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Testosterone Relaxes Rabbit Seminal Vesicle by Calcium Channel Inhibition

  • Kim, Jong-Kok;Han, Woo-Ha;Lee, Moo-Yeol;Myung, Soon-Chul;Kim, Sae-Chul;Kim, Min-Ky
    • The Korean Journal of Physiology and Pharmacology
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    • v.12 no.2
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    • pp.73-77
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    • 2008
  • Recent studies have documented that testosterone relaxes several smooth muscles by modulating $K^+$ channel activities. Smooth muscles of seminal vesicles playa fundamental role in ejaculation, which might involve testosterone. This study was aimed to assess the role of testosterone in seminal vesicular motility by studying its effects on contractile agents and on the ion channels of single vesicular myocytes in a rabbit model. The contractile responses of circular smooth muscle strips of rabbit seminal vesicles to norepinephrine ($10{\mu}M$), a high concentration of KCI (70 mM), and testosterone ($10{\mu}M$) were observed. Single vesicular myocytes of rabbit were isolated using proteolytic enzymes including collagenase and papain. Inside-out, attached, and whole-cell configurations were examined using the patch clamp technique. The applications of $10{\mu}M$ norepinephrine or 70 mM KCl induced tonic contractions, and $10{\mu}M$ testosterone (pharmacological concentration) evoked dose-dependent relaxations of these precontracted strips. Various $K^+$ channel blockers, such as tetraethylammonium (TEA; $10{\mu}M$), iberiotoxin ($0.1{\mu}M$), 4-aminopyridine (4-AP, $10{\mu}M$), or glibenclamide ($10{\mu}M$) rarely affected these relaxations. Single channel data (of inside-out and attached configurations) of BK channel activity were also hardly affected by testosterone ($10{\mu}M$). On the other hand, however, testosterone reduced L-type $Ca^{2+}$ currents significantly, and found to induce acute relaxation of seminal vesicular smooth muscle and this was mediated, at least in part, by $Ca^{2+}$ current inhibition in rabbit.

Binding of Zeolites to Inorganic Fiber using Covalent Linkers (공유결합을 이용한 무기질 섬유와 제올라이트의 결합)

  • Song, Kyeong-Keun;Yoo, Yoon-Jong;Kim, Hong-Soo;Ha, Kwang
    • Korean Chemical Engineering Research
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    • v.44 no.3
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    • pp.254-258
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    • 2006
  • Zeolites with excellent adsorption capacity of volatile organic compounds were attached onto inorganic fibers which were the raw materials of honeycomb-type adsorbers. The amounts of zeolite particles attached onto the fibers considerably increased by treating them with hydrochloric acid, sulfuric acid, or hydrofluoric acid. Various functional groups such as chloropropyl, aminopropyl and epoxy groups of silane compounds, and amine groups of polyethylenimine were employed as covalent linkage materials between the fibers and zeolite particles. The state of the fibers coated with zeolite particles was examined by scanning electron microscopy, and the amounts of zeolite particles bound to the fibers were estimated from their BET surface areas. The largest amount was obtained when polyethylenimine was employed as a linkage material. Polyethylenimine was the most effective for attaching zeolite particles onto the inorganic fibers among various linkers employed.

A Study on the Characteristics of an Air Cavity Attached Under a Flat Plate (평판에 형성된 공기공동 특성에 관한 연구)

  • Kim, Jong-Hyun;Oh, Jae-Young;Seo, Dae-Won;Lee, Seung-Hee
    • Journal of the Society of Naval Architects of Korea
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    • v.48 no.5
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    • pp.396-403
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    • 2011
  • The concept of an air lubrication has long been an object of attention since it can be utilized to reduce the frictional resistance, and what is more, it is eco-friendly. The present study examines the basic characteristics of an air cavity with intention of applying the air lubrication technology to the reduction of the resistance of a ship without excessive power increment. For the purpose, an air cavity was created at the bottom of a flat plate by injecting air behind a backward step and the hydrodynamic properties of the air cavity and the surrounding flow has been investigated experimentally and numerically. The influence of the step height and the air flow rate have been more carefully studied since they are presumed to be the main parameters affecting the characteristics of an air cavity. The results indicates that the shapes of the air cavities attached on the flat plate become "U" or "V" type depending on the incoming flow velocity and air flow rate. The study also confirms that the length of the air cavity increases with increase in air flow rate but there is a certain critical limit in the flow rate above which increase in the air cavity length is no more evident.

