Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
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The Animal Experiments of Total Artificial Heart at the National Cardiovascular Center in Japan

일본국립순환기병센터형 완전 인공심장을 이용한 동물실험

  • Published : 1994.10.01
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Abstract

Recently we developed the concept of totally implantable electrohydraulic artificial heart. We tested the artificial heart which was drived by external compressive air in the calves. All three calves had pneumonia before surgery, so postoperative course was not only bad but also the results was not good. The first calf died severe pneumonia on 76th day, the second calf died from troublesome bleeding and uncertain allergic like reaction, and the third died because of bleeding. However, the performance of the artificial heart was good, and especially the blood contacting surface showed excellent hemocompatibility. The anatomic fitting was also very good even in the 35 Kg small newborn calf. During treadmill test, the first calf did not well tolerate for 1 minute but by the Full Fill Full Empty control method the artificial heart responsed well to the physiologic needs. In conclusion, the artificial heart had the very good hemocompatible surface, however, the volume of the artificial heart was a little deficient for the calf and the control algorithm needed further development.

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