• International Journal of Stem Cells
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• 제17권3호
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• pp.236-252
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• 2024

Spinal cord injury (SCI) is a serious nervous system disease that usually leads to the impairment of the motor, sensory, and autonomic nervous functions of the spinal cord, and it places a heavy burden on families and healthcare systems every year. Due to the complex pathophysiological mechanism of SCI and the poor ability of neurons to regenerate, the current treatment scheme has very limited effects on the recovery of spinal cord function. In addition, due to their unique advantages, exosomes can be used as carriers for cargo transport. In recent years, some studies have confirmed that treatment with mesenchymal stem cells (MSCs) can promote the recovery of SCI nerve function. The therapeutic effect of MSCs is mainly related to exosomes secreted by MSCs, and exosomes may have great potential in SCI therapy. In this review, we summarized the repair mechanism of mesenchymal stem cells-derived exosomes (MSCs-Exos) in SCI treatment and discussed the microRNAs related to SCI treatment based on MSCs-Exos and their mechanism of action, which is helpful to further understand the role of exosomes in SCI.

• 동의신경정신과학회지
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• 제26권2호
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• pp.89-102
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• 2015

Objectives: To examine the medical effectiveness of meditation programs ($\alpha$ version) by psychological types. Methods: MBTI, which was created by Katharine Cook Briggs and Isabel Briggs Myers, was used as the Psychological Type test and to investigate psychological temperament and functions and psychological preferences. Heart rate variability was used to test the effectiveness of meditation by investigating time domains (mean HR, SDNN, PSI) and frequence domain parameters (TP, LF, HF, LF or HF norm, Ln (TP or VLF or LF or HF). Results: 1. The autonomic nervous system became active, and both time domains and frequency domains showed positive responses to meditation in heart rate variability tests, without distinction of Psychological Types. 2. In Psychological Types using sensing over intuition for perception, there were positive responses as well as an increase of the parasympathetic nervous system's activeness to meditation for heart rate variability tests, depending on psychological temperaments and psychological functions. 3. In heart rate variability tests by preferences, there was no difference. Extroversion and Introversion types, Sensing over Intuition Types, Thinking over Feeling Types, Judging over Perception Types had an increase of activeness of the parasympathetic nervous system. Therefore, meditation has a positive physical and psychological relaxing effect. Conclusions: A complex meditation program has a positive effect on overall meditation. Especially in the MBTI test, sensing was superior to intuition when people recognized objects. The Sensing, Thinking and Judging type was more advantageous than Intuition, Feeling and Perception, respectively. In the future, a well-designed control study is needed, to develop a suitable meditation for each personality type.

• 전자공학회논문지SC
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• 제47권2호
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• pp.43-49
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• 2010

자율신경계는 불수의적 활동 기능을 조절해 주는 신경계통으로, 자율신경계의 활성 정도를 정량적으로 평가하기 위해 심박 변이도가 이용된다. 그러나 심박 변이도는 환경 변화나 심리 상태의 변화 등에 민감하게 반응하며, 자세와 수면 박탈에 의해서도 심박 변이도가 달라질 수 있다. 특히 전자파 자원자 연구에서는 자각 증상 및 인지 여부에 의한 수면 박탈로 심박 변이도가 달라질 수 있다. 이에 본 연구에서는 자세에 따른 수면 박탈 횟수와 심박 변이도를 30분간 6 stage에서 측정하였고, 앉은 자세와 누운 자세에서 측정된 심박 변이도를 비교하여 앉은 자세나 누운 자세에서 심박 변이도를 측정하는 실험에 어떠한 자세가 적합한지 결정하고자 하였다. 심박 변이도 분석은 전력 스펙트럼을 이용한 주파수 영역에서의 LF (low frequency) / HF(high frequency)를 이용하였고, stage 1을 100%로 하여 개인 및 성별에 따른 초기 LF/HF 차이를 상쇄시켜 주었다. LF/HF 증가는 교감 신경의 활성 증가를 나타내고 감소는 교감 신경의 활성 감소를 나타낸다. 교차 분석 결과 수면 박탈은 자세의 영향을 받는 것으로 나타났으며 (p=0.002), LF/HF에 대하여 자세만을 변수로 고려하였다. 앉은 자세에서 수면 박탈 횟수는 모든 stage에서 누운 자세보다 유의하게 적었다 (p<0.05). 자세는 LF/HF에 유의한 영향을 끼쳤으며 (p=0.033), 앉은 자세에서는 stage 1과 비교하여 LF/HF가 stage 4, 5, 6에서 유의하게 증가하였고 (p<0.05), 누운 자세에서는 stage 1과 비교하여 모든 stage에서 LF/HF가 유의하게 증가하였다 (p<0.05). 따라서 앉은 자세가 누운 자세보다 수면 박탈 횟수가 적고 LF/HF 변화가 작기 때문에 피험자가 깨어 있어야 하는 심박 변이도 측정 실험에 있어서 더 적합한 자세라고 사료된다.

