• Progress in Superconductivity
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• 제8권1호
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• pp.16-21
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• 2006

In this paper, current status of experimental and theoretical work on quantum bits based on the semiconductor quantum dots in the University of Seoul will be presented. A new proposal utilizing the multi-valley quantum state transitions in a Si quantum dot as a possible candidate for a quantum bit with a long decoherence time will be also given. Qubits are the multi-valley symmetric and anti-symmetric orbitals. Evolution of these orbitals is controlled by an external electric field, which turns on and off the inter-valley interactions. Initialization is achieved by turning on the inter-valley Hamiltonian to let the system settle down to the symmetric orbital state. Estimates of the decoherence time is made for the longitudinal acoustic phonon process.

• 한국분말야금학회:학술대회논문집
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• 한국분말야금학회 2006년도 Extended Abstracts of 2006 POWDER METALLURGY World Congress Part 1
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• pp.266-267
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• 2006

We present a systematic study of the heating and pre-sintering behavior of porous copper powder metal compacts. We employ a TE102 single mode microwave system to position the samples in the separated electric field (E) or magnetic field (H) anti-node of the cavity. We observe significant differences in the heating, pre-sintering, and microstructure evolution of the samples due to the individual fields. We note that sample history (whether heated first in the E-field or H-field) greatly effects a difference in heating trends and subsequent heating behavior and does not appear to be solely a thermal process.

• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.179-189
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• 2019

Although recent advances in molecular targeted therapy and immuno-oncology have revolutionized the landscape of lung cancer therapeutics, cytotoxic chemotherapy remains an essential component of lung cancer treatment. Extensive evidence has demonstrated the clinical benefit of chemotherapy, either alone or in combination with other treatment modalities, on survival and quality of life of patients with early and advanced lung cancer. Combinational approaches with other classes of anti-neoplastic agents and new drug-delivery systems have revealed promising data and are areas of active investigation. Chemotherapy is recommended as a standard of care in patients that have progressed after tyrosine kinase inhibitors or immune checkpoint inhibitors. Chemotherapy remains the fundamental means of lung cancer management and keeps expanding its clinical implication. This review will discuss the current position and future role of chemotherapy, and specific consideration for its clinical application in the era of precision medicine.

• 천문학회보
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• 제44권2호
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• pp.40.1-40.1
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• 2019

We report progress on identifying cosmic voids using cluster halos as the antipode. According to the standard scenario of structure formation, clusters are expected to form at peaks of the initial density field, whereas cosmic voids form at troughs. Then, a cluster would be a void if the sign of the initial density fluctuation of the universe were inverted. To study the relevance of anti-structures of clusters to cosmic voids, we use a pair of simulations whose initial density fields are sign inverted versions to each other. By examining the spatial distribution and environment of the particles in inverted simulation, which are the member particles of clusters in the other simulation, we discuss the characteristics of the antipode structures of clusters including their size, density, internal structure, and redshift evolution as well.

• 천문학회보
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• 제45권1호
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• pp.58.2-58.2
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• 2020

We present a method for determining the abundance ratio of nitrogen to iron ([N/Fe]) from low-resolution (R~2000) stellar spectra from large spectroscopic surveys such as Sloan Digital Sky Survey (SDSS) and Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST). The basic idea of the method is to match a grid of synthetic spectra with an observed spectrum in the CN band region around 3883 Å. To calibrate our estimate of [N/Fe], we make use of the giants observed in Apache Point Observatory Galaxy Evolution Experiment (APOGEE), which are also observed in the SDSS. This method will be applied to the Galactic halo stars to determine [N/Fe], and the measured nitrogen abundance ratios will be used to investigate the C-N anti-correlation, which is observed in globular clusters, to trace their origin with their kinematic properties.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제16권4호
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• pp.240-247
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• 2013

