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Development of an Automatic Seed Marker Registration Algorithm Using CT and kV X-ray Images (CT 영상 및 kV X선 영상을 이용한 자동 표지 맞춤 알고리듬 개발)

  • Cheong, Kwang-Ho;Cho, Byung-Chul;Kang, Sei-Kwon;Kim, Kyoung-Joo;Bae, Hoon-Sik;Suh, Tae-Suk
    • Radiation Oncology Journal
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    • v.25 no.1
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    • pp.54-61
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    • 2007
  • [ $\underline{Purpose}$ ]: The purpose of this study is to develop a practical method for determining accurate marker positions for prostate cancer radiotherapy using CT images and kV x-ray images obtained from the use of the on- board imager (OBI). $\underline{Materials\;and\;Methods}$: Three gold seed markers were implanted into the reference position inside a prostate gland by a urologist. Multiple digital image processing techniques were used to determine seed marker position and the center-of-mass (COM) technique was employed to determine a representative reference seed marker position. A setup discrepancy can be estimated by comparing a computed $COM_{OBI}$ with the reference $COM_{CT}$. A proposed algorithm was applied to a seed phantom and to four prostate cancer patients with seed implants treated in our clinic. $\underline{Results}$: In the phantom study, the calculated $COM_{CT}$ and $COM_{OBI}$ agreed with $COM_{actual}$ within a millimeter. The algorithm also could localize each seed marker correctly and calculated $COM_{CT}$ and $COM_{OBI}$ for all CT and kV x-ray image sets, respectively. Discrepancies of setup errors between 2D-2D matching results using the OBI application and results using the proposed algorithm were less than one millimeter for each axis. The setup error of each patient was in the range of $0.1{\pm}2.7{\sim}1.8{\pm}6.6\;mm$ in the AP direction, $0.8{\pm}1.6{\sim}2.0{\pm}2.7\;mm$ in the SI direction and $-0.9{\pm}1.5{\sim}2.8{\pm}3.0\;mm$ in the lateral direction, even though the setup error was quite patient dependent. $\underline{Conclusion}$: As it took less than 10 seconds to evaluate a setup discrepancy, it can be helpful to reduce the setup correction time while minimizing subjective factors that may be user dependent. However, the on-line correction process should be integrated into the treatment machine control system for a more reliable procedure.

Long-term Results of Modified Lecompte Procedure for the Anomalies of Ventriculoarterial Connection (심실대혈관 연결 이상에 대한 변형된 Lecompte 술식의 장기 성적)

  • 임홍국;한국남;김웅한;이정렬;노준량;김용진
    • Journal of Chest Surgery
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    • v.37 no.9
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    • pp.727-734
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    • 2004
  • The Lecompte procedure for transposition of the great arteries has an advantage because it obviates the need for an extracardiac conduit for the reconstruction of the pulmonary outflow tract. We evaluated the effectiveness and the application of the Lecompte procedure. Material and Method: A retrospective review was conducted of the records of 46 patients who underwent the Lecompte procedure during the past 15 years. Mean age at operation was 29.2$\pm$20.3 (range: 3∼83) months. The diagnoses involved anomalies of the ventriculoarterial connection with ventricular septal defect and pulmonary outflow tract obstruction, such as transposition of the great arteries, double-outlet right ventricle, and double-outlet left ventricle. Result: Early mortality was 4.4% (2 of 46 patients) and late mortality was 6.8% (3 of 44). The mean follow-up was 11.2$\pm$6.9 years. Eighteen patients (43.9% of survivors, n=41) had pulmonary stenosis (pressure gradient above 30 mmHg), the main reason for which was a calcified monocusp valve (n=15, 83.3%). Seventeen of 46 patients (37.0%) underwent reoperation: 15 for pulmonary stenosis, 5 for residual ventricular septal defect, 4 for left ventricular outflow tract obstruction, 3 for pulmonary insufficiency, and 4 for other causes. The cumulative survival rates were 91.3$\pm$4.2%, and 87.0$\pm$5.8% at 10 and 15 years, respectively. The actuarial probabilities of freedom from reoperation for pulmonary stenosis were 90.6$\pm$4.5%, 73.9$\pm$7.3%, and 54.0$\pm$10.4% at 5, 10, and 15 years, respectively. Conclusion: The Lecompte procedure is an effective treatment modality. Repair in early age is possible with acceptable morbidity and mortality, but recurrent right ventricular outflow tract obstruction caused by degeneration of the monocusp valve is a problem that needs resolution.

