• Tribology and Lubricants
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• 제37권5호
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• pp.189-194
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• 2021

A straightforward, yet effective surface modification method of stainless steel mesh and its interesting anti-wetting characteristics are reported in this study. The stainless steel mesh is electrochemically etched, and the specimen has both micro and nano-scale structures on its surface. This process transforms the two types of mesh specimens known as the regular and dense specimens into hydrophobic specimens without applying any hydrophobic chemical coating process. The fundamental wettability of the modified mesh is analyzed through a dedicatedly designed experiment to investigate the waterproof characteristics, for instance, the penetration threshold. The waterproof characteristics are evaluated in a manner that the modified mesh resists as high as approximately 2.7 times the pressure compared with the bare mesh, i.e., the non-modified mesh. The results show that the penetration threshold depends primarily on the advancing contact angles, and the penetration stop behaviors are affected by the contact angle hysteresis on the surfaces. The findings further confirm that the inexpensive waterproof meshes created using the proposed straightforward electrochemical etching process are effective and can be adapted along with appropriate designs for various practical applications, such as underwater devices, passive valves, and transducers. In general, , additional chemical coatings are applied using hydrophobic materials on the surfaces for the applications that require water-repelling capabilities. Although these chemical coatings can often cause aging, the process proposed in this study is not only cost-effective, but also durable implying that it does not lose its waterproof properties over time.

• Computers and Concrete
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• 제4권6호
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• pp.499-510
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• 2007

The densified mixture design algorithm (DMDA) was employed to manufacture high-performance lightweight concrete (LWAC) using silt dredged from reservoirs in southern Taiwan. Dredged silt undergoing hydration and high-temperature sintering was made into a lightweight aggregate for concrete mixing. The workability and durability of the resulting concrete were examined. The LWAC made from dredged silt had high flowability, which implies good workability. Additionally, the LWAC also had good compressive strength and anti-corrosion properties, high surface electrical resistivity and ultrasonic pulse velocity as well as low chloride penetration, all of which are indicators of good durability.

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.228.1-228.1
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• 2002

Hypoxia in solid tumors is known to contribute to intrinsic chemoresistance. Tirapazamine(TPZ). a hypoxia-selective cytotoxin. showed synergism with radiation or cytotoxic agents. Paclitaxel(PTX) is a highly active anti-cancer agent against Non small cell lung cancer(NSCLC), however. due to poor penetration into central hypoxic region of tumor tissue. combination with TPZ has been suggested to enhance its efficacy. (omitted)

• 한국지반환경공학회 논문집
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• 제10권4호
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• pp.15-24
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• 2009

우리 나라는 계절 동토지대로서 겨울에는 기온이 영하로 떨어져 지반에 동상현상이 발생하고, 봄에는 얼었던 지반이 융해하면서 도로포장을 파손하거나 그 수명을 단축시킨다. 이러한 동상 및 융해로 인한 도로포장의 파손을 방지하기 위하여 도로포장 하부에 동상방지층을 설치하고 있다. 그런데 국내에서는 도로 동상방지층의 두께 결정시 사용되는 동결깊이 추정식으로서 미국이나 일본에서 개발된 식을 이용하고 있다. 그러나 이 식들은 자국의 기후 및 지반 조건에서 만들어진 것이므로 국내에서 그대로 적용하는 것이 합리적이라고 말하기는 어렵다. 우리 나라의 기후 및 지반조건에 맞지 않는 동결깊이 산정식을 도로 설계시 적용할 경우 전국에 새로 설치하는 도로 동상방지층의 두께가 달라질 수 있으며, 이에 따라 공사비가 잘못 산정될 수도 있다. 따라서 도로 공사비의 효율적인 집행과 도로의 내구성 향상을 위해 국내 기후 조건과 지반 여건에 맞는 동결깊이 산정식의 개발이 필요하다. 본 연구에서는 전국 89개 포장국도에서 측정한 동결깊이와 기상청 측정 기온으로부터 산정한 동결지수를 함수로 하여 동결깊이 산정식(안)을 만들어 보았다. 아울러 지역별, 음/양지(陰/陽地) 조건별로 동결깊이가 어떻게 다르게 나타나는지 분석하였다. 또한 국내에서 기존에 이용하고 있던 동결깊이 산정식 및 외국의 동결깊이 산정식들과 그 결과가 어떻게 다르게 나타나는지 분석하였다.

