• Journal of Digital Convergence
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• v.20 no.1
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• pp.317-326
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• 2022

This study is an explorer study to investigate the experience of long term care hospital workers on the sexual behaviors of the elderly. The data were collected from August to October in 2019. The depth interview was implemented with using the semi structured questionnaires. The interview data collected from the participants were analyzed with using qualitative thematic analysis methods. The experience of long term care hospital workers regarding the elderly's sexual behaviors consisted of ten sub-categorized themes from the significant statements and was categorized into following four themes; 'Negative feelings related with elderlys' sexual behaviors', 'Difficulty of maintaining caring roles', 'Recognizing the absence of care for elderlys' sexual behavior', 'Accepting the therapeutic roles for elderlys' sexual behavior'. The findings could be the basic data for developing educational programs that help the long term care hospital workers understand the sexual behavior of the elderly.

• Journal of the Korean Society of Marine Environment & Safety
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• v.24 no.7
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• pp.889-897
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• 2018

Since students of the College of Maritime Sciences will become professionals contributing to the development of the Korean shipping industry after graduation, they are required to successfully complete school life including theoretical and practical curriculum with health promotion behavior. The purpose of this study was to investigate the factors influencing health promotion behavior by students of the College of Maritime Science in order to collect basic data through a survey for the development of health promotion programs. Health promotion behavior by students of the College of Maritime Sciences was less frequent than by other college students, and the levels of health promotion behavior sub-domains were lower in order of interpersonal relations, spiritual growth, stress management, nutrition, physical activity, and health responsibility. The most influential factors for health promotion behavior were learner participation, health promotion self-efficacy, self-esteem, and social support. It is necessary to develop a differentiated health promotion program considering the characteristics of students and to apply it systematically from the time of admission to improve health promotion behavior by students of the College of Maritime Sciences.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.5937-5946
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• 2012

The term endocrine disruptors is used to describe a variety of natural and manmade substances that have the capacity to potentially interfere with and modify the normal physiology of endocrine system either by mimicking, blocking or modulating the actions of natural endogenous hormones. The rising incidence of breast cancer over the last 50 years and the documented higher incidence in urban as compared to rural areas suggest a relationship to the introduction and increased use of xenoestrogens in our environment. The literature has developed over the last decades where initial experiments on endocrine disruptors did not support an involvement in breast cancer, and then evidence mounted implicating various environmental factors including hormones, endocrine disrupting chemicals and non-endocrine disrupting environmental carcinogens in the pathogenesis of breast cancer. Available data support the hypothesis that exposure to endocrine disruptors in utero leaves a signature on mammary gland morphogenesis so that the resulting dysgenic gland becomes more predisposed to develop tumors upon exposures to additional insults later on during life. Exceptionally, exposure to phytoestrogens could be beneficial to human health. Most of the available data are from well developed countries while the developing countries are still understudied regarding these issues. Here, we raise a note of caution about potential role of environmental toxins including endocrine disruptors in breast cancer development and call for serious measures to be taken by all involved parties in the developing world.

• Fisheries and Aquatic Sciences
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• v.26 no.1
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• pp.35-47
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• 2023

Myelophycus caespitosus, a brown alga belonging to genus Myelophycus, has been traditionally used as a food and medicinal resource in Northeastern Asia. However, few studies have been conducted on its pharmacological activity. In this study, we evaluated whether methanol extract of M. caespitosus (MEMC) could protect against oxidative damage caused by hydrogen peroxide (H₂O₂) in C2C12 murine myoblasts. Our results revealed that MEMC could suppress H₂O₂-induced growth inhibition and DNA damage while blocking the production of reactive oxygen species. In H₂O₂-treated cells, cell cycle progression was halted at the G2/M phase, accompanied by changes in expression of key cell cycle regulators. However, these effects were attenuated by MEMC. In addition, we found that MEMC protected cells from induction of apoptosis associated with mitochondrial impairment caused by H₂O₂ treatment. Furthermore, MEMC enhanced the phosphorylation of nuclear factor-erythroid-2 related factor 2 (Nrf2) and expression and activity of heme oxygenase-1 (HO-1) in H₂O₂-treaetd C2C12 myoblasts. However, such anti-apoptotic and cytoprotective effects of MEMC were greatly abolished by HO-1 inhibitor, suggesting that MEMC could increase Nrf2-mediated activity of HO-1 to protect C2C12 myoblasts from oxidative stress.