Clinecal Investigation and Acute Complications of Remodelling Plasty of Costochondral Rib Cage For Pectus Excavatum (전흉벽 늑연골의 리모델링 성형술을 이용한 누두흉수술의 임상적 고찰 초기합병증)

  • Her, Keun;Song, Cheol-Min;Jeon, Cheol-Woo;Jang, Won-Ho;Kim, Hyun-Jo;Jeong, Yoon-Seop;Youm, Wook
    • Journal of Chest Surgery
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    • v.35 no.12
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    • pp.882-889
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    • 2002
  • Acute Complications of Remodelling Plasty of Costochondral Rib Cage For Pectus excavatum Recently, Remodelling Plasty of Costochondral Rib Cage has been introduced as an minimally invasive procedure and expanded its application for pectus excavatum. Outcomes and acute complications were reviewed Material and Method: A retrospective survey of 55 patients who underwent Remodelling Plasty of Costochondral Rib Cage from September, 1999 to February, 2002 was conducted to review complications, postoperative treatments, and outcomes. Result: Age ranged from 1 to 27 years(mean 11.4 $\pm$ 7.1). 35(64%) were less than 15-year old and 20(36%) were more than 15-year old. There were 44(80%) Male patients and 11(20%) female patients. Length of hospital stay was 7.8 $\pm$ 2.1 days for less than 15-Y-old group, 10.6 $\pm$ 6.2 days for more than 15-Y-old group(p = 0.042) One substernal bar was inserted in 52 patients and two substernal bars were inserted in 3 patients. As for stabilizer, one lateral side was fastened in 15 patients and both lateral sides were fastened in 6 patients. In the less than 15-Y-old group, 4 patients needed stabilizer, whereas in the more than 15-Y-old group, 18 patients needed stebilizer(s)(p = 0.000). Including all kinds of complications, 28(51 %)patients had postoperative complications. Of them, only 7 patients were treated for complications(C-tube insertion was done in 7 patients and reoperation for bar refixation or removal was done in 3 patients of them). Conclusion: Most complications after Remodelling Plasty of Costochondral Rib Cage For Pectus Excavatum were trivial without treatment although C-tube drainage was needed in some patients. However bar displacement such as rotation and lateral sliding should be corrected as soon as detected in order not to remove the bar(the worst situation).

Surgical Treatment of Patients with Abdominal Aortic Aneurysm (복부 대동맥류에 대한 수술)

  • Ryu, Kyoung-Min;Seo, Pil-Won;Park, Seong-Sik;Ryu, Jae-Wook;Kim, Seok-Kon;Lee, Wook-Ki
    • Journal of Chest Surgery
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    • v.42 no.3
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    • pp.331-336
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    • 2009
  • Background: Open surgical repair of abdominal aortic aneurysms was initiated by Dubost in 1952. Despite the rapid expansion of percutaneous endovascular repair, open surgical repair is still recognized for curative intent. We retrospectively analyzed surgical outcome, complications, and mortality-related factors for patients with abdominal aortic aneurysms over a 6 year period. Material and Method: We analyzed 18 patients who underwent surgery for abdominal aortic aneurysms between March 2002 and March 2008. The indications for surgery were rupture, a maximal aortic diameter >60 mm, medically intractable hypertension, or pain. Result: The mean age was $66.6{\pm}9.3$ years (range, $49\sim81$ years). Twelve patients (66.7%) were males a 6 patients were females. Extension of the aneurysm superior to the renal artery existed in 6 patients (33.3%), and extension to the iliac artery existed in 13 patients (72.2%). Five patients (27.8%) had ruptured aortic aneurysms. The mean maximal diameter of the aorta was $72.2{\pm}12.9$ mm (range, $58\sim109$ mm). Surgery was performed by a midline laparotomy, and 6 patients underwent emergency surgery. The mean total ischemic time from aorta clamping to revascularization was $82{\pm}42$ minutes (range, $35\sim180$ minutes). The mortality rate was 16.7%; the mortality rate for patients with ruptured aneurysms was 60%, and the mortality rate for patients with unruptured aneurysms was 0%. The postoperative complications included one each of renal failure, femoral artery and vein occlusion, and wound infection. The patients who were discharged had a long-term survival of $34{\pm}26$ months (range, $4\sim90$ months). Rupture and emergency surgery had a statistically significant mortality-related factor (p < 0.05). Conclusion: Emergency surgery for ruptured aortic aneurysms continues to have a high mortality, but unruptured cases are repaired with relative safety. Successfully operated patients had long-term survival. Even though endovascular aortic repair is the trend for abdominal aortic aneurysms, aggressive application should be determined with care. Experience and systemic support of each center is important in the treatment plan.