• 한국도로학회논문집
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• 제11권4호
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• pp.143-152
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• 2009

본 연구의 목적은 현재 국내에서 적용되고 있는 동결지수와 동결깊이 산정의 타당성을 검증하는 것이다. 이에 국내에서 운영되고 있는 LTPP-SPS(Long Term Pavement Performance- Specific Pavement Study)구간의 대기온도와 포장체 깊이별 온도 데이터를 이용하여 동결지수와 동결깊이를 산정하였으며, 기존 계산식을 이용하여 산출된 동결깊이와 비교 분석하였다. 또한 이 구간들의 인근 측후소 데이터를 이용하여 연도별 동결지수 추이를 분석하였다. 본 연구 결과, 지구온난화에 의해 1987년 이후에는 동결지수가 급격히 감소하였으며, 현재 도로설계 시 적용되고 있는 동결지수가 과하게 적용되고 있음을 알 수 있었다. 이에 동결지수 산정 시 현행 30년 데이터를 토대로 산정하기보다 기후가 변화된 시점부터 현재까지의 추이를 분석하는 것이 바람직 할 것으로 사료된다. 또한 LTPP-SPS 구간에서 측정된 포장체 깊이별 온도데이터를 분석한 결과, 동상방지층이 설계되어 있는 3개구간에서 대체적으로 보조기층까지만 동결이 발생하는 것으로 나타나, 동상방지층이 제 역할을 수행하지 못하는 것으로 나타났다. 실제 측정된 동결깊이와 계산식을 통해 산정된 동결깊이를 비교한 결과, 노상동결관입허용법을 이용한 설계방법이 실제 측정된 동결깊이와 가장 유사한 경향을 나타내었다.

• BMB Reports
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• 제50권2호
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• pp.85-90
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• 2017

Recently, we demonstrated that superoxide dismutase 3 (SOD3) is a strong candidate for biomedicine. Anti-oxidant function of SOD3 was accomplished without cell penetration, and it inhibited the inflammatory responses via non-enzymatic functions. SOD3 has the heparin binding domain associating cell surface. Interestingly, we found that $Zn^{2+}$ promotes transduction effects of recombinant human SOD3 (rhSOD3) by increasing uptake via the heparin binding domain (HBD). We demonstrated an uptake of rhSOD3 from media to cell lysate via HBD, resulting in an accumulation of rhSOD3 in the nucleus, which was promoted by the presence of $Zn^{2+}$. This resulted in increased inhibitory effects of rhSOD3 on NF-{\kappa}B and STAT3 signals in the presence of $Zn^{2+}$, which shows elevated association of rhSOD3 into the cells. These results suggest that an optimized procedure can help to enhance the inflammatory efficacy of rhSOD3, as a novel biomedicine.

• 한국군사과학기술학회지
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• 제10권2호
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• pp.69-75
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• 2007

So far, anti-piercing depths for concrete slabs have been determined using Conventional Weapon's Effects Program(CONWEP) that was developed by the U. S. Army's Corps of Engineering. However, it has been suggested by a number of field officers that the values computed by CONWEP tend to be too high for protective facilities used in small military units and that indiscriminate application of these values to such facilities would lead to uneconomical penetration-proof designs. In this study, gunshots onto RC slabs were carried out using KM80 bullets in order to measure the piercing depths. The observed depths and the depths offered by the CONWEP system differed greatly from each other by up to 119 centimeters. Based on the depth values obtained through this experiment, we have proposed a new equation to calculate effective anti-piercing depths for RC slabs against small caliber bullets.

