• 한국임상수의학회지
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• 제21권4호
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• pp.343-348
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• 2004

This study was carried out to investigate the difference between sutured anastomosis and stapler anastomosis (open lumina technique) of jejunum in dogs. Fifteen mongrel-breed female dogs weighting 4 to 6 kgs were allocated to three groups; sutured end-to-end anastomosis (Group I), sutured side-to-side anastomosis (Group II) and stapler anastomosis (Group III), five dogs per each group. All dogs in different anastomosis pattern were compared with time for total operation and suture elapsed for intestines to anastomose, clinical signs, status of feces, complications for 14 days after operation. The total operation time and suture time needed for intestinal anastomosis were significantly(p<0.05) shorter in Group III than Group I and II. All dogs showed no significant difference in vitality, appetite, vomiting between groups for 14 days after operation. All dogs, except one dog in Group II, showed normal vitality and appetite since 7-8 days after operation. Initial return of fecal passage showed in all dogs 8 days after operation and thereafter normal feces were observed in most of the dogs. According to results, all dogs with normal vitality and appetite for 8 days showed good prognosis. In complications after operation, only one dog in Group II showed dehiscence of anastomotic site. There was significant(p<0.05) differences between groups in speed of operation. And all dogs, except one dog in Group II, showed good clinical condition and prognosis. In conclusion, the stapler anastomosis is considered to be more reliable, faster, and precision method compared to the sutured anastomosis for intestinal anastomosis in dogs.

• Molecules and Cells
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• 제38권12호
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• pp.1044-1053
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• 2015

This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set of experiments, the metabolic changes occurring at multiple time points over 8 weeks in response to CGH (35.33% wt/wt) were observed in high-fat (HF, 60% of energy as fat) diet-fed SD rats. In lean rats, the hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels of the CGH group were significantly changed in response to CGH administration. In the second part of the study, CGH treatment was found to reduce body weight and perirenal and epididymal fat weight. CGH also prevented an increase in food intake at 2 weeks and lowered plasma leptin and insulin levels in comparison with the HF group. This reduction in the plasma and hepatic lipid levels was followed by improved insulin resistance, and the beneficial metabolic effects of CGH were also partly related to increases in plasma adiponectin levels. The Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), an index of insulin resistance, was markedly improved in the HF-CGH group compared with the HF group at 6 weeks. According to the microarray results, adipose tissue mRNA expression related to G-protein coupled receptor protein signaling pathway and sensory perception was significantly improved after 8 weeks of CGH administration. In conclusion, the present findings suggest that dietary CGH may be effective for improving hyperglycemia, dyslipidemia and insulin resistance in diet-induced obese rats as well as appetite control in lean rats.

• Journal of Pharmaceutical Investigation
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• 제37권6호
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• pp.349-354
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• 2007

For decades, the various virtues of ${\alpha}-lipoic$ acid (ALA), a natural material synthesized in most cells, have been intensively studied and proved. Recently it was reported that ALA caused significant bodyweight reduction via appetite suppression. Unfortunately, the efficacy requires an administration over 50 mg/kg. The low bioavailability and the short plasma half life of ALA lead us to explore novel pharmaceutical dosage forms using nanoparticles. In this study, the effect of polymeric stabilizers on the bioavailability improvement of ALA nanoparticles was investigated. The reduction of particle size via nano-comminution technology was successful resulting in volume average particle sizes of 320 - 340 nm. The in vitro release rate of ALA did not reflect the decrease of particle size, possibly because of the self polymerization of ALA during nano-comminution. The type of polymeric stabilizers could not affect the release rate either. However, the in vivo food intake results of ALA showed that nano-suspensions were more effective than microparticles or a salt form. The nano-suspension containing polyvinyl pyrrolidone as the primary stabilizer and polyacrylic acid as the secondary stabilizer showed more improved efficacy for 2 hours.

