• Journal of Pharmaceutical Investigation
• /
• 제35권4호
• /
• pp.279-285
• /
• 2005

Ground CS-891 (N-[1-(4-methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-5a-androst-1-ene-$17{\beta}$-carboxamide) of poorly water soluble drug was obtained using a Heiko Seisakusho model TI-100 vibration mill, and samples with different crystallinity were prepared at mixture ratios of 10:0, 7:3, 5:5, 3:7 and 0:10 (intact;ground CS-891). Physicochemical characterizations were obtained using qualitative and quantitative X-ray diffractometry, different scanning calorimetry (DSC), scanning electron microscopy (SEM), Quantasorb surface area analyzer, and controlled atmosphere microbalance. With increase of amorphous CS-891 in mixture ratios, the intensities of X-ray diffraction peaks of crystalline CS-891 were decreased, whereas surface area, water absorption, and exothermic peaks in DSC were increased. The apparent solubility of ground CS-891 was $4.4\;{\mu}g/ml$ and the solubility of intact CS-891 was $3.1\;{\mu}g/ml$ at $37{\pm}1^{\circ}C$. The apparent precipitation rates of CS-891 in a supersaturated solution during the solubility test were increased with an increase of amorphous CS-891, and a crystalline form of CS-891 transformed from amorphous CS-891 after the solubility test was found by X-ray diffraction analysis, DSC and SEM. The dissolution profiles of CS-891 with different crystallinity at $37{\pm}1^{\circ}C$ by the USP paddle method were investigated, and the apparent dissolution rate constant of ground CS-891 was about 5.9-fold higher than that of intact CS-891. A linear relationships between the crystallinity of CS-891 and the apparent dissolution rate constant (r>0.96) were obtained.

• Journal of the Korean Wood Science and Technology
• /
• 제47권3호
• /
• pp.290-298
• /
• 2019

The sound absorption coefficient and transmission loss of several types of rice hull mats with varying apparent densities and thicknesses are estimated in this paper using the transfer function and matrix methods, respectively, to evaluate the possibility of using rice hull as an acoustic construction material. The mean sound absorption rates of 10-cm-thick rice hull mats with target densities of $0.10g/cm^3$, $0.12g/cm^3$, and $0.14g/cm^3$ were 0.91, 0.92, and 0.95, respectively, while those of the 1-cm-thick plywood attached to the back of the rice hulls were 0.90, 0.92, and 0.92, respectively. The means of the sound transmission loss of the 10 cm-thick rice hull mats with the target densities of $0.10g/cm^3$, $0.12g/cm^3$, and $0.14g/cm^3$ were 7.66 dB, 10.49 dB, and 14.14 dB, respectively, while those of the 1 cm-thick plywood attached to the back of the rice hulls were 33.34 dB, 36.72 dB, and 38.95 dB, respectively. In conclusion, a rice hull mat could be used as acoustic construction materials because of its high sound absorption coefficient and sound transmission loss.

• Asian-Australasian Journal of Animal Sciences
• /
• 제23권1호
• /
• pp.90-97
• /
• 2010

An experiment was conducted to evaluate the effects of low concentrations of organic and inorganic dietary trace minerals on broiler performance and trace mineral digestibility along the small intestine of 35-day-old broiler chickens reared under floor-pen conditions. Eight hundred male, day-old Cobb broiler chickens were randomly allocated to 4 dietary treatments (25 birds per pen with 8 replicates per treatment). Broilers fed diets supplemented with 4, 20, 40 and 30 mg/kg, respectively, of Cu, Fe, Mn and Zn from organic chelates and inorganic salts achieved the same body weight gain as those supplemented at the NRC levels (8 mg Cu, 40 mg Fe, 60 mg Mn and 40 mg Zn/kg, respectively) from inorganic salts. However, birds fed a control diet without any supplementation at dietary levels of 7.4-8.8, 60.1-69.2, 14.6-15.4 and 19.1-20.6 mg/kg of Cu, Fe, Mn and Zn, respectively, had decreased feed intake and growth rate. There was no significant difference in the digestibility of Cu in all regions of the small intestine. Throughout the small intestine the apparent absorption of Mn from both organic and inorganic sources was small, whereas the digestibility of Zn seemed to be more complex, exhibiting differences in the apparent absorption due to both mineral source and intestinal site. Therefore, the digestibility of organic Zn was improved (p<0.01) in the ileum compared to inorganic Zn. The digestibility of Zn in the duodenum was smaller (p<0.05) than that in the ileum.

