• Journal of Power Electronics
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• 제16권3호
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• pp.1176-1189
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• 2016

In this paper, a novel quasi-direct power control (Q-DPC) scheme based on a resonant frequency adaptive proportional-resonant (PR) current controller with a variable frequency resonant phase locked loop (RPLL) is proposed, which can achieve a fast power response with a unity power factor. It can also adapt to variations of the generator frequency in T-type Three-level shaft synchronous generator (SSG) converters. The PR controller under the static α-β frame is designed to track ac signals and to avert the strong cross coupling under the rotating d-q frame. The fundamental frequency can be precisely acquired by a RPLL from the generator terminal voltage which is distorted by harmonics. Thus, the resonant frequency of the PR controller can be confirmed exactly with optimized performance. Based on an instantaneous power balance, the load power feed-forward is added to the power command to improve the anti-disturbance performance of the dc-link. Simulations based on MATLAB/Simulink and experimental results obtained from a 75kW prototype validate the correctness and effectiveness of the proposed control scheme.

• 한국자원식물학회지
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• 제27권6호
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• pp.593-600
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• 2014

Osteoporosis is a progressive bone disease characterized by low bone mass which is caused by disturbance in the balance between the activities of osteoblasts and osteoclasts. Postmenopausal osteoporosis is one of the most common disorders in women after menopause, which is linked to an estrogen deficiency and characterized by an excessive loss of trabecular bone. Rubus coreanus has been used for their various pharmacological properties in Asia as a traditional medicine. To investigate the effect of unripe fruits of R. coreanus 30% ethanol extract (RCE) on osteoblast-like cells (MG63) differentiation, we examined the effects of RCE on in vitro osteoblastic differentiation markers, alkaline phosphatase (ALP) activity and receptor activator of nuclear factor ${\kappa}$-B ligand (RANKL) and osteoprotegerin (OPG) expression. The high concentration (50 and $100{\mu}g/mL$) of RCE markedly increased ALP activity, whereas decreased the RANKL/OPG. We also investigated the effect of RCE on M-CSF plus RANKL-induced differentiation of pre-osteoclast cells (RAW 264.7). RCE treatment remarkably inhibited M-CSF/RANKL-induced formation of osteoclast-like multinuclear cells from RAW 264.7 cells. Moreover, the inhibitory effect of RCE was reduced by selective estrogen receptor-${\alpha}$ antagonist. Our research suggests that suggested that unripe fruits of R. coreanus may act beneficial effects on bone mass by regulating both osteoblast and osteoclast.

• Journal of Electrical Engineering and Technology
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• 제13권1호
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• pp.20-29
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• 2018

The dynamic characteristics of power systems become more and more complex because of the integration of large-scale wind power, which needs appropriate control strategy to guarantee stable operation. With wide area measurement system(WAMS) creating conditions for realizing realt-ime transient stability analysis, a new coordinated control strategy for power system transient stability control based on phase-plane trajectory was proposed. When the outputs of the wind farms change, the proposed control method is capable of selecting optimal generators to balance the deviation of wind power and prevent transient instability. With small disturbance on the base operating point, the coordinated sensitivity of each synchronous generator is obtained. Then the priority matrix can be formed by sorting the coordinated sensitivity in ascending order. Based on the real-time output change of wind farm, coordinated generators can be selected to accomplish the coordinated control with wind farms. The results in New England 10-genrator 39-bus system validate the effectiveness and superiority of the proposed coordinated control strategy.

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2009년도 춘계학술대회
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• pp.185-188
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• 2009

이 논문에서는 PID 알고리즘을 이용하여 시소 시스템의 균형을 위한 위치 제어기를 설계하고자 한다. 시소 시스템은(Seesaw System) 선박 및 항공 역학, 도립진자, 각종 분석, 로봇 시스템 등의 해석에 광범위하게 응용되는 시스템이자 현대 제어 시스템의 이론과 각종 응용문제를 취급할 수 있는 장치이다. 시소 시스템의 경우 시스템이 비선형성이 강한 제어 대상이므로 시스템의 이해와 해석, 그리고 파라미터의 정확한 선정이 필수요소이다. 사용할 시스템 제어 알고리즘에는 간단하고 오랜 역사를 통해 안정성이 보장된 PID 알고리즘과 정확하고 빠른 PID 파라미터 동조에 필요한 연산 최적화 알고리즘인 PSO(Particle Swarm Optimization) 통해 외란이나 제어기의 변화에 빠르게 적응할 수 있도록 하여 성능과 안정성을 보장한다.