• 한국임상수의학회지
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• 제20권4호
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• pp.449-457
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• 2003

To investigate the renal effects of enrofloxacin administration on rats induced with dehydration or hyperoxaluria, male rats were treated with enrofloxacin of 50 mg to 500 mg/kg b.w.. The microscopical observations of kidney and urine sediment were carried out in the experimental groups. The result obtained were as follows; The male rats deprived of water for 72 hours and administered with enrofloxacin. As enrofloxacin administration dose was increased, clinical signs such as loss of appetite, depression, weakness, and loss of urine output became more severe. In the histopathological findings, there were hyperemia and hemorrhage in renal cortex, vacuolation and necrosis of renal tubular epithelia, proteinous casts within renal tubules. The male rats were orally administered with sodium oxalate and injected with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, and weakness became more severe. In the histopathological findings, there are hemorrhage of glomeruli and cortical hyperemia, vacuolation and necrosis of tubular epithelia, proteinous casts in renal tubules. In the microscopical findings of urine sediment, there are calcium oxalate crystal (diamond-like type) and magnesium ammonium phosphate crystals (rhomboid). The male rats were intraperitoneally injected with sodium oxalate and administered with enrofloxacin for 7days. As enrofloxacin administration dose was increased, clinical signs such as the loss of appetite and water consumption, weakness were more severe. In the histopathological findings, there were hyperemia and hemorrhage in both glomeruli and renal cortex. Severe necrosis of renal tubular epithelia, bluish materials within renal tubules were also found. In the microscopical findings of urine sediment, there were many calcium oxalate crystals. The present results suggest that enrofloxacin has some injurious effects in rats having dehydration or hyperoxaluria, and clinically, we should consider these renal injury effects when we use enrofloxacin in patients accompanied renal disease, dehydration and hyperoxaluria conditions.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5121-5126
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• 2016

Objective: To investigate the impact of chemotherapy on quality of life (QoL) among breast cancer patients and to evaluate the relationship with age, cancer stage and presence of any comorbidity. Methods: A prospective study was conducted among breast cancer patients receiving chemotherapy in Hospital Melaka from 1st January 2014 to 31st July 2014. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) was given to patients to fill in prior chemotherapy (baseline) and after the third cycle of chemotherapy. Socio-demographic and clinical data were collected and analyzed using SPSS version 20. Result: Respondents were 32 female patients [mean age (SD): 49.7(9.93) years]. They reported a significant lower global health status (P < 0.01) and significant higher symptoms of nausea and vomiting (P < 0.01), loss of appetite (P = 0.028) and diarrhea (P = 0.026) after the third cycle of chemotherapy as compared to baseline. Compare to, this study showed significant better emotional functioning (P < 0.01) and social functioning (P < 0.01) than the EORTC QLQ-C30 Reference Values 2008 for breast cancer cases. Under symptom scales higher scores were noted for appetite loss (P = 0.017), nausea and vomiting (P < 0.01). Age, stage and comorbidity had no clear associations with global health status in our patients (P > 0.05). Conclusion: Chemotherapy did reduce the QoL of breast cancer patients. Management of chemotherapy-induced loss of appetite, diarrhea, nausea and vomiting should be improved for a better outcome.

• 영어영문학
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• 제57권1호
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• pp.171-190
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• 2011

Shakespeare's plays deploy an interesting array of food signs in a way to illuminate the historical process of what Stephen Mennell has described as "the civilizing of appetite"-a process in which the changes of food choices and eating habits took place in response to the changes in people's way of life and personality structure over the long-term modern period since the middle ages. Shakespeare's plays suggest that the civilizing of appetite in early modern England was heavily affected by the forces of social mobility as well as the nascent market economy. The Capulets' costly preparation of Juliet's wedding banquet is a showcase of conspicuous consumption which was a structural necessity for the ruling class in Shakespeare's time. Some fifteen years later, the same kinds of foodstuffs are included in a shepherd's shopping list for the sheepshearing festival in Winter's Tale. This is a significant coincidence to prove that food was an important source of emulation and contest among different social classes; and that the rich diet of the upper class gave impetus to social mobility. The Elizabethan subjects, especially among the elite noblemen, were interpellated by the ideology of food that equated the quality of food and the eater's social identity. Faced with bankruptcy as a consequence of his extravagant consumption habit, Bassanio in The Merchant of Venice testifies to the gripping ideology of food onto early modern people, while Poor Tom in King Lear presents a comic parody of the rich people's conspicuous waste. Also in Coriolanus and The Merry Wives of Winsor, Shakespeare uses food as a metaphor for class-motivated social struggles.