• Asian-Australasian Journal of Animal Sciences
• /
• 제20권7호
• /
• pp.1120-1126
• /
• 2007

An iron-fortified whey protein concentrate (Fe-WPC) was prepared by addition of ferric chloride to concentrated whey. A large part of the iron in the Fe-WPC existed as complexes with proteins such as ${\beta}$-lactoglobulin. The bioavailability of iron from Fe-WPC was evaluated using iron-deficient rats, in comparison with heme iron. Rats were separated into a control group and an iron-deficiency group. Rats in the control group were given the standard diet containing ferrous sulfate as the source of iron throughout the experimental feeding period. Rats in the iron-deficiency group were made anemic by feeding on an Fe-deficient diet without any added iron for 3 wk. After the iron-deficiency period, the iron-deficiency group was separated into an Fe-WPC group and a heme iron group fed Fe-WPC and hemin as the sole source of iron, respectively. The hemoglobin content, iron content in liver, hemoglobin regeneration efficiency (HRE) and apparent iron absorption rate were examined when iron-deficient rats were fed either Fe-WPC or hemin as the sole source of iron for 20 d. Hemoglobin content was significantly higher in the rats fed the Fe-WPC diet than in rats fed the hemin diet. HRE in rats fed the Fe-WPC diet was significantly higher than in rats fed the hemin diet. The apparent iron absorption rate in rats fed the Fe-WPC diet tended to be higher than in rats fed the hemin diet (p = 0.054). The solubility of iron in the small intestine of rats at 2.5 h after ingestion of the Fe-WPC diet was approximately twice that of rats fed the hemin diet. These results indicated that the iron bioavailability of Fe-WPC was higher than that of hemin, which seemed due, in part, to the different iron solubility in the intestine.

• Journal of Nutrition and Health
• /
• 제38권1호
• /
• pp.40-47
• /
• 2005

This study was performed to determine the effect of three different concentrations of soy-isoflavones on calcium and phosphorus balance in either sham-operated or ovariectomized female rats. Seventy-two 16-week old Sprague-Dawley rats underwent sham operation or bilateral ovariectomy. They were provided diets containing different levels of soy iso-flavones for 6 weeks: 50 ppm (Jow isoflavone intake; LI) , 250 ppm (medium isoflavone intake; MI) and 500 ppm (high isoflavone intake; HI). The subsequent fecal and urinary excretions of calcium and phosphorus were then measured. In the sham-operated rats, body weight gains and food efficiency ratio of the MI and HI groups were significantly lower than the control group while food intake was not different. However, there was no significant difference in the ovariectomized rats. The fecal excretion of calcium was significantly lower in the LI, MI and HI groups than the control group in sham operated rats, and significantly lower in the HI group than the control group in ovariectomized rats. Also, apparent ab-sorption rate of calcium and phosphorus did not show any significant difference among groups. Urinary excretion of calcium and phosphorus was significantly lower in the HI group than the LI group in the sham-operated rats. Urinary excretion of calcium was significantly higher in the control ovariectomized rats than in the control sham-operated rats. Retention of calcium and phosphorus did not show any significant difference in both groups. From the above result, we see that isoflavone intake increases calcium retention through an increase in calcium absorption and also suppresses the increase of calcium excretion in urine in ovariectomy. Therefore, it is suggested that isoflavone intake is recommended for menopausal women who experience sharp bone loss due to the decrease in estrogen honnone.

