• Title/Summary/Keyword: assessment of safety

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The development of the seismic fragility curves of existing bridges in Indonesia (Case study: DKI Jakarta)

  • Veby Citra Simanjuntak;Iswandi Imran;Muslinang Moestopo;Herlien D. Setio
    • Structural Monitoring and Maintenance
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    • v.10 no.1
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    • pp.87-105
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    • 2023
  • Seismic regulations have been updated from time to time to accommodate an increase in seismic hazards. Comparison of seismic fragility of the existing bridges in Indonesia from different historical periods since the era before 1990 will be the basis for seismic assessment of the bridge stock in Indonesia, most of which are located in earthquake-prone areas, especially those built many years ago with outdated regulations. In this study, seismic fragility curves were developed using incremental non-linear time history analysis and more holistically according to the actual strength of concrete and steel material in Indonesia to determine the uncertainty factor of structural capacity, βc. From the research that has been carried out, based on the current seismic load in SNI 2833:2016/Seismic Map 2017 (7% probability of exceedance in 75 years), the performance level of the bridge in the era before SNI 2833:2016 was Operational-Life Safety whereas the performance level of the bridge designed with SNI 2833:2016 was Elastic - Operational. The potential for more severe damage occurs in greater earthquake intensity. Collapse condition occurs at As = FPGA x PGA value of bridge Era I = 0.93 g; Era II = 1.03 g; Era III = 1.22 g; Era IV = 1.54 g. Furthermore, the fragility analysis was also developed with geometric variations in the same bridge class to see the effect of these variations on the fragility, which is the basis for making bridge risk maps in Indonesia.

Single-dose oral toxicity study of genetically modified silkworm expressing EGFP protein in ICR mouse

  • Jang, Kyung-Min;Kim, Sung-Gun;Park, Ji-Young;Choi, Won-Ho;Lee, Jae-Woo;Jegal, Hyeon-Young;Kweon, Soon-Jong;Choi, Kwang-Ho;Park, Jung-Ho
    • Korean Journal of Agricultural Science
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    • v.43 no.1
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    • pp.109-115
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    • 2016
  • Silk has had a reputation as a luxurious and sensuous fabric but it is not popular due to the expensive price and poor durability. To develop the silk materials that apply the various industries, the artificially synthesized gene can be introduced into the silkworm and expressed in the silk gland. Transgenic silkworms for the mass production of green fluorescent silks are generated using a fibroin H-chain expression system. For commercial use, safety assessment of the transgenic silkworms is essential. The purpose of this study was to examine the potential acute oral toxicity of EGFP protein expressed in genetically modified (GM) fluorescence silkworm and to obtain the approximative lethal dose in the male and female at 6-weeks ICR mice. EGFP protein was fed at a dose of 2,000 mg/kg body weight in five male or five female mice. Mortalities, clinical findings and body weight changes were monitored for 1, 3, 7, 14 days after dosing. At the end of 14 day observation period, all mice were sacrificed, and the postmortem necropsy were performed. The test group was not observed death case. Also the effect was not admitted by test substance administration in common symptoms, the body weight and postmortem. The results of single-dose oral toxicity test showed that approximative lethal dose of EGFP protein expressed in fluorescence silkworm was considered to exceed the 2,000 mg/kg body weight in both sexes.

Microbiological Quality Assessment of Bibimbap Production Flow in Elementary School Foodservice (초등학교 급식의 비빔밥 생산과정에 따른 미생물적 품질평가)

