• 대한후두음성언어의학회지
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• 제8권1호
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• pp.49-53
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• 1997

Aberrations in VOT measures in apraxia of speech are indicative of speech motor programming impairment. In English, overlaps of VOT between voiceless and voiced plosives have been frequently observed in patients with apraxia of speech. Unlike English, Korean plosives constitute trichotomy in terms of manner of production, that is, voiceless aspirated /p', t', k'/ ; voiceless or voiced, weakly aspirated /p-b, t-k, k-g/ ; or voiceless, heavily aspirated /p, t, k/. In this spectrographic study, VOT measures during Korean plosives produced by a patient with apraxia of speech were compared to those by age- and gender- matching normal subjects. The results indicated that there were partial overlaps between VOT of /b, d, g/ and those of /p, t, k/, implying that the errors were phonetic in nature. In addition, larger VOT variabilities in apraxia of speech compared to the normals were noted.

• 음성과학
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• 제12권4호
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• pp.247-254
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• 2005

This study aimed at clarifing clinical effects of eight-step continuum treatment in a patient who showed apraxia of speech after stroke. The eight-step continuum treatment consisted of 8 steps and its clinical efficacy has been proven with American apraxic patients. However, it has not been clinically proven to be effective in Korean patients with apraxia of speech as of yet. Therefore, this study was conducted in an effort to provide preliminary clinical evidence regarding its effectiveness regardless of the linguistic differences between Korean and English. The therapy took place twice a week for 6 months, a total of 48 times. The results showed that the patient's receptive language was improved from 83% to 89% and 37% in accuracy, and expressive language from 15% to 37%. It seemed that spontaneous recovery did not playa role in his improvement since the study was conducted 2 years after the stroke. In addition, the improvement of expressive language was much greater(22%) than that of receptive language(6%), which implied that the therapy was effective in apraxia of speech because apraxia of speech is relatively confined to expressive ability, more specifically motor programming and sequencing.

• 말소리와 음성과학
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• 제6권3호
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• pp.33-40
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• 2014

The purpose of the study was to examine alternating motion rate and its variability in children with childhood apraxia of speech (CAS) compared to typically developing children. Six children with CAS aged 9-12 years old and 10 children who were age-matched participated in the study. This study measured tokens per second and variabilities of the rates during the production of /$p^*$ a/, /$t^*$ a/, and /$k^*$ a/. For variability measures of the rates, each participant was asked to repeat speech tasks three times and the average value of the rates and its standard deviation were obtained. The results revealed that the CAS group showed slower rate only at /$k^*$ a/ than the control group. The CAS group exhibited greater variability of AMR at all the tasks than the control group. The results suggested that variability of AMR might be a more distinctive speech feature to children with CAS than the rate of the speech task.

• 음성과학
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• 제12권2호
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• pp.101-108
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• 2005

Apraxia of phonation (AOP) has often been described as a feature of apraxia of speech or of severe non-fluent type of aphasia. Pure AOP is rare and, to our knowledge, only two cases have been reported. Brain lesion sites of the reported cases were not those sites known to be responsible for apraxia of speech. This study presents a case of AOP which resulted from the secondary stroke in the left corona radiata immediately following the first stroke in the left temporoparietal lobe. A 61-year old right-handed man shwoed a global type of aphasia after the first cerebral infarction, but was able to generate spontaneously some short fragments of speech. On the day after the first infarction, he suffered from the secondary infarction, leaving him a complete loss of voluntary phonation. He did not showed any significant change in language functions. Several occurrences of involuntary phonation were observed upon laughing or crying. He was also able to cough unintentionally. A vidoe-stroboscopic examination failed to reveal any evidence of structural and functional impairment in larynx. Although this case is not of pure form of AOP, AOP appeared after the secondary stroke without significant changes of language impairment since the first stroke. Therefore, AOP may be a consequence of the brain lesion from the secondary stroke even though we cannot rule out the possibility of an additive effect of the secondary to the first stroke.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2003년도 10월 학술대회지
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• pp.125-127
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• 2003

The aim of the paper is to analyze prosodic characteristics in apraxia of speech and establish the fundamental sources in diagnosis of motor speech disorders. The sentences consist of two different types (declarative and interrogative) with different numbers of constituents which are one to three. The stimuli were constructed to assess apraxics speech with articulation and humming skills. The features of speech patterns were examined such as utterance duration, boundary tones, and etc. The results of the analysis are as follow: 1) In the interrogative sentences, the rising boundary tones appeared only in the humming tasks 2) the utterance duration is relatively shorter in the humming tasks than the speech with articulation.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.111-114
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• 2022

