• 한국통신학회논문지
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• 제35권3B호
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• pp.440-452
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• 2010

소프트웨어 제품의 평가를 위해 국제표준 ISO/IEC 품질인증 시스템을 기반으로 국내 외 기관 및 연구소에서 품질에 대한 많은 방법론이 연구 및 적용되고 있으나, 복잡한 차원의 특수한 성질을 지닌 안티바이러스 소프트웨어를 평가하기에는 많은 문제를 동반한다. 따라서 본 논문에서는 적정 수준 이상의 요건을 갖춘 안티바이러스 소프트웨어의 품질평가 방법론을 마련하고자 평가항목 도출을 위한 프로세스와 정량화 방안을 정립하였으며 각 요인간의 상대적 중요도를 분석함으로써 가중치 정보를 객관화하였다. 정의된 정보(평가 항목, 가중치)를 기반으로 포털 사이트에서 수집한 공개용 안티바이러스 소프트웨어 70종에 대하여 리얼 테스트 환경에서 품질평가를 수행하였으며, 사용자들의 오랜 시간동안의 경험을 이용한 실증분석 결과 본 논문에서 정의한 평가항목과 가중치에 대한 정당성을 마련할 수 있었다.

• 정보보호학회논문지
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• 제19권5호
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• pp.189-194
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• 2009

버퍼오버플로 악성코드 탐지를 위해 대부분의 안티바이러스 프로그램은 공격코드의 시그너처만 비교 탐지하고 있어 알려지지 않은 공격코드에 대해 탐지하지 못하는 문제점이 있다. 본 논문에서는 공격코드에서 필수적으로 사용하는 API의 메모리 실행영역 추적기법을 이용하여 알려지지 않은 공격코드에 대한 탐지기법을 제안한다. 제윤기법 검증을 위해 7개의 샘플 공격코드를 선정하여 8개의 안티바이러스 프로그램과 비교 실험한 결과, 대부분의 안티바이러스 프로그램은 Stack영역만 감시하고 Heap영역은 감시하지 않아 제안적인 탐지만 가능하였다. 이에 대부분의 안티 바이러스 프로그램에서 탐지할 수 없는 공격코드를 제안 기법을 이용하여 탐지할 수 있음을 시뮬레이션 하였다.

• Journal of Preventive Medicine and Public Health
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• 제19권2호
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• pp.281-292
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• 1986

Infection by hepatitis B virus is one of the major health problems of this nation. HBsAg positive rates of general population and school children were known to be as about 8 percent and 3.9 to 5.9 percent respectively. To study the incidence rate of hepatitis B infection in school children of rural area, author had examined 475 school children of relatively isolated agricultural area for baseline prevalence of hepatitis B virus serologic markers and followed up 415 school children during 10 months to determined the frequency of serologic conversion. The major results are summarized as followings: 1) Among the 278 susceptible children who were followed up, 26 had seroconversion for HBsAg or Anti-HBs. Therefore, the cumulative incidence rate during 10 months is estimated 9.4%. 2) The incidence rate of hepatitis B infection tends to increase with age (6-9yrs: 3.2%, 10-14yrs: 9.5%, 15-17yrs: 18.9%), and the incidence rate in male (13.0%) was higher than in female (5.7%). 3) The incidence rates of hepatitis B virus infection were not different statistically among three economic classes (The rates of lower, middle and higher class were 11.8%, 7.1% and 10.5%.). 4) The incidence rates of hepatitis B virus infection were not different statistically between visitors and non-visitors of clinic or hospital, dental clinic, persons received IV and not received IV, and persons with familial history and without familial history of liver diseases. Therefore all of these factors were not identified as risk factor of hepatitis B virus infection. And the transmissibility within the class of school was not recognized, too. 5) Among the 25 children who were HBsAg positive when enrolled, 15 (60%) were still HBsAg positive, who were identified as chronic carrier 15 of 415 school children were chronic carriers, then chronic carrier rate was estimated 3.6%, and there was no difference between sexes. 6) Of 38 children who had been Anti-HBs positive when enrolled, 5 (13.2%) lost Anti-HBs. Therefore, the loss rate of Anti-HBs per year is estimated to be 15.8%.

