• Parasites, Hosts and Diseases
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• 제59권5호
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• pp.447-455
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• 2021

Vivax malaria incidence in Korea is now decreased and showing a low plateau. Nowadays, vivax malaria in Korea is expected to be successfully eliminated with anti-malaria chemotherapy, primaquine, and vector control. The glucose-6-phosphate dehydrogenase (G6PD) deficiency is associated with potential hemolytic anemia after primaquine administration. This inborn disorder has a pivotal polymorphism with genetic variants and is the most prevalent X-chromosome-linked disorder. The prevalence of G6PD deficiency was previously reported negligible in Korea. As the population of multicultural families pertaining marriage immigrants and their adolescents increases, it is necessary to check G6PD deficiency for them prior to primaquine treatment for vivax malaria. The prevalence of G6PD variants and G6PD deficiency in multicultural families was performed in 7 counties and 2 cities of Jeollanam-do (Province), Gyeonggi-do, and Gangwon-do. A total of 733 blood samples of multicultural family participants were subjected to test the phenotypic and genetic G6PD deficiency status using G6PD enzyme activity quantitation kit and PCR-based G6PD genotyping kit. The G6PD phenotypic deficiency was observed in 7.8% of male adolescent participants and 3.2% of materfamilias population. Based on the PCR-based genotyping, we observed total 35 participants carrying the mutated alleles. It is proposed that primaquine prescription should seriously be considered prior to malaria treatment.

• Parasites, Hosts and Diseases
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• 제61권2호
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• pp.154-162
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• 2023

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by X-linked recessive disorderliness. It induces severe anemia when a patient with G6PD deficiency is exposed to oxidative stress that occurs with administration of an antimalarial drug, primaquine. The distribution of G6PD deficiency remains unknown while primaquine has been used for malaria treatment in Myanmar. This study aimed to investigate the prevalence of G6PD deficiency and its variants in Chin State, Myanmar. Among 322 participants, 18 (11 males and 7 females) demonstrated a G6PD deficiency. Orissa variant was dominant in the molecular analysis. This would be related to neighboring Indian and Bangladeshi population, in which Orissa variant was also reported as the main mutation type. The screening test for G6PD deficiency before primaquine treatment appears to be important in Myanmar.

• Clinical and Experimental Pediatrics
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• 제49권11호
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• pp.1174-1179
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• 2006

목 적 : 비만과 철 결핍은 가장 중요한 영양문제이다. 비만아에서 철 결핍이 더 많다는 주장이 있지만, 국내에서는 이와 상반된 의견이 제시된바 있다. 본 연구는 인천지역 여중생의 비만과 철 결핍의 유병률을 알아보고 이들 사이에 어떤 관계가 있는지 알아보았다. 방 법 : 2005년 5월 인천시에 거주하는 14, 15세의 여중생 764명을 대상으로 신체 측정과혈액 검사를 실시하였다. 비만은 체질량지수 85 백분위수 이상을 비만으로 정하였다. 철 결핍은 페리틴이 10 ng/mL 미만으로 정의하였고, IDA는 혈색소가 12g/dL 미만이면서 페리틴 10 ng/mL 미만 또는 트랜스페린 포화도가 16% 미만인 경우로 정의하였다. 결 과 : 1) 인천시 여중생의 과체중 유병률은 24.4%(n=186)였다. 비만도에 의한 비만의 유병률은 16.5%(n=126)였다. 페리틴과 트랜스페린 포화도는 정상 체중군에서 가장 낮았다. 2) 철 결핍의 유병률은 18.7%(n=102), IDA의 유병률은 5.3%(n=41)였다. 3) BMI에 따른 철분 영양 상태를 보았을 때, 과체중군과 저체중군보다 정상체중군에서 철 결핍의 유병률이 높았다. 또한 비만군보다 비비만군이 철 결핍과 철 결핍성 빈혈의 유병률이 높았다. 결 론 : 인천 지역 여중생의 비만 유병률은 다른 지역보다 높은 경향을 보였다. 그러나 철 결핍은 크게 차이가 나지 않았다. 또한 정상 체중군에서 철 결핍이 많은 것으로 나타났다. 이는 비만군에서 음식섭취가 많아 철분의 섭취량도 많기 때문에 정상체중군에 비하여 비만군에서 철 결핍이 적은 것으로 생각된다.

