Browse > Article

Effect of the Rosa rugosa Extract on the Rat with the Alcohol-salicylate-induced Gastropathy  

Park, Hee-Juhn (Department of Botanical Resources, Sangji University)
Lim, Sang-Cheol (Department of Botanical Resources, Sangji University)
Kim, Dong-Hoon (College of Pharmacy, Kyungsung University)
Lee, Jeung-Hee (College of Pharmacy, Kyungsung University)
Kang, He-Ok (College of Pharmacy, Kyungsung University)
Choi, Jong-Won (College of Pharmacy, Kyungsung University)
Publication Information
Korean Journal of Pharmacognosy / v.36, no.1, 2005 , pp. 38-43 More about this Journal
Abstract
This study was undertaken to evaluate the gastrotherapeutic effects of the extract of Rosa rugosa. It can be regarded that the antigastric and anti-ulcerative effect of Rosa rugosa is originated from the reduction of total acid output identified by gastric secretion test. To clarify the protective mechanism of the Rosa rugosa extract, the gastropathy was induced in rats with alcohol-salicylate and the activities of the free radical scavenging enzymes were examined. The acitivity of superoxide dismutase and glutathione peroxide were significantly increased and the total content of glutathione was recovered. We concluded that the protective effect of the extract of Rosa rugosa on gastropathy in rats is its ability increased the activities of the free radical scavenging enzymes.
Keywords
Rosa rugosa; alcohol-salicylate; antiulcerative; superoxide dismutase; glutathione peroxidase; glutathione;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Yasusyki, H., Satoshi, T., and Junya, M. (1989) Antimicroboal sesquiterpene from damaged Rosa ruga leaves, Phytochem. 28: 425-430   DOI   ScienceOn
2 Lowry, O. H., Rosebrough, N. J., Farr A L., and Rendall, R. J. (1951) Protein Measurement with folin phenol reagent. J. BioI. Chem. 193: 265-275
3 Sontag, S., Graham, D. Y., Belsito, A, and Weiss, J., Farley, A, Grunt, R, Cohen, N., Kionnear, D., Daois, W., Archarmbault, A. (1984) Cimetidine, cigarette smoking and recurrence of duodenal ulcer. N. Eng. J. Med. 311: 689-693   DOI   ScienceOn
4 Tames, D. L., Warren, B. B., Colleen, B., John, T. F., and Brian, L. S. (2002) Hospitaligation and mortality rates from peptic ulcer disease and GI bleeding in the 1990s. Amer. J. Castro. 97: 2540-2549   DOI   ScienceOn
5 Ashraf, F. Youssef, P. T., and Farrel L. F. (2003) Safety and pharmacokinetics of oral lansoprazole in preadolescent rats exposed from weaning through sexual maturity. Reproductive Taxicol. 17: 109-116   DOI   ScienceOn
6 Martin, J. P., Dailey, M., and Sugarman, E. (1987) Negative and positive assays of superoxide dismutase based on hematoxylin autoxidation. Arch. Biochem. Biophys. 255: 329-336   DOI   ScienceOn
7 Thomxon, A. B. and Mayai, S. (1985) Medical management of uncomplicated peptic ulcer disease Bochus Gastroenterology, Berk J. E., EB Sanders Co., USA, p.1116-1119
8 Yasuyuki, H. (1996) The phytochemistry of Rosa rugosa. Phytochem. 43: 535-549   DOI   ScienceOn
9 Pagila, E. D. and Valentine, W. N. (1967) Studies on the quantitative and qualitative characterization of erythrocytes glutathione peroxidase. J. Lab. Clin. Med. 70: 158-169
10 Hines, O. J., Ryder, N., Chu, J., and McFadden, D. (2000) Lysophosphatidic acid stimulates intestinal restitution via cytoskeletal activation and remodeling. J. Surg. Res. 92: 23-28   DOI   ScienceOn