Purpose: Regurgitation is known to peak at the age of 3-4 months, with a sharp decrease around the age of 6 months. Little is known about the natural evolution of infants who still regurgitate after the age of 6 months. Methods: Hundred thirty-one infants older than 6 months regurgitating more than once a day were followed for a period of 3 months. Results: According to our data, gastroesophageal reflux disease (GERD) is seldom at this age. Most of the infants regurgitated 3 or more times/day and spit up an estimated volume of more than 15 mL. Eighty-five parents were educated regarding frequency of feeding. There were only 6 infants that still had frequent regurgitation (>3 times/day) despite an appropriate feeding schedule. The Infant GER Questionnaire score reached a score of 0 in 50% of the infants after one month of follow-up and in 81.9% at the third month of follow-up. There was an increase of the "weight for age z-score" trends in infants that still regurgitated at the end of follow-up and a declining z-score in infants that no longer regurgitated. An explanation may be that infants that regurgitate drink larger volumes than infants who do not regurgitate. Conservative treatment (reassurance, dietary treatment, behavioral advice) resulted in a significant better outcome than natural evolution. Conclusion: Regurgitation that persisted after the age of 6 months, strongly decreased during a 3-month follow-up with conservative treatment. GERD is rare in this age group; therefore, anti-reflux medication is only seldom needed.

• 분석과 대안
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• 제3권1호
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• pp.93-133
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• 2019

Throughout history, there are three clues of dualistic structures for the development of Hong Kong's nativism. First, inward attribution and outward lookingare two paths to the formation of Hong Kong's nativism. In the dualistic framework of "self-others", nativism is formed. The formation path of "outward looking"can be seen everywhere in the construction history of Hong Kong's nativism. It is under the reflection of "two mirrors" with Britain and Chinese mainland that Hong Kong people acquire the concept of "Hong Kong's nativism". Second, there are two aspects of Hong Kong's nativism: economic and cultural aspect and political aspect. With the gradual development of Hong Kong's history, these two aspects come into being and are closely bound up, thus constituting Hong Kong's nativism today. The third clue is the most critical one. The subjectivity of colonization and decolonization are two different forms of Hong Kong people's subjectivity. These three clues run through the whole process of the construction of Hong Kong nativism, and are carried out in three stages of development: "Origin (1960s-1970s): Preliminary Construction of Hong Kong's Nativism", "Development of Hong Kong's Nativism (1980s-1997): Awakening of Political Aspect" and "Formation and Alienation of Hong Kong's Nativism (1997-present): Deformed "decolonization". Along the evolution of Hong Kong's nativism, with the disintegration of colonialism, Hong Kong people have gradually transited from the subjectivity of colonization to the subjectivity of decolonization, but the process of "decolonization" has not been completed up to now.When nativism loses its native complex from the perspective of "inherent in China", and further develops into the "separatism" of anti-constitutional system and anti-national continuity and unity, it will challenge the stability of the relationship between the central government and the Special Administrative Region under the "one country, two systems". At the same time, it will have a greater impact on the political structure and the rule of law system of Hong Kong, and trigger a series of public law problems that need to be solved urgently. In this regard, on the one hand, we should re-clarify the relationship between the central government and the region under the "one country, two systems" in light of the new situation of democratic political development in Hong Kong, and improve Hong Kong's governance mechanism on the basis of the constitution and the basic law; on the other hand, we should actively learn from the German defensive democracy system to systematically interpret, integrate and apply Hong Kong's existing legal resources so as to effectively curb the development of local separatist forces.

• 대순사상논총
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• 제29집
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• pp.241-278
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• 2017