• 한국정보시스템학회지:정보시스템연구
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• 제15권1호
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• pp.145-168
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• 2006

Current computer viruses are one of the most serious problems in information age due to their potential demage and impact on use of information systems. To make the problem worse, virus development technology has been advanced rapidly, and use of network systems has expanded widely. Therefore computer viruses are much more complex and use of anti-virus software(AV S/W) is not enough to prrevent virus incidents. It implies that computer viruses as well as other information security matters are not solely a technical problem but also a managerial one. This study emphasized on computer virus controls from managerial perspective of information security and investigated factors influencing the effectiveness of computer virus controls. Organization's comprehensive security policies provide guidelines on how organization or individual can protect themselves from computer viruses. Especially, user's education has positive impact on user's security related characteristics. Based on the analysis of research model using structural equation modeling technique, security policies were influencing security controls and improving user's computer viruses related awareness. Also security controls had positive impact on security effectiveness. However, no significant relationship was found between user's security related characteristics and security effectiveness.

• Natural Product Sciences
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• 제2권2호
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• pp.130-136
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• 1996

Evaluation of plant extracts that might inhibit hepatitis B virus (HBV) replication was performed to find potent anti-HBV agents. Eighty-five species of plants from forty-three families were tested for their anti-HBV activities using HBV-producing HepG2-derived 2.2.15 cells. The anti-HBV activity of plant extracts was measured by slot blot hybridization technique and cytotoxicity was determined by crystal violet staining procedure. All plants were extracted with methanol and the extracts were partitioned into n-hexane, ethyl acetate and aqueous layer. The ethyl acetate fractions of Rhus verniciflua $(stem:\;EC_{50},\;8.2{\mu}g/ml;\;CC_{50},\;9.4{\mu}g/ml)$, Gastrodia elata $(root:\;EC_{50},\;17.7{\mu}g/ml;\;CC_{50},\;>20{\mu}g/ml)$, Raphanus sativus $(seeds:\;EC_{50},\;17.3{\mu}g/ml;\;CC_{50},\;>20{\mu}g/ml)$, and Angelica gigas $(root:\;EC_{50},\;8.3{\mu}g/ml;\;CC_{50},\;15.6{\mu}g/ml)$ revealed the anti-HBV activity in 2.2.15 cell culture system and these fractions are under the process of further sequential fractionation by column chromatography to find the active principles against HBV.

• 대한임상검사과학회지
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• 제46권1호
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• pp.17-21
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• 2014

The prevalence of hepatitis A virus (HAV) in a certain community reflects that community's living standard and hygienic condition. The seroprevalence rate of IgG anti-HAV has been changing with regions and times. In this study, we aimed to study the difference of seroprevalence of IgG anti-HAV according to sex, age and type of drinking water, and to know the vaccination rate and seroconversion rate for vaccinated subjects in Busan. A total of 644 samples were analyzed. The overall seroprevalence rate of IgG anti-HAV was 35.4% (228/644). There was no significant difference in sex (male 39.8%, female 32.7) (p>0.05). According to age, seroprevalence rate of anti-HAV were 55.0% in subjects aged 5~9 years old, 47.8% in 10~14 years old, decreced to 10.6% in 15~19 years old, 1.0% in 20~24 years old, 0.0% in 25~29 years old and increced with advacing ages ; 14.7% in 30~34 years old, 39.4% in 35~39 years old, 67.3% in 40~44 years old, 94.1% in 45~49 years old, 100.0% over 50 years (p<0.001). The seroprevalence of IgG anti-HAV was no statistical difference according to the types of drinking water (p>0.05). The vaccinated subject was 42 case only in below 25 years old. The seroconversion rate after vaccination was 88.1%.