• Biomolecules & Therapeutics
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• 제24권1호
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• pp.85-93
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• 2016

We already reported that genetically engineered resveratrol-enriched rice (RR) showed to down-regulate skin melanogenesis. To be developed to increase the bioactivity of RR using calli from plants, RR was adopted for mass production using plant tissue culture technologies. In addition, high-pressure homogenization (HPH) was used to increase the biocompatibility and penetration of the calli from RR into the skin. We aimed to develop anti-melanogenic agents incorporating calli of RR (cRR) and nanoparticles by high-pressure homogenization, examining the synergistic effects on the inhibition of UVB-induced hyperpigmentation. Depigmentation was observed following topical application of micro-cRR, nano-calli of normal rice (cNR), and nano-cRR to ultraviolet B (UVB)-stimulated hyperpigmented guinea pig dorsal skin. Colorimetric analysis, tyrosinase immunostaining, and Fontana-Masson staining for UVB-promoted melanin were performed. Nano-cRR inhibited changes in the melanin color index caused by UVB-promoted hyperpigmentation, and demonstrated stronger anti-melanogenic potential than micro-cRR. In epidermal skin, nano-cRR repressed UVB-promoted melanin granules, thereby suppressing hyperpigmentation. The UVB-enhanced, highly expressed tyrosinase in the basal layer of the epidermis was inhibited by nano-cRR more prominently than by micro-cRR and nano-cNR. The anti-melanogenic potency of nano-cRR also depended on pH and particle size. Nano-cRR shows promising potential to regulate skin pigmentation following UVB exposure.

• 한국응용과학기술학회지
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• 제24권4호
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• pp.410-415
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• 2007

Functional cosmetics are intensively investigated for the effectiveness of skin whitening, anti-aging and slimming. For enhancing the effectiveness, active ingredients should be delivered into the cell in the dermis. The amounts of penetration of caffeine and $Arbutin^{(R)}$ were tested, in vitro, using Franz diffusion cell. Oil-in-water emulsions were used for the vehicles of the transport. For the measuring the amounts of active ingredients delivered into the dermal skin, tape stripping was done after finishing the penetration experiments. The amounts of delivered caffeine were $8.45{\pm}$ 1.26ug/ml before tape stripping and $3.45{\pm}$ 1.80ug/ml after tape stripping, however, the amounts of delivered $Arbutin^{(R)}$ was quite small to detect. From now on, proper vehicles are considered for enhancing the delivery of $Arbutin^{(R)}$ Hairless mouse skin was compared with pig skin as a transdermal delivery membrane. The aspects of delivery were similar, but the amount of delivered ingredients using pig skin was larger than that of using hairless mouse skin. Therefore, the pig skin would be considered as a membrane for drug delivery experiments.

• KCI Concrete Journal
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• 제11권3호
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• pp.79-88
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• 1999

Most difficulties of inducing high fluidity on the concrete mixing design with a strength range of 210 to 240kg/$\textrm{cm}^2$ result from the segregation of aggregates due to the shortage of cementitious binders. To solve the problem, this study concentrated on finding the optimized amount of binder material which does not affect the concrete strength and is also economical. Also there were studies on the use of intermediate sized aggregates to avoid the gap-grading between coarse and fine aggregates so that the material segregation in high flowing concrete was and minimalized the fluidity and penetration capacity of the reinforcing bars was enhanced. Throughout the parametric study with respect to water/binder ratio. superplasticizer. replaceable mineral admixture, the size of coarse aggregate and mixing methods, the effect of each constituent on the characteristics of high flowing concrete could be observed. As a result or partially using stone powder or an intermediate class of aggregate (max. diameter 13mm) . it was fund that the fluidity of concrete significantly increased without material segregation and any change of compressive strengths. It was also proved in this study that proper mixing time and speed are significant factors influence the performence of high flowing concrete.