  • Kim, Bok-Ran;Chae, Sung-Ju
    • Journal of the Korean Home Economics Association
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    • v.43 no.2
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    • pp.19-31
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    • 2005
  • The purpose of this study was to evaluate the microbiological quality and assure the hygienic safety of the Bibimbap production in elementary school foodservice in accordance with the HACCP(Hazzard Analysis Critical Control Point) program. The time-temperature relationship and the microbiological quality(total plate count and coliform bacteria count) were assessed to find the critical control point(CCP) during each of the production phase. In the pre-preparation phase, the risk factors of the raw ingredients exceeded the standard level suggested by Solberg et al. Mungbean starch jelly, egg and Kochujang were satisfactory in that no coliform groups were observed over the standard TPC level. In particular, there was a high the risk of beef from the early stages in terms of the coliform level. In the pre-preparation phase, green pumpkin had more coliform groups than the standard level even after washed, which calls for special attention to washing, sterilization, secondary infection of the handler, and the required time for pre-preparation of raw vegetables. In the cooking phase, the temperature of the soybean sprout and mungbean starch jelly decreased to 42$^{\circ}C$ and 26$^{\circ}C$, respectively, which was within the risk zone. In particular, mungbean starch jelly had a great risk factor even after boiling in hot water. During the storage stage before serving, a lot of ingredients were exposed to poor management of temperature and time and thus exceeded the standard level in the total plate counts. In particular, the microbiological count of beef was five times the standard level. Green pumpkins and soybean sprouts were left at 15-38$^{\circ}C$ that is within the risk zone for a long period of time after they were cooked. It is highly recommended that the time of the storage stage before consumption should be shortened and that proper devices should be used to prevent proliferation of bacteria. The number of TPC of the utensils was satisfactory enough, but the knife used exceeded the standard level and thus was a risk factor of bacteria proliferation.

Assessment of Impact Resistance Performance of Post-tensioned Curved Wall using Numerical Impact Analysis (긴장력이 도입된 곡면벽체의 충돌저항성능 수치해석평가)

  • Chung, Chul-Hun;Lee, Jungwhee;Jung, Raeyoung;Yu, Tae-Yong
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.29 no.2
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    • pp.161-167
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    • 2016
  • In this study, the effect of wall curvature and post-tension force on impact resistance is evaluated by numerical analysis method. A total of twelve cases with two parameters such as wall shape of flat and curved, and consideration of post-tensioning force were included in this study. A 3D detailed finite element model of commercial passenger plane engine is utilized as projectile. The depths of penetration and central displacement calculated from the numerical simulations were compared and analysed. As the results of the numerical simulations of this study, penetration depth was reduced approximately 60~80% due to the application of post-tension force, but the decrease of maximum central displacement was not remarkable. Also, the effect of curvature was relatively insignificant.

Changes in Aurantio-Obtusin and Glucoaurantio-Obtusin Content in Cassiae Semen via Treatment with a Crude Enzyme Extract from Aspergillus usamii

  • Hur, Jong-Moon;Kwon, Soon-Ho;So, Jae-Hyun;Jun, Mi-Ra;Kang, Young-Hwa;Lee, Yu-Mi;Lee, Kyung-Bok;Rhee, In-Koo;Lee, Moon-Soon;Song, Kyung-Sik
    • Journal of Microbiology and Biotechnology
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    • v.17 no.11
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    • pp.1894-1897
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    • 2007
  • Cassiae Semen (seeds of Cassia tora) showed a remarkably different HPLC chromatogram after being treated with a crude enzyme extract from Aspergillus usamii. Increased and decreased compounds were identified as aurantio-obtusin and glucoaurantio-obtusin, respectively. The aurantio-obtusin content reached its maximum level ($133.58{\pm}0.39\;{\mu}g/mg$ extract) after being incubated for 50 min at $37^{\circ}C$, whereas the inactivated crude enzyme-treated control remained unchanged ($54.13{\pm}1.33\;{\mu}g/mg$). On the other hand, the glucoaurantio-obtusin content decreased by less than one-third ($51.09{\pm}1.63\;{\mu}g/mg$) ofthe untreated control ($143.19{\pm}2.12\;{\mu}g/mg$), suggesting that an increase in aurantio-obtusin content originated from the enzymatic cleavage of its glucoside glucoaurantio-obtusin.

