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The Animal Experiments of Total Artificial Heart at the National Cardiovascular Center in Japan (일본국립순환기병센터형 완전 인공심장을 이용한 동물실험)

  • 박영환
    • Journal of Chest Surgery
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    • v.27 no.10
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    • pp.824-832
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    • 1994
  • Recently we developed the concept of totally implantable electrohydraulic artificial heart. We tested the artificial heart which was drived by external compressive air in the calves. All three calves had pneumonia before surgery, so postoperative course was not only bad but also the results was not good. The first calf died severe pneumonia on 76th day, the second calf died from troublesome bleeding and uncertain allergic like reaction, and the third died because of bleeding. However, the performance of the artificial heart was good, and especially the blood contacting surface showed excellent hemocompatibility. The anatomic fitting was also very good even in the 35 Kg small newborn calf. During treadmill test, the first calf did not well tolerate for 1 minute but by the Full Fill Full Empty control method the artificial heart responsed well to the physiologic needs. In conclusion, the artificial heart had the very good hemocompatible surface, however, the volume of the artificial heart was a little deficient for the calf and the control algorithm needed further development.

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Performance Comparison Between the Envelope Peak Detection Method and the HMM Based Method for Heart Sound Segmentation

  • Jang, Hyun-Baek;Chung, Young-Joo
    • The Journal of the Acoustical Society of Korea
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    • v.28 no.2E
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    • pp.72-78
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    • 2009
  • Heart sound segmentation into its components, S1, systole, S2 and diastole is the first step of analysis and the most important part in the automatic diagnosis of heart sounds. Conventionally, the Shannon energy envelope peak detection method has been popularly used due to its superior performance in locating S1 and S2. Recently, the HMM has been shown to be quite suitable in modeling the heart sound signal and its use in segmenting the heart sound signal has been suggested with some success. In this paper, we compared the two methods for heart sound segmentation using a common database. Experimental tests carried out on the 4 different types of heart sound signals showed that the segmentation accuracy relative to the manual segmentation was 97.4% in the HMM based method which was larger than 91.5% in the peak detection method.

Comparison of Form Factors of Heart in ZangFu Diagrams before and after Northern Song Dynasty (북송 이전과 이후 장부도(臟腑圖)의 심장 형태요소의 비교)

  • Jo, Hak-Jun
    • The Journal of Korean Medical History
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    • v.30 no.2
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    • pp.101-118
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    • 2017
  • Purpose : This paper explores the extent to which ZangFu diagrams made after Northern Song Dynasty were influenced by ZangFu diagrams made before Northern Song Dynasty, and how diagrams of the whole body and heart originated from MingTangZangFuTu and affected each other when quoted in books published after Northern Song Dynasty. Method : The author used four form factors including heart shape, internal curved lines, cylinder-like structures above heart, and wuzangxi (五臟系) which resembles a lotus flower which has not yet bloomed, to analyze and compare different ZangFu diagrams before and after the Northern Song Dynasty. Results : Two form factors, the shape of heart and wuzangxi, are described in ZangFu diagrams before Northern Song, and may have influenced ZangFu diagrams after Northern Song. However, the other two form factors (internal curved lines and cylinder-like structures above the heart) did not influence ZangFu diagrams after Northern Song. All form factors of heart found in WuCangLiuFuZhiTu (within the whole body) and diagram of heart in ZhenJiuJuYing (鍼灸聚英) were most similar, but the two paintings became less similar as they were cited in several books. With the exception of the form factor with structures above heart, the three other form factors are almost identical between two paintings produced after Northern Song dynasty, as displayed in the same book. Conclusion : ZangFu diagrams of the heart produced after Northern Song Dynasty, were not completely based on ZangFu diagrams made before Northern Song Dynasty. Diagrams of whole body and those of the heart were changed, while influencing each other after Northern Song.