• The Korean Journal of Physiology and Pharmacology
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• 제1권3호
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• pp.275-284
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• 1997

Unilateral labyrinthectorny (ULX) causes autonomic symptoms, ocular and postural asymmetries, which disappear over tune in the process of equilibrium recovery known as vestibular compensation. In the present study in order to elucidate mechanisms responsible for the effects of electrical stimulation on vestibular compensation and investigate the relationship between vestibular compensation and c-Fos expression in the medial vestibular nuclei following ULX, we measured spontaneous nystagmus, eye movement induced by sinusoidal rotation and c-Fos expression or to 72 hs after ULX in Sprague-Dawley rats. Experimental animals were divided into two groups: ULX group with ULX only, and electrical stimulation (ES) group with electrical stimulation of $-2{\sim}-5V$, 1.0ms, 100 Hz to the lesioned vestibular system for 4 hs/day. Spontaneous nystagmus following ULX disappeared by 72 hs in ULX group and 36 hs in ES group. In eye movement induced by sinusoidal rotation, normal pattern of eye movement by rotation toward the lesioned side was recovered 24 hs after ULX at rotation of 0.1 Hz and 6 hs after at 0.2 Hz, 0.5 Hz in ULX group. In ES group, the eye movement recovered after 12 hs at 0.1 Hz, 6 hs at 0.2 Hz, and 4 hs at 0.5 Hz. Directional Preponderance which represents the symmetry of bilateral vestibular functions showed significantly early recovery in ES group compared with that of ULX group. Expression or c-Fos immunoreactive cells in the bilateral medial vestibular nuclei was severely asymmetrical till 36 hs in ULX group, and then it became a symmetry and disappeared after 72 hs. However, ES group showed the symmetry of c-Fos expression after 6 hs, which was significantly early recovery in 25 group. All these findings suggest that electrical stimulation ameliorates recovery of vestibuloocular reflex following ULX by the restoration of the balance of the resting activity between bilateral medial vestibular nuclei. In addition, c-Fos expression in the medial vestibular nuclei could be used as a marker of vestibular compensation since c-Fos expression is closely related to the course of recovery following ULX.

• 동의신경정신과학회지
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• 제20권2호
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• pp.85-99
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• 2009

Objectives : This study aimed to understand the influence of acupuncture on the human body by comparing changes within human bodies before and after people in normal health are treated with acupuncture at the acupoints HT7 and PC9, which are related to mental functions. Methods : The study was performed from January 3, 2008 to March 5, 2008 on 60 healthy males and females in their 20s. HRV, EEG, skin conductance response, respiration and peripheral skin temperature were measured for 5 minutes before acupuncture simulation was applied to the acupoints HT7 and PC9. During 20 minutes of acupuncture treatment, the same items were continuously measured to determine whether there had been any changes, and they were then measured for 5 minutes after the removal of the acupuncture needles in order to implement a comparative analysis. Results : 1. The HRV measurement showed that in the course of before, during and after acupuncture stimulation, heart rate, HF and HF norm decreased significantly (P<0.05) at HT7. LF, LF norm, and LF/HF ratio increased significantly (P>0.05), while heart rate, HF and HF norm decreased significantly (P<0.05) at PC9. 2. Skin conductance response increased significantly (P<0.05) at PC9 during and after the acupuncture simulation periods, compared with the pre acupuncture period. 3. the peripheral skin temperature increased significantly (P<0.05) both at HT7 and PC9 in the course of before, during and after acupuncture stimulation. 4. Compared with the pre-acupuncture period, respiration rate increased both at HT7 and at PC9 during and after the acupuncture simulation periods, but not in a statistically significance. 5. In the EEG measurement, when compared with the pre-acupuncture period at HT7, mid ${\beta}$ wave decreased significantly (P<0.05) during acupuncture treatment. Compared with the measurements during acupuncture treatment at PC9, low ${\beta}$ wave increased significantly (P<0.05) after the acupuncture needles were removed. Conclusions : When acupuncture treatment is applied at the acupoints HT7 and PC9, the activation of parasympathetic nerves decreases and the activation of sympathetic nerves increases in the HRV measurement. It was determined that PC9 makes the sympathetic nerves become highly activated in a skin conduction response. The effect of stability in the brain wave seemed to bo shown at HT7 than PC9.

