• Korean Journal of Adult Nursing
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• v.27 no.2
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• pp.211-222
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• 2015

Purpose: This study was conducted to test the model for sleep in community-dwelling older adults. The hypothetical model based on a senescent sleep model was constructed using the multiple influencing factors of sleep and associated adverse outcomes of changes in sleep in the older adults. Methods: Data were collected from 203 community-dwelling older adults living in Korea, and analyzed using IBM SPSS 21.0 and AMOS 21.0. Results: Increased age and multiple comorbidities were associated with decreased physical activities. Decreased physical activities were associated with smaller social networks, and smaller social networks were associated with higher level of loneliness. Multiple comorbidities, decreased physical activities, larger social networks, and higher level of loneliness were associated with maladaptive sleep hygiene. Decreased physical activities, higher level loneliness, and shorter actual sleep duration were associated with worse sleep quality. Smaller social networks and shorter actual sleep duration were associated with lower cognitive functions. Smaller social networks, higher loneliness, and worse sleep quality were associated with more severe depressive symptoms. Conclusion: These findings suggest that the sleep improvement interventions not only with physical perspectives but psychosocial ones for older adults may improve depressive symptoms as well as sleep quality.

• BMB Reports
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• v.48 no.10
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• pp.549-558
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• 2015

Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases. However, the mechanism by which cellular senescence contributes to aging and age-associated pathologies remains unclear. Recent studies showed that senescent cells exert detrimental effects on the tissue microenvironment, generating pathological facilitators or aggravators. The most significant environmental effector resulting from senescent cells is the senescence-associated secretory phenotype (SASP), which is constituted by a strikingly increased expression and secretion of diverse pro-inflammatory cytokines. Careful investigation into the components of SASPs and their mechanism of action, may improve our understanding of the pathological backgrounds of age-associated diseases. In this review, we focus on the differential expression of SASP-related genes, in addition to SASP components, during the progress of senescence. We also provide a perspective on the possible action mechanisms of SASP components, and potential contributions of SASP-expressing senescent cells, to age-associated pathologies.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.132.2-132.2
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• 2012

We have investigated the characteristics of magnetic cloud (MC) and ejecta (EJ) associated coronal mass ejections (CMEs) based on the assumption that all CMEs have a flux rope structure. For this, we used 54 CMEs and their interplanetary counter parts (interplanetary CMEs: ICMEs) that constitute the list of events used by the NASA/LWS Coordinated Data Analysis Workshop (CDAW) on CME flux ropes. We considered the location, angular width, and speed as well as the direction parameter, D. The direction parameter quantifies the degree of asymmetry of the CME shape, and shows how closely the CME propagation is directed to Earth. For the 54 CDAW events, we found several properties of the CMEs as follows: (1) the average value of D for the 23 MCs (0.62) is larger than that for the 31 EJs (0.49), which indicates that the MC-associated CMEs propagate more directly to the Earth than the EJ-associated CMEs; (2) comparison between the direction parameter and the source location shows that the majority of the MC-associated CMEs are ejected along the radial direction, while many of the EJ-associated CMEs are ejected non-radially; (3) the mean speed of MC-associated CMEs (946 km/s) is faster than that of EJ-associated CMEs (771 km/s). For seven very fast CMEs (>1500 km/s), all CMEs with large D (>0.4) are associated with MCs and the CMEs with small D are associated with EJs. From the statistical analysis of CME parameters, we found the superiority of the direction parameter. Based on these results, we suggest that the CME trajectory essentially decides the observed ICME structure.

• Journal of Trauma and Injury
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• v.33 no.4
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• pp.242-247
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• 2020

Purpose: The purpose of this study was to determine the incidence and characteristics of associated injuries in patients with spine trauma. Methods: Data of 3,920 consecutive patients admitted to a regional trauma center during a 3-year period were analyzed retrospectively. Results: Of the 3,920 patients who were admitted to the trauma center during the 3-year study period, 389 (9.9%) had major spinal injuries. Among these 389 patients, 303 (77.9%) had associated injuries outside the spine. The most common body region of associated injuries was the extremities or pelvis (194 cases, 49.4%), followed by the chest (154 cases, 39.6%) and face (127 cases, 32.6%). Of these 303 patients, 149 (64%) had associated injuries that required surgical treatment such as laparotomy or internal fixation. Associated injuries were more common in patients with lumbar injuries (93.3%) or multiple spinal injuries (100%) than in those with lower cervical injuries (67.4%). There was a significant correlation between the location of the spinal injury and the body region of the associated injury. However, distant associated injuries were also common. Conclusions: Associated injuries were very common in spinal injury patients. Based on demographic groups, the trauma mechanism, and the location of spinal injury, an associated injury should be suspected until proven otherwise. Using a multidisciplinary and integrated approach to treat trauma victims is of the paramount importance.

