• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7747-7752
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• 2014

Kr$\ddot{u}$ppel-like factor 4 is a transcription factor which plays an important role in development and progression of various carcinomas. Curcumin characterized by excellent anti-cancer properties is regarded as a serviceable natural compound used in carcinoma therapy. This study aimed at exploring the impact of KLF4 overexpression in cooperation with curcumin on the proliferation, apoptosis and invasion of human gastric carcinoma BGC-823 cells. Flow cytometry analysis, CCK-8 assays, transwell assays and Western blot results showed that KLF4 overexpression combined with curcumin had significant anti-proliferation, pro-apoptosis and anti-invasion effects on BGC-823 cells. We also found that KLF4 had synergistic effects with curcumin, better promoting apoptosis and inhibiting proliferation and invasion of gastric carcinona cells. These results indicate that KLF4 could be used as a potential therapeutic target; curcumin could act as an auxiliary and provide a promising therapeutic strategy in stomach cancer.

• Journal of Power Electronics
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• 제16권4호
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• pp.1469-1482
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• 2016

In hybrid energy storage systems, supercapacitors are usually connected in series to meet the required voltage levels. Equalizers are effective in prolonging the life of hybrid energy storage systems because they eliminate the voltage imbalance on cells. This study proposes a modularized equalizer, which is based on a combination of a half-bridge inverter, an inductor, and two auxiliary capacitors. The proposed equalizer inherits the advantages of inductor-based equalization systems, but it also offers unique merits, such as low switching losses and an easy-to-use control algorithm. The zero-voltage switching scheme is analyzed, and the power model is established. A fixed-frequency operation strategy is proposed to simplify the control and lower the cost. The switching patterns and conditions for zero-voltage switching are discussed. Simulation results based on PSIM are presented to verify the validity of the proposed equalizer. An equalization test for two supercapacitor cells is performed. An experimental hybrid energy storage system, which consists of batteries and supercapacitors, is established to verify the performance of the proposed equalizer. The analysis, simulation results, and experimental results are in good agreement, thus indicating that the circuit is practical.

• 전력전자학회논문지
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• 제20권2호
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• pp.160-166
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• 2015

This study proposes an improved cell balancing circuit for fast equalization among lithium-ion (Li-ion) batteries. A simple voltage sensorless charge balancing circuit has been proposed in the past. This cell balancing circuit automatically transfers energy from high-to low-voltage battery cells. However, the circuit requires a switch with low on-resistance because the balancing speed is limited by the on-resistance of the switch. Balancing speed decreases as the voltage difference among the battery cells decrease. In this study, the balancing speed of the cell balancing circuit is enhanced by using the auxiliary circuit, which boosts the balancing current. The charging current is determined by the nominal battery cell voltage and thus, the balancing speed is almost constant despite the very small voltage differences among the batteries. Simulation results are provided to verify the validity of the proposed cell balancing circuit.

• Journal of Plant Biology
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• 제39권1호
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• pp.23-29
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• 1996

Morphology and reproduction of Polysiphonia atlantica Kapraun et J. Norris were studied on the basis of field and laboratory cultured materials collected from the coast of Korea. The plants consisted of prostrate and erect axes with an extremely soft flaccid texture. Axes were ecorticated and had four pericentral cells. The plants except for female gametophytes had few trichoblasts. Branches in the upper portion of the thallus grew to the same level, resulting in a flat-top form. Tetrasporangia were arranged in straight series. Spermatangial branches replaced whole trichoblasts and had a 1-2 celled serile tip. The procarp had a four celled carpogonial branch. After fertilization, the carpogonium contancted the surface of the supporting cell. The formation of the auxiliary cell from the supporting cell was somewhat delayed P. atlantica from Korea was similar to P. subtilissima Montagne in some features. However, the taxonomic differences between the two species were identified in the development of branches and the number of sterile cells at the tip of spermatangial branches.