11 Hentschel, E., Brandstaffer, G, Pragosics, B., Hirschi, A.M., Nemec, H., Schutze, K., Taufer, M., and Wurzer, H. (1993) Effect of ranitidine and amoxacillinplus metronidazole of the eradication of H. pylori and the recurrence of duodenal ulcer. N. Eng. J. Med. 328: 308-312   DOI   ScienceOn
12 Dai, S. and Ogle, C. W. (1973) A simple method for the production of peptic ulceration in rat. Life Science, 12: 505-512   DOI
13 Griffith, O. W. (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106: 207-212   DOI   PUBMED   ScienceOn
14 Harmam, D. (1998) Free radical theory of aging. Age. 7: 169-177
15 Rugao. L., Garry, R B., and Larry, W. O. (2000) Oxygen free radicals mediate the induction of manganese superoxide dismutase gene expression by TNF-$\alpha$. Free Rad. BioI. Med. 29: 434-441   DOI   ScienceOn
16 Menard, A, Altendorf, K., Breves, D., Mock, M., and Cesare Montecucco, C. (1996) The vascular ATPase proton pump is required for the cytotoxicity of Bacillus anthracis lethal toxin. FEBS Letters, 386: 161-164   DOI   PUBMED   ScienceOn
17 Hawkey, C. J. (2000) Management of gastroduodenal ulcers caused by non-steroidal anti-inflammatory drugs. Best practice & Res. Clin. Castroenter. 14: 173-192   DOI   ScienceOn
18 Sandoval, M., Okuhama, N. N., Zhang, X.-J., Condezo, L. A, Lao, J., Angeles, F. M., Musah, R. A., Bobroxski P., and Miller, M. J. (2000) Anti-inflammatory and antioxidant activities of cat's clav (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomed. 9: 325-337   DOI   ScienceOn
19 Halliwell, B. and Gutteridge, J. M. C. (1984) Lipid peroxidation, oxygen radicals, cell damage and antioxidant therapy. Lancet. 1: 1396-1397
20 Saik, R. P. and Peskin, G. W. (1981) Bleeding from gastritis : Usefulness of vasopressin. Amer. J. Surg. 92: 23-28
21 Mizui, T. and Dodeuchi, M. (1983) Effect of polyamines on daidified ethanol induced gastric lesion in rats. Jpn. J. Pharmacol. 33: 939-945   DOI
22 Soybel, D. I. and Modlin, I. M. (1992) Implications of sustained suppression of gastric acid secretion. Amer. J. Surg. 163: 613-622   DOI   ScienceOn
23 Lin, Y. and Julian, E. S. (1993) Generation of reactive oxygen species from the reaction of selenium compounds with thiols and mammary tumor cells. Biochem. Pharmacal. 45: 429-437   DOI   PUBMED   ScienceOn
24 Zhang, X. J., Ruiz, B., Correa, P., and Miller, M. J. S. (2000) Cellular dissociation of NF-B and inducible nitric oxide synthase in Helicobacter pylori infection. Free Rad. Biol. Med. 29: 730-735   DOI   ScienceOn
25 Mc Cue, J. P. (1979) Changes in oxygen radical scavenging by buman blood cell lysates concurrent with viral infections. Exp. Hematal. 7: 361-368
26 Riester, K. A., Peduzzi P., Holford, T. R., Richard, T., Ellison, R. T., and Donta, S. T. (1997) Statistical evaluation of the role of Helicobacter pylori in stress gastritis: Applications of splines and bootstrapping to the logistic model. J. Clin. Epidem. 50: 1273-1279   DOI   ScienceOn
27 Mercer, D. W., Kirshner, M. S., Ritchie, W. P., and Dempsey, D. T. (1994) Topical prostaglandin $E_2$ and isoproterenol reduce bile acid-induced gastric bucosal injury in shocked rats. J. Surg. Res. 56: 184-191   DOI   ScienceOn
28 Lee, S. Y., Kan, J. D., Lee, Y. H., Rhee, H. I. and Choi, Y. S. (1991) Influence of extract of Rosa rugosa roots on lipid levels in serum and liver of rats. Life Science, 49: 947-951   DOI   PUBMED   ScienceOn