• 유기물자원화
• /
• 제12권4호
• /
• pp.85-94
• /
• 2004

본 연구에서는 가연성 건설폐기물인 폐목재와 폐발포폴리스티렌의 유효이용을 목적으로 열압성형법에의한 폐목재-플라스틱 복합패널을 제조하였다. 전열프레스를 이용하여 다양한 성형조건하에서 복합패널 공시체를 제조하였으며, 그 겉보기 밀도, 흡수율, 흡수에 의한 두께 팽창률, 휨강도 등에 관한 일련의 실험을 행하였다. 폐목재-플라스틱 복합패널의 밀도는, 성형 온도 및 성형 시간에 관계없이, 성형 압력의 증가에 따라 높아지는 반면, 그 흡수율의 성형압력의 증가에 따라 작아진다. 복합패널의 흡수에 의한 두께 팽창률은, 성형 조건에 관계없이, 모두 1.2~2.0%의 범위에 있어, 높은 치수 안정성을 보인다. 복합패널의 휨강도는, 성형 온도 $120^{\circ}C$, 성형 시간 15min에서 일정하게 되는 경향이 있으며, 성형 온도 및 성형 시간에 관계없이, 성형 압력의 증가에 따라 현저하게 증가한다. 중합 반응과 성형을 동시에 하는 리액션프로세싱인 이 방법은, 그 제조 공정이 간단하고, 또한, 결합재로서 폐발포폴리스티렌 용액을, 골재로서 폐목재 칩을 이용하기 때문에, 공업 생산성이 있는 건설 발생 폐목재 및 폐발포폴리스티렌의 리사이클 방법으로서 지극히 유효하다고 생각된다.

• 대한치과기공학회지
• /
• 제36권1호
• /
• pp.9-15
• /
• 2014

Purpose: Generally dental technicians clinically decide the sintering temperature of zirconia artificial teeth to match the color of the teeth. However, the sintering temperature influence the microstructure and mechanical strength of ceramic body. In this study, to evaluate the free choice of sintering temperature which leads to color the problems in zirconia false teeth, the variation of microstructure, mechanical strength, and colortone of zirconia ceramics according to the change of sintering temperature was investigated. Methods: Bar type specimens were prepared from commercial zirconia blocks by cutting and polishing into $0.8cm(L){\times}1.0cm(W){\times}4.8cm(H)$. Specimens were fired from 1,400 to $1,700^{\circ}C$ at $50^{\circ}C$ intervals and held for 1hour at highest temperature. Apparent porosity, water absorption, firing shrinkage, bulk density, bend strength, whiteness were tested. Microstructures were observed by SEM. Results: When fired above $1450^{\circ}C$, all specimens showed 0% apparent porosity and water absorption, 20% firing shrinkage, and $6.1g/cm^3$ bulk density regardless of firing temperatures. SEM photomicrographs showed grain growth of zirconia occurred above $1,600^{\circ}C$. Whiteness was also largely changed above this temperature. Maximum bend strength of 1,05MPa was obtained at $1,550^{\circ}C$. Bend strength lowered slightly above this temperature and showed $950{\ss}\acute{A}$ at $1,700^{\circ}C$. Conclusion: In order to fit the colortone of zirconia artificial teeth, arbitrary choice of firing temperature higher than $1,500^{\circ}C$, up to $1,700^{\circ}C$ did not influence the mechanical strength.

