• The Journal of Pediatrics of Korean Medicine
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• v.1 no.1
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• pp.1-12
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• 1986

The Woo-Whang-po-Lyong-Whan has been used as one of the traditional medicines in the field of pediatrics so far since Song dynasty, and still it is widely being used nowadays. It might be considered to be a contribution to do further basic experimental studies on antipyretic, anticonvulsive and analgetic action of the Woo-Whang-po-Lyong-Whan. So it's pharmacological studies were carried out comparing to control drugs. ?Following conclusions were obtained. 1. It's antipyretic action was compared to that of aspirin by Writhing response using acetic acid-method. Mice were given one twentith, one tenth and one fifth tablets of the Woo-Whang-po-Lyong-Whan per Kg of body weight, respecitively. Writhing syndrome frequencies were noted as 38.4 in control group. and $18.0{\pm}12$, $13.17{\pm}2.28$, $7.33{\pm}12$ in above esperimental groups, respectively. In aspirin group it was $18.5{\pm}1.0$ when 2mg aspirin per body weight of mice was given. So it was recognized that antipyretic action of the Woo-Whang-Po-Lyong-Whan become remarkable by increasing amounts of the Woo-Whang-Po-Lyong-Whan. ?2. Antipyretic action in normal temperature mice group was not significant by increasing concentration of the Woo-Whang-Po-Lyong-Whan, but body temperature dropping in normal mice group was slightly noted than control. group, but less temperature dropping was noted than aminopyrin group. ?3. In fever provocated rats groups using Salmonella typhimurium, antipyretic action of the Woo-Whang-Po-Lyong-Whan was not observed significantly than control group. And slight antipyretic action was noted in aminopyrin group. So that antipyretic action of the Woo-Whang-Po-Lyong-Whan was not significant than those of general antipyretic used nowadays, but slower action was recognized. ?4. Anticonvulsive action of the Woo-Whang-Po-Lyong-Whan was studies comparing to that of phenobarbital. Action was not remarkable than phenobarbital, but was significant than control group. No significant intesifying action was noted by increasing amounts of the Woo-Whang-Po- Lyong-Whang.

• YAKHAK HOEJI
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• v.7 no.2_3
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• pp.55-57
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• 1963

Antipyretic substance is isolated from roots of Scrophularia Oldhami which is used as antipyretic and anti-inflammatory drug. This substance is identified as p-methoxycinnamic acid which rarely occurs in plants.

• The Journal of Korean Medicine
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• v.23 no.4
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• pp.32-44
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• 2002

Objective: In this study, we investigated the effects of Rhizoma Cimicifugae (RC) on the induction of nitric oxide (NO) in RAW 264.7 murine macrophages treated with lipopolysaccharide (LPS). Methods: We examined whether RC have an antipyretic effect by inhibition of COX and/or NOS in fever that is evoked by an intraperitoneal injection of LPS in rats. Results: 1. RC inhibited NO metabolites produced by activated murine macrophage in a dose-dependent manner. 2. RC had an antipyretic effect in a dose-dependent manner in LPS-induced fever. 3. RC inhibited levels of both COX-2 protein and iNOS protein increased by the treatment of LPS in brain tissues as well as brain blood vessels. 4. There were no changes in proteins of nNOS/COX-1. Conclusions: RC has an antipyretic effect by attenuating the level of iNOS and COX-2 protein.

• Natural Product Sciences
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• v.9 no.3
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• pp.180-182
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• 2003

In the present study the whole plant of Ammania baccifera Linn was extracted with petroleum ether, chloroform, ethyl acetate and ethanol. The extracts were vacuum dried to yield the respective petroleum ether (PEE), chloroform (CE), ethyl acetate (EAE) and ethanol extracts (EE). PEE, CE, EAE and EE were evaluated for their antipyretic and diuretic activity at 200 mg/kg dose level. Significant antipyretic activity was associated with PEE, CE, EAE and EE. CE was found to exhibit higher antipyretic activity as paracetamol at 100 mg/kg dose level. Significant diuretic activity was exhibited by EAE, EE and PEE. The present study supports the claims of Ammania baccifera mentioned in the Indian system of medicine.

• YAKHAK HOEJI
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• v.25 no.3
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• pp.109-114
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• 1981

The authors investigated drug interaction of ibuprofen and prednisolone in antiinflammatory and antipyretic activities. We have found significant differences of the antiinflammatory and antipyretic activities between single and concurrent administration of ibuprofen and prednisolone, using Sprague-Dawley Strain rats, carrageenin as a phlogistic agent and brewer's yeast as a fever inducing agent. 1) Ibuprofen(20mg/kg) was administered to the rats orally and resulted in significant reduction of (31.70 %) the swelling of rat paw induced by carrageenin, 2) prednisolone (9mg/kg) showed significant reduction of (45.76%) the swelling, 3) concurrent administration of ibuprofen (20mg/kg) and prednisolone (9mg/kg) also reduced (57.40%) the swelling. In ibuprofen (125mg/kg) administration, the inhibition rate of edema was 39.32% and in prednisolone (1mg/kg) administration, the rate was 39.04%. In concurrent administration of ibuprofen (125mg/kg) and prednisolone (1mg/kg), the inhibition rate of edema was 63.09%. Concurrent administration of ibuprofen and prednisolone showed more anti-inflammatory effects than single administration of ibuprofen and prednisolone respectively. Prednisolone itself did not show antipyretic effect, but concurrent administration of ibuprofen and prednisolone showed more antipyretic effects than ibuprofen single administratron.

