• Steel and Composite Structures
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• v.34 no.6
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• pp.853-862
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• 2020

In recent years, due to the many advantages cable-stayed bridges have often constructed in medium and long span. These advantages can be listed as an aesthetically pleasing appearance, economic and easy construction, etc. The main structural elements of cable-stayed bridges are listed as deck, pylon, cables and foundation. Perhaps one of the most vital and expensive of these structural elements is stay-cables. Stay-cables ensure the allowable displacement and distribution of bending moments along the bridge deck with prestressing force. Therefore the optimum design of the stay-cables and prestressing force are very important in achieving the performance expected from the cable-stayed bridges. This paper aims to obtain the stay-cables size and prestressing force optimization of the cable-stayed bridge. For this purpose, single pylon and fan type cable configuration Manavgat Cable-Stayed Bridge was selected as an example. The three dimensional (3D) finite element model (FEM) of the bridge was created with SAP2000. Analysis of the 3D FEM of the bridge was conducted under the different combined effects of the self-weight of the structural element, prestressing force of stay-cable and live load. Stay-cable stress and deck displacement were taken into account as constraints for the optimization problem. To optimize this existing bridge a metaheuristic algorithm named Jaya was used in the optimization process. 3D FEM of the selected bridge was repeatedly analyzed by using Open Applicable Programming Interface (OAPI) properties of SAP2000. To carry out the optimization process the developed program which integrates the Jaya algorithm and the required codes for calling SAP2000 is coded in MATLAB. At the end of the study, the total weight of the stay-cables was reduced more than 40% according to existing stay cables under loads taken into account.

• Korean Journal of Materials Research
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• v.11 no.10
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• pp.879-888
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• 2001

The effects of final annealing temperature on the microstructure and creep characteristics were investigated for the Zr-lNb-0.2X (X=0, Mo, Cu) and Zr-lNb- 1Sn-0.3Fe-0.1X (X=0, Mo, Cu) alloys. The microstructures were observed by using TEM/EDS, and grain size and distributions of precipitates were analyzed using a image analyzer. The creep test was performed at $400^{\circ}C$ under applied stress of 150 MPa for 10 days. The $\beta$-Zr was observed at annealing temperature above $600^{\circ}C$. In the temperature above$ 600^{\circ}C$, the grain sizes of both alloy systems appeared to be increased with increasing the final annealing temperature. The creep strengths of Zr-1Nb-1Sn-0.3Fe-0.1X alloys were higher than those of Zr-1Nb-0.2X ones due to the effect of solid solution hardening by Sn in Zr-lNb-lSn-0.3Fe-0.1X alloy system. Also, Mo addition showed the strong effect of precipitate hardening in both alloy systems. The creep strength rapidly decreased with increasing the annealing temperature up to $600^{\circ}C$. However, a superior creep resistance was obtained in the sample that annealed to have a second phase of $\beta$-Zr. It was considered that the appearance of $\beta$-Zr would play an important role in the strengthening mechanism of creep deformation.

• Molecules and Cells
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• v.38 no.5
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• pp.416-425
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• 2015

NF-E2-related factor 2 (Nrf2), a basic leucine zipper transcription factor, has recently received a great deal of attention as an important molecule that enhances antioxidative defenses and induces resistance to chemotherapy or radiotherapy. In this study, we investigated the apoptosis-inducing and Nrf2- upregulating effects of quercetin on malignant mesothelioma (MM) MSTO-211H and H2452 cells. Quercetin treatment inhibited cell growth and led to upregulation of Nrf2 at both the mRNA and protein levels without altering the ubiquitination and extending the half-life of the Nrf2 protein. Following treatment with quercetin, analyses of the nuclear level of Nrf2, Nrf2 antioxidant response element-binding assay, Nrf2 promoter-luc assay, and RT-PCR toward the Nrf2-regulated gene, heme oxygenase-1, demonstrated that the induced Nrf2 is transcriptionally active. Knockdown of Nrf2 expression with siRNA enhanced cytotoxicity due to the induction of apoptosis, as evidenced by an increase in the level of proapoptotic Bax, a decrease in the level of antiapoptotic Bcl-2 with enhanced cleavage of caspase-3 and PARP proteins, the appearance of a sub-$G_0/G_1$ peak in the flow cytometric assay, and increased percentage of apoptotic propensities in the annexin V binding assay. Effective reversal of apoptosis was observed following pretreatment with the pan-caspase inhibitor Z-VAD. Moreover, Nrf2 knockdown exhibited increased sensitivity to the anticancer drug, cisplatin, presumably by potentiating the oxidative stress induced by cisplatin. Collectively, our data demonstrate the importance of Nrf2 in cytoprotection, survival, and drug resistance with implications for the potential significance of targeting Nrf2 as a promising strategy for overcoming resistance to chemotherapeutics in MM.