• Clinical and Experimental Pediatrics
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• 제51권5호
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• pp.468-473
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• 2008

목 적 : IDA로 진단된 영유아의 어머니를 대상으로 수유 방법과 이유 진행사항 등의 실태를 조사하였고, 설문지 답변을 통하여 어머니가 가지고 있는 이유식에 대한 지식을 알아보았고, 그들의 이유식 관련 지식과 실제 나타나는 현실과의 차이점을 분석하였다. 방 법 : 2006년 3월부터 2007년 5월까지 인하대병원 외래 또는 입원한 영유아 중 IDA로 진단 받은 6-40개월 환아 111명(남:여=1.6:1)의 어머니를 대상으로 이유 실태 조사 및 이유지식에 관한 설문조사를 하여 다음과 같은 결과를 얻었다. 결 과 : 1) 혈액학적인 분포는 Hb는 $9.5{\pm}1.0g/dL$이었고, Hb 8 g/dL미만이 8.1%이었고, 9 g/dL 미만이 27.9%에 달하였다. MCV 70미만이 92명(82.8%)이었다. IDA가 분명한데도 페리틴 10 ng/dL 이상인 경우가 54명(48.6%)에 달하였다. 2) 이유식을 3개월 또는 그 이전에 이유식을 시작한 경우는 한 예도 없었고, 7개월 이후에 시작한 경우가 33.3%에 달하였다. 이유식의 평균 시작시기는 6.4 개월이었으며, 4-6개월에 시작한 경우(n=74)의 Hb은 $9.6{\pm}1.0g/dL$으로서, 7개월 이후에 시작한 경우(n=37)의 Hb $9.3{\pm}1.0g/dL$에 비하여 유의하게 높았다. 3) 이유식의 시작 시기가 늦을수록 Hb 수치가 낮게 나타났고, 생후 6개월까지 모유수유만 하고 이유식을 시작하지 않은 영유아들의 Hb 수치가 낮게 나타났다(P<0.05). 4) 처음 시도하는 이유식으로는 미음(82.6%), 과일즙(10.8%), 선식(4.5%) 등 순이었고, 주로 먹는 이유식의 종류는 야채죽(38.7%), 미음(36.9%), 과일즙(17.1%)의 순이었다. 주로 사용한 이유식은 집에서 만든 것이 87명(78.3%)이었고, 상품화된 이유식 사용은 7명(6.3%)이었다. 5) 어머니의 이유지식 점수는 대졸이상 그룹과 고졸 그룹 사이에 유의한 차이를 보이지 않았다. 또한 이유지식이 IDA중증도에 미치는 영향도 유의하지 않았다. 6) 이유식을 시도하여 4주 이내에 완성된 경우가 56명(50.4 %) 이었고, 나머지는 1개월 이상 걸렸으며, 3개월 이상 걸린 경우도 22명(20.0%)에 달하였다. 결 론 : 급성 감염이나 발열시에 페리틴 측정만으로 철결핍 및 IDA 진단을 내리기에는 한계가 있으며, 소구성 적혈구증 역시 IDA를 판정하는 중요한 지표가 될 수 있을 것이다. 많은 어머니가 이유지식이 부족하였고, 또한 상당한 이유지식을 가지고 있음에도 그 자녀에서 IDA가 발견되었으므로, 현재와 같은 이유식 방법을 지양하고, 이유식에 관한 교육 및 홍보를 강화한 좀더 개선된 방법이 모색되어야 할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권9호
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• pp.4391-4394
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• 2016

