• Bulletin of the Korean Chemical Society
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• v.32 no.9
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• pp.3327-3332
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• 2011

Antimicrobial peptides have recently gained the much attention because of their ability to make defense system from attacking bacterial infections. Drosocin has been considered as very attractive antibiotic agents because of low toxicity against human erythrocytes and active at the low concentration. We have studied the structureactivity relationship of a glycopeptide drosocin focused on the N-acetyl-D-galactoside at $Thr^{11}$ residue. Based on the radial diffusion assay, we found that the acetylation of carbohydrate moiety increased the antimicrobial activity and the $Pro^{10}$, present in the middle of drosocin plays an important role in the antimicrobial activity. Our results provide a good lead compound for further studies on the design of drosocin-based analogues targeting glyco linked Thr site.

• Progress in Superconductivity and Cryogenics
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• v.18 no.1
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• pp.41-45
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• 2016

The technology of supplying the electric power by wireless power transfer (WPT) is expected for the next generation power feeding system since it can supply the power to portable devices without any connectors through large air gap. As such a technology based on strongly coupled electromagnetic resonators is possible to deliver the large power and recharge them seamlessly; it has been considered as a noble option to wireless power charging system in the various power applications. Recently, various HTS wires have now been manufactured for demonstrations of transmission cables, motors, MAGLEV, and other electrical power components. However, since the HTS magnets have a lower index n value intrinsically, they are required to be charged from external power system through leads or internal power system. The portable area is limited as well as the cryogen system is bulkier. Thus, we proposed a novel design of wireless power charging system for superconducting HTS magnet (WPC4SM) based on resonance coupling method. As the novel system makes possible a wireless power charging using copper resonance coupled coils, it enables to portable charging conveniently in the superconducting applications. This paper presented the conceptual design and operating characteristics of WPC4SM using different shapes' copper resonance coil. The proposed system consists of four components; RF generator of 370 kHz, copper resonance coupling coils, impedance matching (IM) subsystem and HTS magnet including rectifier system.

• Bulletin of the Korean Chemical Society
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• v.34 no.11
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• pp.3243-3248
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• 2013

The tissue inhibitor of metalloproteinase-2 (TIMP-2) inhibits matrix metalloproteinases activity and modulates cellular proliferation and apoptosis. The human serum albumin-TIMP-2 with folic acid conjugate (termed HT2-folate) was synthesized to promote uptake through folate receptors (FRs), and a corresponding radio-labeled compound was prepared for tumor diagnosis by positron emission tomography (PET). $^{68}Ga$-NOTA-HT2-folate was synthesized from $^{68}Ga$ and the NOTA chelator with HT2-folate. The fusion protein was identified using MALDI-TOF mass spectrometry. The radioligand was prepared with a high radiochemical yield. Cell-surface association of $^{68}Ga$-NOTA-HT2-folate significantly increased over time in FR-positive tumor cells. In animal PET and biodistribution studies, tumor uptake was very high as early as 1 h after radioligand injection. Folate conjugation enhanced the selective receptor-targeting efficacy of HT2 in FRexpressing tumors, and its radioligand will be useful as an in vitro tool and for in vivo tumor diagnosis by PET imaging.

• Bulletin of the Korean Chemical Society
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• v.33 no.6
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• pp.1890-1894
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• 2012

Vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been implicated in the pathogenesis of rheumatoid arthritis, which is angiogenesis dependent. Antibody-based molecular imaging improves targeting, and antibody radiolabeling is useful for monitoring biological events $in$ $vivo$ $via$ PET or SPECT. We investigated the potential of molecular imaging to diagnose arthritis with VEGFR-2 $in$ $vivo$. The $^{123}I$-VEGFR-2 antibody was prepared by the iodogen tube method. The radioligand was injected into arthritic mice, and micro SPECT/CT was performed. The arthritic mice were examined by 4.7-T MRI and immunohistochemistry. The $^{123}I$-VEGFR-2 antibody showed high uptake in the arthritic region at 1 h postinjection on SPECT/CT but no uptake in the control animals after radioligand injection. In MR images, the arthritic tissue of the mice was correlated with regions labeled by the $^{123}I$-VEGFR-2 antibody. Immunohistochemical localization showed markedly increased expression of VEGFR-2 in the endothelial cells, fibroblasts, and macrophages of the arthritic mice.