Early Clinical Experience with Sutureless Aortic Valve Replacement for Severe Aortic Stenosis

  • Kim, Do Jung;Kim, Hyo-Hyun;Lee, Shin-Young;Lee, Sak;Chang, Byung-Chul
    • Journal of Chest Surgery
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    • v.51 no.1
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    • pp.1-7
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    • 2018
  • Background: Sutureless aortic valve replacement (SU-AVR) has been developed as an alternative surgical treatment for patients with symptomatic severe aortic stenosis (AS). The aim of this study was to evaluate the clinical outcomes of SU-AVR through an assessment of hemodynamic performance and safety. Methods: From December 2014 to June 2016, a total of 12 consecutive patients with severe AS underwent SU-AVR. The endpoints were overall survival and valve-related complications (paravalvular leakage, valve thrombosis, migration, endocarditis, and permanent pacemaker implantation). The mean follow-up duration was $18.1{\pm}8.6months$. Results: The mean age of the patients was $77.1{\pm}5.8years$ and their mean Society of Thoracic Surgeons score was $9.2{\pm}17.7$. The mean cardiopulmonary bypass and aortic cross-clamp times were $94.5{\pm}37.3$ minutes and $54.9{\pm}12.5minutes$, respectively. Follow-up echocardiography showed good prosthesis function with low transvalvular pressure gradients (mean, $13.9{\pm}8.6mm\;Hg$ and peak, $27.2{\pm}15.0mm\;Hg$) at a mean of $9.9{\pm}4.2months$. No cases of primary paravalvular leakage, valve thrombosis, migration, or endocarditis were reported. A new permanent pacemaker was implanted in 1 patient (8.3%). The 1-year overall survival rate was $83.3%{\pm}10.8%$. Conclusion: Our initial experience with SU-AVR demonstrated excellent early clinical outcomes with good hemodynamic results. However, there was a high incidence of permanent pacemaker implantation compared to the rate for conventional AVR, which is a problem that should be solved.

Clinical Significance of Tumor Infiltration at the Resection Margin in Gastric Cancer Surgery (위암 수술 시 절제연 암침윤의 임상적 의미)

  • Kwon, Sung-Joon
    • Journal of Gastric Cancer
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    • v.1 no.1
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    • pp.24-31
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    • 2001
  • Purpose: Despite knowledge of the adverse effects of resection-line disease, surgeons continue to perform inadequate resections. This demonstrates the need for a more aggressive approach to assessment of resection margins at operation. Materials and Methods: Seven hundred fifteen gastric cancer patients who were operated on at our hospital from 1992 to 1998 were included in this analysis. Various clinicopathological factors, including resection-line involvement, were ascertained from the surgical and histopathological records. Results: Of the 715 evaluable patients, 27 patients ($3.8\%$) had involvement of one or both resection lines; in 10 patients the proximal resection line only, in 16 the distal resection line only, and 1 both resection lines were involved. Presence of resection-line involvement was significantly associated with T3 and T4 stage, N (+) stage, M (+) stage, type of operation (total gastrectomy), tumor location (entire stomach), size$\geq$11 cm), and gross type of tumor (Borrmann 4 type). When performing a distal subtotal gastrectomy, no involvement was found when the cranial and caudal distances between the lesion and the line of transection was equal to or greater than 2 cm and 3 cm, respectively, for early cancer and 7 cm and 3 cm, respectively, for advanced cancer. When performing a total gastrectomy for upper 1/3 or middle 1/3 gastric cancer, no involvement was found when the cranial distances between the lesion and the line of transection were equal to or greater than 3 cm and 4 cm, respectively, without distinction of the presence of serosal invasion. Conclusions: The difference in survival between positive and negative margin patients is limited to the group of patients with curative surgery. An important principle of treatment is that the entire tumor must be removed with a 3 cm distal margin and a 2- to 7 cm margin depending on the location and the depth of wall invasion of the tumor, to provide histologically negative margins.

