• The Korean Journal of Physiology and Pharmacology
• /
• v.18 no.3
• /
• pp.191-200
• /
• 2014

We investigated the anxiolytic-like activity of ${\alpha}$-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The putative anxiolytic effect of AAS was studied in behavioral tests of anxiety, such as the elevated plus maze (EPM) test and the hole-board test (HBT) in rats. For 21 consecutive days, male rats received 50, 100, or 200 mg/kg AAS (i.p.) 30 min prior to a daily injection of CORT. Dysregulation of the HPA axis in response to the repeated CORT injections was confirmed by measuring serum levels of CORT and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Daily AAS (200 mg/kg) administration increased open-arm exploration significantly in the EPM test, and it increased the duration of head dipping activity in the HBT. It also blocked the increase in tyrosine hydroxylase (TH) expression in the locus coeruleus (LC) and decreased mRNA expression of brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, in the hippocampus. These results indicated that the administration of AAS prior to high-dose exogenous CORT significantly improved anxiety-like behaviors, which are associated with modification of the central noradrenergic system and with BDNF function in rats. The current finding may improve understanding of the neurobiological mechanisms responsible for changes in emotions induced by repeated administration of high doses of CORT or by elevated levels of hormones associated with chronic stress. Thus, AAS did exhibit an anxiolytic-like effects in animal models of anxiety.

• Journal of Microbiology and Biotechnology
• /
• v.21 no.10
• /
• pp.1088-1096
• /
• 2011

The purpose of this study was to evaluate whether wild ginseng (WG) administration could attenuate anxiety- and depression-like behaviors and expression of corticotrophin-releasing factor (CRF) and neuropeptide Y (NPY) following withdrawal from repeated morphine administration in rats. Male rats were administered daily doses of WG (50, 100, or 200 mg/kg, i.p.) for 5 days, 30 min before morphine injection (40 mg/kg, s.c). The anxiety- and depression-like behavioral responses were measured 72 h after the last morphine injection using an elevated plus maze (EPM) and forced swimming test (FST), respectively. Changes in hypothalamic CRF and NPY expressions were also examined by analyzing their immunoreactivities in the hypothalamus. Daily administration of WG significantly reduced anxiety- and depression-like behavior, and elicited the suppression of CRF expression and the stimulation of NPY expression in the hypothalamus. Our results demonstrated that WG extract might be effective at inhibiting the anxiety and depression responses due to morphine withdrawal by possibly modulating the hypothalamus CRF and NPY systems. Furthermore, these findings imply that WG extract can be used for developing new medication to cure or alleviate morphine withdrawal symptoms and to prevent relapses of morphine use.

• Journal of the Korean School Mathematics Society
• /
• v.17 no.4
• /
• pp.589-611
• /
• 2014

Since most people experience mathematics anxiety(MA), the research on mathematics anxiety has been the main theme in the research of mathematics education. The study of brain science related to MA has recently been begun due to the advent of apparatuses so this study might have revisited MA as time passed and aimed to obtain realistic implications for the future study. For this purpose, we analyzed previous studies how to measure MA and how to develop the intervention to reduce MA. As the result, the researchers based on brain science studied the relevance of specific parts of the brain according to the degree of MA using only simple computational tasks. The research for developing the MA scale has upgraded how to measure both the cognitive and affective domains with more efficient ways. The research on intervention for MA has developed the programs using systematic desensitization, clinical counseling, STAD teaching method, writing methods, etc. However, we realized that more specified and reliable studies to solve the MA must be done in the future.

• Journal of Korean Biological Nursing Science
• /
• v.11 no.1
• /
• pp.85-91
• /
• 2009

Purpose: The purpose of this study was to investigate effect of aroma oil inhalation using lavender mixed with bergamot, and sandalwood oil in the ratio of 3:2:1 to the anxiety of colonoscopy patients. Method: The research design was a nonequivalent control group pre-post time experimental research. The data were collected from December, 2004 to March 2005. The total subjects were 60 patients who received colonoscopy at K-hospital in Chuncheon City. An aroma oil inhalation group inhaled for 10 min the mixed aroma oil, 3 drops of which were dropped on the gauze, 20 min before colonoscopy. Result: The anxiety of the intervention group was significantly lower than that of the control group (p=.001). The degree of systolic blood pressure on the intervention group was significantly lower than that of the control group (p=.031). There was no significant difference between the 2 groups in the diastolic pressure (p=.065). Pulse has no significant difference between the aroma oil inhalation and control group (p=.546). Conclusion: The result showed that aroma oil inhalation before colonoscopy has an effect on decreasing anxiety. Thus, the intervention with aroma oil inhalation can be used for relieve anxiety of patients for colonoscopy.