• Korean Journal of Radiology
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• v.1 no.3
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• pp.142-151
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• 2000

Objective: To determine the optimal scan timing for contrast-enhanced magnetic resonance angiography and to evaluate a new timing method based on the arteriovenous circulation time. Materials and Methods: Eighty-nine contrast-enhanced magnetic resonance angiographic examinations were performed mainly in the extremities. A 1.5T scanner with a 3-D turbo-FLASH sequence was used, and during each study, two consecutive arterial phases and one venous phase were acquired. Scan delay time was calculated from the time-intensity curve by the traditional (n = 48) and/or the new (n = 41) method. This latter was based on arteriovenous circulation time rather than peak arterial enhancement time, as used in the traditional method. The numbers of first-phase images showing a properly enhanced arterial phase were compared between the two methods. Results: Mean scan delay time was 5.4 sec longer with the new method than with the traditional. Properly enhanced first-phase images were found in 65% of cases (31/48) using the traditional timing method, and 95% (39/41) using the new method. When cases in which there was mismatch between the target vessel and the time-intensity curve acquisition site are excluded, erroneous acquisition occurred in seven cases with the traditional method, but in none with the new method. Conclusion: The calculation of scan delay time on the basis of arteriovenous circulation time provides better timing for arterial phase acquisition than the traditional method.

• Journal of the Korean Magnetics Society
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• v.5 no.2
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• pp.99-102
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• 1995

When the low magnetic field is applied to the synunetry axis of the axial synunetric electric field gradient tensor of the quadrupolar nucleus in the crystal with nuclear spin, I=1, two split resonance frequencies are observed by the Zeeman effect on the nuclear quadrupole resonance. The applied magnetic field is proportional to the difference of the two resonance frequencies and this proportionality constant for the $^{14}N$ of ${(CH_{2})}_{6}N_{4}$ single crystal is 0.16 mT/kHz. The NQR spectrometer is interfaced with a personal computer from which the resonance signals are displayed and the value of magnetic field is obtained directly from the difference of the two resonance frequeocies. The lowestest measured magnetic field was 0.20 mT using this NQR technique.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.15 no.6
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• pp.8-14
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• 2001

MetalHalid lamps have good efficiency, good color rendition and good focusing capability. But the shortcoming of metalhalid lamps is blown as acoustic resonance phenomena in the arc tube. Such acoustic resonance produce annoying fluctuations in the intensity and distribution of the emitted light, they can raise the voltage to the point where the arc is extinguished and they can move the arc close enough to the wall to cause local overheating and tube cracking. The objective of this research is to reduce acoustic resonance in the arc tube of the Pulse Start MetaIHaide lamp(MH200[W]). To reduce the acoustic resonance phenomena the electronic ballast was designed for high frequency operation with the constant frequency sinusoidal wave of 89[kHz] in the 84.6[kHz]∼94.2[kHz] range. Experimental results show that the acoustic resonance phenomena are not in the arc tube of Pulse Start MetalHalide lamp (MH200[W]) .

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.4
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• pp.905-912
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• 2011

Interaocular pressure (IOP) sensor and external coil to detect the resonance frequency of the IOP sensor are designed and implemented using MEMS technology. The IOP sensor is designed using 3-D electromagnetic (EM) simulation. The resonance frequency of IOP sensor needs to be lower than that of the external coil. Additionally, the resonance frequency of the IOP sensor needs to be located near the resonance frequency of the coil to get the sufficient amplitude of phase variation. The frequency where the phase peak appears must be constant according to the distance between the IOP sensor and the external coil. From the measurement results, we demonstrated that the designed IOP sensor has the same resonance frequency with various distances between the IOP sensor and the coil.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.11 no.2
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• pp.11-18
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• 1989

Advancement of surgical techniques has made it necessary to accurately diagnose internal derangements. Arthrography and computerized tomography have been used to diagnose the majority of temporomandibular joint disorders, however, these methods have had their disadvantages. Magnetic resonance imaging utilizing surface coils has greatly improved the ability to diagnose meniscus abnormalities without using intrarticular injections or ionizing radiation. Ninety-two patients (184 joints) were evaluated by means of magnetic resonance imaging(MRI). Thirty-one patients (39 joints) were diagnosed as having meniscus perforation. Retrospective review of fifteen patients (20 joints) with a perforated meniscus diagnosed by magnetic resonance imaging pre-operatively demonstrated a sixty-five percent correlation between the radiographic diagnosis and the surgical findings.

• Journal of Power System Engineering
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• v.17 no.3
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• pp.23-27
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• 2013

In this research paper, we study on how to decrease the high vibration of turbine hood casings which are main facilities of power generation industry. Cause of Standard coal-fired power 500MW facilities turbine hoods' high vibration is that Natural frequency of hood casing designed in near domain frequency, when they are making hoods. We investigate to reduce high vibration at hood casing. We use FEM method to found how to avoid resonance, and test to confirm that our FEM result. We Finally attach minium mass plate at hood casing to avoid resonance and high vibration reduce lower $100{\mu}m$.