• 대한화장품학회지
• /
• 제13권1호
• /
• pp.29-35
• /
• 1987

Purely synthesized L-ascorbic acid 2 phosphate Mg salt (1 AsA PMg) improved the weak point of ascorbic acid which is easily decomposed in water solution. This compound is hydrolyzed with phosphatase of skin to corresponding ascorbic acid giving Vitamine C activities. The buffer solution of potassium acetate 0.5% and citric acid 0.005% and the sodium sulfite respectively showed good stabilizing effect of the AsA PMg solution. Compared to the other ascorbic acid derivatives the good solubility of AsA PMg gives broad application to cosmetic field.

• 한국식품위생안전성학회지
• /
• 제13권3호
• /
• pp.232-237
• /
• 1998

광독성 및 광알러지를 일으키는 물질인 phenothiazine계 약물중 chlopromazine(CPZ), perphenazine(PPZ), trifluoperazine(TFZ), promethazine(PMZ)을 택하여 적혈구에서의 광용혈현상을 Kahn 등의 방법에 의하여 UVB(UV irradiation RMX-3W, $1.5\;J/\textrm{cm}^2$)을 조사하여 약물 농도별로 측정한 결과 CPZ, PPZ은 UVB 조사에 의해 약물농도에 따라 현저히 적혈구 용혈현상이 증가 되었으며 이는 ascorbic acid에 의해 유의성 있게 감소되었고, 각 약물의 광독성 물질 생성 여부와 이에 의한 용혈독성을 조사해 보니 CPZ, PMZ에서 관찰되었고 ascorbic acid에 의해 그 현상이 감소되었다.

• 한국식품위생안전성학회지
• /
• 제7권4호
• /
• pp.143-147
• /
• 1992

Phenothiazines류의 약물 중 Chlorpromazine, perhenazine, trifluoperazine, thioridazin의 광독성에 대한 ascorbic acid의 영향을 조사 연구하였다. 각 약물 농도를 $50;\mu\textrm{g}$/ml로하고 UVA(350nm, 2.5mV/cm)로 조사기간은 30분으로 하여 적혈구의 광용혈현상을 Kahn 등의 방법에 의해 spectrophotometer로 측정한 결과 Chlorpromazine, perphenazine, thioridazine에 의한 광용혈도 정도는 ascorbic acid에 의해 유의성 있게 감소되었다. 또한 적혈구를 가하기 전 각 약물을 미리 조사시켜 생성된 물질에 의한 광용혈현상의 광독성 생성물질은 chlorpromazine과 thioridazine에서 보여졌으며, chlorpromazine의 광독성 생성물질에 의한 적혈구 용혈현상만 ascorbic acid에 의해 감소되었다.

• 한국식품영양과학회지
• /
• 제27권6호
• /
• pp.1071-1076
• /
• 1998

Threetypes of Korean traditional kimchi were prepared using green onion, leek or godulbaegi as raw materials and stored at 5oC and 20oC for 13 days. Changes in salt and ascorbic acid contents, pH and total acidity as well as the relationship of the decomposition of chlorophylls and the production of their derivatives were investigated. For the all kimchi samples tested, salt content was not significantly changed during storage at both temperatures, whereas pH and total acidity were decreased and increased, respectively. Especially their remarkable changes were shown at the third day of storage. Ascorbic acid content was remained at high level in the leek kimchi for the experimental period at both storage temperatures, meanwhile godulbaegi kimchi retained the least amount of ascorbic acid. Chlorophylls were decomposed to pheophytin and pheophorbide during storage at both storage temperatures, and this phenomenon was apparent at the third day of storage. Reduction of chlorophylls and increasements of its decomposed products such as pheophytin and pheophorbide were the least in leek kimchi and the greatest in godulbaegi kimchi during storage at both temperatures. These results indicate that decomposition of chlorophylls in kimchi and increasements of pheophytin and pheophorbide were closely related to the ascorbic acid content in kimchi.

• 대한화장품학회지
• /
• 제37권1호
• /
• pp.91-96
• /
• 2011

외부 자극에 대하여 개개인의 건강한 피부를 유지하는데 있어서 악화 원인으로는 콜라겐 섬유 감소, 탄력섬유 변성, 멜라닌 생성, 활성산소종 등이 있다. 이로 인한 피부탄력감소 및 기미, 잡티 등의 피부 문제점을 개선하기 위해 대표적으로 비타민 A, C 및 그 유도체들이 화장품에 적용되고 있지만 안정성의 문제점이 있어 새로운 유도체들의 합성 개발에 노력을 기울이고 있다. 본 연구에서는 피부개선을 위한 화장품 원료로 비타민 C로부터 새롭게 합성된 3-o-cetyl-L-ascorbic acid (VCCE)의 미백 개선과 관련된 효능 효과를 평가하였다. VCCE의 in vitro 실험 결과 멜라닌의 합성을 $20\;{\mu}g/mL $에서 대조군과 비교하여 최대 44 % 억제시켰으며 세포 내 tyrosinase 발현을 저해하였다. 또한 인체적용시험에서 자외선 조사에 의한 인공 색소 침착을 유발한 후 8주 동안 피부 밝기를 측정한 결과 8주 후 통계적으로 유의한 수준의 피부 미백 효과를 나타내었다. 결론적으로 VCCE는 미백 개선을 위한 화장품 성분으로서 높은 응용 가치를 제시한다.