• Molecules and Cells
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• 제21권2호
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• pp.213-217
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• 2006

Although AIMP1 (previously known as p43) is one of three auxiliary proteins bound to a macromolecular aminoacyl tRNA complex, it is also secreted as a cytokine controlling both angiogenesis and immune responses. Here we show that systemically administered purified recombinant human AIMP1 had anti-tumor activity in mouse xenograft models. In Meth A-bearing Balb/c mice, tumor volume increased about 28 fold in the vehicle treatment group, while an increase of about 16.7 fold was observed in the AIMP1-treated group. We also evaluated the anti-tumor activity of AIMP1 in combination with a sub-clinical dose of the cytotoxic anti-tumor drug, paclitaxel. The growth of NUGC-3 human stomach cancer cells was suppressed by 84% and 94% by the combinations of 5 mg/kg paclitaxel + 25 mg/kg AIMP1 (p = 0.03), and 5 mg/kg paclitaxel + 50 mg/kg AIMP1 (p = 0.02), respectively, while 5 mg/kg paclitaxel alone suppressed growth by only 54% (p = 0.02). A similar cooperative effect of AIMP1 and paclitaxel was observed in a lung cancer xenograft model. These results suggest that AIMP1 may be useful as a novel anti-tumor agent.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2003년도 가을 학술논문집
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• pp.671-675
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• 2003

연구로 1,2호기 해체 사업이 본격적으로 착수하게 됨에 따라 2001년 8월부터 2002년 12월까지 연구로 2호기 부속시설인 동위원소 생산시설을 제염 및 해체하였다. 이 시설은 동위원소 생산용 콘크리트 핫셀, 납 핫셀 및 실험실로 구성되어 있다. 제염ㆍ해체의 대상물은 흄후드, 실험대, 씽크 및 오염된 내부 시설물이다. 안전한 해체 활동을 위해서 각종 지침서 및 절차서가 수립되었다. 해체 활동을 위해 총 20,933 man-hour의 인력이 소요되었고, 드릴링 머신 등 여러 장비가 투입되었다. 실험실에서의 최대 오염도는 유리성 오염도가 $\beta$ : 9.24 Bq/$\textrm{cm}^2$이였고, 고착성 오염도는 350,000 cpm이였다. 해체폐기물은 콘크리트류, 목재류 및 철재류 등으로 총 62.146 Ton이고, 작업자들의 피폭량은 0.33 mam-mSv로 나타났다.

• Bulletin of the Korean Chemical Society
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• 제35권5호
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• pp.1305-1311
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• 2014

The nickel oxide, the most widely used cathode material for the molten carbonate fuel cell (MCFC), has several disadvantages including NiO dissolution, poor mechanical strength, and corrosion phenomena during MCFC operation. The surface modification of NiO with lanthanum maintains the advantages, such as performance and stability, and suppresses the disadvantages of NiO cathode because the modification results in the formation of $LaNiO_3$ phase which has high conductivity, stability, and catalytic activity. As a result, La-modified NiO cathode shows low NiO dissolution, high degree of lithiation, and mechanical strength, and high cell performance and catalytic activity in comparison with the pristine NiO. These enhanced physico-chemical and electrochemical properties and the durability in marine environment allow MCFC to marine application as a auxiliary propulsion system.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2007년도 춘계학술대회
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• pp.137-140
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• 2007

We consider the optimum air flow channel design for DMFC's in the present study. The effect of pressure drop across the inlet and outlet of a stack on the performance of a DMFC is the optimization of such geometric parameters is crucial to minimize the parasitic power usage by the auxiliary devices such as fuel pumps and blowers. In this paper, we present how the pressure drop control can optimize the driving point of a DMFC stack. Further, we show how the optimal fuel utilization ratio can be achieved, not degrading the performance of DMFC stacks. Overall, we discuss how the flow channel design affects the selection of balance of plant(BOP) components, the design of DMFC systems and the system efficiency.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 하계학술대회 논문집 B
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• pp.1322-1324
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• 2001

FuelCell/Battery hybrid power systems were studied to develop high efficient zero-emission fuel cell electric vehicles. Fuel cells were used as an auxiliary energy source and batteries were used as a transient power source. The fuel cell system is used to supply the average power demand. Dynamic response of the hybrid systems was simulated using PSPICE program and also tested experimentally. The results can be used to design the interface module and to determine the power requirement between the fuel cell unit and the battery pack.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2008년도 International Meeting on Information Display
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• pp.1189-1192
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• 2008

A new mercury-free flat fluorescent lamp with a single cell having dimension 2.2inches across the diagonal, had been developed which shows a wide, stable operating voltage margin, high luminance and luminous efficacy by adopting the bipolar pulse drive scheme. In this paper, the single cell is expanded into a multi-structured configuration to realize a 32inch sized panel across the diagonal by a simple repetition of the single cells. A driving scheme is proposed for a 2-bit areal selective dimming using dual auxiliary electrodes and bipolar drive scheme.