• Journal of Fashion Business
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• v.17 no.6
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• pp.28-43
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• 2013

Recent trends toward the collaborations among various sectors of academia and research areas have brought interests and significances in new activities especially in the fashion and textile areas. One of the collaboration examples is the recent research projects on 3D virtual clothing systems based on the 3D CAD software. The 3D virtual clothing systems provide simulated apparels with high degrees of fidelity in terms of color, texture, and structural details. However, since real fabrics exhibit strong nonlinearity, anisotropy, viscoelasticity, and hysteresis, the 3D virtual clothing systems need fine tuning parameters for the simulation process. In this study, characteristics of silk fabrics, which are woven by using degummed silk and raw silk yarns, are being analyzed and compared. Anisotropic properties may be measured as warp and filling direction properties separately in woven fabrics, such as warp tensile stress or filling bending rigidity. Hysteretic properties may be measured as bending hysteresis or shear hysteresis by using KES measurements. These data provide deformation-force relationships of the fabric specimen. Three-dimensional effects obtained when using these characteristic fabrics are also analyzed. The methods to control the three-dimensional appearance of the sewn fabric specimens when utilizing a programmable microprocessor-based motor device, as prepared in this study, are presented. Based on the physical and mechanical properties measured when using the KES equipment, the property parameters are being into a 3-dimensional virtual digital clothing system, in order to generate a virtual clothing product based on the measured silk fabric properties.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.4
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• pp.1589-1594
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• 2013

V.M.D(Visual Merchandising Design) covers every space, environment, and visually stimulating factor. This includes not only the architectural appearance but interior, graphic sign boards, window display, layout, store appliances, lighting, and even the looks and service attitude that sales employees have and show to customers. V.M.D aims to display merchandise in multiple ways; to heighten brand images; to steadily lure many customers to the store. One of the characteristics that V.M.D has is, that this abandons the previous design concept which solely puts stress on luxurious interior-focused display; that this displays merchandise in a rational and systemic way and induces customers to buy products. In this regard, the objective of this study is to study brand perception and effect of V.M.D displayed in the stores, on customers, and thereby to present the concepts of V.M.D, suitable for display in the stores, which can be used continuously in the future.

• Journal of the Korean Society of Clothing and Textiles
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• v.34 no.2
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• pp.189-199
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• 2010

This study develops a coverall design for the body shape and movement of infants. This research analyzed these processes: 1. The current coverall styles preferred for infants. 2. The appropriate products for the real size, body shape, movement, and fit of infants. 3. The observations of the 6 months to 9 months movement and development of infants. 4. The design and creation of a new coverall base in this study, and to check the suitable test the developed coverall design for the infant. The result of this study are: A coverall for infants that lie or crawl on the floor must avoid opening in the center front and a gore has to be added at the crotch of the pants for the better movement of infants. These ways provide infants a neat appearance and easy movement. The test of developed designs shows that the developed coverall design covers the size gap of the trunk loop according to the growth of the infant and the movement of the legs; in addition it provides a positive aesthetic effect. The waistline in the developed coverall (a waistline that should exist lower than the body waistline of the infant) can reduce seam stress because the pressure of the seam line can be absorbed in a dipper. It is one of the suitable design points for infants lying prone all day long in this study.

• Nuclear Engineering and Technology
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• v.51 no.8
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• pp.1905-1915
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• 2019

This paper investigated the influence of simple support girds on flow, irrespective of having mixing vanes, in a 1 × 3 array rod bundle by using CFD methodology and the most accurate turbulence model which could reflect the actual physics of the flow was determined. In this context, a CFD model was created simulating the experimental studies on a single-phase flow [1] and the results were compared with the experimental data. In the first part of the study, influence of mesh was examined. Tetra, hybrid and poly type meshes were analyzed and convergence study was carried out on each in order to determine the most appropriate type and density. k - ε Standard and RSM LPS turbulence models were used in this section. In the second part of the study, the most appropriate turbulence model that could reflect the physics of the actual flow was investigated. RANS based turbulence models were examined using the mesh that was determined in the first part. Velocity and turbulence intensity results obtained on the upstream and downstream of the spacer grid at -3d_h, +3d_h and +40d_h locations were compared with the experimental data. In the last section of the study, the behavior of flow through the spacer grid was examined and its prominent aspects were highlighted on the most appropriate turbulence model determined in the second part. Results of the study revealed the importance of mesh type. Hybrid mesh having the largest number of structured elements performed remarkably better than the other two on results. While comparisons of numerical and experimental results showed an overall agreement within all turbulence models, RSM LPS presented better results than the others. Lastly, physical appearance of the flow through spacer grids revealed that springs has more influence on flow than dimples and induces transient flow behaviors. As a result, flow through a simple support grid was examined and the most appropriate turbulence model reflecting the actual physics of the flow was determined.

