• Journal of the Korean Society of Safety
• /
• v.30 no.6
• /
• pp.94-101
• /
• 2015

When a severe disaster such as a building collapse occurs, a first priority for rapid rescue is to find a location where people are highly expected to be buried but alive. It is, however, very difficult to correctly designate the location of such cavities by conventional geophysical survey due to a pile of debris of building members. In this study, location of possible lifeguard cavities were evaluated through a series of simulations of building collapse by explosion depending on the height of the building, a structure of basement floor and a location of explosion. Three types of building structure: five-story, ten-story and fifteen-story were prepared as a model for the simulation. As a results, in the case of low building, only basement floor partially collapsed. On the other hand, in the case of high building, a collapsed range on the inside of the building increased and lifeguard spaces were formed only in the lateral side or corner of the building. In addition, when a wall exists in the basement floor, the possibility that cavities could be formed increased compared to the cases without wall. However, for the fifteen-story building case, no possible lifeguard cavity was found. It is noted that for a high rise building, the height of building more affect forming of safeguard cavity than the structure of the basement floor.

• The Korean Journal of Petroleum Geology
• /
• v.1 no.1 s.1
• /
• pp.37-46
• /
• 1993

Two-dimensional gravity and magnetic models were constructed for seismic profiles in Block Ⅵ-2, offshore Korea. For each seismic profile, a longer length model showing geometric configurations of all employed polygonal bodies and an expanded version of the area of interests were made. The results of this modeling study indicate 1) that the depth to the deeper basement surface appear to be shallower than indicated in the seismic sections, 2) that the Middle Miocene section (the bottom formations in the models) appears to contain significant amounts of volcanic materials, 3) that identification and/or determination of depth to the top of basement is difficult in the study area due to thick volcanic materials in the lowermost formation (Middle Miocene), and 4) that the study area is unfavorable for hydrocarbon generation and accumulation due to wide spread volcanic activities during the Middle Miocene Epoch. The maximum calculated depth to the magnetic basement in the study area is approximately $4{\cal}km$ sub-sea.

• Applied Microscopy
• /
• v.38 no.2
• /
• pp.107-115
• /
• 2008

The filtration barrier of kidney consists of endothelial cell, glomerular capillary, glomerular basement membrane, mesangial matrix, and podocyte. In aged rats, the morphological changes were shown in various parts, including the glomerulus. These changes were thickening of basement membrane and mesangial matrix, crescent formation of glomerular capillary, deformity of foot processes, glomerular sclerosis and obsolescence. But these glomerular morphologies are partial images or few serial images analysis. In this study, we examined the morphological alteration of glomerulus in the young and aged rats by light microscopy, transmission electron microscopy and three dimensional reconstruction. We were found in aged rat glomerulus, expansion of urinary space and mesangial matrix, thickening and degrading of glomerular basement membrane, decreasing in podocyte foot processes, fragmentation of podocytic nucleus membrane. These observations indicate that may provide useful data for investigating the pathogenesis of age-related dysfunction of kidney.

• Journal of the Korea Concrete Institute
• /
• v.14 no.3
• /
• pp.321-330
• /
• 2002

This paper presents the experimental results of composite basement wall in which H-pile and reinforced concrete wall are combined using shear connector Twelve specimens are tested to evaluate the shear capacity of the wall. Main variables in the test are composite ratio, distribution of shear connector, thickness of wall, shear-span ratio, and shear reinforcement. Test results indicate that the shear capacity of test specimens varies with the foregoing variables except the composite ratio. The results are compared with strengths predicted using the equations of ACI 318-99, Zsutty, and Bazant. Based on this investigation, a method for predicting the shear strength of composite basement walls is proposed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• v.28 no.6
• /
• pp.434-439
• /
• 2002

Oral squamous cell carcinoma (OSCC) is one of the most common head and neck cancers. OSCC generally has a poor prognosis due to its tendency towards a local invasion and subsequent metastasis, which is mediated by multiple proteolytic enzymes and angiogenesis. Soy products contain high levels of isoflavonoids, including the tyrosine kinase inhibitor, genistein, which has been identified as a potent inhibitor of cell proliferation and in vitro angiogenesis. The purpose of this in vitro study is to evaluate the anti-cancer effect of genistein with respect to the angiogenesis and basement membrane invasion in OSCC. The highly invasive OSCC cell line, HSC-3 cells were cultured in the presence of $10{\mu}M$ genistein for 24h. To evaluate the effects of genistein on the invasiveness and the gelatinolytic activity, in vitro invasion assay and zymography were performed. In order to evaluate the effect on the VEGF and bFGF mRNA expression, RT-PCR and northern hybridization reaction, and chemiluminescence detection were applied. The in vitro invasion assay showed that the genistein treatment reduced the cellular invasion through the artificial basement membrane and significant difference between the control group and the genistein treated group was shown in MMP-2 activity. Especially, the 62 kDa activated form of MMP-2 in the control group was 1.8 times higher than that in the genistein treated group. The results of the northern blot analyses indicated that VEGF mRNA expression in the genistein treated group was significantly down regulated. This study showed that genistein inhibits angiogenesis and reduces basement membrane invasion in OSCC. It seems to support the possibility of genistein as an anti-cancer agent.