• 한국동물학회지
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• 제28권4호
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• pp.257-278
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• 1985

Phenyalanine, tryptophan, tyrosine 과 같은 방향족 아미노산을 계배 초기에 투여하였을 때 somite 형성에 미치는 영향을 광학 및 전자현미경을 사용하여 형태적으로 추구한 결과 아미노산을 투여한 계배에서는 불완전한 체절 분절 현상이 일어나고 신경계에도 감쇠 영향을 미치며 somite의 발생이 불완전하고 그 크기도 다양하였다. 또한 체절 세포는 chromatin이 응축되고 미토콘드리아의 일부는 파괴되었고 핵이 변형된 경우도 있었다. 부란 24시간 후 아미노산을 투여하고 15일간 부란한 계배의 경우 단백질이나 핵산은 대조군에 비해 크게 저하되지는 않았으나 lactate dehydrogenase, succinate dehydrogenase, malate dehydrogenase 및 glucose 6-phosphate dehydrogenase와 같은 기초대사에 중요한 구실을 하는 효소활성은 크게 저하되었다. 이와 같은 실험결과로부터 초기계배에 아미노산을 투여하면 아마도 yolk granule의 분해가 지연되며 결과적으로 세포내의 아미노산 균형이 파괴되어 정상 대사가 이루어지지 못하여 비정상적인 체절형성의 현상이 나타나게 되는 것으로 생각된다.

• The Korean Journal of Physiology and Pharmacology
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• 제14권1호
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• pp.15-20
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• 2010

It has been shown that CA repeats in the 3'-untranslated region (UTR) of bcl-2 mRNA contribute the constitutive decay of bcl-2 mRNA and that hnRNP L (heterogenous nuclear ribonucleoprotein L) interacts with CA repeats in the 3'-UTR of bcl-2 mRNA, both in vitro and in vivo. The aim of this study was to determine whether the alteration of hnRNP L affects the stability of bcl-2 mRNA in vivo. Human breast carcinoma MCF-7 cells were transfected with hnRNP L-specific shRNA or hnRNP L-expressing vector to decrease or increase hnRNP L levels, respectively, followed by an actinomycin D chase. An RT-PCR analysis showed that the rate of degradation of endogenous bcl-2 mRNA was not affected by the decrease or increase in the hnRNP L levels. Furthermore, during apoptosis or autophagy, in which bcl-2 expression has been reported to decrease, no difference in the degradation of bcl-2 mRNA was observed between control and hnRNP L-knock down MCF-7 Cells. On the other hand, the levels of AUF-1 and nucleolin, transacting factors for ARE in the 3'UTR of bcl-2 mRNA, were not significantly affected by the decrease in hnRNP L, suggesting that a disturbance in the quantitative balance between these transacting factors is not likely to interfere with the effect of hnRNP L. Collectively, the findings indicate that the decay of bcl-2 mRNA does not appear to be directly controlled by hnRNP L in vivo.

• Wind and Structures
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• 제15권6호
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• pp.531-553
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• 2012

Many tall buildings possess through-building gaps at middle levels of the building elevation. Some of these floors are used as sky gardens, or refuge floors, through which wind can flow with limited blockage. It has been reported in the literature that through-building gaps can be effective in reducing across-wind excitation of tall buildings. This paper systematically examines the effectiveness of two configurations of a through-building gap, at the mid-height of a tall building, in reducing the wind-induced dynamic responses of the building. The two configurations differ in the pattern of through-building opening on the gap floor, one with opening through the central portion of the floor and the other with opening on the perimeter of the floor around a central core. Wind forces and moments on the building models were measured with a high-frequency force balance from which dynamic building responses were computed. The results show that both configurations of a through-building gap are effective in reducing the across-wind excitation with the one with opening around the perimeter of the floor being significantly more effective. Wind pressures were measured on the building faces with electronic pressure scanners to help understand the generation of wind excitation loading. The data suggest that the through-building gap reduces the fluctuating across-wind forces through a disturbance of the coherence and phase-alignment of vortex excitation.

