• 대한치과보철학회지
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• 제30권3호
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• pp.361-378
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• 1992

The purpose of this investigation was to evaluate the effect of the porous hydroxyapatite particles (Interpore $200^{(R)}$) and guided tissue regeneration membrane ($Gore-Tex^{TM}$ augmentation material) on amount and shape of generating new bone adjacent to implant. Implants were placed immediately after extraction in the bilateral 3rd, 4th premolars of the mandible of the adult dogs. In all experimental groups, artificial bony defects were formed at the buccal cortex area, 3.3mm in width and 3.0mm in depth. In the control group : sutured without HA particles & membranes after placing implants, the experimental group 1 : membrane was place over the artificial bony defect, the experimental group 2 : bony defect was filled with HA particles and covered with membrane. The examination of bone-implant interfaces using light microscope and fluorescent microscope concluded as follows. 1. In all three experimental groups, osseointegration was observed without epithelial migration. 2. In the healing degree of bony defect area, the experimental group 1, 2 showed more prominent healing than control group, and the experimental group 1 showed the most excellent bone formation. 3. In fluorescent microscopic finding, bone remodeling was observed in regenerated bone tissue at defect area of experimental group 1, but in experimental group 2, irregular, discontinuous linear fluorescence was observed at the lower portion of defect area and sign of bone remodeling was weak.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2004년도 추계학술대회 논문집
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• pp.1038-1041
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• 2004

In this study, developed a micro-level experimental setup to measure pore pressure and poroelastic modulus in various strain and strain rate about a stress in micro-structure of bone tissue. It is essential device in the development of the model to analysis the interstitial bone fluid flow of the lacuno-canalicular system to be known that would effect on the bone remodeling. The constitution of the experimental setup is as follows, microscopic image processing system; actuator control unit; load measurement system. A pilot study was used an artificial chemical wood to have similar poroelastic property of bone matrix and conducted to validate the suitability of the measurement system.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1994년도 추계학술대회
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• pp.75-78
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• 1994

Clinically, proximal bone resorption in the femur is frequently seen postoperatively on the follow up X-rays after total hip replacement(THR). We developed the finite element model of cementless THR. The model is two dimensional side plate model, whereby the three dimensional structural integrity of the bone can be accounted for by a separate two dimensional mesh, a side plate. The subject of this article is the development and application of this two dimensional side plate FEM to study the reverse effect of the various degree of bone resorption of femur after THR. The results of this study indicates that two dimensional side plate model is good and simple alternative to complex three dimensional model and the severity of the proximal bone resorption has the effect of more increasing stress on the cortex at the level of femoral stem tip.

• 대한의용생체공학회:의공학회지
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• 제31권1호
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• pp.56-66
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• 2010

The various total replacement artificial discs have developed because spinal fusion has shown a lesser mobility of an operated segment and an accelerated degeneration at adjacent discs. But almost artificial discs have not yet been reached on the substitute surgery of fusion because many problems such as those clinical success rates were not more than them of fusion have not solved. In this paper, vertically inserted assemble-screw fixture in vertebrae was proposed to improve the fixed capability of artificial disc. And also, to evaluate the design suitability of newly designed screw-type, including fixtures of commercial discs such as wedge and plate type, the 1/4 finite element model with a vertebra and various implanted fixtures were generated, and next, 3 bending motions such as flexion, bending and twisting under the moment of 10Nm and compression under the force of 1000N were considered, respectively and finally, FE analyses were performed. Results of three fixture types were compared, such as Range of Motion and maximal stress, and so on. For ROM, the screw type was average 58% less than the wedge type and was average 42% less than the plate type under all loading conditions. For average stress ratio at closer nodes between vertebra and each fixture, the wedge type was the lowest as minimum 0.02 in twisting, screw types were the highest as maximum 0.28 in compression. As the results of using cement material, it was predicted that the instability problem of the wedge type was better solved. The screw type which could be increased by implanting depth according to the number of assembling mid screws, showed that the decreased tendency of ROMs and maximal cancellous bone stresses. In further study, controlling the number of assembling screws that was suitable for a patient's bone quality, development of surgical tools and keeping on design supplementations, which will be able to develop the competitive artificial disc.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제38권
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• pp.26.1-26.6
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• 2016

