• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.71-74
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• 1997

MR acoustic sound or noise due to gradient pulsings has been one of the problems in MRI, both in patient scanning as well as in many areas of psychiatric and neuroscience research, such as brain fMRI. Especially in brain fMRI, sound noise is one of the serious noise sources which obscures the small signals obtainable from the subtle changes occurring in oxygenation status in the cortex and blood capillaries. Therefore, we have studied the effects of acoustic or sound noise arising in fMR imaging of the auditory, motor and visual cortices. The results show that the acoustical noise effects on motor and visual responses are opposite. That is, for the motor activity, it shows an increased total motor activation while for the visual stimulation, corresponding (visual) cortical activity has diminished substantially when the subject is exposed to a loud acoustic sound. Although the current observations are preliminary and require more experimental confirmation, it appears that the observed acoustic-noise effects on brain unctions, such as in the motor and visual cortices, are new observations and could have significant consequences in data observation and interpretation in future fMRI studies.

• 한국초전도ㆍ저온공학회논문지
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• 제17권4호
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• pp.34-37
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• 2015

Developing Magnetoencephalography (MEG) based on Superconducting Quantum Interference Device (SQUID) facilitates to observe the human brain functions in non-invasively and high temporal and high spatial resolution. By using this MEG, we studied alpha rhythm (8-13 Hz) that is one of the most predominant spontaneous rhythm in human brain. The 8-13 Hz rhythm is observed in several sensory region in the brain. In visual related region of occipital, we call to alpha rhythm, and auditory related region of temporal call to tau rhythm, sensorimotor related region of parietal call to mu rhythm. These rhythms are decreased in task related region and increased in task irrelevant regions. This means that these rhythms play a pivotal role of inhibition in task irrelevant region. It may be helpful to attention to the task. In several literature about the alpha-band inhibition in multi-sensory modality experiment, they observed this effect in the occipital and somatosensory region. In this study, we hypothesized that we can also observe the alpha-band inhibition in the auditory cortex, mediated by the tau rhythm. Before that, we first investigated the existence of the alpha and tau rhythm in occipital and temporal region, respectively. To see these rhythms, we applied the visual and auditory stimulation, in turns, suppressed in task relevant regions, respectively.

• 문화기술의 융합
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• 제4권4호
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• pp.349-354
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• 2018

인류는 과학기술의 발전과 함께 의학기술도 눈부신 발전을 거듭해왔다. 그러나 과거에도 난치성 질환은 여전히 존재하였듯이 지금도 난치성 질환이 존재하는데, 그 중 턱관절장애가 있다. 현재 의료선진국이라 불리는 대한민국 의료진들의 진단은 환자의 발언, 의사의 청음진단과 자를 이용한 진단, X-ray 촬영 진단 방식을 고수하며 시대에 뒤떨어지고 있다. 그렇기 때문에 환자의 정확한 증상 여부, 의사 본인의 진단 실력과 경력이 중요하고, 증상의 경중에 따른 진단 횟수의 증가와 이로 인해 발생하는 의료비용은 막대하다. 본 연구에서는 이를 해결하기 위해 저작운동(최대폐구)시 교근에서 발생되는 근전도 신호를 %MVC를 통해 정량화하였다. 정량화된 근전도는 Cortex로 비교, 평가하여 턱관절 상태 평가 기준 지표를 확립할 것이다.

• Korean Journal of Radiology
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• 제22권1호
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• pp.118-130
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• 2021

