• Bulletin of the Korean Chemical Society
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• 제7권1호
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• pp.1-5
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• 1986

The influences of $LiNO_3\;and\;AgNO_3$ on the N-C(O) rotational barrier of N,N-dimethylacetamide and N,N-dimethylpropionamide have been investigated. The rotational activation free energy $({\Delta}G^{\neq})\;for\;Li^{+}$-amide complexes is found to increase with increasing salt concentration. On the other hand, that for $Ag^+$-amide complexes increases in the presence of $Ag^+$ ion up to 0.25 M ion concentration and then decreases as the concentration of $Ag^+$ ion is further increased. Such an unusual behavior of $Ag^+$-amide complexes has been interpreted in terms of ion-pairing and diluent effect on the amides. However, $^{13}C$ nmr chemical shift data for the amides have shown that both of these ions interact primarily with the carbonyl group in amides.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.10-26
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• 2019

Magnetic resonance-guided focused ultrasound (MRgFUS) is an emerging new technology with considerable potential to treat various neurological diseases. With refinement of ultrasound transducer technology and integration with magnetic resonance imaging guidance, transcranial sonication of precise cerebral targets has become a therapeutic option. Intensity is a key determinant of ultrasound effects. High-intensity focused ultrasound can produce targeted lesions via thermal ablation of tissue. MRgFUS-mediated stereotactic ablation is non-invasive, incision-free, and confers immediate therapeutic effects. Since the US Food and Drug Administration approval of MRgFUS in 2016 for unilateral thalamotomy in medication-refractory essential tremor, studies on novel indications such as Parkinson's disease, psychiatric disease, and brain tumors are underway. MRgFUS is also used in the context of blood-brain barrier (BBB) opening at low intensities, in combination with intravenously-administered microbubbles. Preclinical studies show that MRgFUS-mediated BBB opening safely enhances the delivery of targeted chemotherapeutic agents to the brain and improves tumor control as well as survival. In addition, BBB opening has been shown to activate the innate immune system in animal models of Alzheimer's disease. Amyloid plaque clearance and promotion of neurogenesis in these studies suggest that MRgFUS-mediated BBB opening may be a new paradigm for neurodegenerative disease treatment in the future. Here, we review the current status of preclinical and clinical trials of MRgFUS-mediated thermal ablation and BBB opening, described their mechanisms of action, and discuss future prospects.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.220-222
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• 2004

Feasibility of BaO-ZnO-$B_2O_3$ (BZB) based glass system in the light of dielectric and thermal expansion properties are reported in the literature. Effects of addition of various types of ceramic fillers to the BZB-based glass on the thermochemical stability and mechanical properties were investigated in the present work. The studied filler-glass system demonstrated a capability to host various types of ceramic fillers to form thermochemically stable microcomposites at the processing temperature suitable for PDP systems. At the same time, mechanical strength of the filler-glass composites was much improved as compared to the glass itself These observations brighten the feasibility of the Pb-free BZB-based glass system as a host to employ various types of crystalline ceramic fillers so that it can be applied to barrier rib material in plasma display panels.

• 한국ITS학회 논문지
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• 제6권1호
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• pp.58-71
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• 2007

교통약자 즉, 장애인과 노약자의 자립생활과 사회통합을 위한 장애물 없는 생활환경(Barrier-Free)의 실현은 건축, 도시, 교통, 도로 등 통합적인 측면에서 생활환경의 설계기준 재정비 등 하드웨어적인 측면과 함께 사회활동에 필요한 편의시설의 다양한 정보접근과 이용 등 소프트웨어적인 측면이 동시에 충족되어야 하며, 소프트웨어적인 측면은 편의시설의 이용성을 제고하는데 있어 매우 중요한 문제이다. 이러한 측면에서 편의시설의 이용성 향상을 위해 유비쿼터스 기술 등 정보통신기술을 활용한 지원시스템 구축이 필요하다. 대표적 교통약자인 장애인 노약자가 사회생활을 하기 위하여 주거지를 넘어 다른 장소로 이동하고자 할 경우에도 이들의 목적을 달성하기에 어려움이 없도록 정보를 제공하고 지원하는 시스템이 필요하다. 장애인, 노약자의 행태조사 및 요구조사를 통한 요구사항분석과 장애인, 노약자 중심의 생활 및 이동지원시스템관련 국외 연구동향 및 관련 기술요소파악 및 시스템 요구조건과 유즈케이스를 도출하였다.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제15권2호
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• pp.23-30
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• 2009