Heat Transfer in Rotating Duct with $70^{\circ}$ Angled Ribs (회전하는 덕트내 설치된 $70^{\circ}$ 경사요철의 열전달 특성)

  • Choi, Chung;Lee, Sei Young;Won, Jung Ho;Cho, Hyung Hee;Park, Byung kyu
    • The KSFM Journal of Fluid Machinery
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    • v.4 no.3 s.12
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    • pp.7-13
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    • 2001
  • The present study investigates convective heat/mass transfer and flow characteristics inside a cooling passage of rotating gas-turbine blades. The rotating duct has staggered ribs with $70^{\circ}$ attack angle, which are attached on leading and trailing surfaces. Naphthalene sublimation technique is employed to determine detailed local heat transfer coefficients using the heat and mass transfer analogy. Additional numerical calculations are conducted to analyze the flow patterns in the cooling passage. The present experiments employ two-surface heating conditions in the rotating duct because the exposed surfaces to hot gas stream are pressure and suction side surfaces in the middle passages of an actual gas-turbine blade. Secondary flows are generated by Coriolis and centrifugal forces in the spanwise and streamwise directions. The ribs attached on the walls disturb the mainflow resulting in recirculation and secondary flows near the ribbed wall. The local heat transfer and flow patterns in the passage are changed significantly according to rib configurations and duct rotation speeds. Therefore, the geometry and arrangement of the ribs are important for the advantageous cooling performance. The experimental results show that the ribs enhance the heat transfer more than $70\%$ from that of the smooth duct. The duct rotation generates the heat transfer discrepancy between the leading and trailing walls due to the secondary flows induced by the Coriolis force. The overal heat transfer pattern on the leading and trailing walls for the first and second passes are depended on the rotating speed, but the local heat transfer trend is affected mainly by the rib arrangements.

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Expressive Characteristics of Fringe in Modern Fashion (현대패션에 나타난 술 장식의 표현특성)

  • Kim, Sun-Young
    • Fashion & Textile Research Journal
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    • v.13 no.6
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    • pp.856-865
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    • 2011
  • This paper intends to examine how Fringe, which is in an inseparable relationship with modern fashion, has been changed and what characteristics it is expressed to have in fashion on the basis of its formative property expressed in modern fashion. In order to empirically analyze Fringe, this paper analyzed a total of 346 Fringe of every type that were generally found in the worldis four biggest collections, from 2006S/S to 2011S/S. This paper found some methods Fringe is made, which are: using a snagged fabric or knit as it is; intentionally snagging or tearing a fabric to make the effect of being snagged; knotting the tail or the edge of clothes, and then, macram$\grave{E}$; and cutting leather or suede, which canit be snagged easily, and making Fringe strands. Fringe strands which are made in the above ways are made into a band and then, attached, or Fringe strands, a feathers, a comb, or beads are attached one by one. Or a tassel is independently or consecutively applied to clothes or ornaments, which are expressed in the form of fringes. Threads, strings, leather, suede, metals, plastics, raffia, horsehair, paper, beads, pearls, crystals, or felt were used for rich texture or unique visual effects. Colors of various brightness and chromas were used in consideration of materials. Through the effects of sameness, similarity, contrast, harmony and gradation with colors of clothes, emphasis or unified harmony was expressed. The expressive characteristics of Fringe, which were found in the modern fashion through those formative characteristics, were organic rhythmical beauty, handicraft decorative beauty, and folksy natural beauty.

What is the Mantidis Oothea? (상표소(桑螵蛸)는 무엇인가? (약명(藥名), 이명(異名), 채집(採集), 수치(修治)에 관하여))

  • Park, myung jae;Seo, Young Bae
    • Journal of Haehwa Medicine
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    • v.25 no.1
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    • pp.155-163
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    • 2016
  • Objectives : Since the Korean pronunciation of the Mantidis Oothea is not unified, it is necessary to unify pronunciation of this particular herb. According to ancient herbal literature, genuine Mantidis Oothea has been regarded as the product which is attached to mulberry tree. However, all forms of Mantidis Oothea need to be used as a medicinal ingredient. Methods : The current study explores pronunciations of the herbal medicinal names, Collection, and the herbal processes of the Mantidis Oothea. There are approximately about 30 herbal manuals dealing with the Mantidis Oothea after Shen Nong's herbal manual(神農本草經) was published. Results & Conclusions : 1. Sangbicho, Sangpyeojo, Sangpyeocho, and other names have been used as a name of medicinal ingredient for the Mantidis Oothea. 2. The Other names of medicinal ingredient for the Mantidis Oothea were Sik woo, Danglangja(螳螂子), Danglanglan(螳螂卵), Danglangso(螳螂巢), Danglangwa(螳螂窩), Danglanggag(螳螂殼), etc.. 3. The name of medicinal ingredient for the Mantidis Oothea should not be pronounced as Sangpyoso but Sangpyocho. 4. The name of medicinal ingredient for the Mantidis Oothea was originated from a type of the egg case, eating habit, therapy of the Mantidis Oothea and so on. 5. Collecting real thing of The Mantidis Oothea does not really matter whether it is attached to the mulberry tree or not. 6. The herbal processes of the Mantidis Oothea is to kill the eggs, so typical methods were to steam, roast, boil with vinegar and so on. In addition, the main effect seemed to be protection from the diarrhea.