• The KSFM Journal of Fluid Machinery
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• v.15 no.5
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• pp.60-66
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• 2012

One of commonly physical phenomena encountered in pump sump systems in which its significant influence to the hydraulic performance of pump system plays an important role in the field of fluid engineering, is the appearance of free surface and submerged vortices. In this paper, a study of the vortices behavior and their formative mechanism of asymmetry is considered in this paper by using numerical approach. The Reynolds-Averaged Navier-Stokes (RANS) equations and k-omega Shear Stress Transport turbulence model used to describe the properties of turbulent flows, in company with VOF multiphase model, are implemented by Fluent code with multi-block structured grid system. In the numerical simulation, the calculated elevation of air-water interface and vortex core contours are used to classify visually surface vortices as well as submerged vortices. It is shown that the free surface vortex is identified by the concavity of liquid region from the free surface and swirling flow at that own plane. To investigate the distinctive behavior of these vortices corresponding to each given flow rate at the same water level, some numerical testing of them are considered here in such a manner that the flow pattern of surface vortex are obtained similarly to the obtained results from experiment. Furthermore, the influence due to the change of grid refinement and the variation of depth of the concavity are also considered in this paper. From that, these influential factors will be implemented to design a good pump sump with higher performance in the future.

• Journal of Ginseng Research
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• v.42 no.4
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• pp.540-548
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• 2018

Background: Acute hepatic failure is a life-threatening critical condition associated with rapid deterioration of liver function and liver transplantation. Several studies have shown that Panax ginseng Mayer has antidiabetic and hepatoprotective effects. However, the hepatoprotective effect of ginseng berry is still unveiled. In this study, we evaluated the hepatoprotective effects of ultrasonication-processed ginseng berry extract (UGBE) on acute hepatic failure model in rats. Methods: Ginseng berry extract (GBE) was ultrasonically processed. The GBE, silymarin, and UGBE were orally administered to male Sprague-Dawley rats for 4 wk. Twenty-four h after the last administration, rats were challenged with D-galactosamine (D-GalN)/lipopolysaccharide (LPS). Results: After ultrasonication, the component ratio of ginsenosides Rg2, Rg3, Rh1, Rh4, Rk1, Rk3, and F4 in GBE had been elevated. Administration of UGBE significantly increased the survival rate of D-GalN/LPS-challenged rats. Pretreatment with UGBE significantly decreased serum alanine aminotransferase, aspartate aminotransferase, and total bilirubin levels in D-GalN/LPS-challenged rats in a dose-dependent manner. The levels of enzymatic markers for oxidative stress (superoxide dismutase, glutathione peroxidase, catalase, and glutathione) were increased by UGBE treatment in a dose-dependent manner. Tumor necrosis factor alphalevel, inducible nitric oxide synthase activities, and nitric oxide productions were reduced by UGBE treatment. In addition, hemeoxygenase-1 levels in liver were also significantly increased in the UGBE-treated group. The protein expression of toll-like receptor 4 was decreased by UGBE administration. Hematoxylin and eosin staining results also supported the results of this study showing normal appearance of liver histopathology in the UGBE-treated group. Conclusion: UGBE showed a great hepatoprotective effect on D-GalN/LPS-challenged rats via the toll-like receptor 4 signaling pathway.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.597-600
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• 2008

In this study the reason which researches the feature of the exposure type waterproofing it uses the technique of the soft FRP it uses the soft unsaturated polyester and the square groove cutting technique with respects and solves the interface separate problem because of the rigid FRP it is used with the repairs and retrofit materials it is caused by in adhesion of concrete insufficiency. The feature of this technique was the dispersion and the reinforcement of the fatigue stress due to the integration behavior and the reinforcement due to the glass-fibre of the concrete due to the soft FRP resin and, it investigated the crack appearance confrontation of concrete and the cohesion stability of the concrete due to the square groove cutting technique with importance. The result of research when it applies the soft FRP with the exposure type waterproofing, is judged with the fact that it will be able to expect a bulge resistance confrontation and creak confrontation ability and cohesion stability improvement.