A Study on the Method for Removing the Paraffin used on Iron Artifacts as Surface Coating Agent - As Focused on the Iron Artifacts Owned by the Kyunghee University Central Museum - (철제유물 표면코팅제로 사용된 파라핀 제거방법에 관한 연구 - 경희대학교박물관 소장 철제유물을 중심으로 -)

  • Kang, Seokin;Wi, Koangchul;Lee, Hoyeon;Lim, Seongjin
    • Conservation Science in Museum
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    • v.13
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    • pp.23-31
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    • 2012
  • The object artifacts of this study are the iron artifacts owned by the Kyunghee University Central Museum. The surfaces of the iron artifacts are opaque due to the coated materials which are presumed to be paraffin or bee's wax while they are plate-shaped and exist in thickly exfoliated condition caused by severe corrosion developed on the overall surfaces. Therefore, in order to remove the coated materials away from the surfaces of the artifacts rather safely, reversibility tests have been carried out and the conservation treatment was performed upon the basis of and in application of the experimental results. The study methodologies are that: first, the FT-IR analysis was carried out to determine the ingredients of the coating-treated material on the surface; second, by applying various kinds of organic solvents, the kinds of agents that allow the artifact's surface-coating material to be reversible have been identified through experiments; third, the most suitable agent for removing coating material was selected and applied to the real artifacts on the basis of the results of the reversibility tests. Results from the study: first, as a result of the FT-IR analysis, the coating agent used on the artifacts was identified to be of the same ingredients as those of paraffin; second, among organic solvents, xylene, toluene, trichloroethylene and methyl alcohol were identified to be usable for dissolving paraffin whereas toluene was judged to be the most suitable for removing the coating agent; third, when applying the selected agents on the real artifacts, due to the fact that removing the whole paraffin might cause the artifact to disintegrate, the paraffin of only the part that covered the surfaces opaquely was removed using cotton swab or gauze, thus completing the conservation treatment.

Usefulness of $^{99m}Tc$-MDP Bone Scintigraphy for Assessing Vascular Ingrowth on Hydroxyapatite Ocular Implant ($^{99m}Tc$-MDP 골신티그라피를 이용한 Hydroxyapatite 안구 보충물의 혈관 신생 평가 및 임상적 유용성)

  • Kang, Bong-Joo;Sohn, Hyung-Sun
    • The Korean Journal of Nuclear Medicine
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    • v.33 no.6
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    • pp.484-492
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    • 1999
  • Purpose: This study was to evaluate the clinical usefulness of $^{99m}Tc$-MDP bone scintigraphy for assessing vascular ingrowth into the ocular implants after enucleation or evisceration. Materials and Methods: Twenty-four patients (M:F=7:17, mean age: 36 years), who buried a coralline hydroxyapatite after uncomplicated enucleation or evisceration surgery were studied. Dynamic and static scintigraphy on the orbit fossa were obtained after injection of 740 MBq $^{99m}Tc$-MDP to evaluate the status of vascularization. The study was performed from the 3 to 33 weeks after surgery. According to the visual analysis, activity greater than nasal bridge was graded as 4, equal to the nasal bridge as 3, less than nasal bridge but greater than normal orbit as 2, greater than normal orbit but less than grade 2 as 1. Uptake ratio was also calculated by measuring the implants activity (H) and contralateral orbit activity (N). Grading score and uptake ratio were compared with clinical outcome of vascularization. Additionally, we also analyzed the vascularization status as time lapse between primary surgery and scintigraphic study and surgical methods. Results: Twenty-one patients who had bone scintigraphy at 11 weeks after surgery showed increased uptake above grade 2 and greater H/N ratio than 1.16. Of these, 19 patients who had drilling surgery for permanent peg application showed adequate bleeding during the procedure. The activity grade and uptake ratio were inversely correlated with vascular ingrowth. Higher than grade 2 or greater than 1.56 in H/N ratio seemed to be an indicator for better prognosis. Accomplishment of vascularization was not affected by the surgical way such as enucleation or evisceration. Conclusion: $^{99m}Tc$-MDP bone scintigraphy can be a useful method to evaluate the vascularized status of implants. Adequate time for $^{99m}Tc$-MDP bone scintigraphy may be 11-20 weeks after enucleation or evisceration.

