• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 1998년도 Advances in Ginseng Research - Proceedings of the 7th International Symposium on Ginseng -
• /
• pp.182-189
• /
• 1998

Administration of ginsenosides, a mixture of saponin extracted from Panax ginseng, decreased blood pressure in rat. Previous studies have shown that ginsenosides caused endothelium-dependent relaxation, which was associated with the formation of cyclic GMP, suggested that ginsenosides caused release of nitric oxide (NO) from the vascular endothelium. The aim of the present study was to characterize the endothelium-independent relaxation to ginsenosides in the isolated rat aorta. Ginsenosides caused a concentration-dependent relaxation of rat aortic rings without endothelium constricted with 25 mM KCI but affected only minimally those constricted with 60 mM KCI. Ginsenoside Rg3 (Rg3) was a more potent vasorelaxing agonist than total ginsenoside mixture and also the ginsenoside PPT and PPD groups. Relaxation to ginsenosides were markedly reduced by TEA, but not by glibenclamide. Rg3 significantly inhibited Cal'-induced concentration-contraction curves and the "50a2'influx in aortic rings incubated in 25 mM KCI whereas those responses were not affected in 60 mM KCI. Rg3 caused efflux of $"Rb in aortic rings that was inhibited by tetraethy- lammonium (TEA), an inhibitor of Ca"-dependent K'channels, but not by glibenclamide, an inhibitor of AfP-dependent K'channels. These findings indicate that ginsenosides may induce vasorelaxation via activation of Ca2'-dependent K'channels resulting in hyperpolarization of the vas- cular smooth muscle with subsequent inhibition of the opening of voltage-dependent Caf'channels. These effects could contribute to explain the red ginseng-associated vasodilation and the beneficial effect on the cardiovascular system.

• 전기학회논문지
• /
• 제65권12호
• /
• pp.1971-1978
• /
• 2016

In this paper, electrical and physical characteristics associated with the ionization growth of soil under impulse voltages in a coaxial cylindrical electrode system to simulate a horizontally-buried ground electrode were experimentally investigated. The results were summarized as follows: Transient ground resistances decreased significantly by soil ionization. The voltage-current (V-I) curves for non-ionization in soil lined up in a straight line with the nearly same slope that is the ground resistance, but they showed a 'cross-closed loop' of ${\infty}$-shape under ionization. The conventional ground resistance and equivalent soil resistivity were inversely proportional to the peak value of injected impulse currents. On the other hand, the equivalent ionization radius and time-lag to the maximum value of ionization radius were increased with increasing the incident impulse voltages. An analysis method for the transient ground resistances of the ground electrode based on the ionization phenomena was proposed. The proposed method can be applied to analyze the transient performances of grounding systems for lightning protection in power system installations.

• Structural Engineering and Mechanics
• /
• 제43권1호
• /
• pp.31-51
• /
• 2012

This paper presents a computational study that explores the design of rigid steel frames by considering construction related costs. More specifically, two different aspects are investigated in this study focusing on the effects of (a) reducing the number of labor intensive rigid connections within a frame of given geometric layout, and (b) reducing the number of different member section types used in the frame. A genetic algorithm based optimization framework searches design space for these objectives. Unlike some studies that express connection cost as a factor of the entire frame weight, here connections and their associated cost factors are explicitly represented at the member level to evaluate the cost of connections associated with each beam. In addition, because variety in member section types can drive up construction related costs, its effects are evaluated implicitly by generating curves that show the trade off between cost and different numbers of section types used within the frame. Our results show that designs in which all connections are considered to be rigid can be excessively conservative: rigid connections can often be eliminated without any appreciable increase in frame weight, resulting in a reduction in overall cost. Eliminating additional rigid connections leads to further reductions in cost, even as frame weight increases, up to a certain point. These complex relationships between overall cost, rigid connections, and member section types are presented for a representative five-story steel frame.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.2753-2758
• /
• 2013

Various studies examining the relationship between Ezrin overexpression and response to chemotherapy and clinical outcome in patients with osteosarcoma have yielded inconclusive results. We accordingly conducted a meta-analysis of 7 studies (n = 318 patients) that evaluated the correlation between Ezrin and histologic response to chemotherapy and clinical prognosis (death). Data were synthesized in receiver operating characteristic curves and with fixed-effects and random-effects likelihood ratios and risk ratios. Quantitative synthesis showed that Ezrin is not a prognostic factor for the response to chemotherapy. The positive likelihood ratio was 0.538 (95% confidence interval [95% CI], 0.296- 0.979; random-effects calculation), and the negative likelihood ratio was 2.151 (95% CI, 0.905- 5.114; random-effects calculations). There was some between-study heterogeneity, but no study showed strong discriminating ability. Conversely, Ezrin positive status tended to be associated with a lower 2-year survival (risk ratio, 2.45; 95% CI, 1.26-4.76; random-effects calculation) with some between-study heterogeneity that disappeared when only studies that employed immunohistochemistry were considered (risk ratio, 2.97; 95% CI, 2.01- 4.40; fixed-effects calculation). To conclude, Ezrin is not associated with the histologic response to chemotherapy in patients with osteosarcoma, whereas Ezrin positivity was associated with a lower 2-year survival rate regarding risk of death at 2 years. Expression change of Ezrin is an independent prognostic factor in patients with osteosarcoma.