Many monogenic neurodevelopmental disorders have been newly identified in recent years owing to the rapid development of genetic sequencing technology. These include variants of the epigenetic machinery - up to 300 known epigenetic factors of which about 50 have been linked to specific clinical phenotypes. Chromodomain, helicase, DNA binding 1 (CHD1) is an ATP-dependent chromatin remodeler, known to be the causative gene of the autosomal dominant neurodevelopmental disorder Pilarowski-Bjornsson syndrome. Patients exhibit various degrees of global developmental delay, autism, speech apraxia, seizures, growth retardation, and craniofacial dysmorphism. We report the first case of Pilarowski-Bjornsson syndrome in Korea, due to a de novo missense variant of the CHD1 gene (c.862A>G, p.Thr288Ala) in a previously undiagnosed 17-year-old male. His infantile onset of severe global developmental delay, intellectual disability, speech apraxia, and failure to thrive are compatible with Pilarowski-Bjornsson syndrome. We also noted some features not previously reported in this syndrome such as skeletal dysplasia and ichthyosis. Further studies are needed to discover the specific phenotypes and pathogenic mechanisms behind this rare disorder.

• 대한음성언어의학회:학술대회논문집
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• 대한음성언어의학회 2006년도 제25회 학술대회
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• pp.152-152
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• 2006

• 대한음성학회:학술대회논문집
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• 대한음성학회 2007년도 한국음성과학회 공동학술대회 발표논문집
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• pp.265-269
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• 2007

This paper reports an compared acoustic analysis on speech produced by two Korean groups, normal and AOS, focusing on utterances of V-CV structures. Major concerns include: 1) types of errors (distortion/substitution) according to the place of articulation, 2) duration of each syllable, 3) VOTs of stop sounds, and 4) F1 and F2 of vowels. In terms of the differences in these phonetic characteristics between the two groups, we aim to clarify some characteristics of AOS and to provide fundamental criteria for diagnosing and evaluating the disease.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2007년도 한국음성과학회 공동학술대회 발표논문집
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• pp.149-151
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• 2007

This study was designed to investigate fast ab/adduction rate of articulation valves in normal adults. The measurement of fast ab/aduction rate has traditionally been used for assessment, diagnosis and therapy in patients who suffered from dysarthria, functional articulation disorders or apraxia of speech. Fast ab/adduction rate shows the documented structural and physiological changes in the central nervous system and the peripheral components of oral and speech production mechanism. Fast ab/adduction rates were obtained from 20 normal subjects by producing the repetition of vocal function (/ihi/), tongue function (/t${\wedge}$/), velopharyngeal function (/m/), and labial function (/p${\wedge}$/). The Aerophone II was used for data recording. The results of finding as follows: average fast ab/adduction rates were vocal function(6.21cps), tongue function(7.42cps), velopharyngeal function(5.23cps), labial function (6.93cps). The results of this study are guidelines of normal diadochokinetic rates. In addition, they can indicate the severity of diseases and evaluation of treatment.

• 재활복지
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• 제20권3호
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• pp.45-65
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• 2016

일차 진행성 실어증(Primary Progressive Aphasia, PPA) 환자군을 대상으로 한 효율적이고 체계적인 진단과 중재가 이루어지기 위해 기초연구가 많이 필요함에도 불구하고, 신경언어장애 내 치매 하위분야에서도 이들에 대한 연구는 부진한 편이다. 본 연구에서는 최근 10년간 국내외 관련 학술지에서 다루어진 PPA 연구논문의 동향을 분석하여 국내 PPA 연구의 향후 방향을 제시하는데 목적을 두었다. 일차적으로 선별된 171편의 논문을 대상으로 연구대상, 연구목적, 연구영역으로 나누고 연도별 연구동향에 대한 분석을 실시하였다. 연구대상은 국내외 모두 '실문법형'이 가장 많았고, 연구목적은 PPA의 전반적 특성이나 세 아형별 비교를 다룬 '특성연구'가 가장 많이 차지하고 있었다. 연구영역은 국외 연구에서는 의미(언어) 영역을 가장 많이 다루고 있으면서 '말'과 '기타'연구도 골고루 이루어져 있었던 반면, 우리나라는 '언어' 영역을 제외한 '말'과 '기타' 영역에 대한 연구가 아직 시행되지 않은 것으로 나타났다. 국외에서는 기존의 3가지 아형으로 나누어지던 PPA 분류에 말실행증(apraxia of speech) 분류가 추가되어 4가지 증상의 구별에 대한 연구가 활발히 모색되고 있는 반면, 국내는 환자 사례 발출이 어려워 이들이 보이는 증상이 의사소통장애에 상당히 초점이 맞춰져 있음에도 불구하고 시행된 연구가 거의 없었다. 기본적으로 관련 연구의 수가 절대적으로 부족하고 연구 영역의 다양성이 부족한 것으로 나타난 만큼, 향후 이에 대한 관심과 연구 확대가 필요하다.