• Journal of the Korean Society of School Health
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• v.30 no.2
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• pp.93-102
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• 2017

Purpose: The purpose of this study is to identify the factors that influence the practices and the intentions of human papillomavirus (HPV) vaccination among adolescent daughters' mothers. The focus is on the mothers' HPV knowledge and sex-related communication with their daughters. Methods: The participants were 298 mothers with middle or high school student daughters. Participants were conveniently selected from a mothers' association and churches in Seoul, Cheonan and Asan city. Information on their demographics, HPV vaccination-related knowledge, sex-related communication, and intention of receiving HPV vaccination were obtained through questionnaires. The results were analyzed using descriptive statistics, the $x^2$ test and logistic regression with SPSS for Windows 21.0 software. Results: The rate of HPV vaccination, the awareness of the HPV vaccine and the rate of giving correct answers to HPV knowledge questions were 13.1%. 84.6%, and 36.3%, respectively. The factors that influenced HPV vaccination most were their family history of cervical cancer, educational backgrounds and awareness of the HPV vaccine. The intention to receive HPV vaccination was mainly influenced by HPV knowledge. However, sex-related communication did not affect the mothers' intention of obtaining HPV vaccination. Conclusion: The results of this study suggest that strategies to educate mothers with adolescent daughters on HPV are necessary. In addition, this study strongly recommends further studies be planned to examine sex-related communication between mothers and daughters.

• Biomedical Science Letters
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• v.13 no.2
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• pp.119-125
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• 2007

It is widely known that protein tyrosine kinases (PTKs) are involved in controlling many biological processes such as cell growth, differentiation, proliferation, survival and apoptosis. An $\alpha3\beta4$ subunit combination acts as a major functional acetylcholine receptor (nAChRs) in male rat major pelvic ganglion (MPG) neurons, and their activation induces fast inward currents and intracellular calcium increases. Recently it has been reported that the activity of acetylcholine receptors (AChRs) in some neurons can be negatively regulated by PTKs. However, the exact mechanism of regulation of nAChRs by PTKs is poorly understood. Therefore, we examined the potential role particular in nAChR by PTK using electrophysiology and calcium imaging in male rat MPG neurons. ACh induced inward currents and $(Ca^{2+})_i$ increases in MPG neurons, concomitantly. These responses were inhibited by more than 90% in $Na^+$- or $Ca^{2+}$- free solution. $\alpha$-conotoxin AuIB, a selective $\alpha3\beta4$ nAChR blocket, inhibited ACh-induced inward currents. Genistein (10 $\mu$M), a broad-spectrum tyrosine kinase inhibitor, markedly decreased ACh-induced currents and $Ca^{2+}$ transients, whereas 10 $\mu$M genistin, an inactive analogue, had little effect. Overall these data suggest that the activities of $\alpha3\beta4$ AChRs in MPG neurons are positively regulated by PTK. In conclusion, trosine kinase may be one of the key factors in the regulation of $\alpha3\beta4$ nAChRs in rat MPG neurons, which may play an important roles in the autonomic neuronal function such as synaptic transmission, autonomic reflex, and neuronal plasticity.

• Journal of the Korean Society of School Health
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• v.26 no.1
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• pp.13-25
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• 2013

Purpose: This study is a descriptive correlation study to identify how factors such as motivation to learn, school adaptation, self-control, and self-esteem influence the degree of Internet game addiction and to provide basic data for nursing interventions for male middle school students. Methods: The subjects of this study were 418 male students in lst, 2nd and 3rd grade at three middle schools located in Ulsan. Data were collected from May 1, 2011 to May 31, 2011 and analyzed through descriptive statistical methods, such as the t-test, ANOVA, Sheffe's test, Pearson correlation coefficient and multiple regression analysis, via SPSS 18.0 program. The study's structured questionnaire was composed of 25 items of 'the Motivation to Learn Scale', 41 items of 'the School Adaptation Scale', 20 items of 'the Self-Control Scale', 10 items of 'the Self-esteem Scale', and 20 items of 'the Internet Game Addiction Scale'. Results: 163 students (39.0%) belonged to the non-addiction group while 255 students (61.0%) fell into the addiction risk group. The addiction risk group showed a higher degree of addiction than ones in the non-addiction group. The addiction risk group's average scores for motivation to learn, school adaptation, self-control, and self-esteem were lower than those of the non-addiction group. The statistically significant factors (p<.05) that increase the chance of addiction were grade, family atmosphere, self-control, trading of online game items, and the amount of time playing online games. Conclusion: On the basis of the findings of this study, it is suggested that; qualitative research on the routes of addiction be conducted to find out ways to prevent and nurse addicted students; considering the fact that the average age of Internet users is getting lower and lower, a study targeting primary school students be implemented; since the influences of the variables covered in this study turned out to be relatively low, other factors, especially environmental factors, should also be investigated.

