• Asian Pacific Journal of Cancer Prevention
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• 제16권10호
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• pp.4435-4438
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• 2015

p21 is a cyclin-dependent kinase inhibitor, which can arrest cell proliferation and serve as a tumor suppressor. Though many studies were published to assess the relationship between p21 rs1059234 polymorphism and various cancer risks, there was no definite conclusion on this association. To derive a more precise quantitative assessment of the relationship, a large scale meta-analysis of 5,963 cases and 8,405 controls from 16 eligible published case-control studies was performed. Our analysis suggested that rs1059234 was not associated with the integral cancer risk for both dominant model [(T/T+C/T) vs C/C, OR=1.00, 95% CI: 0.84-1.18] and recessive model [T/T vs (C/C+C/T), OR=1.03, 95% CI: 0.93-1.15)]. However, further stratified analysis showed rs1059234 was greatly associated with the risk of squamous cell carcinoma of head and neck (SCCHN). Thus, larger scale primary studies are still required to further evaluate the interaction of p21 rs1059234 polymorphism and cancer risk in specific cancer subtypes.

• 한국자기공명학회:학술대회논문집
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• 한국자기공명학회 2002년도 International Symposium on Magnetic Resonance
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• pp.89-89
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• 2002

• Journal of Korean Vacuum Science & Technology
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• 제6권4호
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• pp.149-152
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• 2002

We performed the modeling of the dielectric functions of C $d_{0.77}$M $g_{0.23}$Te by using parametric semiconductor model. Parametric model describes the analytic dielectric function as the summation of several energy-bounded Gaussian-broadened polynomials and provides a reasonably well parameterized function which can accurately reproduce the optical constants of semiconductor materials. We obtained the values of fitting parameters of the Mg composition 0.23 in the parametric model. From these parameters we could remove interference oscillations to obtain the dielectric function of C $d_{0.77}$M $g_{0.23}$Te alloy film for full 0.5-6.0 eV energy range.y range.

• 오토저널
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• 제5권3호
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• pp.45-55
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• 1983

This paper discussed about Application Technique of Numerical Methods for large structure. The dynamic behaviours of a vehicle were investigated through finite element modelling. After dividing a vehicle body into three substructures, Basic Mass System was composed of 60 flexual modes which was obtained from the dynamic characteristics of each substructure using Modal Synthesis Method. Engine, transmission and rear axle, etc. were added to Basic Mass Model, consequently Full Mass System was constructed by 72 degree of freedoms. Full Mass System was analyzed over the frequency range 0.5-50.0 Hz under the loading conditions which were Stationary Gaussian Random Process. Results and discussions provided the guidelines to eliminate resonances among the parts and to improve the Ride Quality. The Absorbed Power was used as a standard to determine the Ride Quality. The RMS value of driver's vertical acceleration was obtained 0.423g from the basic model and 0.415g from the modified model.

• Wind and Structures
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• 제12권3호
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• pp.205-217
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• 2009

Aerodynamic flutter control for long-span cable-supported bridges was investigated based on three basic girder sections, i.e. streamlined box girder section, box girder section with cantilevered slabs and two-isolated-girder section. Totally four kinds of aerodynamic flutter control measures (adding fairings, central-slotting, adding central stabilizers and adjusting the position of inspection rail) were included in this research. Their flutter control effects on different basic girder sections were evaluated by sectional model or aeroelastic model wind tunnel tests. It is found that all basic girder sections can get aerodynamically more stabled with appropriate aerodynamic flutter control measures, while the control effects are influenced by the details of control measures and girder section configurations. The control effects of the combinations of these four kinds of aerodynamic flutter control measures, such as central-slotting plus central-stabilizer, were also investigated through sectional model wind tunnel tests, summarized and compared to the flutter control effect of single measure respectively.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1988년도 가을 학술발표회 논문집
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• pp.7-12
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• 1988

This study presents rational methods for probability-based estimates of basic design wind speeds in Korea and develops a risk-bases nation-wide map of design wind speeds. The paper examines the fitting of the Type-I extreme model to maximum yearly non-typhoon wind data from long-term records based on the conventional method and to maximum monthly nod-typhoon wind data from short-term records following Grigorin's approach. The paper also reviews the applicability of the method using short records of about 5 years. The basic design wind speeds for typhoon and non-typhoon wind at a station are made to be obtained from a mixed model which is given as a product of typhoon and non-typhoon extreme wind distributions. A practical method which is based on the fitting of the Type I model to records or typhoon and non-typhoon mixed wind data at a station is also preposed in this study.

• 소성∙가공
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• 제11권5호
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• pp.394-404
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• 2002

The drawbead model for a three-dimensional a finite element analysis of sheet metal forming processes is developed. The mathematical models of the basic drawbeads like circular drawbead, stepped drawbead, and squared drawbaed are first derived using the bending theory, belt-pulley equation, and Coulomb friction law. Next, the experiments for finding the drawing characteristics of the drawbead are performed. Based on mathematical models and drawing test results, expert models of basic drawbeads are then developed employing a linear multiple regression method. For the expert models of combined drawbeads such as the double circular drawbead, double stepped drawbead, circular-and-stepped drawbead, etc., those of the basic drawbeads are summed. Finally, in order to verify the expert models developed, the drawing characteristics calculated by the expert models of the double circular drawbead and circular-and-stepped drawbead are compared with those obtained from the experiments. The predictions by expert models agree well with the measurements by experiments.

• Mass Spectrometry Letters
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• 제1권1호
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• pp.5-8
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• 2010

In the present study, collisionally-activated dissociation (CAD) experiments were performed under low energy collision conditions in six peptides containing a disulfide bond. Fragments produced as a result of the cleavage of a disulfide bond were obtained after CAD in four peptides (bactenecin, TGF-$\alpha$, cortistantin, and linearly linked peptide, Scheme 1) with basic amino acid residues. In contrast, the CAD analysis of two peptides with no basic residue (oxytocin and tocinoic acid) rarely produced fragments indicative of cleavage of a disulfide bond. These results are consistent with the mobile proton model suggested by the McLuckey and O'air groups (ref. 22 and 23); nonmobile protons sequestered at basic amino acid residues appear to promote the cleavage of disulfide bonds.

• 아동학회지
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• 제24권4호
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• pp.89-102
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• 2003

A model for teaching traditional Korean rhythmic patterns using Orff's ear training approach was developed and implemented with aim that it could be used as basic data for the operation of Korean music education. Children's rhythmic sense improved through teaching of sound searching, body rhythm, playing instruments, and improvising. Teaching the order of connective rhythmic patterns and a basic patterns-centered approach was more effective than teaching modified rhythmic patterns. With ear training, children perceived the stress of rhythmic patterns in advance and they perceived the length of sound. These results show that this model can be used as a basic approach in the operation of Korean music education.

• 대한조선학회 특별논문집
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• 대한조선학회 2015년도 특별논문집
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• pp.41-45
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• 2015

In this study reviewed the validity of the estimated optimum trim by the numerical analysis. For this purpose, the numerical analysis of the trim optimization for 6500TEU container carrier and capesize bulk carrier were carried out using Star-CCM+, which results were compared with the results of model tests. The reliability of results of the numerical analysis was confirmed via comparing the resistance determined by the numerical analysis and model test. The performance of self-propulsion at each trim conditions were estimated using the calculated resistance by numerical analysis. The BHP at each trim condition were calculated by estimated performance of self-propulsion, which trend of results were confirmed similar trend of result of model test.