• 한국한의학연구원논문집
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• 제3권1호
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• pp.67-83
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• 1997

In order to search for anti-influenza virus type A agents from Korean medicinal herbs, we selected 100 medicinal herbs, based on a review of the Korean traditional medicine books. Four of 100 Korean medicinal herbs, MM-40, MM-55, MM-63, MM-110, exhibited very strong anti-influenza virus activity. The fractions of four medicinal herbs, which had very strong anti-influenza virus activity, were tested for antiviral activity by means of Haemagglutination inhibition test(HTT), 40% MeOH fraction of MM-40, $H_2O$ fraction of MM-55, 20% fraction of MM-63 3nd $H_2O$ fraction of MM-110 had strong anti-influenza virus activity at the range of $78{\mu}g/ml$ to $156{\mu}g/ml$, 1.56mg/ml to 100mg/ml, 6.25mg/ml to 50mg/ml and $48.7{\mu}g/ml$ to $780{\mu}g/ml$, respectively. These results of HIT indicated that fractions of Korean medicinal herbs might inhibit either attachment of virus to cell surface receptor or penetration of virus into cell during the initial stage of infection. In the cytotoxicity of fractions against red blood cells, 40% MeOH fraction of MM-40, 20% fraction of MM-63 and $H_2O$ fraction of MM-110 showed cytotoxicity at the range of $78{\mu}g/ml$ to 10mg/ml, 50mg/ml to 100mg/ml and $195{\mu}g/ml$ to 100mg/ml, respectively, whereas $H_2O$ fraction of MM-55 did not show cytotoxicity. In order to establish influenza virus adapted animal model, influenza virus type A were passaged 3 and 4 times successively in Balb/c mouse. As a result, we had 4 HA unit titers on the 5 days of 3rd passages and 7 days of 4th passages after infection, respectively.

• Plant Resources
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• 제4권3호
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• pp.192-195
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• 2001

Human immunodeficiency virus (HIV), the causative agent of AIDS, still continues to spread rapidly in the world population, especially in Africa and Southeast Asia. At present, two kinds of therapeutic approaches are used for treatment of AIDS. One is to target HIV reverse transcriptase, which is responsible for the viral genome transcription. The other is to inhibit HIV pretense PR, which is essential for the processing of viral proteins. Drug combinations based on these approaches can reduce the blood virus to an undetectable level. However, a small amount of virus may lurk inside the immune cells in a dormant state. Another major obstacle of long-term treatment of the disease is remarkable mutation in HIV. Most of the clinical chemotherapeutic agents have one or more of these problems. High cost and harmful side-effects further reduced the desirability of these drugs. In the course our studies on development of anti-HIV agents from natural products, we investigated various crude drugs for their inhibitory activity against HIV-induced cytopathic effects (CPE) in culture cells, HIV-pretense (PR), HIV-reverse transcriptase (RT) including ribonuclease H (RNase H), and HIV integrase (INT). In the present paper, some inhibitory substances relating to the development of anti-HIV agents are reported.

• 약학회지
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• 제43권4호
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• pp.458-463
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• 1999

This study was undertaken to test for antiviral activity of the aqueous extracts prepared from 4 medicinal plants of Korea (Terminalia chebula, Sanguisorba officinalia, Rubus coreanus, Rheum palmatum). Aqueous extracts were assayed for the inhibition of hepatitis B virus (HBV) replication by measurement of HBV DNA and surface antigen (HBsAg) levels in the extracellular medium of HepG2 2.2.15 cells. All extracts decreased the levels of extracellular HBV virion DNA at concentrations ranging from 64 to $128{\;}\mu\textrm{g}/ml$ and inhibited the production of HBsAg dose-dependently. Among the 4 tested plants, Terminalia chebula exhibits the most prominent anti-HBV activities. Our findings suggest that these 4 medicinal plants may have potential to develop as specific anti-HBV drugs in the future.

• 약학회지
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• 제43권4호
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• pp.469-473
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• 1999

EA, the water soluble substance, was prepared from the carpophores of Elfvingia applanata (Pers). Karst. Anti-influenza A virus (anti-Flu A) activity of EA was examined of Vero cells by plaque reduction assay in vitro. And the combined antiviral effects fo EA with interferon (IFN) alpha and gamma were examined on the multiplication of Flu A with 50% effective concentration ($EC_50$) of 1.50 mg/ml. The results of combination assay were evaluated by the combination index (CI) that was analysed by the multiple drug effect analysis. The combination of EA with IFN alpha on Flu A showed more potent synergism with CI values of 0.50~0.52 of 50%, 70%, 90% effective levels than that with IFN gamma with CI values of 0.82~0.99.