• Biomolecules & Therapeutics
• /
• 제4권2호
• /
• pp.162-166
• /
• 1996

This study was done to investigate whether cholic acid derivatives have anti-stress activity and what is a cause of this anti-stress effect. Seven cholic acid derivatives (cholic acid, taurocholic acid, ursodeoxycholic acid, tauroursodeoxychoic acid, chenodeoxy cholic acid, dehydrocholic acid, hyodeoxycholic acid) were used, silymarin and valproic acid were used as positive controls. Stress was induced by restraint immobilization technique plus water immersion (24hrs) and adrenal weight, spleen weight, adrenal ascorbic acid, serum cholesterol, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), adrenal cholesterol, glucose and corticosterone levels were measured as stress indicators. Most cholic acid derivatives markedly decreased the adrenal weight, and TUDCA and DHCA increased the spleen weight. The restraint stress induced increments in serum LDH, ALP and cholesterol were attenuated by most cholic acid derivatives. Cholic acid, taurocholic acid and tauroursodeoxycholic acid only increased the content of adrenal ascorbate. While valproic acid showed an inhibitory effect against stress, silymarin did not. Our findings suggest that most cholic acid derivatives have anti-stress effect and that their anti-stress effect is, in part, related to choleretic activity.

• 대한화장품학회지
• /
• 제26권1호
• /
• pp.199-212
• /
• 2000

A series of novel ascorbic acid derivatives, polyethoxylated ascorbic acid (PEAA) were synthesized by coupling ascorbic acid with polyethylene glycol (PEG) of two molecular weights (MW: 350 and 550) at the C-2 or C-3 hydroxyl group (2PEAA350, 3PEAA350, 2PEAA550, 3PEAA550) to increase the stability and retain the activity, as a skin whitening agent. Their stability, scavenging activity against free radical, inhibitory activity against tyroxinase and inhibitory activity of melanin synthesis in Bl6 melanoma cell of PEAAs were evaluated in viかo and compared with those of ascorbic acid and 3-O-ethyl ascorbic acid (3OEAA), a Con stable vitamin C derivative. Among PEAAs, 2PEAA350 and 2PEAA550 tad high scaveniging activity against See radical, inhibitory activity against tyrosinase and inhibitory activity if melanogenesis but low stability, 3PEAA350 had high stability and moderate scavenging activity against free radical, infibitory activity against tyrosinase and inhibitory activity of melanogenesis. The stability, scavenging activity against free radical and inhibitory activity of melanogenesis of 3PEAA350 were higher than those of 30EAA. The most stable 3PEAA350 among PEAAs was nontoxic in various toxicological tests. These results suggest that PEAA would be a good whitening agent far enhancing stability and bioavailability.

• 한국응용과학기술학회지
• /
• 제29권2호
• /
• pp.348-355
• /
• 2012

hydroxycinnamic acid인 ferulic acid와 caffeic acid는 강력한 식물성 항산화제 이다. DPPH 수용액에서 이들의 자유라디칼 소거능과 높은 온도, 금속 이온과 같은 산화촉진 요인에 대한 화학적 안정성 등을 살펴보았다. 아스코르빅 산의 안정성 향상을 위해 ferulic acid와 caffeic acid를 아스코르빅산 수용액에 첨가하였다. 아스코르빅 산의 안정성 향상은 시간경과에 따른 $SC_{50}$ 값의 변화로부터 확인하였다. 아스코르빅 산을 ferulic acid 또는 caffeic acid와 조합하여 BGsome 안에 포집시켜본 결과, 아스코르빅 산의 안정성이 순수한 용액 상태로 있을 때에 비해 크게 향상되었다.

• 산업식품공학
• /
• 제15권1호
• /
• pp.75-79
• /
• 2011

산화방지제인 아스코르빈산(AA), 에리쏘르빈산(isoAA), 아스코르빌파르미테이트(AP), 아스코르빌스테아레이트(AS)에 대한 '식품 중 식품첨가물 분석법'을 검증하고 미비점을 개선하였다. 고속액체크로마토그래피 자외선검출기법을 이용하여 검출한계(LOD), 정량한계(LOQ), 상관계수($R^2$) 등을 측정하였고 돼지기름(lard), 사이다를 이용한 모델식품에서의 회수율과 재현성을 측정하였다. AA와 isoAA의 검출한계는 각각 0.46, 0.48 ${\mu}g/mL$이었으며, 회수율은 각각 86.35-94.78, 84.76-95.02%를 나타내었고 상관계수는 모두 0.999이상을 보였다. AP와 AS의 현 분석법은 메탄올을 용매로 사용하지만 메탄올 용매에서 AP와 AS는 불안정하였다. 냉장온도에서 에탄올을 용매로 사용 시 다른 용매에 비해 유의적으로 높은 안정성을 나타내어 기존 용매의 불안정성을 개선할 수 있었다.

• 대한화장품학회:학술대회논문집
• /
• 대한화장품학회 2003년도 IFSCC Conference Proceeding Book I
• /
• pp.313-319
• /
• 2003

It is well known that ascorbic acid (VC) is an important factor for several physiological reactions. In the skin, VC works as an anti-aging agent due to removing of oxidative stress generated by UV irradiation and stimulation of collagen synthesis. Thus, developing more effective VC derivatives is an important issue in creating anti-aging skin care products. Our study succeeded to develop a novel ascorbic acid derivative, ascorbic acid tetra-2-hexyldecanoate (VC-IP), which is a lipid-soluble pro-VC. The purpose of this study was to indicate the effects of VC-IP as pro-VC and anti-aging agent. First, it was examined whether VC-IP is converted to VC in physiological conditions. Since VC was detected from the cell extracts treated with VC-IP, it was indicated that VC-IP is a pro- VC.(omiited)