The Characters of Autonomic Nervous System in Heart Weak Children through Analysis of Heart Rate Variability (심박변이도 분석을 통한 심계 허약아의 자율신경계 특성)

  • Lee, Hye Lim;Han, Jae Kyung;Kim, Yun Hee
    • The Journal of Pediatrics of Korean Medicine
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    • v.27 no.3
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    • pp.1-11
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    • 2013
  • Objectives The purpose of this study is to evaluate the characteristics of autonomic nervous system in heart-weakened children via analyzing heart rate variability (HRV) compare to healthy children. Methods Among the children who have visited the department of pediatrics at OO oriental medicine hospital, the subjects were composed of 62 elementary school students without cardiac disorder, who have yet develop secondary sexual characteristics. Results 1. Mean HRT and SDNN of the heart-weakened group of children were lower than the healthy group, but with no statistical significance. 2. Heart-weakened children had higher LF norm and LF/HF ratio, but lower HF norm than healthy children. The rest of the Frequency Domain Index have no significant differences. 3. Heart-weak score showed a positive correlation with Mean HRT and LF/HF ratio. Conclusions Heart-weakened children had an imbalance in autonomic nervous system due to increase of sympathetic nerve activity and decrease of parasympathetic nerve activity.

Reliable Prognostic Cardiopulmonary Function Variables in 110 Patients With Acute Ischemic Heart Disease

  • Lee, Jeong Jae;Park, Chan-hee;You, Joshua (Sung) Hyun
    • Physical Therapy Korea
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    • v.29 no.3
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    • pp.200-207
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    • 2022
  • Background: The oxygen uptake efficiency slope (OUES) is the most important index for accurately measuring cardiopulmonary function in patients with acute ischemic heart disease. However, the relationship between the OUES variables and important cardiopulmonary function parameters remain unelucidated for patients with acute ischemic heart disease, which accounts for the largest proportion of heart disease. Objects: The present cross sectional clinical study aimed to determine the multiple relationships among the cardiopulmonary function variables mentioned above in adults with acute ischemic heart disease. Methods: A convenience sample of 110 adult inpatients with ischemic heart disease (age: 57.4 ± 11.3 y; 95 males, 15 females) was enrolled at the hospital cardiac rehabilitation center. The correlation between the important cardiopulmonary function indicators including peak oxygen uptake (VO2 peak), minute ventilation (VE)/carbon dioxide production (VCO2) slope, heart rate recovery (HRR), and ejection fraction (EF) and OUES was confirmed. Results: This study showed that OUES was highly correlated with VO2 peak, VE/VCO2 slope, and HRR parameters. Conclusion: The OUES can be used as an accurate indicator for cardiopulmonary function. There are other factors that influence aerobic capacity besides EF, so there is no correlation with EF. Effective cardiopulmonary rehabilitation programs can be designed based on OUES during submaximal exercise in patients with acute ischemic heart disease.

Mortality Analysis of Open Heart Surgery (75 Cases) (개심수술후의 사망예에 대한 임상적 고찰)

  • 김광택
    • Journal of Chest Surgery
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    • v.13 no.3
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    • pp.167-173
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    • 1980
  • From 1976 through June 1980, 75 patients underwent Open heart operation at Korea University Hospital.Of the 75 patients, 39 were congenital heart cases and 36 were acquired heart disease cases. 39 cases of congenital heart disease were consisting of 16 T.O.F.,4 A.S.D., 10 V.S.D., 3 P.S., 1 P.D.A., 1 V.S.D. + Mi, 1 Truncus arteriosus, 1 Ebstein, 1 D.C.R.V., 1 Single ventricle. Among 36 valvular replacement cases, 18 cases of MVR, 3 cases of AVR, 6 cases of Double valve replacement, and 10 cases of Open Mitral commissurotomy, were performed. Postoperative mortality rate of congenital heart disease was 25.6% and that of acquired heart disease was 8.3%. Overall mortality rate of open heart surgery was 17.3%. Among 16 cases of postoperative death cases, 5 cases of autopsy were performed. Postoperative cause of death of our series were intracranial bleeding, pacemaker failure, low output syndrome, protamine anaphylaxis, bleeding, prosthetic valve embolism, C V A, miliary tuberculosis, hypothermia due to pump failure.

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Numerical Investigation of Hemodynamics in a Bileaflet Mechanical Heart Valve using an Implicit FSI Based on the ALE Approach

  • Hong, Tae-Hyub;Choi, Choeng-Ryul;Kim, Chang-Nyung
    • Proceedings of the KSME Conference
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    • 2008.11b
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    • pp.2410-2414
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    • 2008
  • Human heart valves diseased by congenital heart defects, rheumatic fever, bacterial infection, cancer may cause stenosis or insufficiency in the valves. Treatment may be with medication but often involves valve repair or replacement (insertion of an artificial heart valve). Bileaflet mechanical heart valves (BMHVs) are widely implanted to replace the diseased heart valves, but still suffer from complications such as hemolysis, platelet activation, tissue overgrowth and device failure. These complications are closely related to both flow characteristics through the valves and leaflet dynamics. In this study, the physiological flow interacting with the moving leaflets in a bileaflet mechanical heart valve (BMHV) is simulated with a strongly coupled implicit fluid-structure interaction (FSI) method which is newly organized based on the Arbitrary-Lagrangian-Eulerian (ALE) approach and the dynamic mesh method (remeshing) in FLUENT. The simulated results are in good agreement with previous experimental studies. This study shows the applicability of the present FSI model to the complicated physics interacting between fluid flow and moving boundary.