• YAKHAK HOEJI
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• v.25 no.4
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• pp.137-143
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• 1981

In order to confirm the exact antipyretic component in the earthworm, etherial extract of American earthworm(Red Worm) was fractionated into five fractions by using silica gel column chromatography and thin layer chromatography. The fraction including free fatty acids was found to possess artipyretic response and standard arachidonic acid showed marked antipyretic response on typhoid vaccinated rabbits. Arachidonic acid was identified from the free fatty acid fraction of the earthworm by using gas liquid chromatography. Thus it was considered that the antipyretic activity of the free fatty acid may be due to the presence of arachidonic acid. Lipid-free earthworm powder was extracted with phosphate buffer (pH, 8.0, 0.1M) and all the proteins was salted out by ammonium sulfate. The crude precipitate was dialyzed and the impure proteins were eliminated at pH 5.4 and 4.6. The remaining protein solution was fractionated with various concentrations of acetone. The acetone fractions were identified by using S.D.S. polyacrylamide gel electrophoresis and disc gel electrophoresis. The precipitate at 85% acetone concentration and the remaining proteins in the supernatant did not exhibit the antipyretic activity.

• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.391-397
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• 2013

In the present study, we aimed to analyze the antinociceptive, immunomodulatory and antipyretic activities of nymphayol were investigated in wistar rats and mice. Antinociceptive effect was evaluated by acetic acid induced writhing, formalin induced paw licking and hot-plate tests. Immunomodulatory activity was assessed by neutrophil adhesion test, humoral response to sheep red blood cells, delayed-type hypersensitivity, phagocytic activity and cyclophosphamide induced myelosuppression. Antipyretic activity was evaluated by yeast induced hyperthermia in rats. Nymphayol produced significant (p<0.05) antinociceptive activity in acetic acid induced writhing response and late phase of the formalin induced paw licking response. Pre-treatment with nymphayol (50 mg/kg, oral) evoked a significant increase in neutrophil adhesion to nylon fibres. The augmentation of humoral immune response to sheep red blood cells by nymphayol (50 mg/kg) was evidenced by increase in antibody titres in rats. Oral administration of nymphayol (50 mg/kg) to rats potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells. Treatment with nymphayol showed a significant (p<0.05) reduction in pyrexia in rats. The results suggest that nymphayol possesses potent anti-nociceptive, immunomodulatory and antipyretic activities.

• Korean Journal of Pharmacognosy
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• v.32 no.3 s.126
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• pp.242-247
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• 2001

The anti-inflammatory activity of water extract of Mahaengeuigam-Tang(MHEGTWE) was examined using the carrageenin and acetic acid induced edema, croton oil induced granuloma pouch, and adjuvant arthritis in rats. In addition, the acute toxicity, analgesic and antipyretic effects of MHEGTWE were investigated by the general experimental methods. In acute toxicity test in mice, MHEGTWE showed 10% mortality at 2400 mg/kg(p.o), but it did not showed at 1200 mg/kg(i.p). It was also showed significant analgesic action on the writhing syndrome induced by 0.7% acetic acid at 600 mg/kg(p.o) and its antipyretic activity was observed in the typhoid vaccine induced fevered rats at 300 mg/kg(p.o). By the oral administration of the MHEGTWE, the significant anti-inflammatory activity was observed on 1% carrageenin induced edema, and it significantly inhibited the granuloma and exudate formation in rats. In the adjuvant arthritis experiment, the MHEGTWE decreased the hind paw edema in rats for 19 days. The results suggest that MHEGTWE has analgesic, anti-inflammatory and antipyretic action.

• The Journal of Korean Medicine
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• v.33 no.4
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• pp.26-36
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• 2012

Objectives: To establish scientific and objective evidence for the use of a Korean medicine, articles regarding Hwangryeonhaedok-tang (HRHDT), a herbal medicine frequently used in Korean medical clinics and hospitals, were gathered and analyzed. Methods: The articles were classified as being from domestic or international journals, and by their year of publication. The mechanisms of the anti-inflammatory and antipyretic effects of HRHDT were investigated. Results: Of the 25 articles analyzed, 7 were published from Korea, 7 were from China, and 11 were from Japan. HRHDT showed anti-inflammatory and antipyretic effects through the regulation of the expression of Th1 cytokines including interleukin-2 (IL-2), IL-8, interferon-${\gamma}$ (IFN-${\gamma}$), and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$); and Th2 cytokines including IL-4, IL-6, and IL-12, which inhibit leukotriene B4 (LTB4), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and inflammatory cells. It also lowered preprodynorphin (PPD), and corticotropin-releasing factor (CRF) in the peripheral nerve system and hypothalamus. Conclusions: We speculate that the anti-inflammatory and antipyretic effects could be related to the therapeutic efficacy of HRHDT in removing pathogenic fire and heat.

• Natural Product Sciences
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• v.12 no.1
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• pp.24-28
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• 2006

The analgesic and the antipyretic activity of the methanol, chloroform, hexane and acetonitrile extracts of the aerial parts of Stachys schimperi Vatke were investigated in mice. The nociceptive response was tested using acetic acid-induced writhing and tail flick method; while hypothermia affect was examined via yeast-induced fever test. The chloroform extract at 500 mg and hexane and acetonitrile extracts at 250 mg produced significant analgesic and antipyretic activity.