Analysis of Propagation of Deflagration and Fire Cause in the Busan lndoor Shooting Range (부산 실내사격장 화재의 연소 확대 및 발화원인 분석)

  • Song, Jae-Yong;Sa, Seung-Hun;Nam, Jung-Woo;Kim, Jin-Pyo;Kim, Dong-Hwan
    • Fire Science and Engineering
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    • v.25 no.3
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    • pp.1-7
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    • 2011
  • This paper studied analysis of deflagration rapid propagation of burning through only a few second and fire cause into the Busan indoor shooting range. We carried out combustion experiment of sound-absorbing materials extensively used, to analyze propagation path of burning in indoor shooting range. From the experimental results, general sound-absorbing materials were rapid burned simultaneously with ignition and in case of attached gunpowder residue, they were burning about tripled by comparison with general sound-absorbing materials. The incombustibility sound-absorbing materials had all gone out simultaneously with ignition, but they were burning similar to general type materials in case of attached gunpowder residues. In order to analysis of the cause of fire, we calculated kinetic energy of bounced off bullet, from result, if the bounced off bullet impacted gunpowder residues, the gunpowder residues were possible to ignite by the bullet.

Development and Evaluation of Smart Foundation with Heating Devices (발열장치를 이용한 보온 기능성 스마트 파운데이션의 개발 및 평가)

  • Hwang, Young-Mi;Lee, Jeong-Ran
    • Fashion & Textile Research Journal
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    • v.15 no.2
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    • pp.231-239
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    • 2013
  • This research developed a smart girdle for adult women in their 20's that has an inserted carbon weaving heater to help with relief from coldness and abdominal disease through the thermal insulation effect. A pocket of powernet fabric was attached to the inside of the girdle for the easy insertion and separation of the heating device, while the heating device was fixed to a mesh material by cotton yarn and was wrapped with elastic lining material to prevent the mechanical devices from being exposed. A set of 3 hooks was attached to the center of the back of the heating device in consideration of convenience and mobility. Whereas the switch was inserted into around the right waistband, and the battery into the inner pocket around the waist, to integrate the heating device with the girdle. The satisfaction and usability of the fabricated smart girdle was verified by having research participants wear it to evaluate the appearance change caused by the device, the inconvenience of wearing/unwearing, mobility, and the satisfactory functionality of the device. As a result, the grand mean was evaluated to be high, with appearance (4.19), mobility (4.17), and functionality (4.51) being higher than 4.00; which indicates that the heat generation function of the smart girdle is effective. It may be said that such collection and analysis of data that reflect users' opinions have value and significance in that they can be grafted onto future research on new technology as well as they contribute to taking a step forward in the rapidly increasing research of smart clothing, with the new-type clothing equipped with new function.

Subcellular Responses in Nonhost Plant Infected with Pathogenic and Non-pathogenic Strains of Xanthomonas axonopodis pv. glycines

  • Jeong, Yong-Ho;Kim, Jung-Gun;Chang, Sung-Pae;Hwang, In-Gyu;Kim, Young-Ho
    • The Plant Pathology Journal
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    • v.18 no.3
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    • pp.115-120
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    • 2002
  • Xanthomonas axonopodis pv. glycines, the causal agent of bacterial pustule of soybean, induces hypersensitive response (HR) in a non-host plant, hot pepper (Capsicum annuum). A wild-type strain (8ra) and its non-patho-genic mutant (8-13) of X. axonopodis pv. glycines were inoculated into the pepper leaf tissues and their subcellular responses to the bacterial infections were examined by electron microscopy. Intrastructural changes related to HR were found in the leaf tissues infected with 8ra from 8 h after inoculation, characterized by separation of plasmalemma from the cell wall, formation of small vacuoles and vesicles, formation of cell wall apposition, and cellular necrosis. No such responses were observed in the tissues infected with the mutant. In 8ra, the bacterial cells were attached to the cell walls, with the cell wall material dissolved into and appearing to encapsulate the bacterial cells. The bacterial cells later became entirely embedded in the cell wall material. On the other hand, in 8-13, the bacterial cells were usually not attached tightly to the plant cell wall, and no or poor encapsulation of the bacteria by the wall material occurred, although these were encircled by rather loose wall materials at the later stages.

Elastic Wave Detection using Fiber Optic FBG Sensor (광섬유 FBG 센서를 이용한 탄성파 검출)

  • Seo, Dae-Cheol;Kwon, Il-Bum;Yoon, Dong-Jin;Lee, Seung-Suk;Lee, Jung-Ryul
    • Journal of the Korean Society for Nondestructive Testing
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    • v.30 no.1
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    • pp.1-5
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    • 2010
  • Acoustic emission(AE) has emerged as a powerful nondestructive tool to detect or monitor preexisting defects and leaks in the vessel structures. A Bragg grating based acoustic emission sensor system is developed. Various type of fiber Bragg grating sensor including the variable length of sensing part was fabricated and prototype sensor system was tested by using PZT pulser and pencil lead break sources. Two types of sensor attachment were used. First, the fiber Bragg grating sensor was attached fully to the surface using bonding agent. Second one is that one part of fiber was attached to the surface partly by bonding and the other part of fiber will be act as a cantilever. That is, the resonant frequency of the fiber Bragg grating sensor will depend on the length of sensing part. The final goal of the sensor system is to provide on-line monitoring of cracks or leaks in reactor vessel head penetration of nuclear power plants.