• Investigative Magnetic Resonance Imaging
• /
• 제20권4호
• /
• pp.231-240
• /
• 2016

Purpose: To determine whether liver stiffness (LS) measured by magnetic resonance elastography (MRE) can predict the outcome of radiofrequency ablation (RFA) in hepatocellular carcinoma (HCC) patients. Materials and Methods: A total of 107 patients with Child-Pugh class A liver function who were treated with RFA for single HCC and who had undergone a gradient-echo MRE within 6 months before RFA were included. We evaluated the relationship between the LS values and the ablation volume, local tumor progression (LTP), and intrahepatic distant recurrence (IDR). We also constructed receiver operating characteristic (ROC) curves to examine the role of LS in predicting liver function deterioration, which was defined as an increase of Child-Pugh score by one point or more at 1 year after RFA. Results: There was no significant correlation between LS and ablation volume, and neither time to LTP nor IDR was associated with LS. Among the 66 patients who did not have recurrence 1 year after RFA, 5 patients (7.6%) developed liver function deterioration. A high LS value was significantly associated with development of liver function deterioration after RFA and the area under the ROC curve was 0.764 (95% CI 0.598-0.929, P = 0.003). Conclusion: LS measured by MRE could not predict ablation volume and tumor recurrence. However, high LS values were significantly associated with development of liver function deterioration.

• Clinical Endoscopy
• /
• 제57권5호
• /
• pp.656-665
• /
• 2024

Background/Aims: Although endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is performed globally, the procedure remains challenging. Guidewire manipulation is the most difficult step, and there are few reports on the factors associated with unsuccessful guidewire manipulation. This study aimed to assess the significance of the puncture angle on EUS images and identify the most effective guidewire rescue method for patients with unsuccessful guidewire manipulation. Methods: We retrospectively enrolled 115 patients who underwent EUS-HGS between May 2016 and April 2022 at two centers. The puncture angle between the needle and the intrahepatic bile duct was measured through EUS movie records. Results: Guidewire manipulation was unsuccessful in 28 patients. Receiver operating characteristic (ROC) curves identified an optimal puncture angle cutoff value of 85° (cutoff value, 85°; area under the ROC curve, 0.826; sensitivity, 85.7%; specificity, 81.6%). Multivariate analysis demonstrated that a puncture angle <85° was a significant risk factor for unsuccessful guidewire manipulation (odds ratio, 19.8; 95% confidence interval, 6.42-61.5; p<0.001). Among the 28 unsuccessful cases, 24 patients (85.7%) achieved successful guidewire manipulation using various rescue methods. Conclusions: The puncture angle observed on EUS is crucial for guidewire manipulation. A puncture angle of <85° was associated with unsuccessful guidewire manipulation.

• Journal of Astronomy and Space Sciences
• /
• 제30권3호
• /
• pp.123-125
• /
• 2013

2FGL J1823.8+4312 and 2FGL J1304.1-2415 are two unidentified Fermi objects which are associated with cluster of galaxies. In order to exam the possibility of cluster of galaxies as gamma-ray emitters, we search for counterpart of these two unidentified Fermi objects in other wavebands. However, we find other candidate to be more likely the counterpart of the unidentified Fermi object for both sources. We compare their light curves and SEDs in order to identify their source types. However, data at millimeter and sub-millimeter wavebands, which is important for us to constrain the SED at synchrotron peak, is lacking of measurement. Therefore, we proposed to SMA observation for these two sources. We have got data and are doing further analysis.

• 대한기계학회논문집
• /
• 제19권6호
• /
• pp.1460-1468
• /
• 1995

The objective of this paper is to evaluate the material properties of SA106 Gr. C carbon steel and its associated weld manufactured for main steam system of Yonggwang 3,4 nuclear generating stations. A total of 43 tensile and 35 fracture toughness tests were performed and the effects of various parameters such as pipe size, crack plane orientation, test temperature, welding on material properties were discussed. Test results show that the effects of crack plane orientation, test temperature, and welding on fracture toughness were significant while the effects of pipe size, specimen orientation and test temperature on tensile properties were negligible. Especially the dependence of J-R curves on the crack plane orientation appears to be the characteristics of carbon steel.

• 대한산업공학회지
• /
• 제21권3호
• /
• pp.299-311
• /
• 1995

Conventional discounted cash flow techniques fail to capture the risk associated with investments. This paper proposes an annual cash flow model that considers risk, cost structure and inventory liquidation in the evaluation of investment alternatives. The risk differential of investments is included using the capital asset pricing model while the stochastic version of the cost-volume-profit approach is used to consider inventory liquidation and cost structure. Tradeoffs between fixed and variable costs have been investigated, and portrayed using iso-cash flow curves. The proposed cash flow model has been developed, in particular, to enable an accurate evaluation of advanced manufacturing systems.

• Journal of Advanced Research in Ocean Engineering
• /
• 제3권3호
• /
• pp.112-124
• /
• 2017

As an LNG carrier preserves and transports liquefied natural gas under minus $163^{\circ}C$, the cargo tank has to have sufficient hull strength against not only the wave loads but also against loads caused by loading and unloading and thermal expansion to keep the LNG safely. The main insulation types for a CCS are No.96 and Mark III from GTT for the membrane LNG carrier. Particularly, the invar membrane plate in No.96 is very thin and its connections could experience high local stresses owing to such dynamic loads. Therefore, it should be verified whether those connections have sufficient fatigue lives for the purpose of operation and maintenance. This research aims at performing fatigue analysis with 0.1 fatigue damage criteria for 40 years of design life to support new membrane CCS development using proper S-N curves and the associated finite element modeling technique for each connection and then propose a reasonable design methodology.