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Animal Experiments of Heart Transplantation for Complicated Congenital Heart Disease in Neonate (신생아의 복잡심장기형에서 심장이식을 위한 동물실험)

  • 박영환;윤치순;정원석;김명옥;조범구
    • Journal of Chest Surgery
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    • v.32 no.6
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    • pp.504-509
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    • 1999
  • Background: Heart transplantation is considerated for a selected certain group of complicated congenital heart disease in neonates because corrective surgery is very difficult and has high mortality. Precise planning of transplantation is necessary to adequately fit the donor heart to the recipient. Material and Method: We have performed 4 neonatal pig heart transplantations to test the technical feasibility. Experiment 1: The transplantation was performed using the same technique as the adult heart transplantation. Experiment 2: The transplantation for hypoplastic left heart syndrome was simulated as we reconstructed the whole aortic arch with donor aorta. Experiment 3: The heart transplantation was done with radical pulmonary artery reconstruction. Experiment 4: The experiment was performed for a long term survival. Result: Preoperative planning was very important for adequate fitting. All animals could be weaned from cardiopulmonary bypass, however, two animals died due to bleeding at pulmonary artery and left atrium. Conclusion: We concluded that the neonatal heart transplantation can be applied in some complicated Further using animal model is mandatory.

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Clinical Experience of Cleft Lip and/or Palate Repair in Complex Congenital Heart Disease (선천성 복잡심장병 환아의 구순 구개열의 치험례)

  • Koh, Kyung Suk;Lee, Sang Hyuk;Eom, Jin Sup
    • Archives of Plastic Surgery
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    • v.32 no.3
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    • pp.385-388
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    • 2005
  • In cleft lip and/or palate patients with the complex congenital heart diseases, surgical repair of the cleft lip and/or palate has been postponed after the open heart surgery because the heart problem of the patient might cause more complications associated with anesthesia and surgery. There has been little report about experiences in the surgical management of these patients and optimal time of surgical intervention. Authors are introducing the experiences of performing corrective surgery of cleft lip and/or palate in the patients with congenital heart diseases before and after the open heart surgery. We managed five patients from May 1992 to March 2004. Two patients were male and the rest were female. One of them had cleft lip alone and others had cleft lip and palate. Two of them underwent delayed cleft lip and/or palate surgery after open heart surgery, and the rest had immediate intervention for cleft lip and/or palate. There was no complication during the operation and postoperative period. There would be no need to delay the corrective surgery of the cleft lip and/or palate after the open heart surgery, if solid medical team approach was available with the pediatric cardiologist and the anesthesiologist.

A Corpus-Based Study of the Use of HEART and HEAD in English

  • Oh, Sang-suk
    • Language and Information
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    • v.18 no.2
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    • pp.81-102
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    • 2014
  • The purpose of this paper is to provide corpus-based quantitative analyses of HEART and HEAD in order to examine their actual usage status and to consider some cognitive linguistic aspects associated with their use. The two corpora COCA and COHA are used for analysis in this study. The analysis of COCA corpus reveals that the total frequency of HEAD is much higher than that of HEART, and that the figurative use of HEART (60%) is two times higher than its literal use (32%); by contrast, the figurative use of HEAD (41%) is a bit higher than its literal use (38%). Among all four genres, both lexemes occur most frequently in fictions and then in magazines. Over the past two centuries, the use of HEART has been steadily decreasing; by contrast, that the use of HEAD has been steadily increasing. It is assumed that the decreasing use of HEART has partially to do with the decrease in its figurative use and that the increasing use of HEAD is attributable to its diverse meanings, the increase of its lexical use, and the partial increase in its figurative use. The analysis of the collocation of verbs and adjectives preceding HEART and HEAD, as well the modifying and predicating forms of HEART and HEAD also provides some relevant information of the usage of the two lexemes. This paper showcases that the quantitative information helps understanding not only of the actual usage of the two lexemes but also of the cognitive forces working behind it.

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