• Safety and Health at Work
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• 제2권2호
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• pp.194-200
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• 2011

Objectives: Stressors in nursing put high demands on cognitive control and, therefore, may increase the risk of cognitive failures that put patients at risk. Task-related stressors were expected to be positively associated with cognitive failure at work and job control was expected to be negatively associated with cognitive failure at work. Methods: Ninety-six registered nurses from 11 Swiss hospitals were investigated (89 women, 7 men, mean age = 36 years, standard deviation = 12 years, 80% supervisors, response rate 48%). A new German version of the Workplace Cognitive Failure Scale (WCFS) was employed to assess failure in memory function, failure in attention regulation, and failure in action exertion. In linear regression analyses, WCFS was related to work characteristics, neuroticism, and conscientiousness. Results: The German WCFS was valid and reliable. The factorial structure of the original WCF could be replicated. Multilevel regression task-related stressors and conscientiousness were significantly related to attention control and action exertion. Conclusion: The study sheds light on the association between job characteristics and work-related cognitive failure. These associations were unique, i.e. associations were shown even when individual differences in conscientiousness and neuroticism were controlled for. A job redesign in nursing should address task stressors.

• BMB Reports
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• 제55권9호
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• pp.417-428
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• 2022

Herbal medicine, a multi-component treatment, has been extensively practiced for treating various symptoms and diseases. However, its molecular mechanism of action on the human body is unknown, which impedes the development and application of herbal medicine. To address this, recent studies are increasingly adopting systems pharmacology, which interprets pharmacological effects of drugs from consequences of the interaction networks that drugs might have. Most conventional network-based approaches collect associations of herb-compound, compound-target, and target-disease from individual databases, respectively, and construct an integrated network of herb-compound-target-disease to study the complex mechanisms underlying herbal treatment. More recently, rapid advances in high-throughput omics technology have led numerous studies to exploring gene expression profiles induced by herbal treatments to elicit information on direct associations between herbs and genes at the genome-wide scale. In this review, we summarize key databases and computational methods utilized in systems pharmacology for studying herbal medicine. We also highlight recent studies that identify modes of action or novel indications of herbal medicine by harnessing drug-induced transcriptome data.

• Nutrition Research and Practice
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• 제17권4호
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• pp.717-734
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• 2023

BACKGROUND/OBJECTIVES: This study aimed to identify preschool children's eating behaviors associated with early childhood obesity and its multi-level, socio-ecological determinants. SUBJECTS/METHODS: In a cross-sectional study of 364 mothers of preschool children aged 3-5 years, these children's healthy eating behaviors were assessed using a validated preschool nutrition quotient (NQ-P) questionnaire. The children's overweight or obesity statuses were determined based on body mass index percentiles from the 2017 Korean National Growth Chart. The associations between the NQ-P score and risk of overweight or obesity were examined using multivariable logistic regression. The associations of individual, maternal, physical, and media environmental factors with the NQ-P score were also examined using multivariable linear regression. RESULTS: Preschool children with greater NQ-P scores were at a significantly lower risk of overweight or obesity (P < 0.01). The NQ-P score had a significantly positive association with maternal body mass index and an inverse association with household income (all P < 0.05). Maternal parenting and feeding practices exhibited associations with the NQ-P score. Positive associations were observed with "warm," "structured," and "autonomy-supportive" parenting as well as monitoring feeding practices (all P < 0.05). In addition, the NQ-P score had a significantly positive association with the childcare center's anti-obesogenic environment, such as the provision of nutritional and physical-activity support and vicinity of the built food environment to the home, including access to good-quality food, fruits and vegetables, and low-fat foods (all P < 0.05). Regarding media environments, the NQ-P score demonstrated more significant associations with viewing and eating and/or cooking content displayed on online video platforms (all P < 0.05) than with that on television. CONCLUSIONS: Our findings confirm the significance of healthy eating behaviors in early-childhood-obesity prevention and underscore the importance of multilevel maternal, physical, and media environmental interventions that effectively guide eating behaviors in preschool children.

• Journal of Preventive Medicine and Public Health
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• 제45권2호
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• pp.90-97
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• 2012

Objectives: While there have been many quantitative studies on the public's attitude towards mental illnesses, it is hard to find quantitative study which focused on the contextual effect on the public's attitude. The purpose of this study was to identify factors that affect the public's beliefs and attitudes including contextual effects. Methods: We analyzed survey on the public's beliefs and attitudes towards mental illness in Korea with multi-level analysis. We analyzed the public's beliefs and attitudes in terms of prejudice as an intermediate outcome and social distance as a final outcome. Then, we focused on the associations of factors, which were individual and regional socioeconomic factors, familiarity, and knowledge based on the comparison of the intermediate and final outcomes. Results: Prejudice was not explained by regional variables but was only correlated with individual factors. Prejudice increased with age and decreased by high education level. However, social distance controlling for prejudice increased in females, in people with a high education level, and in regions with a high education level and a high proportion of the old. Therefore, social distance without controlling for prejudice increased in females, in the elderly, in highly educated people, and in regions with a high education and aged community. Conclusions: The result of the multi-level analysis for the regional variables suggests that social distance for mental illness are not only determined by individual factors but also influenced by the surroundings so that it could be tackled sufficiently with appropriate considering of the relevant regional context with individual characteristics.

