society
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• v.15 no.12
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• pp.43-51
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• 2014

Organic matter in dredged soil has a lot of engineering problem in ground including a large settlement, crack propagation, low bearing capacity and low friction angle. From an agricultural point of view, however, organic matter contributes greatly soil quality and plant health. This paper investigated the relationship between engineering and germination characteristics of stabilized mixture consisting of different ratios of organic content (0 %, 10 %, 20 %, 30 %) for recycling dredged soil including organic matter. Several series of laboratory tests such as flow test, unconfined compressive test and consolidation test were performed to find out engineering characteristics. pH, percent of germination and growth of plants were also measured to investigate the germination characteristics. The experimental results indicated that, as organic content increased, unconfined compressive stress decreased and compression and swelling indices increased. However, percent of germination and plant growth increases as organic content increases.

• Tribology and Lubricants
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• v.31 no.1
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• pp.1-5
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• 2015

In this study, we apply an ultrasonic nanocrystal surface modification (UNSM) technique to radial journal bearings (JBs) and disks made of SUJ2 and SCM440, respectively. We investigate frictional properties of untreated and UNSM-treated specimens using a ball-on-disk tester. We construct the Stribeck curve at the boundary, under mixed and full hydrodynamic lubrication conditions for the specimens using friction data obtained from JB tests. The friction at the boundary lubrication condition and the transition period to mixed lubrication condition on the UNSM-treated specimens is reduced, which improves the service life of JBs. The major effects of this reduction in the three lubrication regimes can be explained in the terms of improved mechanical properties and the presence of micro dimples. Moreover, we estimate the friction and fatigue properties of SCM440 specimens using a ball-on-disk specimen under dry and oil-lubricated conditions. Friction test results reveal that the UNSM-treated specimens show lower friction coefficient than the untreated specimens under both dry and oil-lubricated conditions. We evaluate the fatigue properties of SCM440 specimens by calculating the Hertzian stress with respect to the failure cycles. Fatigue tests results also reveal that the UNSM-treated specimens possess a longer fatigue life than the untreated specimens. The improved properties are effective in increasing the energy efficiency of bearings.

• Tribology and Lubricants
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• v.36 no.1
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• pp.47-54
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• 2020

In this study, the effects of ultrasonic nanocrystal surface modification (UNSM) treatment at room and high temperatures (RT and HT of 400℃) on friction and wear behavior of Ti-6Al-4V alloy prepared by selective laser melting (SLM) were investigated. The objective of this study is to improve the mechanical properties and frictional behavior of Ti-6Al-4V alloy by UNSM treatment. Dry friction and wear tests were conducted using a ball-on-disk method at RT with a bearing steel as the counter ball. Due to the high HT and UNSM treatment, the surface hardness tended to increase and surface roughness tended to reduce. X-ray diffraction (XRD) analysis showed that nanocrystallization structure and compressive residual stress were formed at the surface layer after UNSM treatment at both RT and HT. After UNSM treatment, it was observed that the wear rate was reduced by about 6% for the specimen treated at RT and a 28% reduction for the specimen treated at HT in comparison with the untreated one. Based on scanning electron microscope (SEM) images showed that the damage caused by fatigue wear occurred in the wear track of the heat-treated specimen, and it is believed to be the cause of the highest wear rate. Mechanical properties and wear resistance of Ti-6Al-4V alloy were improved and prospect of industrial application was confirmed. Further research is still required to improve the characteristics of SLM Ti-6Al-4V alloy to the level of wrought Ti-6Al-4V alloy.