The purpose of this study is to suggest planning directions of architectural integrates model by analysing the foreign case of integrated services for the aged and the disabled. For this study, we have researched on three different aspects. Three aspects are the element of barrier-free, architectural planning, information technology and operation. Based on the analysis of overseas examples, the good circumstance for both the disabled and the elder as one of member in the local societies could be defined like the following conditions: that is, (1) IT technology facilitates both barrier-free architecture and life to be easier and safer, and (2) both the disabled and the elder in local societies live together with the non-disabled in the same community. To realize this purpose, for a short-term plan, the system of feedback, examining the results of the research through the examples of housing plan, should be improved. In addition to, the system of public service, such as introducing the institutes for social educations, should be developed to result in the change of social insight. For a long-term plan, the whole society should have the research and plan of the unified model in a dimension of cities, where the network of public welfare is deeply associated with the system of the architecture, traffic, streets, and living-supporting information.

• Biomolecules & Therapeutics
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• 제27권3호
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• pp.290-301
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• 2019

Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of paeonol through blood-brain barrier (BBB). Brain transport of paeonol was characterized by internal carotid artery perfusion (ICAP), carotid artery single injection technique (brain uptake index, BUI) and intravenous (IV) injection technique in vivo. The transport mechanism of paeonol was examined using conditionally immortalized rat brain capillary endothelial cell line (TR-BBB) as an in vitro model of BBB. Brain volume of distribution (VD) of [$^3H$]paeonol in rat brain was about 6-fold higher than that of [$^{14}C$]sucrose, the vascular space marker of BBB. The uptake of [$^3H$]paeonol was concentration-dependent. Brain volume of distribution of paeonol and BUI as in vivo and inhibition of analog as in vitro studies presented significant reduction effect in the presence of unlabeled lipophilic compounds such as paeonol, imperatorin, diphenhydramine, pyrilamine, tramadol and ALC during the uptake of [$^3H$]paeonol. In addition, the uptake significantly decreased and increased at the acidic and alkaline pH in both extracellular and intracellular study, respectively. In the presence of metabolic inhibitor, the uptake reduced significantly but not affected by sodium free or membrane potential disruption. Similarly, paeonol uptake was not affected on OCTN2 or rPMAT siRNA transfection BBB cells. Interestingly. Paeonol is actively transported from the blood to brain across the BBB by a carrier mediated transporter system.

• 한국산업정보학회논문지
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• 제29권1호
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• pp.1-13
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• 2024

본 연구는 키오스크 사용 증가로 인한 변화에 대응하기 위해 사용자 특성을 고려한 맞춤형 동적 키오스크 화면을 제공하는 것을 목표로 한다. 디지털 취약계층인 시각장애인, 노인, 어린이, 휠체어 사용자 등의 특성에 따른 화면 구성의 최적화를 위해 객체 탐지, 걸음걸이 인식, 음성발화 인식기술을 종합하여 사용자의 특성(휠체어 사용 여부, 시각 장애, 연령 등)을 실시간으로 분석하고, 이를 기반으로 9개의 카테고리로 사용자를 분류한다. 키오스크 화면은 사용자의 특성에 따라 동적으로 조정되어 효율적인 서비스 제공이 가능하다. 본 연구는 임베디드 환경에서 시스템 통신 및 운용이 이루어졌으며, 사용된 객체 탐지, 걸음걸이 인식, 음성발화 인식 기술은 각각 74%, 98.9%, 96%의 정확도를 보여준다. 제안된 기술은 프로토타입을 구현하여 그 효용성을 검증하였으며, 이를 통해 본 연구가 디지털 격차의 축소와 사용자 친화적인 "배리어 프리 키오스크" 서비스 제공의 가능성을 보였다.