• Journal of Nutrition and Health
• /
• 제37권8호
• /
• pp.645-654
• /
• 2004

This study examined the effect of excess calcium (Ca) on the iron (Fe) bioavailability and bone growth of marginally Fe deficient animals. Two groups of weanling female SD rats were fed either normal Fe (35 ppm) or Fe deficient diet (8 ppm) for 3 weeks. Then each group of animals were assigned randomly to one of three groups and were fed one of six experimental diets additionally for 4 weeks, containing normal (35 ppm) or low (15 ppm) Fe and one of three levels of Ca as normal (0.5%), high (1.0%), or excess (1.5%). Feces and urine were collected during the last 3 days of treatment. After sacrifice blood, organs, and femur bone were collected for analysis. Final body weight and average food intake were not affected by either the levels of dietary Ca or Fe. Low Fe diet significantly reduced the level of serum ferritin, however, for Hb, Hct, and TIBC no difference was shown than those in the normal Fe group. TIBC increased slightly by high and excess Ca intake in low Fe groups. For both normal and low Fe groups, high and excess Ca intakes reduced the apparent absorption of Fe and Fe contents of liver significantly (p < 0.05). Calcium contents in kidney and Femur of rats that were fed high and excess levels of Ca were significantly greater than those of normal Ca groups. However, weight, length, and breaking force of the bone were not affected by increased Ca intakes. Both in control and low Fe groups, high and excess intakes of Ca decreased the apparent absorption of Ca. These results indicate that the excess intakes of calcium than the normal needs would be undesirable for Fe bioavailability and that the adverse effects be more serious in marginally iron deficient growing animals. In addition bone growth and strength would not be favorably affected by high Ca intakes, though, the long term effect of increased Ca contents in bone requires further examination.

• 콘크리트학회논문집
• /
• 제20권5호
• /
• pp.653-660
• /
• 2008

본 연구는 펄라이트를 이용한 흡음재료의 흡음성능을 개선시키기 위한 최적배합에 대한 분석을 실시하였다. 결합재로서 폴리머 시멘트 슬러리와 무기질 결합재를 사용하여 흡음재료를 각종 배합조건에 따라 제작하여, 강도, 동결 융해 저항성, 그리고 흡음성능에 대하여 실험을 실시하였다. 실험 결과, 관내법에 의한 흠음재의 흠음계수는 배합에 따라 약간의 차이가 있으나 폴리머 디스퍼션을 결합재로 사용한 경우 흡음재의 감음계수 (NRC)는 $0.48{\sim}0.51$로 시멘트만 결합재로 사용한 경우에 비해 약간 크게 나타났으나, 방음벽의 환경부 고시 기준에서의 흡음재로서 감음계수 0.70에 비하면 낮은 수치이다. 그러나 잔향실법에 의한 흡음용 패널의 저주파수 영역($250\;Hz{\sim}500\;Hz$)에서 흡음계수가 $0.84{\sim}1.00$로 매우 높게 나타났으며, 고주파 영역에서도 $0.57{\sim}0.77$ 정도로 비교적 높은 흡음률을 나타내 감음계수가 0.77로 높게 나타났다. 폴리머 디스퍼션을 결합재로 사용한 흡음재는 압축강도, 휨강도 및 동결융해 저항성 등에서 방음벽 재료로서 적당한 성능을 발휘하였으며, 성능과 가격면에서 밸런스를 확보할 수 있는 배합을 도출할 수 있었다.

• Journal of Radiation Protection and Research
• /
• 제26권2호
• /
• pp.51-58
• /
• 2001

환경방사능과 같은 저준위 방사능 측정에서는 원통형과 Marinelli형 측정용기가 가장 일반적으로 사용된다. 효율교정용 표준선원과 측정시료의 높이 또는 매질의 밀도가 다르면 자체흡수 효과의 차이로 인한 보정이 필요하다. 본 연구에서는 Monte Carlo 방법을 이용하여 HPGe 검출기의 전에너지 피크 효율을 계산하여 측정치와 비교하였다. 원통형 용기에 대해서는 높이에 대한 효율변화 정도를 계산하였고, 원통형 및 Marinelli 측정용기에 대해서는 밀도변화에 따른 효율을 계산하였다. 밀도에 따른 효율의 감소 정도는 1000keV 이하의 에너지 영역에 대해 자체흡수 효과의 보정치 필요하다는 것을 알았다. 또한 계산의 타당성을 검증하기 위하여 NIST SRM 4353 표준물질을 이용하여 계산값과 인증값을 상호비교한 결과 오차범위 이내로 잘 맞는 다는 것을 확인하였다.