• Journal of Conservation Science
• /
• v.7 no.2
• /
• pp.68-79
• /
• 1998

The protecting-chamber for a standing Buddha of Mireuk-ri temple site at Jungwon is composed of granite of Cretaceous age which mainly consists of quartz, perthite, plagioclase, and biotite with minor amounts of muscovite, apatite, chlorite, sericite and opaque mineral. There are abundant cracks which may be developed by strong weathering and differential loading by structural unbalances of the whole protecting-chamber. Cracks can be divided into three types based on genesis as those formed by exfoliation, intrinsic, and pressure. The exfoliation occurred along the onion structure of the granite. The pressure cracks are generally superimposed on the exfoliation ones, which might be developed by structural unbalance of the protecting-chamber resulted from differential loading in places. The structural unbalance may be due to change in physical properties of the rocks according to strong weathering, differential settling of basement soil by difference in loading in places of protecting-chamber, westward creep of the basement soil below the West wall and related different resistance of the basement soil against the loading, and partial depression of the West wall. For the conservation of the protecting-chamber, it must be considered the method of stabilizing the basement and treatment of the cracks.

• The Korean Journal of Physiology and Pharmacology
• /
• v.23 no.1
• /
• pp.63-70
• /
• 2019

We aimed to propose a novel computational approach to predict the electromechanical performance of pre- and post-mitral valve cerclage annuloplasty (MVCA). Furthermore, we tested a virtual estimation method to optimize the left ventricular basement tightening scheme using a pre-MVCA computer model. The present model combines the three-dimensional (3D) electromechanics of the ventricles with the vascular hemodynamics implemented in a lumped parameter model. 3D models of pre- and post-MVCA were reconstructed from the computed tomography (CT) images of two patients and simulated by solving the electromechanical-governing equations with the finite element method. Computed results indicate that reduction of the dilated heart chambers volume (reverse remodeling) appears to be dependent on ventricular stress distribution. Reduced ventricular stresses in the basement after MVCA treatment were observed in the patients who showed reverse remodeling of heart during follow up over 6 months. In the case who failed to show reverse remodeling after MVCA, more virtual tightening of the ventricular basement diameter than the actual model can induce stress unloading, aiding in heart recovery. The simulation result that virtual tightening of the ventricular basement resulted in a marked increase of myocardial stress unloading provides in silico evidence for a functional impact of MVCA treatment on cardiac mechanics and post-operative heart recovery. This technique contributes to establishing a pre-operative virtual rehearsal procedure before MVCA treatment by using patient-specific cardiac electromechanical modeling of pre-MVCA.

• Childhood Kidney Diseases
• /
• v.5 no.1
• /
• pp.1-8
• /
• 2001

Purpose : Clinical manifestations and pathologic findings of thin glumerular basement membrane disease, recognized as a common underlying disease of benign, familaiar and asymptomatic hematuria has not been reported systemically in Korera. We analyzed clinical and pathologic findings of patients who were diagnosed as thin glomerular basement membrane disease Methods : We analyzed clinical and pathologic findings of twenty-six patients who were diagnosed as thin glomerular basement membrane disease by renal biopsy among who complained asymptomatic hematuria from 1990 to 2000. Results : The subjects were aged 9.4${\pm}$3.2 (3.0-15.8) years-old at onset of hematuria, and 11.1${\pm}$2.2 (4.7-16.3) years-old at renal biopsy. Sexual discrepancy was more common in girls (eight boys and eighteen girls). A family history of hematuria was found in 8 patients(30.7$\%$). Major clinical manifestation on admission was microscopic hematuria according to the findings of 3case(11.5$\%$) of gross hematuria, 23cases(88.5$\%$9) of microscopic hematuria, and 1 case(3.8$\%$) of proteinuria. Microscopic hematuria persisted in all cases. Kidney biopsy showed few changes by light microscopy, but IgM, C3 and fibrinogen deposit in mesangium was found by immunofluorescent microscopy in a few cases. Electron microscopic findings have revealed thinning of the glomerular basement membrane varied from 180.9${\pm}$35.8nm. Conclusion : Thin glomerular basement membrane disease might be a common cause of microscopic hematuria of children and family history was revealed in about 30$\%$. Clinical progression was good in majorities.(J. Korean Soc Pediatr Nephrol 5 : 1-8, 2001)

• Molecules and Cells
• /
• v.27 no.5
• /
• pp.503-513
• /
• 2009

Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional homology with numerous extracellular matrix proteins, growth factors and surface receptors. They mainly carry heparan sulfate side chains and these contribute not only to storing and preserving the biological activity of various heparan sulfate-binding cytokines and growth factors, but also in presenting them in a more "active configuration" to their cognate receptors. Abnormal expression or deregulated function of these proteoglycans affect cancer and angiogenesis, and are critical for the evolution of the tumor microenvironment. This review will focus on the functional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis.

• Economic and Environmental Geology
• /
• v.28 no.1
• /
• pp.69-77
• /
• 1995

Tertiary Pohang basin distributed in south western part of the Korean peninsula, is composed of Chunbuk formation as the basal conglomerate, Hakjon formation, Duho formation and intrusive basalt having 15 Ma by absolute age data. The basement of the basin is represented to Cretaceous sedimentary rocks, Hakjon welded tuff and Chilpo welded tuff and rhyolite. The fault systems in the basement of Tertiary Pohang basin are consist of $N20^{\circ}E$ fault, $N60^{\circ}W$ and E-W trend. NNE fault is not only strike-slip but also normal dip-slip. WNW fault has sinistral strike-slip sense and the geometry of E-W fault is strike-slip and normal faults. In the basin, the fault system is represented to $N20^{\circ}E$ strike-slip, E-W normal and NNE thrust faults. By these fault relationship and geometry, it is interpreted that NNE sinistral strike-slip fault and N-S normal faults have acted at the Cretaceous basement. After Miocene NNE dextral strike-slip fault has acted and created E-W normal fault. Progressively Tertiary basin was influenced by the transpression to make thrust and fold, namely inversion tectonics.