• Parasites, Hosts and Diseases
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• 제52권2호
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• pp.183-188
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• 2014

Mosquitoes secrete saliva that contains biological substances, including anticoagulants that counteract a host's hemostatic response and prevent blood clotting during blood feeding. This study aimed to detect heparin, an anticoagulant in Aedes togoi using an immunohistochemical detection method, in the salivary canal, salivary gland, and midgut of male and female mosquitoes. Comparisons showed that female mosquitoes contained higher concentrations of heparin than male mosquitoes. On average, the level of heparin was higher in blood-fed female mosquitoes than in non-blood-fed female mosquitoes. Heparin concentrations were higher in the midgut than in the salivary gland. This indicates presence of heparin in tissues of A. togoi.

• Journal of Chest Surgery
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• 제43권6호
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• pp.778-780
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• 2010

48세 여자 환자가 좌측 팔의 통증으로 1개월간 한의원에서 침술치료를 받던 중 좌측 경부의 부종과 통증으로 내원하였다. 컴퓨터 촬영상 좌측 내경정맥 혈전증이 발견되었다. 환자는 항생제와 함께 항응고 치료를 받고는 증세 호전이 되어 현재 통원 치료 중이다. 침술치료에 따른 내경정맥 혈전증은 아직 증례보고가 없는 바 이에 문헌고찰과 함께 보고하는 바이다.

• 대한두경부종양학회지
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• 제16권1호
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• pp.20-25
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• 2000

The medicinal leech, Hirudo medicinalis, has been used for salvage of the venous-congested flap following reconstructive surgery, with increasing frequency during the last two decades. Medicinal leech therapy is a safe, efficacious, economical, and well-tolerated intervention. The flap salvage with leeching occurs in approximately 70% of cases, and leeches need to be used as early as possible. At the time of the bite, evacuation of blood and injection of the leech saliva products, including anticoagulants and inhibitors of platelet aggregation, maintain capillary circulation of the flap, and then venous capillary return is established across the wound by angiogenesis. One of the salivary products, hirudin, represents the first parenteral anticoagulant introduced since the discovery of heparin. We analyzed two cases in which flap salvage with leeching was attempted, and reviewed medicinal leech therapy on the basis of our experiences and literature review. This has not been documented in the head and neck surgery literature in our country.

• 생명과학회지
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• 제14권3호
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• pp.441-444
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• 2004

본 연구는 피브린의 무게를 측정하는 방법에 의하여 간단하고 단순하게 트롬빈활성을 측정하는 방법을 확립하기 위하여 수행되었다. 이 새로운 트롬빈측정 법은 트롬빈이 기질인 피브리노겐과 반응 후 생성된 피브린의 무게를 측정한다. 피브린의 생성은 사용한 트롬빈의 효소활성, 반응온도, 반응시간 및 원심분리의 시간에 의존하였다. 피브린의 생성은 37$^{\circ}C$에서 트롬빈활성이 1.0 unit/ml 이내, 4.0mg/ml의 피브리노겐 농도 및 반응시간이 5분 이내에는 직선적으로 증가하였다. 그리고 생성된 피브린은 3,000$\times$g에서 5분간 원심분리의 경우에 안정하였다. 이 새로운 피브린 측정 법은 트롬빈을 저해하는 천연물질을 탐색하는데 유행하게 사용될 것으로 기대된다.

• Tuberculosis and Respiratory Diseases
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• 제72권3호
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• pp.328-331
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• 2012

A Septic embolism is a type of embolism infected with bacteria containing pus. These may become dangerous if dislodged from their original location. Embolisms of this type in the azygos vein are potentially fatal. The diagnosis of septic azygos vein embolism is difficult, so rapid diagnosis and treatment is important to avoid complications. Generally, treatment is enough for appropriate antibiotic therapy without anticoagulant therapy. We report a case of staphylococcal septic embolism in the azygos vein, which was discovered in a 51-year-old man exhibiting chest pain, dyspnea and fever. The patient was treated with antibiotic therapy alone without the use of anticoagulants.