• 한국식생활문화학회지
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• 제38권4호
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• pp.224-238
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• 2023

To develop customized food products for gastric cancer patients, it is crucial to understand their dietary characteristics and changes in their perception of smell and taste due to their condition. This study conducted in-depth interviews and administered olfactory and gustatory tests on 20 patients with gastric cancer. A control group of 20 healthy, gender and age matched individuals, was included for comparison. Patients reported difficulties in sustaining their appetite, particularly during chemotherapy. This could be attributed to gastrointestinal discomfort and an altered perception of smell and taste. The olfactory test revealed that cancer patients were significantly less sensitive than the control group. Also, a smaller number of participants in the cancer group were reported to have a normal taste function, which enabled them to perceive umami, one of the five basic taste compared to those in the control group. These findings demonstrated that gastric cancer patients experience post-surgical digestive issues, chemotherapy-induced changes in smell and taste, and appetite loss. To improve the quality of life of these patients and the efficacy of the treatment, it is necessary to consider not only their nutritional requirements but also other factors such as appetite loss and discomfort when developing meals specifically for them.

• Asian-Australasian Journal of Animal Sciences
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• 제26권2호
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• pp.171-177
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• 2013

The aim of the present study was to determine the evidence of post-parturient disorders and backfat loss during lactation in sows raised in tropical areas in relation to their backfat thickness before farrowing and postpartum intravenous supportive treatment. Backfat thickness was measured using A-mode ultrasonography at farrowing and weaning ($25.5{\pm}1.4$ d) in 70 sows. The sows were divided into three groups according to backfat thickness before farrowing, i.e., 15.0 to 20.0 mm (n = 21), 20.5 to 25.0 mm (n = 35), >25.0 mm (n = 14) and were categorized into two groups according to the postpartum supportive treatment, i.e., control (n = 31) and treatment (n = 39). After farrowing, the sows in treatment group received the same medications as in control sows. Furthermore an intravenous supportive treatment with amino acids and vitamins was administered in treatment groups. Rectal temperature and clinical signs of the sows including vaginal discharge, udder problems and appetite were determined at d 0, 1, 2 and 3 of parturition. It was found that, on average, the backfat thickness was $22.4{\pm}3.9$ mm at farrowing and $19.9{\pm}2.9$ mm at weaning. The backfat loss and the relative backfat loss during the lactation period were 2.6 mm and 10.6%, respectively. The sows with a backfat of 15.0 to 20.0 mm before farrowing lost less backfat than those with a backfat of 20.5 to 25.0 mm and >25.0 mm (p<0.05). Sows with a backfat of 15.0 to 20.0 mm had a better appetite on d 1 postpartum than sows with a backfat of 20.5 to 25.0 mm (p = 0.020). The percentage of sows losing backfat >10% during lactation were higher in sows with a backfat of >25.0 mm before farrowing (85.7%) than sows with a backfat of 15.0 to 20.0 mm before farrowing (35.0%) (p = 0.008). The percentage of sows with a reduced appetite on d 1 (90.3% vs 71.8%, p = 0.018) and d 2 (61.3% versus 33.3%, p = 0.005) postpartum in the treatment group was lower than the control group. In conclusion, the backfat thickness of sows at farrowing influenced backfat loss during lactation under hot and humid climates. The intravenous supportive treatment of sows with amino acid and vitamins significantly improved the appetite of postpartum sows.

• 대한지역사회영양학회지
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• 제17권3호
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• pp.290-301
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• 2012