Objective: This study aimed to investigate the blood-brain barrier (BBB) disruption in mild traumatic brain injury (mTBI) patients with post-concussion syndrome (PCS) using dynamic contrast-enhanced (DCE) magnetic resonance (MR) imaging and automatic whole brain segmentation. Materials and Methods: Forty-two consecutive mTBI patients with PCS who had undergone post-traumatic MR imaging, including DCE MR imaging, between October 2016 and April 2018, and 29 controls with DCE MR imaging were included in this retrospective study. After performing three-dimensional T1-based brain segmentation with FreeSurfer software (Laboratory for Computational Neuroimaging), the mean K^trans and v_p from DCE MR imaging (derived using the Patlak model and extended Tofts and Kermode model) were analyzed in the bilateral cerebral/cerebellar cortex, bilateral cerebral/cerebellar white matter (WM), and brainstem. K^trans values of the mTBI patients and controls were calculated using both models to identify the model that better reflected the increased permeability owing to mTBI (tendency toward higher K^trans values in mTBI patients than in controls). The Mann-Whitney U test and Spearman rank correlation test were performed to compare the mean K^trans and v_p between the two groups and correlate K^trans and v_p with neuropsychological tests for mTBI patients. Results: Increased permeability owing to mTBI was observed in the Patlak model but not in the extended Tofts and Kermode model. In the Patlak model, the mean K^trans in the bilateral cerebral cortex was significantly higher in mTBI patients than in controls (p = 0.042). The mean v_p values in the bilateral cerebellar WM and brainstem were significantly lower in mTBI patients than in controls (p = 0.009 and p = 0.011, respectively). The mean K^trans of the bilateral cerebral cortex was significantly higher in patients with atypical performance in the auditory continuous performance test (commission errors) than in average or good performers (p = 0.041). Conclusion: BBB disruption, as reflected by the increased K^trans and decreased v_p values from the Patlak model, was observed throughout the bilateral cerebral cortex, bilateral cerebellar WM, and brainstem in mTBI patients with PCS.

• Investigative Magnetic Resonance Imaging
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• 제2권1호
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• pp.50-57
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• 1998

경사 자계 펄스에 의한 MR 소음은 환자의 촬영뿐만 아니라 뇌기능 영상과 같은 신경 과학 영상에도 문제점 중의 하나이다. 특히 뇌기능 영상에서 소음은 피질과 혈관의 산소량의 변화로부터 생기는 작은 신호의 변화에 영향을 미치는 심각한 잡음 중의 하나이다. 본 연구에서는 청각, 운동, 및 시각피질에서 소음이 뇌기능 영상에 미치는 영향을 알아보고자 하였다. 그 결과 소음이 운동과 시각 피질에 미치는 여향은 서로 반대였다. 즉, 운동 피질에서는 소음이 총반응을 증가시켰고, 반대로 시각 피질에서는 소음이 총반응을 감소시켰다. 현재의 연구가 시작 단계에 있고, 앞으로 더 많은 실험적 검증이 필요한 실정이나, 소음이 운동과 시각 피질의 뇌기능 영상에 미치는 여향에 관한 첫번째 보고이며, 이결과는 앞으로 뇌기능 연구의 데이터 해석에 기초 자료로 이용될 수 있다.

• 한국콘텐츠학회논문지
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• 제16권8호
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• pp.427-434
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• 2016

본 논문은 인간이 인지할 수 있는 감각들 중 인체의 회전, 방향 변화 및 움직임의 정도를 알 수 있는 근감각에서 시각 및 청각 요소로의 변환 알고리즘을 이용하여 ARM Cortex-M4에 기반한 실시간 임베디드시스템으로 구현한 방법에 초점을 맞추었다. 근감각의 입력 방식으로는 자세측정장치(AHRS : Attitude Heading Reference System)를 이용해 롤(Roll), 피치(Pitch) 및 요(Yaw) 값을 실시간 획득하고, 이들 각각의 색을 표현하는 HSI 컬러 모델의 명도(Intensity), 색상(Hue) 및 채도(Saturation)에 대응하여 변환하였다. 최종 컬러신호는 HSI 에서 RGB 컬러모델로 변환하여 획득하였다. 또한, 근감각의 세 가지 입력 값들을 음을 표현하는 요소인 옥타브(Octave), 음계(Scale) 및 음의 세기(Velocity)에 대응하여 변환한 값을 MIDI(Musical Instrument Digital Interface)를 이용해 사운드를 합성하여 출력하였다. 출력 컬러신호 및 사운드를 분석한 결과, 근감각 입력 신호가 제안한 변환 방식에 따라 실시간으로 정확하게 색과 음으로 변환, 출력됨을 확인하였다.

