• Korean Journal of Veterinary Research
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• v.48 no.2
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• pp.197-201
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• 2008

Plasmodium spp. in domestic and wild birds are microscopic, intracellular parasitic protozoa within the blood cells and tissues cause avian malaria. A 17-month-old Magellan penguin (Spheniscus magellanicus) with a clinical signs of anorexia, depression, and respiratory distress for 3 days was submitted to the Pathology Department of Veterinary Medicine, Cheju National University in October 2005. It was born and reared in the Jeju Island. Grossly, the liver was enlarged, pale and friable. The spleen was also enlarged with dark red coloration and friable. Histopathologically, the lesions in the liver were characterized by multifocal infiltration of macrophages and lymphocytes especially in perivascular regions. The schizonts of Plasmodium spp. contained up to 30 merozoites were found in numerous infiltrated mononuclear cells. Similarly, histiocytic cells were proliferated in red pulp of spleen and the schizonts were found in these cells. Numerous dark brown pigments were widely distributed in the liver and spleen. The result of the nested polymerase chain reaction clarified the causative agent of this case was Plasmodium spp.. This is the first report for the outbreak of avian malaria caused by Plasmodium spp. in a penguin that was born and reared in Jeju Island in Korea.

• Parasites, Hosts and Diseases
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• v.22 no.2
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• pp.267-272
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• 1984

In June of 1983 authors had investigated the occurrence of the avian malaria in the Humboldt penguins imported from Japan to the Farmland Zoo in central district of Korea. The disease was characterized by acute course and high mortality. The peripheral blood smears from the affected penguins demonstrated different developmental stages of Plasmodium sp. in the mature erythrocytes. The predominant gross lesions noticed were pulmonary and epicardial edema and hepato-splenomegaly. Microscopically the lesions were characterized by extensive reticuloendothelial cell hyperplasia with striking feature of exoerythrocytic schizogony affecting a variety of tissues. The report also signifies the first description of a disastrous epizootic of avian malaria in Korea.

• KOREAN POULTRY JOURNAL
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• v.16 no.8 s.178
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• pp.99-102
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• 1984

닭 말라리아는 여름철 모기발생이 많은 시기에 주로 발생하는데 발생국으로서는 일본, 대만, 말레이지아, 필리핀, 태국, 인도네시아, 스리랑카, 브라질, 멕시코, 우루과이 등을 들 수 있다.

• Korean Journal of Veterinary Research
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• v.59 no.2
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• pp.69-74
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• 2019

Avian malaria is one of the most important general blood parasites of poultry in Southeast Asia. Plasmodium (P.) juxtanucleare causes avian malaria in wild and domestic fowl. This study aimed to identify and characterize the Plasmodium species infecting in Thai native fowl. Blood samples were collected for microscopic examination, followed by detection of the Plasmodium cox I gene by using PCR. Five of the 10 sampled fowl had the desired 588 base pair amplicons. Sequence analysis of the five amplicons indicated that the nucleotide and amino acid sequences were homologous to each other and were closely related (100% identity) to a P. juxtanucleare strain isolated in Japan (AB250415). Furthermore, the phylogenetic tree of the cox I gene showed that the P. juxtanucleare in this study were grouped together and clustered with the Japan strain. The presence of P. juxtanucleare described in this study is the first report of P. juxtanucleare in the Thai native fowl of Thailand.

• Journal of Veterinary Clinics
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• v.38 no.1
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• pp.1-6
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• 2021

Avian haemosporidia, including malarial parasites, are geologically and biologically widespread. The protozoal pathogen has been a subject of intensive research in the past, which has resulted in major medical progress. Haemosporidia infection in avian species in South Korea has been studied in wild birds and layer flocks, but not in pet birds. At the Veterinary Teaching Hospital of Chungbuk National University, 75 birds that presented for health check-up were tested to evaluate the infection rate of Haemoproteus, Plasmodium and Leucocytozoon in birds without clinical symptoms. Haemoproteus spp. and Leucocytozoon spp. were simultaneously detected in a Major Mitchell's cockatoo (Lophochroa leadbeateri) by polymerase chain reaction, representing 1.33% of the tested birds. Phylogenetic analysis suggested that the infective Haemoproteus and Leucocytozoon strains were similar to those detected in foreign countries rather than those detected in the wild birds of Korea. Although the infection rate may not be indicative of a substantial infection in healthy pet parrots, the import of infected birds can pose a threat by allowing foreign pathogens to infect the local wild flocks or livestock. This is the first surveillance study of avian haemosporidia in pet parrots in South Korea.

• Proceedings of the Korean Information Science Society Conference
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• 2010.06b
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• pp.514-517
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• 2010

그리드 인프라를 활용하여 대규모 계산 자원이 필요한 가상 스크리닝(Virtual Screening)에 관한 연구가 국제 WISDOM 프로젝트를 중심으로 활발하게 진행 중에 있다. 기존의 연구들은 싱글 클러스터나 개인의 컴퓨터를 중심으로 계산 자원을 활용하는 방식으로 연구가 진행이 되었다. WISDOM을 중심으로 대규모 말라리아(Malaria), 조류 독감(Avian Flu) 에 대한 대규모 신약 후보 탐색에 관한 연구들이 진행이 되었으며 한국과학기술정보연구원(KISTI)의 그리드 개발팀은 2007년도부터 국제 공동 파트너로 연구에 참여하고 있다. 공동연구에 참여하면서 신약 연구 개발자들이 Docking 및 그리드 자원을 활용하기 위한 접근 방식에 있어서 기존 방식들을 활용하기 어려운 점과 검색된 신약 물질을 분석하는 도구의 활용이 어려움이 많아 그리드 기반의 가상스크리닝 도구인 DrugScreenr-G(이하, DSG-G 클라리언트)를 개발하게 되었다. 본 논문은 개발된 DSG-G 클라이언트에 관한 개발 및 구조에 관한 내용이다.

• Proceedings of the Korea Contents Association Conference
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• 2007.11a
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• pp.569-573
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• 2007

e-Science is a new paradigm to increase the research efficiency by applying the state-of-the-art information technology to the classical research methodology. Among the research fields influenced by e-Science, Biology and Bioinformatics are the fields that are using IT very actively. And virtual screening, a procedure for the drug discovery, is one of the bioinformatics applications which requires a large amount of computing resources. In this paper, WISDOM, which is a e-Science project to design a new drug for Malaria and Avian flu, and related projects are introduced and the joint research between KISTI and Chun-nam university planned for the virtual screening research is explained.