• Asian Oncology Nursing
• /
• v.10 no.1
• /
• pp.112-118
• /
• 2010

Purpose: The purpose of this study was to examine the effects of music therapy on pain, depression, and anxiety in terminally ill patients. Methods: Twenty patients in the experimental group were provided with music via headphones for 30-40 min at a time as they requested for 2 weeks, whereas no music was provided for the nineteen patients in the control group. Data were collected using a questionnaire. The research instruments included Visual Analog Scale (VAS) and Depression & Anxiety Inventory Scale. Data were analyzed using ${\chi}^2$-test, t-test, and Fisher's exact test, using SPSS 15.0. Results: There were significant decreases in the scores of pain at present (t=-2.54, p<.05), depression (t=-2.187, p<.05) and anxiety (Z=-2.114, p<.05) in the experimental group compared to those in the control group. Conclusion: Music therapy is considered non-invasive and inexpensive intervention and can be easily applied to alleviate pain, depression and anxiety for terminally ill patients.

• Korean Journal of Biological Psychiatry
• /
• v.19 no.1
• /
• pp.9-16
• /
• 2012

This article aimed to describe typical event-related potentials (ERP) components of emotional processing in patients with anxiety disorder and highly anxious individuals. ERP components associated with emotional processing could be broadly divided into three components with short, middle and long, respectively. Many studies show that patients with anxiety disorders are characterized by different emotional bias to specific stimuli and more sensitive to emotional stimuli than normal individuals. In addition, these emotional biases were stronger and quicker in patients with anxiety disorder than normal individuals. Some studies reported that anxious people show abnormality at the initial stage (e.g. P1) of emotional processing. However, other studies reported the abnormality at the late stage (e.g. LPP) or wholeness of emotional processing in anxious individuals. We summarized the updated finding of possible ERP components of emotional processing in patients with anxiety disorder and highly anxious individuals. The significance and clinical implication were discussed.

• Research in Community and Public Health Nursing
• /
• v.17 no.1
• /
• pp.91-101
• /
• 2006

Purpose: This research is to know whether aroma foot massage has influence on the relief of anxiety and pain during colonoscopy under conscious sedation. Method: This research was designed as a quasi-experiment of non-equivalent control group pretest-posttest. Data were collected from April 1 2005 to August 30 2005. The subjects were divided into three groups (control group, foot massage group and aroma foot massage group) with 30 persons each. Anxiety was evaluated with Visual Analogue Scale (VAS), blood pressure and pulse. Pain response was measured with VAS and non-verbal pain behavior score. Sleep satisfaction was measured with a graphic rating scale. Data were analyzed through Chi-square test, t-test and repeated measure ANOVA. Results: Systolic blood pressure, pulse, subjective anxiety and pain scores from the aroma foot massage group decreased significantly. Sleep satisfaction score of the aroma foot massage group increased significantly. Diastolic blood pressure from the aroma foot massage group did not decrease. Conclusion: The results show that aroma foot massage with refined oils can increase sleep satisfaction and decrease anxiety and pain during colonoscopy under conscious sedation.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.5
• /
• pp.2109-2114
• /
• 2014

Background: The aim of this planned research was to determine the comfort and anxiety levels of women with breast cancer receiving radiotherapy. Materials and Methods: This descriptive type study covered patients that applied to the radiation oncology breast polyclinic of our university hospital between January and May 2011. Patient Identification Form, Radiation Therapy Comfort Questionnaire (RTCQ), Spielberger State Trait Anxiety Inventory (STAI) were completed and analysed. Results: The mean age of the women who participated in the study was $51.6{\pm}10.4$ years. Mean scores of women were $3.73{\pm}0.31$ for RTCQ, $29.1{\pm}5.88$ for SAI and $37.8{\pm}6.91$ for TAI. While the comfort levels of the women with breast cancer receiving radiotherapy were moderate, they experienced only low levels of anxiety. Conclusions: By determining the comfort level of the patient before radiotherapy, besides providing comfort in this direction, eliminating/minimizing anxiety and stress will positively affect radiotherapy application. More attention of nurses to this issue is to be recommended.

• Journal of Fisheries and Marine Sciences Education
• /
• v.27 no.3
• /
• pp.644-655
• /
• 2015

This study was planned to examine the moderating effects of depression and anxiety and the relationship between online game addiction and adolescents' delinquency. Data were collected from children and youth's mental health advocacy research by National Youth Policy Institute. The subjects were 409 adolescents aged between 14 and 18. Correlational analysis and hierarchical regression analysis were conducted to test research hypotheses. Results of this study were as follows: first, online game addiction had a significant positive relations with adolescents' delinquency. Second, depression and anxiety were significant positive relations with each other. And depression and anxiety were significant positive relations with adolescents' delinquency. The result from hierarchical regression analysis showed that significant moderating effect of depression was found. But the result wasn't exhibited twithin hat the two-way interaction effects of depression. On the other hand, result from hierarchical regression analysis showed that significant moderating effect of anxiety wasn't found. In conclusion, this study proposed the need for counseling approach focused on 'depression' in order to reduce the adolescent's delinquency.

• Korean Journal of Psychosomatic Medicine
• /
• v.15 no.1
• /
• pp.3-6
• /
• 2007

Anxiety disorders are common illness to general physician. The comorbidity between anxiety disorders and medical illness is not only a diagnostic issue, but also has implications of the course of the disease and its outcome. The comorbid condition requires consideration of each individual illness, their psychological and physiological condition. This article aims to review the literature on the prevalence of anxiety disorders in patients prescribing to psychiatrists and to discuss pharmacological treatment options for patients with a comorbid anxiety disorder and medical illness.