Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
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Prevalence and molecular analysis of glucose-6-phosphate dehydrogenase deficiency in Chin State, Myanmar

  • Ja Moon Aung (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University) ;
  • Zin Moon (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University) ;
  • Dorene VanBik (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University) ;
  • Sylvatrie-Danne Dinzouna-Boutamba (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University) ;
  • Sanghyun Lee (Division of Healthcare and Artificial Intelligence, Department of Precision Medicine, Korea National Institute of Health, Korea Disease Control and Prevention Agency) ;
  • Zau Ring (Vector Borne Diseases Control Unit, Kachin State Public Health Department) ;
  • Dong-Il Chung (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University) ;
  • Yeonchul Hong (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University) ;
  • Youn-Kyoung Goo (Department of Parasitology and Tropical Medicine, School of Medicine, Kyungpook National University)
  • Received : 2023.01.10
  • Accepted : 2023.04.05
  • Published : 2023.05.31
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Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is caused by X-linked recessive disorderliness. It induces severe anemia when a patient with G6PD deficiency is exposed to oxidative stress that occurs with administration of an antimalarial drug, primaquine. The distribution of G6PD deficiency remains unknown while primaquine has been used for malaria treatment in Myanmar. This study aimed to investigate the prevalence of G6PD deficiency and its variants in Chin State, Myanmar. Among 322 participants, 18 (11 males and 7 females) demonstrated a G6PD deficiency. Orissa variant was dominant in the molecular analysis. This would be related to neighboring Indian and Bangladeshi population, in which Orissa variant was also reported as the main mutation type. The screening test for G6PD deficiency before primaquine treatment appears to be important in Myanmar.

Keywords

Acknowledgement

We acknowledge all the blood sample givers and all the staff from Chin Christian University who helped throughout the survey process. This research was financially supported by the Basic Science Research Program (NRF-2019R1C1C1002170) and the framework of the international cooperation program (2022K2A9A1A01098057, FY2022) funded by the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF).

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