• 한국방사선학회논문지
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• 제10권1호
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• pp.59-64
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• 2016

본 연구의 목적은 자기공명영상을 이용하여 외국인 환자를 검사할 때 언어의 소통을 위하여 자동음성시스템을 개발하고자 하였다. 자동음성을 위해 사용된 문장은 병원에서 자주 사용하고 있는 12개의 문장과 5개의 외국어를 선택하였다. 이러한 번역된 문장은 Oddcast's website로 부터 무료로 재공 되며 Wav 파일로서 각 언어 특징에 소리로 기록하게 된다. 기록된 오디오 파일은 Mobile phone 환경에서 적용되는 PHP 프로그램을 사용하여 MS-파워포인트(extension; ppsx) 와 Web-enabled system 형태로 재생하게 된다. 음성 시스템 개발은 방사선사에게 언어 소통의 어려움에 관하여 스트레스를 해소될 것이며, 다양한 언어로 설계된 자동음성시스템은 외국인 환자를 검사 할 때 환자에게 진단적 정보를 증가시킬 것이다. 본 연구를 위해 개발된 음성 시스템은 한국의 방사선사와 외국인 환자 사이에서 검사의 이해를 증가시킬 수 있기 때문에 임상실무에서 더욱더 유용하게 이용될 것이라고 기대된다.

• International Journal of Railway
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• 제1권4호
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• pp.143-148
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• 2008

This paper is the output of a collaborative European project concerning the barrier free accessibility for disabled persons to regional and long distance trains in Europe. Disabled people represent around 13% of the population in Europe. This is approximately 63 million people. The range of disabilities includes people with reduced mobility including wheel chair users, viewing and hearing impaired people and other forms of impairment. Improving accessibility aims at contributing to the provision of public transport services to all citizens in an equitable way. The purpose of the project was to analyse and to evaluate the existing solutions at selected European railways for all required modules at the entrance (doors, information and safety solutions), to derive a design concept, to develop a mock-up in meeting the needs of rail travellers with the above mentioned impairments and to test it with user groups. The project also aims at deriving components for the determination of standards. The EUPAX Design Mock-up test was performed to verify the advantages of the layout of the train segment including the different modules such as access area (including the access door, gaps between platform and train as well as boarding aid devices), entrance vestibule, information systems inside and outside the train, emergency facilities, toilet with all conveniences and the additional test arrangements regarding push buttons, steps and emergency equipment. For this purpose a questionnaire was developed for the assessment of the EUPAX segment and the additional test arrangements. With the help of this questionnaire it was possible to execute a quantitative and qualitative evaluation. During three test phases 67 experts and handicapped persons from 6 countries have evaluated the Industrial Design mock-up based on this questionnaire. The test group covered persons from North (Denmark) to the South (Italy) and from the West (Spain) to the Middle of Europe (Germany). This is especially important for the generalization (harmonisation) of the results for all European countries. According to COST 335 the information for people with reduced mobility should be clear, concise, accurate and timely. So that all information can be received from persons, they must be transferred on at least two of the three possible ways (acoustical, visual, tactile), a so called "2-sense-principle". Based on the results ergonomic specifications/ solutions for the ergonomic design of the access area, the acoustic, visual and tactile information and the emergency devices including the emergency communication system were developed, related to the benefiting passenger groups.

• 대한건축학회연합논문집
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• 제21권5호
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• pp.141-152
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• 2019

A gradual increase in the number of people with disabilities and the elderly in our everyday life has changed our perceptions toward them. The concept of barrier free space has been gradually incorporated into the social system and into our everyday life, and has further developed into the universal design concept so that creating an environment where all inhabitants of a city are able to enjoy the space of everyday life. Against this backdrop, this study has conducted research on how to improve the accessibility of major public spaces in Wonju, Chuncheon, and Gangneung, or major metropolitan cities of Gangwon Province. The research has been conducted under the assumption that the conditions of utilizing public spaces in those cities will not meet public expectations compared to private spaced despite being iconic cities of Gangwon Province. The field survey results show that the concept of barrier free space is reflected, to some extent, in planning and development although its role in terms of using such space is not up to expectations. In particular, the buildings and facilities built prior to the enforcement of relevant policies are found to leave much to be desired due to unsatisfactory development plans between architecture and urban public space, which necessitates improvement on relevant policies, sincere efforts of local governments, and practical guidelines that can be useful in the implementation stage. Above all, building owners and public administrations are advised to raise their awareness on the concept of universal design so that it is firmly rooted in our everyday life as one of the universal values. It should lead to the efforts of the members of local cities in providing the environment where people are able to enjoy these utilities from the perspective of promoting public welfare.