• Biomedical Science Letters
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• v.14 no.2
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• pp.69-76
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• 2008

${\gamma}$-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system, and its actions are mediated by subtypes of GABA receptors named as $GABA_A$, $GABA_B,\;and\;GABA_C,\;GABA_A$, receptor consisting of ${\alpha},\;{\beta},\;{\gamma}\;and\;{\delta}$ subunits is a heterooligomeric ligand-gated chloride channel. This study was performed to investigate regulation of $GABA_A$ receptor by protein kinase C(PKC). Ion currents were recorded using gramicidine-perforated patch and whole cell patch clamp. mRNA encoding the subunits of PKC expressed in major pelvic ganglion (MPG) neurons was detected by using RT-PCR. The GABA-induced inward current was increased by PKC activators and decreased by PKC inhibitors, respectively. These effects were not associated with intracellular $Ca^{2+}$ and GAG (1-oleoyl-2-acetyl-sn-glycerol), a membrane permeable diacylglycerol (DAG) analogue. These results mean that the subfamily of PKC participating in activation of $GABA_A$ receptor would be an atypical PKC (aPKC). Among theses, ${\xi}$ isoform of aPKC was detected by RT-PCR. Taking together, we suggest that excitable $GABA_A$ receptor in sympathetic MPG neuron seemed to be regulated by aPKC, particular in ${\xi}$ isoform. The regulatory roles of PKC on excitatory $GABA_A$ receptors in sympathetic neurons of MPG may be an important factor to control the functional activity of various pelvic organs such as bowel movement, micturition and erection.

• Biomedical Science Letters
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• v.15 no.4
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• pp.319-326
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• 2009

Extracellular ATP elicits diverse physiological effects by binding to the G-protein-coupled P2Y receptors on the plasma membrane. In addition to the short-term effects of extracellular nucleotides on cell functions, there is evidence that such purinergic signalling can have long-term effects on cell proliferation, differentiation and death. The 3T3-L1 cell line derived from mouse embryo is a well-established and commonly utilized in vitro model for adipocytes differentiation and function. However, the distributions and roles of P2Y subtypes are still unknown in the preadipocyte. In this study, we identified the distributions and roles of P2Y subtypes in preadipocyte using $Ca^{2+}$ imaging and realtime PCR. ATP increased the $[Ca^{2+}]_i$ in a concentration-dependent manner. ATP increased $Ca^{2+}$ in absence and/or presence of extracellular $Ca^{2+}$. Suramin, non-selective P2Y blocker, largely blocked the ATP-induced $Ca^{2+}$ response. U73122, a PLC inhibitor, completely inhibited $Ca^{2+}$ mobilization in 3T3-L1 cells. The mRNA expression by realtime PCR of P2Y subtypes was $P2Y_2:P2Y_5:P2Y_6=1.0:12.5:0.3$. In conclusion, we showed that $P2Y_5$ receptor is a dominant purinergic receptor in preadipocytes, and multiple P2Y receptors could involve in differentiation and migration via regulating of intracellular calcium concentration.

• Stress
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• v.25 no.3
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• pp.155-161
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• 2017

Background: This study was conducted to investigate the factors that influence sexual intercourse experience of university students in Korea. Methods: We selected 244 students who completed a questionnaire about general characteristics, sexual attitude, sexual intercourse experience, depression. It was analyzed by logistic regression using sexual attitude of university student, father, and mother as explanatory variables. Results: The results showed that sexual intercourse experience was more frequent in the respondents who were more open about sexual attitude, those whose mothers have more open mind to sexual attitude, and those who were less depressed. Conclusions: The sexual intercourse experience is important to affect the upcoming adult period in university students. This study suggests that it is necessary to develop systematically the sexual education program in university and society.