• Journal of Gastric Cancer
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• 제6권3호
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• pp.198-201
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• 2006

저나트륨혈증은 항암화학요법 중에 발생하는 전해질 장애 중의 하나이며, 조기에 발견하여 치료하지 않을 경우 급사할 수 있다. 저나트륨혈증을 유발하는 여러 원인중에 항이뇨호르몬과다분비증후군(syndrome of inappropriate antidiuretic hormone, SIADH)이 항암화학요법을 시행받은 환자들에게서 발생하였다고 보고되고 있다. SIADH를 유발하는 항암제는 아직까지 몇 가지 외에는 많이 알려져 있지 않다. 본 예는 위암으로 위전절제술, 비장절제술, 횡행결장구역절제술을 시행 받은 55세 여자로 수술 후 복막전이가 발견되어 S-1 ($80\;mg/m^{2}$)과 cisplatin ($60\;mg/m^{2}$)을 이용한 항암화학요법 중 SIADH가 발생하였다. 환자는 3% 생리식염수를 투여한 후 저나트륨혈증이 정상화되어 퇴원하였다.

• 해양환경안전학회지
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• 제11권1호
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• pp.23-28
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• 2005

선박 횡동요는 물적 손실을 초래할 뿐만 아니라, 승선자의 거주성, 안전성 및 작업능률을 저하시키는 가장 큰 요인이 된다. 횡동요억제를 위한 많은 연구는 다양한 형태의 장치개발이라는 결과를 가져왔으며 상당한 효과를 얻고 있다. 지금까지 개발 된 대부분의 장치는 그 성능을 고려하지 야더라도 특수한 목적의 선박을 대상으로 설치$\cdot$운영되고 있으며, 고가이고 복잡하여 설치 상에도 많은 문제점을 안고 있다. 따라서 본 논문에서는 선박의 선미측에 설치한 플랩을 이용하여 운항중인 선박의 횡동요 억제에 관해 고찰하고 있다. 본 장치는 중$\cdot$소형의 선박에도 쉽게 설치하여 운용이 용이할 뿐만 아니라, 적절한 제어시스템 구축으로 피칭운동도 제어할 수 있는 장점이 있다. 본 논문에서는 이러한 장치를 설치한 선박에 대해 실험적 기법을 이용하여 모델링을 행하고 시뮬레이션을 통해 장치의 횡동요 억제효과를 검증하고 있다.

• 대한수의학회지
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• 제25권2호
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• pp.133-144
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• 1985

The changes of acid-base status in vitro of the venous blood for 24 hours in ten Korean native goat were investigated. The acid-base parameters were measured within ten minutes after collection of the blood, and every hour during the first six hours and finally after twenty four hours of storage. Blood samples were stored at two different temperatures ($0-4^{\circ}C$ and $21-24^{\circ}C$). Twelve goats were induced acute acid-base disturbances by intravenous infusion of either hydrochloric acid or sodium bicarbonate and inhalated with $CO_2$ gas mixture (20% $CO_2$, 80% $O_2$) or hyperventilation were performed by means of respirator. The results were as follows; 1. Blood samples could be stored during the first two hours in ice water ($0-4^{\circ}C$) and one hour at room temperature without significant changes in pH. The magnitudes of changes were similar to those of cow, and lower than those of men and dogs. 2. The mean values of acid-base parameters in normal goat were arterial pH, 7.40; $P_{CO_2}$, 35.4mmHg; $HCO_3{^-}$, 21.8mEq/L. 3. Both the base excess and the bicarbonate showed high correlation (r=0.99) during the metabolic disturbance and were represented as $B.E.=1.38\;HCO^-{_3}-29.7$. 4. The slope of blood buffer curve obtained from the in vivo experiment was 16.3mEq/L/pH. 5. The magnitudes of changes in hydrogen ion concentration per unit change of $P_{CO_2}$ were 0.8nM/mmHg in hypercapnia and 1.0nM/mmHg in hypocapnia. 6. The ranges of acid-base parameters in normal goat urine were pH, 6.0-8.1; $P_{CO_2}$, 42-61mmHg; $HCO_3{^-}$, 2-110mEq/L. The concentration of potassium was higher (60-200mEq/L), and that of sodium was lower (8-70mEq/L) than those of human urine.