• Advances in pediatric surgery
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• v.1 no.2
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• pp.190-194
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• 1995

Diphallus is a rare congenital anomaly and is frequently associated with duplication of the urinary tract and rectosigmoid, and commonly associated with vertebral anomalies. Remzi reported less than 100 cases of duplication of all or a portion of the penis, but about 10 cases of complete diphallus with exstrophy of cloaca was reported, and a case of complete diphallus associated with hindgut duplication was reported, and complete diphallus with displacement of bladder associated hindgut duplication and imperforate anus was not reported in Korea. We experienced a case of the complete diphallus associated with displacement of bladder, hindgut duplication, and imperforate anus as a variant of cloacal exstrophy. A review of published cases suggests that this may be the first example of a complete diphallus with displacement of bladder coexisting with the hindgut duplication and imperforate anus.

• Communications for Statistical Applications and Methods
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• v.9 no.2
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• pp.451-457
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• 2002

We derive the strong laws of large numbers for weighted averages of partial sums of random variables which are either associated or negatively associated. Our theorems extend and generalize strong law of large numbers for weighted sums of associated and negatively associated random variables of Matula(1996; Probab. Math. Statist. 16) and some results in Birkel(1989; Statist. Probab. Lett. 7) and Matula (1992; Statist. Probab. Lett. 15 ).

• Pediatric Infection and Vaccine
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• v.3 no.2
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• pp.200-206
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• 1996

Virus associated hemophagocytic syndrome(VAHS), a class II histiocytosis syndrome, is characterized by high fever, liver dysfunction, coagulation abnormalities, and generalized histiocytic proliferation with marked hemophagocytosis in bone marrow and lymph nodes. VAHS is associated with several viral infections including Epstein Barr virus which has a relatively high mortality rate. We report a fatal case of Epstein Barr virus associated hemophagocytic syndrome and its diagnosis by mRNA in situ hybridization and polymerase chain reaction. A brief review of related literaure is also presented.

• Journal of Digestive Cancer Research
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• v.12 no.1
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• pp.1-5
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• 2024

The incidence and prevalence of upper gastrointestinal neuroendocrine tumors (NETs), including gastric NETs (GNETs) and duodenal NETs (DNETs), have been gradually increasing. These trends may be associated with the increased use of health checkups, which includes upper endoscopy, in conjunction with better disease recognition. However, the clinical factors associated with GNETs and DNETs remain unknown; previous studies revealed discrepancies. Recently, metabolic disorders have been indicated as potential factors that are associated with GNETs and DNETs. This review summarizes the results of previous studies and briefly introduces the results of a recent Korean multicenter study on the factors associated with GNETs and DNETs.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.1
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• pp.185-190
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• 2014

Influence of loneliness on human survival has been established epidemiologically, but genomic research remains undeveloped. We identified 34 loneliness-associated genes which were statistically significant for high-lonely and low-lonely individuals. With the univariate Cox proportional hazards regression model, we obtained corresponding regression coefficients for loneliness-associated genes fo individual cancer patients. Furthermore, risk scores could be generated with the combination of gene expression level multiplied by corresponding regression coefficients of loneliness-associated genes. We verified that high-risk score cancer patients had shorter mean survival time than their low-risk score counterparts. Then we validated the loneliness-associated gene signature in three independent brain cancer cohorts with Kaplan-Meier survival curves (n=77, 85 and 191), significantly separable by log-rank test with hazard ratios (HR) >1 and p-values <0.0001 (HR=2.94, 3.82, and 1.78). Moreover, we validated the loneliness-associated gene signature in bone cancer (HR=5.10, p-value=4.69e-3), lung cancer (HR=2.86, p-value=4.71e-5), ovarian cancer (HR=1.97, p-value=3.11e-5), and leukemia (HR=2.06, p-value=1.79e-4) cohorts. The last lymphoma cohort proved to have an HR=3.50, p-value=1.15e-7. Loneliness-associated genes had good survival prediction for cancer patients, especially bone cancer patients. Our study provided the first indication that expression of loneliness-associated genes are related to survival time of cancer patients.

• Journal of Environmental Health Sciences
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• v.46 no.2
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• pp.128-135
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• 2020

Objective: The objectives of this study are to report the number of humidifier disinfectant (HD) associated health problems, including HD associated lung injury (HDLI), by year. This data was analyzed by the type of HD and HD brand. Methods: A total of 530 patients registered with the national program on HD through its third round were distributed based on the year when they developed their first health problem including HDLI (N=221). The distribution of health problems at diagnosis was clinically evaluated in order to examine the association between their lung injury and the use of HD. Results: The number of HD associated victims and HDLI patients was found to rise sharply from 2008 to 2011, with a peak in 2011. This trend was found not only for HD brands containing polyhexamethylene guanidine phosphate (PHMG), but also chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT). The number of patients who responded as developing health problems in the specific year was 35 for 2008, 51 for 2009, 108 for 2010 and 182 for 2011. Other types of HD brands and HD chemicals did not follow the trend of abrupt increase in HD associated patients since 2008. Conclusion: This study found the number of HD associated victims and HDLI patients who used HD brands containing PHMG sharply increased starting in 2008. A significant change in the process of manufacturing PHMG can be suspected with the abrupt rise in HD associated patients in specific years.