• 생약학회지
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• 제13권2호
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• pp.87-91
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• 1982

This study was undertaken to investigate the effect of 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' on anti-inflammatory and antiulcerative actions, and motility of isolated intestine of mice. The results of this study were summarized as follows; Anti-inflammatory effect was showed markedly by the administration of water extract of 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang'. Isolated intestine of mice was relaxed with the treatment of 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' and intestinal contraction induced by $BaCl_2$ and acetylcholine was also inhibited. The water extract of 'Jakyakgamcho-Tang' and parched 'Jakyakgamcho-Tang' were significantly inhibited Shay's ulceration in rats.

• 한국식품영양과학회지
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• 제26권1호
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• pp.98-102
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• 1997

소화기계에 대한 식혜의 생리적 영향을 알아보기 위 한 일환으로 식혜를 섭취 시킨 마우스에 에탄올을 이용하여 위궤양을 유발시켜 식혜의 위궤양 예방효과를 살펴보고자 하였다. 사용된 식혜는 산업화된 시판식혜 및 가정용 식혜의 두 가지였으며 각각 식이에 대해 0.3% 및 3%농도로 첨가하여 45일간 투여하였다. 위궤양에 대한 식혜의 예방효과를 알아보기 위하여 위점막 표면의 pH, 위점액량 및 궤양지수를 측정하였다. 위점막표면 pH는 대조군은 3.4, 식혜투여군은 3.8~3.9의 값을 나타내어 대조군에 비하여 식혜투여군에서 다소 높은 경향을 나타내었으나, 유의한 차이는 관찰되지 않았다(p>0.05). 위점액량과 제양지수에 있어서도 대조군이 556.4$\mu\textrm{g}$ alcian blue/g wet tissue와 18.6mm의 값을 나타낸 반면, 식혜투여군에서는 595.2~673.5$\mu\textrm{g}$ alcian blue/g wet tissue와 13.7~17.8mm의 값을 나타내어 식혜투여군에서 위점액량은 증가되고 궤양지수는 감소되는 경향을 나타내어 식혜의 위궤양 예방효과의 가능성을 시사하였으나, 실험군간의 유의한 차이는 관찰되지 않았다(p>0.05).

• 생약학회지
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• 제36권1호통권140호
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• pp.38-43
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• 2005

This study was undertaken to evaluate the gastrotherapeutic effects of the extract of Rosa rugosa. It can be regarded that the antigastric and anti-ulcerative effect of Rosa rugosa is originated from the reduction of total acid output identified by gastric secretion test. To clarify the protective mechanism of the Rosa rugosa extract, the gastropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. The acitivity of superoxide dismutase and glutathione peroxide were significantly increased and the total content of glutathione was recovered. We concluded that the protective effect of the extract of Rosa rugosa on gastropathy in rats is its ability increased the activities of the free radical scavenging enzymes.

• 약학회지
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• 제55권2호
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• pp.160-167
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• 2011

Cirsium japonicum var. ussuriense (CJ) is used as a folk medicine for diuretic, arthritis, dyspepsia, and bleeding in Korea. Until now, more than fifteen kinds of CJ were identified and among them, Cirsium japonicum var. nakaianum Nakai was selected as experimental material. Both that from The Medical Herb Garden of Seoul National University located at Gayang-dong, Koyang city and native that from a hillock near Dangjin, Chungnam were collected and analyzed to determine whether it is varied in efficacy on their habitats. Extracts and fractions of CJ had a strong effect of antibacterial activity on H. pylori and antioxidant effects. And the CJ from Garden and Dangjin were showed to be more efficient in acute gastritis through the HCl${\cdot}$ethanol-induced gastric lesion test and chronic gastritis through the indomethacin-induced gastric lesion test, respectively. This study proved that the effects of CJ are varied by their habitats. Also, these results suggest that the CJ has potentials for use as functional food and medicine.

• Biomolecules & Therapeutics
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• 제4권3호
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• pp.285-290
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• 1996

This study was designed to determine the effect of newly synthesized antiulcer agent, 5-pyrrolyl-6-halo-2-(pyridyl-2-methylthio)benzimidazole derivatives (IY-81233), on various experimental ulcers and on the secretion of prostaglandin $E_2(PGE_2)$ into the gastric lumen of rat. IY-81233 was previously reported to have a strong inhibitory effect on $H^+/K^$-ATPase and on gastric acid secretion in rats. Oral administration of IY-81233 at concentrations of 0.2, 2.0, and 20 mg/kg inhibited gastric lesions and duodenal ulcer induced by indomethacin, HCI-ethanol, water-immersion stress, cysteamine, and acetic acid in a dose dependent manner. Their IC$IC_{50}$ values were 3.4, 1.4, 0.8, 1.3, and 1.2 mg/kg, respectively. These results indicate that IY-81233 is a potent antiulcer agent although it is slightly less potent than omeprazole in healing of gastritis and ulcers. The secretion of $PGE_2$ into gastric lumen was also investigated in relation to the cytoprotective effect by IY-81233 in rats. The $PGE_2$ level was not changed significantly by an oral administration of IY-81233, suggesting that IY-81233 has little effect on the gastric protection. Therefore, it can be concluded that IY-81233 exerts prominent antiulcer activity by suppressing gastric acid secretion via an inhibition of a proton pump and not by protecting the gastrointestinal mucosa against various ulcerative stimuli.

• 약학회지
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• 제49권3호
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• pp.237-243
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• 2005

Present study was performed for the development of a new supplementary product with gastroprotective effect. The preliminary screening were conducted for the effects of HCl-ethanol-induced gastric lesions in rats. Samples were aloe gel, active hexose correlated compound (AHCC) mentioned that have GI protective property and pulmuone healthy aloe gel (PHAG) that mixture of natural products from Pulmuone company. Aloe gel significantly inhibited HCl-ethanol-induced gastric lesions at the oral dose of 5 ml/kg. AHCC showed the strongest effectiveness at the oral dose of 1,200 mg/kg. PHAG also showed the significant effects at the oral dose of 10, 20 g/kg. In pylorus ligated rats, the treatments of aloe gel, AHCC and PHAG showed decrease in the volume of gastric secretion and acid output. And aloe gel, AHCC and PHAG significantly suppressed the aspirin-induced ulcer and chronic ulcer in pylorus ligated rats. The treatments of aloe gel and PHAG significantly reduced acetic acid-induced ulcer at the oral dose of 5 ml/kg and 10 g/kg for 12 days. In this study; we have found that PHAG had significant improvement in acute gastritis and ulcer at the dose of 20 g/kg and in chronic gastritis and ulcer at the dose of 10 g/kg. Also we evaluated the anti-bacterial activity against H. pylori treated with aloe gel, AHCC and PHAG. PHAG had a equivalent anti bacterial activity with ampicillin against H. pylori at the dose of 1 g/kg.