Background: Platinum-based regimens are effective treatments for advanced non-small cell lung cancer (NSCLC), but the five-year survival rate is still less than 20%. One possible factor appears to be resistance involving polymorphisms in the CTR1 gene which plays an importance role in accumulation of platinum in the cytoplasm. Purpose: To establish both prevalence of CTR1 polymorphism and its impact on treatment related toxicity in Thai advanced NSCLC patients. Materials and Methods: Thirty-two advanced NSCLC participants received carboplatin and gemcitabine during January to June 2016 at King Chulalongkorn Memorial Hospital (KCMH) were recruited for analysis of the CTR1 rs12686377 genotype. These participants were planning to be treated with platinum-based chemotherapy for at least two cycles. Results: Allele frequency of CTR1 polymorphism $G{\rightarrow}T$ was found to be 25%. The results showed that genetic polymorphism at CTR1 rs12686377 was associated with emesis side effects (P = 0.020) and neuropathic symptoms (P = 0.010). In addition, hematologic side effects in terms of anemia also tended to be related to this polymorphism. Conclusions: This is the first study suggesting that polymorphism at CTR1 rs12686377 may be associated with toxicity from platinum-based regimens. Therefore, it could be a factor to aid in treatment decision-making.

• 한국어병학회지
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• 제30권1호
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• pp.11-24
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• 2017

The current investigation dealing with the causative agent of mass mortalities in cultured Oreochromis niloticus. The diseased fish showed external hemorrhage, unilateral and bilateral eye opacity, ended by blindness and fish death. The postmortem lesions revealed congested friable kidney and spleen, and liver has yellow nodules. Obtained isolates were identified as Aeromonas hydrophila (the causative agent of Motile Aeromonas Septicemia) and found to be highly pathogenic as they contained hemolysin virulence gene causing mortality reached to 100 and 70% in intraperitoneal and intramuscular infection. The prevalence of MAS was 80% among the surveyed O. niloticus. Blood and serum were collected from naturally diseased, intraperitoneal and intramuscular injected O. niloticus for hematological and biochemical examination. Similarly, gills, musculature, kidney, liver and spleen were collected for histopathological evaluation, and micropathomorphological analysis of spleen was done. Macrocytic hypochromic anemia was recorded in the intraperitoneal infection. Serum protein, albumin and globulin were decrease only in naturally diseased fish. Leucocytosis with heterophilia and lymphocytosis were observed in naturally diseased and intraperitoneal infected fish. There were severe degenerative changes and hemorrhagic necrosis in the examined tissues which were more obvious in intraperitoneal than intramuscular infection. Activation and proliferation of melanocytes macrophages centers with severe hemosiderosis were recorded in spleen of naturally diseased and experimentally infected fish.

• Clinical Endoscopy
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• 제51권6호
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• pp.563-569
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• 2018

Background/Aims: To evaluate patients with portal hypertension (PH) of varied etiologies for portal hypertensive enteropathy (PHE) using the PillCam SB3 capsule endoscopy (CE) system. Methods: Consecutive patients with PH presenting with unexplained anemia and/or occult gastrointestinal bleeding were evaluated using the PillCam SB3 CE system. Abnormal findings were categorized as vascular or non-vascular. The patients with ongoing bleeding caused by PHE were treated. The correlation of the CE scores of PHE with the clinical, laboratory, and endoscopic features was determined. Results: Of the 43 patients included in the study, 41 (95.3%) showed PHE findings. These included varices (67.4%), red spots (60.5%), erythema (44.2%), villous edema (46.5%), telangiectasia (16.3%), and polyps (16.3%). The CE scores varied from 0 to 8 ($mean{\pm}standard$ deviation, $4.09{\pm}1.8$). Five patients (11.6%) showed evidence of ongoing or recent bleeding due to PHE. Three of these five patients underwent endotherapy, and one patient underwent radiological coil placement. Conclusions: The PillCam SB3 CE system revealed a high prevalence of PHE in the patients with PH. Using this system, evidence of bleeding due to PHE was found in a small but definite proportion of the patients.