This survey of 836 midlife women ($51.0{\pm}4.0$ yrs) was undertaken by exclusively a face to face interview by well-trained interviewers guarantying data collection of higher quality. This survey data was analyzed using the SPSS program. The main purpose of this study was to describe the factors affecting self-rated health status, including dietary habits and physical mental social factors. In the self-rated health status of a 'good' group, age was lower (p < 0.05), monthly income was higher (p < 0.01), dietary habits score (p < 0.001) and appetite (p < 0.001) and the degree of movement (p < 0.001) and life satisfaction (p < 0.001), marital intimacy (p < 0.001) and relationship satisfaction with their children (p < 0.001) were significantly higher than the 'bad' group. The level of depression (p < 0.001) and severe feeling of menopausal symptoms (p < 0.001) were significantly higher in the 'poor' group. The results of correlation analysis demonstrated that educational level (r = 0.069, p < 0.05), income (r = 0.157, p < 0.001), eating habits (r = 0.235, p < 0.001), appetite (r = 0.263, p < 0.001), life satisfaction (r = 0.197, p < 0.001), marital intimacy (r = 0.167, p < 0.001), child relationship satisfaction (r = 0.149, p < 0.001), positive attitude toward menopause (r = 0.070, p < 0.05) showed a positive correlation, but depression (r = -0.122, p < 0.001) and menopausal symptoms (r = -0.292, p < 0.001) showed a negative association with self-rated health status. The predictable factors affecting the self-rated health status of middle-aged women were examined by multiple regression analysis. The 'menopausal symptoms - physical discomfort' was the most important variables followed by the 'appetite', 'eating habits', 'menopause symptoms - sensory problems', 'BMI', 'positive attitude toward menopause' and 'high marital intimacy'. These results showed that the 'appetite' and 'eating habits' are important factors affecting the self-rated health status. Therefore, a program of dietary education must be considered for the effective health education and counseling of middle-aged women.

• 한국식품영양과학회지
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• 제43권9호
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• pp.1431-1438
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• 2014

본 연구는 국내 노인의 삶의 질과 영양개선 및 건강을 증진시킬 수 있는 기초자료를 얻고자 실시된 단면연구로서 재가 노인의 식욕부진 유병 상태를 조사하고, 식욕부진과 관련된 사회 인구학적 특성, 병리적 특성과 심리 특성 및 일상생활 수행능력 등을 조사하였다. 자료 수집은 서울, 경기, 충북 지역의 65세 이상 재가 노인 419명을 대상으로 2012년 9월에서 12월까지 구조화된 설문지를 이용하여 일대일 면접방법으로 수행하였다. 연구 결과 국내 노인의 식욕부진 유병률은 전체 응답자 가운데 35.1%였고, 특히 남성노인의 식욕부진 유병률이 여성노인보다 유의하게 높았다. 남성노인의 식욕부진은 중추신경계 질환을 진단받은 경우가 가장 많았고 여성노인의 경우 식욕부진은 내분비 질환이 있는 경우가 가장 많았다. 또한 우울증 증상이 있거나 일상생활에서 의존도가 높은 경우 식욕부진이 현저한 것으로 관찰되었다. 이상의 결과로부터 국내 재가 노인들의 식욕부진이 심각한 수준임을 알 수 있었고, 노인의 식욕부진은 생리적 특성과 병리적 특성은 물론 우울과 같은 심리적 특성과도 깊은 상관성이 있음을 알 수 있었다. 향후 노인의 식욕부진 개선이나 예방을 위하여 구체적인 영양중재와 영양치료가 필요하며, 노인인구 증가에 따라 노인의 식욕증진을 고려한 노인식품 개발이 시급히 필요할 것으로 생각된다. 본 연구 결과는 다음과 같은 제한점을 갖는다. 본 조사는 단면연구이므로 연구 결과에서 나타난 식욕 수준에 관련된 인자들이 노인의 식욕부진 원인으로 작용했는지는 알 수 없다. 따라서 추후 보다 대표성을 갖는 한국 노인을 대상으로 노인의 식욕부진 유병률의 조사는 물론 식욕부진과 관련된 원인 규명을 위하여 횡단연구가 필요하다. 또한 노인을 일대일 대면하여 자가보고 하는 방법으로 자료를 수집하였으므로 문항에 따라서는 노인에 따라 사실보다 과장하거나 축소하는 등 응답 수준이 주관적일 수도 있다. 그럼에도 불구하고 본 연구에서 나타난 식욕부진과 관련된 인자들은 선행 연구와 유사하며 따라서 자가보고에 의한 사회적 기대 효과는 다소 적었다고 판단된다. 향후 재가노인의 범위를 성별, 연령별, 지역별, 거주형태별 등으로 일치시키고 확대하여 노인의 식욕부진 실태와 관련 인자 연구의 확대를 제안한다.