• Progress in Superconductivity
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• 제12권1호
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• pp.57-61
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• 2010

We have developed a whole-head MEG system for basic brain research and clinical application. The sensor system consists of a 152 SQUID gradiometer array oriented and located in a suitable way to cover a whole head of the human. The system measures magnetic fields generated by neuronal currents in the brain to get information on the brain activities. For this purpose, the field sensitivity determined by the position, orientation and geometry of the pickup coil as well as amplification factor of the electronic circuits should be known precisely. However, the position and orientation of the pickup coil might be changed from the designed specifications during cool down of the dewar and it is necessary to characterize the field sensitivity. In this study, we made calibration systems to determine the actual position and orientation of the 152 pickup coils and compared the localization results of the N100m source in the auditory cortex.

• 한국지능시스템학회논문지
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• 제23권2호
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• pp.178-183
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• 2013

In this study, we proposed a method for electroencephalogram (EEG) classification using invariant CSP at special channels for improving the accuracy of classification. Based on the naive EEG signals from left and right hand movement experiment, the noises of contaminated data set should be eliminate and the proposed method can deal with the de-noising of data set. The considering data set are collected from the special channels for right and left hand movements around the motor cortex area. The proposed method is based on the fit of the adjusted parameter to decline the affect of invariant parts in raw signals and can increase the classification accuracy. We have run the simulation for hundreds time for each parameter and get averaged value to get the last result for comparison. The experimental results show the accuracy is improved more than the original method, the highest result reach to 89.74%.

• Annals of Clinical Neurophysiology
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• 제1권1호
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• pp.26-30
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• 1999

본 연구에서는 ERP검사 중에는 중뇌동맥의 MFV가 검사전후와 비교하여 유의하게 증가힌 소견을 보였다. 비록 중뇌동맥의 혈류속도의 변화가 뇌활동정도를 직접 반영할 수는 없다고 생각이 되지만 이 연구의 결과로 P300의 생성에 중뇌동맥에 의해서 영양받는 전두엽, 측두엽 및 두정엽이나 다른 대뇌부위가 관여할 것으로 사료된다. 경두개도플러검사는 다른 뇌기능활동을 반영할 수 있는 양전자방출단층촬영이나 단일광자방출단층촬영과 같이 혈류역학을 볼 수 있는 검사와 병행하여 연구하면 P300의 발생부위를 규명하는데 도움을 줄 것으로 사료되며 뇌활동을 역동적으로 평가하는데 도움을 줄 것으로 생각된다.

• Journal of Preventive Medicine and Public Health
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• 제26권4호
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• pp.565-573
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• 1993

Noise is not only affecting the ear and the auditory cortex locally, but its influence is widely spread throughout the brain structures, e. g., the reticular formation, the brain stem nuclei or the subcortical forebrain area. Hence, any of the organism's activities can be hindered or stimulated by noise. High noise is a stressor and the catecholamine level can be used both as a stress marker and as an indicator of modified sympathetic nervous system activity. Several recent studies have found that the urinary excretion of catecholamines is increased due to high noise intensity, especially unexpectedly high and long lasting noise. The present study was conducted in order to examine the effects of noise stress on urinary excretion of ctecholamines in rats and humans. Rats were exposed to 90 dB noise for 10, 30, and 60 minutes, 3 and 12 hours. 24 hour . urinary samples were collected and the catecholamones were extracted by alumina and analyzed by HPLC-ECD. Catecholamine levels increased with time of exposure up to 60 minutes : norepinephrine concentration at 60 min of noise=1.038 ng/ml, epinephrine=0.636 ng/ml. Urine catecholamines of blue collar workers exposed to 90 dB of noise at the work place were collected between 2 and 4 p.m. and compared to that of white collar workers exposed to 70 dB. Mean norepinephrine level of the blue collar workers was 0.89 ng/ml (${\pm}0.25$), epinephrine 0.24ng/m1 (${\pm}0.09$), and that of the white collar workers 0.48 ng/ml (${\pm}0.12$), epinephrine 0.19 ng/ml(${\pm}0.05$). It was concluded that noise acts as a stressor and increases the catecholamine levels in both rats and humans.