이 논문은 한국 종교에 대한 비판적인 견해의 대대적인 표출 현상(안티 종교운동)을 정리하고 유형화한 뒤 그 의미를 분석한 글이다. 이를 위해 먼저 현대의 범세계적인 종교변동부터 살폈다. 세계종교는 지구촌 의식 출현에 영향을 받아왔다. 그 결과 그들은 과거와의 연속성을 유지한 채 여러 종교의 공통 기반 위에서 보편성을 획득하려하고 있다. 그러한 모습은 스스로의 정체성을 계속 유지하려들거나, 전통을 재창조하려하거나 혹은 현대에 맞게 변용시키거나, 혁신적으로 변화를 추구하거나, 민족주의와 결탁하거나 하는 여러 유형으로 중첩되어 나타나곤 한다. 세계종교에서 살필 수 있는 이러한 변동들이 한국 사회에서는 어떻게 관찰되는가? 대체로 현 시대의 한국 종교상황은 개신교에 대한 비판이나 혁신 요구, 소수종교에 대한 공격, 학계와 언론의 종교 개혁요구, 종교무용론 전파, 유튜브 등 인터넷과 멀티미디어를 활용한 종교 비판 등으로 나타나고 있는 것으로 보인다. 이러한 종교 비판은 안티 종교운동으로 읽혀진다. 종교 외적으로는 서구 학자들이 제기하고 있는 종교무용론이나 과학 또는 역사적 관점에서의 종교 비판 이론이 서점을 중심으로 전파되고 있으며, 종교 내적으로는 개신교를 중심으로 자신의 내부를 반성하고 새로운 초종교적 영성을 강조하는 방향으로 흐르고 있다는 것이 그 내용이다. 과거에도 물론 종교 일반과 특정 종교에 대한 비판은 제기되었다. 그러나 최근에 우리나라에서 진행되고 있는 안티 종교운동은 그 내용과 맥락에서 과거와는 다른 양상으로 전개되고 있다. 특히 개신교에 대한 적극적이고 전반적인 비판 운동은 분명 새로운 현상임에 틀림없다. 적어도 개신교가 주요 대상이기는 하지만 현재 우리나라에서 진행되고 있는 안티 종교운동은 앞으로 우리나라의 종교변동을 살필 수 있는 주요 자료가 될 수 있을 것이다.

• Geomechanics and Engineering
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• 제8권4호
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• pp.541-557
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• 2015

This research aims to analyze the fracture coalescence characteristics of brittle sandstone specimen ($80{\times}160{\times}30mm$ in size) containing various flaws (a single fissure, double squares and combined flaws). Using a rock mechanics servo-controlled testing system, the strength and deformation behaviours of sandstone specimen containing various flaws are experimentally investigated. The results show that the crack initiation stress, uniaxial compressive strength and peak axial strain of specimen containing a single fissure are all higher than those containing double squares, while which are higher than those containing combined flaws. For sandstone specimen containing combined flaws, the uniaxial compressive strength of sandstone increase as fissure angle (${\alpha}$) increases from $30^{\circ}$ to $90^{\circ}$, which indicates that the specimens with steeper fissure angles can support higher axial capacity for ${\alpha}$ greater than $30^{\circ}$. In the entire deformation process of flawed sandstone specimen, crack evolution process is discussed detailed using photographic monitoring technique. For the specimen containing a single fissure, tensile wing cracks are first initiated at the upper and under tips of fissure, and anti-tensile cracks and far-field cracks are also observed in the deformation process; moreover anti-tensile cracks usually accompanies with tensile wing cracks. For the specimen containing double squares, tensile cracks are usually initiated from the top and bottom edge of two squares along the direction of axial stress, and in the process of final unstable failure, more vertical splitting failures are observed in the ligament region. When a single fissure and double squares are formed together into combined flaws, the crack coalescence between the fissure tips and double squares plays a significant role for ultimate failure of the specimen containing combined flaws.

• BMB Reports
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• 제47권5호
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• pp.262-267
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• 2014

Bcl-2 interacting cell death suppressor (Bis) has been shown to have anti-apoptotic and anti-stress functions. Recently, increased Bis expression was reported to correlate with glioma aggressiveness. Here, we investigated the effect of Bis knockdown on the acquisition of the invasive phenotype of A172 glioma cells, induced by 12-O-Tetradecanoylphorbol-3-acetate (TPA), using a Transwell assay. Bis knockdown resulted in a significant decrease in the migration and invasion of A172 cells. Furthermore, Bis knockdown notably decreased TPA-induced matrix metalloproteinase-9 (MMP-9) activity and mRNA expression, as measured by zymography and quantitative real time PCR, respectively. A luciferase reporter assay indicated that Bis suppression significantly down-regulated NF-${\kappa}B$-driven transcription. Finally, we demonstrated that the rapid phosphorylation and subsequent degradation of $I{\kappa}B-{\alpha}$ induced by TPA was remarkably delayed by Bis knockdown. These results suggest that Bis regulates the invasive ability of glioma cells elicited by TPA, by modulating NF-${\kappa}B$ activation, and subsequent induction of MMP-9 mRNA.