Background: Xenologous or synthetic graft materials are commonly used as an alternative for autografts for guided bone regeneration. The purpose of this study was to evaluate effectiveness of carbonate apatite on the critical-size bone defect of rat's calvarium. Methods: Thirty-six critical-size defects were created on 18 adult male Sprague-Dawley rat calvaria under general anesthesia. Calvarial bones were grinded with 8 mm in daimeter bilaterally and then filled with (1) no grafts (control, n = 10 defects), (2) bovine bone mineral (Bio-$Oss^{(R)}$, Geistlich Pharma Ag. Swiss, n = 11 defects), and (3) hydroxyapatite ($Bongros^{(R)}$, Bio@ Inc., Seongnam, Korea, n = 15 defects). At 4 and 8 weeks after surgery, the rats were sacrificed and all samples were processed for histological and histomorphometric analysis. Results: At 4 weeks after surgery, group 3 ($42.90{\pm}9.33%$) showed a significant difference (p < 0.05) compared to the control ($30.50{\pm}6.05%$) and group 2 ($28.53{\pm}8.62%$). At 8 weeks after surgery, group 1 ($50.21{\pm}6.23%$), group 2 ($54.12{\pm}10.54%$), and group 3 ($50.92{\pm}6.05%$) showed no significant difference in the new bone formation. Conclusions: $Bongros^{(R)}$-HA was thought to be the available material for regenerating the new bone formation.

• 대한치과교정학회지
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• 제46권6호
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• pp.386-394
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• 2016

Objective: The objective of the study was to evaluate the practicality and the validity of different surface treatments of self-drilling orthodontic mini-implants (OMIs) by comparing bone cutting capacity and osseointegration. Methods: Self-drilling OMIs were surface-treated in three ways: Acid etched (Etched), resorbable blasting media (RBM), partially resorbabla balsting media (Hybrid). We compared the bone cutting capacity by measuring insertion depths into artificial bone (polyurethane foam). To compare osseointegration, OMIs were placed in the tibia of 25 rabbits and the removal torque value was measured at 1, 2, 4, and 8 weeks after placement. The specimens were analyzed by optical microscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS). Results: The bone cutting capacity of the etched and hybrid group was lower than the machined (control) group, and was most inhibited in the RBM group (p < 0.05). At 4 weeks, the removal torque in the machined group was significantly decreased (p < 0.05), but was increased in the etched group (p < 0.05). In the hybrid group, the removal torque significantly increased at 2 weeks, and was the highest among all measured values at 8 weeks (p < 0.05). The infiltration of bone-like tissue surface was evaluated by SEM, and calcium and phosphorus were detected via EDS only in the hybrid group. Conclusions: Partial RBM surface treatment (hybrid type in this study) produced the most stable self-drilling OMIs, without a corresponding reduction in bone cutting capacity.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제26권6호
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• pp.613-619
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• 2000

The purpose of the present study was to investigate the effect of Bioactive glass on bone regeneration in the experimental mandibular bone defects. Five rabbits, weighing about 2.0kg, were used. Three artificial bone defects, $5{\times}5{\times}5mm$ in size, were made at the inferior border of the mandible. In the experimental group 1, the bone defect was grafted with $Biogran^{(R)}$ and covered with $Bio-Gide^{(R)}$ resorbable membrane. In the experimental group 2, $Biogran^{(R)}$ was grafted only. In the control group, the bone defect was filled with blood clot and was spontaneously healed. The animals were sacrificed at 1, 2, 4, and 8 weeks after the graft. Microscopic examination was performed. Results obtained were as follows: In the control group, the osteoid tissue was observed at week 1 and the bone trabeculi were connected each other and matured at week 2. The lamellar bone formation appeared at week 4, and the amount of bone tissue was increased at week 8. In the experimental group 1, the fibrous tissue was filled between the granules of Bioactive glass and the cartilage formation was found adjacent to the normal bone at week 1. The bone tissue was formed between the granules at week 2, while the amount of bone tissue increased and the lamellar bone formation was observed at week 4. The lamellar bone was increased at week 8. Histologic findings were Similar between the experimental groups 1 and 2, although the amount of Bioactive glass granules lost was increased in the latter. These results suggest that new bone formation is found around the Bioactive glass granules grafted into the bone defects, and the membrane plays a role in keeping the granules and preventing the fibrous tissue invasion.