• 대한지리학회지
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• 제39권3호
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• pp.457-472
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• 2004

본 연구의 목적은 GIS와 공간 데이터마이닝 방법을 이용하여 교통사고의 공간적 패턴을 살펴보고 이웃한 공간 객체와의 공간적 연관성을 탐색하는 것이다. 이를 위하여 서울시 강남구 교통사고 데이터를 이용하여 공간적 경향 분석, 군집 분석 및 군집의 특성 기술, 이웃한 공간 객체와의 연관 분석을 실시하였다. 그 결과, 강남구의 교통사고는 특징적인 4개의 군집 유형을 통해 분류될 수 있으며, 각 군집별로 차별적인 특성들을 보여주고 있다. 또한, 교통사고의 발생 위치와 이웃한 공간 객체들과의 연관성에서는 공간 객체들의 개념수준이나 공간적 관계의 수준에 따라 다양한 규칙들이 발견되었다. 이러한 규칙들은 모두가 유의미하거나 흥미로울 수는 없지만, 맥락에 따라 다양하게 해석될 수 있으며, 보다 심화된 인구를 위한 새로운 가설들로 사용될 수 있을 것이다.

• BMB Reports
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• 제43권12호
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• pp.836-841
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• 2010

In the era of personal genomics, predicting the individual response to drug-treatment is a challenge of biomedical research. The aim of this study was to validate whether interaction information between genetic and transcriptional signatures are promising features to predict a drug response. Because drug resistance/susceptibilities result from the complex associations of genetic and transcriptional activities, we predicted the inter-relationships between genetic and transcriptional signatures. With this concept, captured genetic polymorphisms and transcriptional profiles were prepared in cancer samples. By splitting ninety-nine samples into a trial set (n = 30) and a test set (n = 69), the outperformance of relationship-focused model (0.84 of area under the curve in trial set, P = $2.90{\times}10^{-4}$) was presented in the trial set and validated in the test set, respectively. The prediction results of modeling show that considering the relationships between genetic and transcriptional features is an effective approach to determine outcome predictions of drug-treatment.

• Communications for Statistical Applications and Methods
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• 제27권5호
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• pp.535-546
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• 2020

In genetic association studies, pleiotropy is a phenomenon where a variant or a genetic region affects multiple traits or diseases. There have been many studies identifying cross-phenotype genetic associations. But, most of statistical approaches for detection of pleiotropy are based on individual tests where a single variant association with multiple traits is tested one at a time. These approaches fail to account for relations among correlated variants. Recently, multivariate regularization methods have been proposed to detect pleiotropy in analysis of high-dimensional genomic data. However, they suffer a problem of tuning parameter selection, which often results in either too many false positives or too small true positives. In this article, we applied selection probability to multivariate regularization methods in order to identify pleiotropic variants associated with multiple phenotypes. Selection probability was applied to individual elastic-net, unified elastic-net and multi-response elastic-net regularization methods. In simulation studies, selection performance of three multivariate regularization methods was evaluated when the total number of phenotypes, the number of phenotypes associated with a variant, and correlations among phenotypes are different. We also applied the regularization methods to a wild bean dataset consisting of 169,028 variants and 17 phenotypes.

• 천문학회지
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• 제34권3호
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• pp.149-155
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• 2001

UBV RI and H$\alpha$ photometry has been performed for the open cluster NGC 6531. A total of 56 bright main sequence (MS) members were selected from their positions in photometric diagrams. We also classified 7 pre-main sequence (PMS) stars and 6 PMS candidates with Ha: emission from H$\alpha$ photometry. We determined a reddening of < E(B - V) >= 0.29 $\pm$ 0.03 and a distance modulus of Vo - Mv = 10.5 for the cluster. From the comparison of our photometric results to theoretical evolution models, we derived a MS turnoff age of 7.5 Myr and a PMS age spread of $\~$4 Myr. The IMF slope $\Gamma$, calculated in the mass range of 0.45 $\le$ log m $\le$ 1.35 is a steep value of $\Gamma$ = -1.8 $\pm$ 0.6.

• 천문학회지
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• 제35권1호
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• pp.9-28
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• 2002

We present UBVI CCD photometry of the stellar contents and globular cluster(GC) candidates in the spiral galaxy NGC 300 in the Sculptor group. Color-magnitude diagrams for 18 OB associations having more than 30 member stars are presented. The slope of the initial mass function for the bright stars in NGC 300 is estimated to be ${\Gamma}= -2.6{\pm} 0.3$. Assuming the distance to NGC 300 of (m - M)o = 26.53 $\pm$ 0.07, the mean absolute magnitude of three brightest blue stars is obtained to be < $M_v^{BSG}$ (3) > = -8.95 mag. We have performed search for GCs in NGC 300 and have found 17 GC candidates in this galaxy. Some characteristics of these GC candidates are discussed.

• 천문학회지
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• 제36권1호
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• pp.13-19
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• 2003

We present a study of the old open cluster Trumpler 5 (Tr 5), based on the CDS archival data. From the color-magnitude diagrams of Tr 5, we have found the positions of main-sequence turn-off (MSTO) and red giant clump (RGC) stars. Using the mean magnitude of the RGC stars, we have estimated the reddening toward Tr 5, E(B - V) = 0.60 $\pm$ 0.10. Using the stars common in two data sets and the theoretical isochrones of Padova group, we have estimated the distance modulus $V_o - M_v = 12.64 {\pm} 0.20 (d = 3.4 {\pm} 0.3 kpc)$, the metallicity [Fe/H) = -0.30 $\pm$ 0.10, and the age of 2.4 $\pm$ 0.2 Gyr (log t = 9.38). These metallicity and distance values are consistent with the relation between the metallicity and the Galactocentric distance of other old open clusters, for which we obtain the slope of ${\Delta}[Fe/H]/ R_{gc} = -0.064 {\pm} 0.010\;dex\;kpc^{-1}$.