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The Detection Distance of Colored Target using Various Automotive Headlamps

  • Kim, Jung-Yong;Lee, Ho-Sang;Min, Seung-Nam;Lee, Min-Ho
    • Journal of the Ergonomics Society of Korea
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    • v.31 no.3
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    • pp.421-426
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    • 2012
  • As headlamp technology advances, newly developed various headlamps were introduced in the market. The objective of this study is to quantitatively analyze the detection distance of the recently developed LED headlamps and existing headlamps, complying with specific technical standard. Background: The detection distance of headlamps is very important to prevent automobile accident at night time. The studies of detection distance of LED, Halogen and HID headlamp have been conducted, but no study has shown the detection distance of pedestrian target with various colors (Black, White, Blue). Method: The experiment of detection distance was conducted with 30 people, which divide into 2 groups as 15 men and 15 women. Automatic transferable target on the rail was manufactured in order to reduce the error of study's result, and ANOVA also conducted to analyze the main effect with sign color, sex and headlamp classified by detection distance. In addition, the luminance by average detection distance was measured as well. Results: The detection distance of headlamps was HID > LED > Halogen. The luminance measure of LED headlamp was lower than HID and Halogen headlamps. Conclusion: The headlamp performs a very significant role for safety at night time but it needs to be improved through assessment of visual characteristics. Also, it needs to be suggested the need of test method for dynamic detection distance concerning technical development is suggested.

Field and laboratory assessment of ground subsidence induced by underground cavity under the sewer pipe

  • Kong, Suk-Min;Kim, Dong-Min;Lee, Dae-Young;Jung, Hyuk-Sang;Lee, Yong-Joo
    • Geomechanics and Engineering
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    • v.16 no.3
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    • pp.285-293
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    • 2018
  • In densely populated urban areas with a large amount of infrastructure, ground subsidence events can result in massive casualties and economic losses. In South Korea, the incidence of ground subsidence in urban areas has increased in recent years and the number of underground cavities suspected of causing such events has significantly increased. Therefore, it is essential to develop techniques to prevent the occurrence of underground and ground subsidence. In this study, a field test, laboratory test, and numerical analysis were conducted to determine the optimal compaction degree of the upper support layer of any underground cavity below the level of sewer pipes in order to prevent such cavities from collapsing and leading to ground subsidence accidents. During the field test, an underground cavity was simulated using ice, and the generation of the cavity was confirmed using ground penetrating radar. The ground investigation was performed using a cone penetration test, and the compaction of the ground where ground subsidence occurred was evaluated with a laboratory test. The behaviour of the ground under various conditions was predicted using a numerical analysis based on the data obtained from the field test and previous studies. Based on these results, the optimal compaction degree of the ground required to prevent the underground cavity from causing ground subsidence was predicted and presented.

The Seasonal Microbiological Quality Assessment of Kimbap(seaweed roll) Production flow in Foodservice facilities for Univ. students - HACCP model - (대학생 대상 급식시설의 김밥 생산과정에 따른 계절별 미생물적 품질평가)

  • 이혜상;류승연
    • Korean journal of food and cookery science
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    • v.14 no.4
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    • pp.367-374
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    • 1998
  • The purpose of this study was to evaluate the microbiological quality of, and to assure the hygienic safety of, the kimbap production in the university foodservice facilities in accordance with the HACCP (Hazard Analysis Critical Control Point) Program. The time-temperature relationship and the microbiological quality (specifically, total plate count and coliform bacteria count) were assessed to find the critical control point (CCP) during each of the production phases. The average of the daily longest duration time of the kimbap at the facilities was 23.4 hours in summer, while 29.6 hours in winter. In the purchasing phase of the raw materials, the microbiological quality of laver, fish paste, carrot and cucumber in summer was not at an acceptable level according to the standard set by the Natick research center, especially the number of TPC and the coliform level of laver was higher than the threshold level. In the refrigerator storage phase, the temperature of the carrot was 7.4$^{\circ}C$. This temperature is far exceeding the standard so that the microbiological counts was increased by the 2 log cycle during the average storage time of 17 hours or more. In the preparation phase, the temperature of the blanching is too low compared to the standard. In the holding phase before serving, its time-temperature relationship was out of the FDA food code standard both in winter and summer. In the sewing phase, the number of microbiological count was higher than the threshold level in summer while that in winter was up to standard. According to the Harrigan and McCance standard, the number of microbiological count of the utensils was higher than the threshold level in summer while that in winter was up to standard.

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