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Evaluation of Bacillus subtilis Native Strains for Plant Growth Promotion and Induced Systemic Resistance in Tomato and Red-pepper (토마토, 고추의 생육촉진 및 병 저항성 의 농업적 활용을 위한 토착 Bacillus subtilis의 생물활성 평가)

  • Park, Jin-Woo;Jahaggirdar, Shamarao;Cho, Yung-Eun;Park, Kyoung-Soo;Lee, Seo-Hyun;Park, Kyung-Seok
    • The Korean Journal of Pesticide Science
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    • v.14 no.4
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    • pp.407-414
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    • 2010
  • Bacillus subtilis strains isolated from different regions of Korea were screened for their plant growth promotion and induced systemic resistance (ISR) in tomato and red-pepper. The plant growth promotion on red-pepper and tomato revealed maximum plant height (22.73 cm) on red pepper treated with B. subtilis strain JE 21-1 and 30.18cm in case of tomato treated with B. subtilis strain JE 8-1. There was also significant improvement in root and shoot dry weight in both the plants. The strain JE 21-1 showed better promise for all growth parameters in red-pepper and tomato when compared to other strains and positive check BTH. Different strains screened in square plate method also revealed maximum plant height and leaf width, and suppressed anthracnose on red pepper in case of strain JE 21-1 at $10^6$ and $10^7$ cells/ml when compared to other strains. In all the bacterial inoculations the population was significantly high when compared to untreated check. In plant growth promotion with respect to fruit length and weight, fruit length was maximal in treating with JE 9-4 and ES 2-2, while fruit weight was maximal in treating with JE 3-6, ES4-2, ES2-2 and JE 21-2 on red pepper. In case of tomato, comparatively better fruit weight was in JE 21-1, ES 3-3 and JE 10-2 when compared to BTH and untreated control. The soft rot disease caused by Pectobacterium carotovorum SCCI was completely suppressed in case of transgenic tobacco harboring GUS gene related to PR1a and increased the level of salicylic acid significantly in combined application of JE 9-4 on par with BTH. Thus, this study clarified some potential Bacillus subtilis strains for plant growth promotion and ISR in red-pepper and tomato.

Establishment and Application of Landscape Control Point Selection Method for Landscape Assessment of Urban Development Projects (도시개발사업의 경관평가를 위한 조망점 선정체계 구축 및 적용)