• 대한치과보철학회지
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• 제32권4호
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• pp.593-607
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• 1994

The purpose of this study is to evaluate the effect of the bone morphogenetic protein, bone matrix gelatin and collagen matrix on the amount and shape of generating new bone adjacent to the implant. Implants were inserted in the mandible of adult dogs at 2 months after teeth extraction. Artificial bony defects, 3mm in width and 4mm in depth were made at the mesial and distal side of implant. Experimental groups were divided into three groups ; Group 1 : Defects filled with collagen matrix and bone morphogenetic protein, Group 2 : Defects filled with bone matrix gelatin. Control group : Defects filled with only collagen matrix. After implantation, the animals were sacrificed at 1,3,5 and 10 weeks for light microscopic examination. For the fluorescent microscopic examination. each tertracycline Hcl and calcein were injected at 1, 3, 5, 8 and 10 weeks after implantation. The results obtained were as follows : 1. The molecular weight of bovine BMP was about 18,100 by hydroxyapatite chromatography. 2. Osseointegration was observed in experimental groups 1 & 2, and BMG and BMP had an excellent bone forming capability as a filling materials to the repair of the bone defects. 3. The degree of healing of bone defect area, the experimental group 1 showed more prominent bone formation than control group, and the control group showed fibrous connective tissue between the implant and the bone. 4. In the fluorescent microscopic findings, bone remodelling was observed regenerative lamellar bone at defect area in experimental group 1, and partial remodelling in experimental group 2, In the control group, fibrous connective tissue was observed between the implant and bone surface and sign of remodelling was not apperaed. Above results suggest that BMP has rapid osteoinductive property and can be used clinically as a bone substitute on bone defects around implants.

• Journal of Korean Dental Science
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• 제16권2호
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• pp.156-163
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• 2023

Purpose: The aim of this study was to evaluate the feasibility of deep learning techniques to classify the morphology and severity of peri-implantitis bone defects based on periapical radiographs. Materials and Methods: Based on a pre-trained and fine-tuned ResNet-50 deep learning algorithm, the morphology and severity of peri-implantitis bone defects on periapical radiographs were classified into six groups (class I/II and slight/moderate/severe). Accuracy, precision, recall, and F1 scores were calculated to measure accuracy. Result: A total of 971 dental images were included in this study. Deep-learning-based classification achieved an accuracy of 86.0% with precision, recall, and F1 score values of 84.45%, 81.22%, and 82.80%, respectively. Class II and moderate groups had the highest F1 scores (92.23%), whereas class I and severe groups had the lowest F1 scores (69.33%). Conclusion: The artificial intelligence-based deep learning technique is promising for classifying the morphology and severity of peri-implantitis. However, further studies are required to validate their feasibility in clinical practice.

• 한국인공지능학회지
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• 제12권1호
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• pp.1-6
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• 2024

Recently, various techniques are being applied through the development of medical AI, and research has been conducted on the application of super-resolution AI models. In this study, evaluate the results of the application of the super-resolution AI model to brain CT as the basic data for future research. Acquiring CT images of the brain, algorithm for brain and bone windowing setting, and the resolution was downscaled to 5 types resolution image based on the original resolution image, and then upscaled to resolution to create an LR image and used for network input with the original imaging. The SRCNN model was applied to each of these images and analyzed using PSNR, SSIM, Loss. As a result of quantitative index analysis, the results were the best at 256×256, the brain and bone window setting PSNR were the same at 33.72, 35.2, and SSIM at 0.98 respectively, and the loss was 0.0004 and 0.0003, respectively, showing relatively excellent performance in the bone window setting CT image. The possibility of future studies aimed image quality and exposure dose is confirmed, and additional studies that need to be verified are also presented, which can be used as basic data for the above studies.