• 감성과학
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• 제13권1호
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• pp.187-196
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• 2010

최근 늘어나고 있는 스트레스로 인한 피로와 심리적 장애로 인해 현대인들은 고통 받고 있다. 다수의 사람들이 고통을 완화시키기 위해 약물치료에 의존하고 있는 추세이며 대체의학이나 대체요법으로 치료하는 사람들도 많이 있다. 그러나 약물치료는 약물 복용 후 더 많은 스트레스를 겪는 등 여러 가지 부작용을 가지고 있다. 이에 비해 대체요법의 테라피분야, 마사지, 발반사요법 등은 비 약물치료로써 인체에 부담이 덜하며 편안한 심신을 유지하며 치료받을 수 있는 부분이다. 이에 본 저자는 컬러테라피요법과 발반사요법의 장점을 종합하여 고통이 없이 간단한 방법으로 치료효과를 볼 수 있는 컬러 발반사요법(color foot reflexology)을 전 연구에서 공동개발한 바 있다. 이를 본 논문에서는 자극시 효과에 플라시보 효과를 대조군으로 비교하여 인체생리신호측정반응을 평가하여 발 컬러 반사요법이 인체생리반응에 어떠한 영향을 미치는지 정량적으로 연구하였다. 최적화된 실험환경과 객관화된 시스템에서 건강한 성인군을 대상으로 실험하였다. 그 결과 자극을 주었을 때는 HRV에서 부교감신경의 증가세가 나타났으며 혈압, 맥박, 체온 말초혈류량이 활발하게 작용하는 변화를 보였다. 그러나 플라시보에서는 거의 변화가 없거나 뷸규칙적인 결과가 나타났다. 이결과는 컬러 발반사요법이 자율신경계와 인체생리적반응에 긍정적인 영향에 관계됨을 알 수 있으며 이는 개발 기기의 유효성을 증명하는데 좋은 자료로써 충분한 근거이다. 그리고 이의 연구결과를 바탕으로 향 후 발과 관련하여 불규칙적인 생리현상에 의한 질병이나 질환에 관하여 특정군을 대상으로 실험 연구하여 객관적인 실험검증을 할 계획이다.

• 대한한의학회지
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• 제31권1호
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• pp.81-92
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• 2010

Objectives: The objective of this study was to assess bra in activation and difference by LI11 or ST36 acupuncture stimulation using functional MRI (fMRI). Methods: A total of 10 healthy right-handed volunteers were studied. LI11 acupuncture and ST36 acupuncture stimulations were applied in order on the left. The block design paradigm of RARARA was used for the task, with R representing rest and A representing stimulation, and each period lasted 30 seconds. fMRI data were analyzed using SPM2. Results: The left LI11 acupuncture stimulation activated both sides of the inferior parietal lobule, the left side of the extra-nuclear, culmen and inferior semi-lunar lobules. On the right side, the nodule and midbrain regions were activated by the left LI11 acupuncture stimulation. The left ST36 acupuncture stimulation activated the right side of the superior frontal gyrus, middle frontal gyrus, superior parietal lobule, inferior semi-lunar lobule and pyramis. On the left side, the sub-gyral, middle temporal gyrus, fusiform gyrus, supramarginal gyrus, extra-nuclear, cingulate gyrus and fastigium regions were activated by the left ST36 acupuncture stimulation. Besides, both sides of the paracentral lobule, inferior parietal lobule, culmen, cerebellar tonsil and midbrain regions were activated. Conclusions: In conclusion, brain signal activation patterns according to acupoints were observed to differ, and ST36 acupuncture stimulation activated more regions than LI11. It is supposed that LI11 and ST36 acupuncture stimulations have an influence on motor function and sensory aphasia, and these stimulations thus represent potential for ocular motor dysfunction, discriminative touch or position sense disorder. Moreover, ST36 acupuncture stimulation activated the cingulate gyrus of the limbic system, so it seems to have an influence over autonomic functions.