  • Jang, Cheol-Kyu;Jung, Sung-Gwan;Kim, Kyung-Tae
    • Journal of the Korean Institute of Landscape Architecture
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    • v.39 no.3
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    • pp.39-50
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    • 2011
  • This study furnishes basis data for plan foundation and proper valuation of view by presenting objective and concrete selection standards and ways of Landscape Control Point(LCP) on valuation of development projects. To sum up the results of study, it establishes the prospect, publicity and direction of view as a selection standard LCP on precedent studies. The prospect, which includes visual range, direction of view, geographical features, and visibility, sets up as a valuation basis picking out the available places which have alterations according to direction and distance in practice. In the case of publicity, to select the place as there presentative area where public activities often happen than others, thirteen evaluation indexes including administration facilities, educational facilities, commercial facilities and so on. And variation of landscape is set up as an assessment index to know how much the land has changed from the beginning to the end of development. To apply the selection standards to sample places, the preliminary LCP is founded by analyzing both the prospect and published; a series of courses for selecting the final LCP is founded by analyzing the preliminary LCP and variableness of landscape on a basic of placed which have many alterations of view. At last, in the case of a selection system for LCP, the preliminary LCP is founded by analyzing both the prospect and publicity; a series of courses for selecting the final LCP is found by analyzing the preliminary LCP and variableness of landscape. Applying selection standards and the assessment index to the Sam-deok 3 residence improvement area, in the case of prospect, the southern distant view area has the largest extent. Next, the results of the assessment using the system of publicity show that a five-lane road is taking up the largest area. Hence, a total of 48 preliminary LCPs are set up by analyzing both the prospect and publicity. The results of analyzing landscape variation, one of the valuation indexes, show that Sam-deok dong around the post office has the highest rate of variation at 28.07%. Finally, three LCPs in each part, which are close range, middle range and distance view, are selected; thus, a total of nine LCPs are selected. The selected LCPs that go through a series of practical courses like a GIS program have a lot of professional opinions and are expected to secure objectivity of landscape assessment.

Evaluation of polymerization shrinkage stress in silorane-based composites (Silorane계 복합레진의 중합수축응력의 평가)

  • Ryu, Seung-Ji;Cheon, Ji-Hoon;Min, Jeong-Bum
    • Restorative Dentistry and Endodontics
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    • v.36 no.3
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    • pp.188-195
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    • 2011
  • Objectives: The purpose of this study was to evaluate the polymerization shrinkage stress among conventional methacrylate-based composite resins and a silorane-based composite resin. Materials and Methods: The strain gauge method was used for the determination of polymerization shrinkage strain. Specimens were divided by 3 groups according to various composite materials. Filtek Z-250 (3M ESPE) and Filtek P-60 (3M ESPE) were used as a conventional methacrylate-based composites and Filtek P-90 (3M ESPE) was used as a silorane-based composites. Measurements were recorded at each 1 second for the total of 800 seconds including the periods of light application. The results of polymerization shrinkage stress were statistically analyzed using One way ANOVA and Tukey test (p = 0.05). Results: The polymerization shrinkage stress of a silorane-based composite resin was lower than those of conventional methacrylate-based composite resins (p < 0.05). The shrinkage stress between methacrylate-based composite resin groups did not show significant difference (p > 0.05). Conclusions: Within the limitation of this study, silorane-based composites showed lower polymerization shrinkage stress than methacrylate-based composites. We need to investigate more into polymerization shrinkage stress with regard to elastic modulus of silorane-based composites for the precise result.

Competition between Crop and Weed and Weed Control in Dry Direct Seeded Rice (벼 직파재배(直播栽培)의 잡초(雜草)와 작물간(作物間)의 경합(競合) 및 방제(防除))

  • Yeun, K.B.;Kim, K.U.;Shin, D.H.;Lee, I.J.;Jung, J.W.;Kim, H.K.
    • Korean Journal of Weed Science
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    • v.11 no.3
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    • pp.178-186
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    • 1991
  • This study was conducted to evaluate the major weeds occurred in direct seeded rice and their compition with rice, and to establish the effective weed control method. The important weeds occurring in dry direct seeded rice were Echinochloa crusgalli, Cyperus amuricus, Rorippa islandica, etc. Among them, Echinochloa crusgalli was the most dominant weed species. In view of the Simpson's dominance index, the maximum number of the weeds was observed at 30 days after seeding, showing 0.26, but decreased as the time passed. In other hand, Simpson's dominance index of weed dry weight increased from 0.09 at 15DAS(days after seeding) to 0.28 at 60DAS indicating that particular weed such as barnyardgrass was dominating the fields. The plant height and the tiller number of rice in the dry direct seeded rice were not greatly affected by the time and duration of competition with weeds, but rice yield was greatly influenced by them. The yield reduction was observed when compition between rice and weeds were initiated at 20 to 40 DAS till the harvesting time. The highest weed control efficacy was observed at the treatment of systematic herbicide application such as soil applied Butachlor followed by Mefenacet/Bensulfuron-methyl/Dymron at 30 DAS after seeding, and soil applied Dimepiperate/Bensulfuron-methyl mixture as a preemergence type gave also an excellent control.

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