• Archives of Reconstructive Microsurgery
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• 제2권1호
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• pp.77-81
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• 1993

Free tissue transplantation is commonly performed with the brilliant achievement in microsurgery and anticoagulants and antithrombotic agents have been prescribed in the procedures. However, there is no clean-cut indication as to which agents would be more effective in every steps and final consequences. Low molecular weight heparins inhibiting coagulation in plateletrich plasma and acting on the vascular endothelium have antithrombotic and fibrinolysis action. The experiment with rat groin free flap transplantation after 6-hour ischemia and injection of the low molecular weight heparin was performed and the results between the injection and non-injection group were analysed as follows, 1. Both of the 24-hour groups, vessel patency was not proportional to color change of the groin flap. 2. On the second day after anastomois, heparin-injection group showed intact intima, patent lumen without thrombus, and mild granulomatous inflammation around the suture material and control group with doubtful patency revealed intimal loss and thrombus formation. 3. On the 5th, 7th, and 9th postoperative day, heparin group was patent in anastomosis and showed acute inflammatory cells. 4. The 7th-week period, heparin-injection group showed intact flap color, patent lumen with intact intima and persistent foreign body granuloma.

• Journal of Chest Surgery
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• 제50권3호
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• pp.224-227
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• 2017

A 20-year-old man presented with a femur fracture and epidural hemorrhage (EDH) following a fall. One month after fracture surgery, swelling developed in both legs, and he was diagnosed as having a deep-vein thrombosis and pulmonary embolism. A retrievable inferior vena cava filter (IVCF) was inserted, because EDH is a contraindication to anticoagulants. Four months later, he complained of abdominal pain, and a computed tomography scan showed a fractured IVCF strut. After percutaneous removal failed 3 times, the IVCF was surgically removed by orthopedists using a portable image intensifier without cardiopulmonary bypass.

• Clinical and Experimental Pediatrics
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• 제48권6호
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• pp.675-677
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• 2005

가성혈소판감소증은 항응고제인 ethylenediaminetetraacetic acid (EDTA)를 사용 시 주로 발생한다. 이 때 관찰되는 혈소판 응고는 헤파린이나 구연산나트륨 같은 항응고제를 EDTA 대신 사용하면 일어나지 않기도 하여 가성혈소판감소증과 진성혈소판 감소증을 감별할 수 있다. 저자들은 이러한 감별을 위하여 6세된 EDTA 의존성 가성혈소판감소증 남아에서 아미노글리코사이드 계열의 약물인 가나마이신을 채혈 전에 EDTA 용기에 미리 넣거나, EDTA 용기에 이미 채혈된 혈액에 첨가한 후 각각 혈소판수와 혈소판 응고 양상을 조사하여 보았다. 그 결과 가나마이신 채혈 전 혹은 후에 처리한 경우 모두 혈소판응고 없이 정상적인 혈소판수를 나타내어 소아에서도 임상적으로 쉽게 검사 할 수 있는 방법으로 생각되어 보고하는 바이다.

• Clinical and Experimental Reproductive Medicine
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• 제25권3호
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• pp.277-280
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• 1998

Antiphospholipid antibody is an immunoglobulin which may be of any class and which reacts with any phospholipid. For clinical use the definition of the term anti-phospholipid antibody is usually restricted to IgG and/or IgM antibody directed against the negatively charged phopholipids, cardiolipin, phosphatidyl inositol, phosphatidyl serine, or phosphatidic acid. The antigen of the serological test for syphilis is cardiolipin; negatively charged phopholipids are understood to be antigens to which lupus anticoagulants are directed. The term 'anticardiolipin' antibody syndrome, 'antiphospholipid' antibody syndrome, and 'lupus anticoagulant' syndrome are often, imprecisely, used interchangeably. We have experienced a case of recurrent spontaneous abortion with antiphospholipid antibody. So we report this case with a brief review of literatures.

• Journal of Korean Neurosurgical Society
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• 제55권1호
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• pp.51-53
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• 2014

Mild traumatic brain injury is common in elderly patients, many of whom are on anticoagulant. The common practice is to discharge these patients from the emergency room if the computed tomography (CT) of the brain is normal. However, a very small proportion of these patients may develop a life threatening intracranial haematoma in the following days. We present here a case of a 66-year-old male on anticoagulant therapy that developed a subdural haematoma 48 hours after a mild head injury, with a normal initial CT scan of the brain. The patient underwent a craniotomy with evacuation of a large subdural clot. Postoperatively he had progressively improved and six months later has a Glasgow Outcome Score of three. This case is characterized by the delayed onset of a subdural haematoma in a patient on anticoagulation and we discuss here the possible pathogenesis related to this phenomenon. We also briefly review the pertinent literature and the current guidelines for the management of this type of head injuries.