• Journal of Veterinary Science
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• 제23권6호
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• pp.81.1-81.10
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• 2022

Background: Snakebites remain a devastating and life-threatening environmental hazard. While the management of snakebites has been well described in humans, few clinical data and guidelines exist for dogs, especially in Korea. Objectives: This retrospective study evaluated the clinical features of 70 dogs with snakebite wounds in Korea. Methods: The medical records of 72 dogs that presented to three animal hospitals from June 2008 to July 2021 were reviewed; among these, 70 dogs that met the inclusion criteria were enrolled. Their signalment, history, clinical signs, physical examination, blood analysis, treatment, and prognosis were also evaluated. Results: Of 70 dog owners, 35 (50%) witnessed the bite, with a mean time between bite and hospital presentation of 9.7 ± 4.1 h in 58 dogs. Blood smears were evaluated in 45 dogs, of which 28 (62%) showed echinocytosis. Anemia and acute kidney injury were found in 21 (29%) and 2 dogs (3%), respectively. A total of 37 dogs (53%) were hospitalized, 5 (7%) of which died. Conclusions: The most significant finding was the high prevalence of echinocytosis. The data from this retrospective study could inform the management of dogs bitten by snakes in Korea.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제27권2호
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• pp.113-124
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• 2024

Purpose: Alarm symptoms (red flag signs) are crucial indications for management decisions on pediatric gastrointestinal endoscopy. We aimed to identify items in the alarm symptoms and pre-endoscopic investigations that predict abnormal endoscopy results. Methods: A retrospective descriptive study was conducted among children aged under 18 years undergoing endoscopy. The patients were classified into normal and abnormal endoscopic groups. The incidence of alarm symptoms and pre-endoscopic investigations were compared between the groups. Univariate and multivariate logistic regression analyses were performed to determine independent risk factors for abnormal endoscopy. Results: Of 148 participants, 66 were classified in the abnormal endoscopy group. Compared with the normal group, the abnormal group had a significantly higher prevalence of alarm symptoms. Moreover, hematemesis/hematochezia, anemia, low hemoglobin level, hypoalbuminemia, rising erythrocyte sedimentation rate, increased serum lipase, and blood urea nitrogen/creatinine ratio were significantly higher in the abnormal endoscopy group than in the normal group. Multivariate logistic regression analysis indicated that hematemesis/hematochezia and low hemoglobin level were independent risk factors for abnormal endoscopy. Conclusion: The alarm symptoms and pre-endoscopic investigations were evaluated using predictive factors for abnormal pediatric endoscopic findings. According to multivariate logistic regression analysis, hematemesis/hematochezia and low hemoglobin levels were independent risk factors for abnormal endoscopy.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.9005-9008
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• 2014

Background: Gastric cancer is the second leading course of cancer death worldwide and H. pylori infection is an important risk factor for gastric cancer development. This study was design to evaluate the clinical, pathological features, survival rate and prevalence of H. pylori infection in gastric cancer in Thailand. Materials and Methods: Clinical information, histological features, endoscopic findings and H. pylori status were collected from gastric cancer patients from Thammasat university hospital during June 1996-December 2011. H. pylori infection was assessed by histological evaluation, rapid urease test and serological test. Clinical information, endoscopic findings and histopathology of all patients were recorded and compared between patients with active or non-active H. pylori infection. Results: A total of 100 gastric cancer patients (55 men and 45 women with mean age of $55{\pm}16.8years$) were enrolled in this study. Common presenting symptoms were dyspepsia (74%), weight loss (66%), anemia (63%) and anorexia (38%). Mean duration of symptoms prior to diagnosis was 98 days. Overall prevalence of H. pylori infection was 83% and active H. pylori infection was 40%. 1-year and 5-year survival rates were 43% and 0%. There was no significant difference between active H. pylori infection in different locations (proximal vs non-proximal: 47.1% vs 48.5%; P-value = 0.9, OR=0.9; 95%CI=0.3-3.1) and histology of gastric cancer (diffuse type vs intestinal type: 47.4% vs 50%; P-value = 0.8, OR=0.9, 95%CI=0.3-2.7). However, linitis plastica was significantly more common in non-active than active H. pylori infection (27.9% vs 0%; P-value<0.0001, OR=13.3, 95%CI=3.2-64.5). Moreover, gastric cancer stage 4 was higher in non-active than active H. pylori infection (93% vs 50%, P-value<0.001). Conclusions: Prevalence of H. pylori infection in Thai gastric cancer patients was high but active infection was low. Most gastric cancer patients presented in advance stage and had a grave prognosis. Screening for gastric cancer in high risk individuals might be an appropriate tool for early detection and improve the treatment outcome for this particular disease in Thailand.